Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 387-406 of 3585
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Brief Report: The Genetic Profile of Rheumatoid Factor?Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis
(Journal article; Peer reviewed, 2018) -
Broad-Spectrum Antibacterial Peptide Kills Extracellular and Intracellular Bacteria Without Affecting Epithelialization
(Peer reviewed; Journal article, 2021)New antibacterial drugs with novel modes of action are urgently needed as antibiotic resistance in bacteria is increasing and spreading throughout the world. In this study, we aimed to explore the possibility of using ... -
Broad-Spectrum Antiviral monotherapies: in silico drug repositioning against emergent viruses
(Master thesis, 2022)Utbruddet av SARS-CoV-2 har demonstrert realiteten av globale virale trusler. SARS-CoV-2 krysset arts barrierer og forårsaket en pandemi som verden ikke var forberedt på. Antiviraler er medikamenter som hemmer formeringen ... -
Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in nonhuman primates
(Peer reviewed; Journal article, 2023)The COVID-19 pandemic represents a global challenge that has impacted and is expected to continue to impact the lives and health of people across the world for the foreseeable future. The rollout of vaccines has provided ... -
Bronchial microdialysis monitoring of inflammatory response in open abdominal aortic aneurysm repair; an observational study.
(Journal article; Peer reviewed, 2017)Aortic surgery results in ischemia–reperfusion injury that induces an inflammatory response and frequent complications. The magnitude of the inflammatory response in blood and bronchi may be associated with the risk of ... -
Bronchoalveolar lavage fluid IFN- γ + Th17 cells and regulatory T cells in pulmonary sarcoidosis
(Journal article; Peer reviewed, 2014)In sarcoidosis, increased Th17 cell fractions have been reported in bronchoalveolar lavage fluid, and elevated numbers of Th17 cells producing IFN-𝛾 have been observed in peripheral blood. The balance between Th1, Th17, ... -
Bruk av antiepileptika i Norge og mulig virkningsmekanisme ved bipolar- og angstlidelse
(Master thesis, 2024)Bakgrunn og hensikt: Bruken av antiepileptika er økende i ikke-epilepsi indikasjoner som nevropatisk smerte, bipolar- og angstlidelse, migrene og alkoholabstinenser. Dette til tross for at kunnskapen om virkningsmekanismene ... -
Bruk av antiepileptika ved nevropatisk smerte i Norge, og mulig virkningsmekanisme
(Master thesis, 2024)Bakgrunn og hensikt: Gabapentin, pregabalin og karbamazepin er tre antiepileptiske legemidler (AEDs) som er godkjent ved indikasjonen nevropatiske smerter hos voksne over 18 år, i Norge. En del av denne oppgaven var å ... -
Bruk av botulinumtoksin A til barn med cerebral parese
(Peer reviewed; Journal article, 2019)BAKGRUNN Intramuskulære injeksjoner med botulinumtoksin A har i over 20 år vært en etablert behandling av spastisitet hos barn med cerebral parese. Vi undersøkte hvor mange barn med cerebral parese i Norge som får slik ... -
Bruk av gentamicin som oppstartsantibiotikum ved St. Olavs hospital HF - en prospektiv observasjonsstudie
(Master thesis, 2024)Hensikt: Antibiotisk terapi med aminoglykosidet gentamicin i kombinasjon med enkelte betalaktam-antibiotika er anbefalt som standard empirisk oppstartsbehandling ved en rekke infeksjoner, spesielt alvorlige infeksjoner, i ... -
Bruk av piperacillin/tazobaktam ved behandling av infeksjoner i abdomen - Kan intervensjoner bidra til å optimalisere forskrivningen?
(Master thesis, 2022)Introduksjon: Antibiotikaresistens er en trussel mot folkehelsen. Effektive tiltak for å bremse utviklingen er viktig for å kunne ha effektiv antibiotikabehandling også i fremtiden. De nasjonale retningslinjene for ... -
Bruk av psykofarmaka der farmakogenetiske analyser er aktuelt
(Master thesis, 2022)Bakgrunn: En betydelig andel av den norske befolkningen vil rammes av psykiske lidelser i løpet av ett år, og mange vil ha behov for medikamentell behandling med psykofarmaka. Det er imidlertid flere utfordringer knyttet ... -
Burden of bloodstream infection in an area of Mid-Norway 2002-2013: A prospective population-based observational study
(Journal article; Peer reviewed, 2017)Background Studies from several countries indicate that the incidence and mortality of bloodstream infection (BSI) have been increasing over time. Methods We studied the burden of disease and death related to BSI in ... -
The burden of hospital-attended influenza in Norwegian children
(Journal article; Peer reviewed, 2022) -
The Burden of Human Bocavirus 1 in Hospitalized Children with Respiratory Tract Infections
(Peer reviewed; Journal article, 2023)Background Human bocavirus 1 (HBoV1) is frequently codetected with other viruses, and detected in asymptomatic children. Thus, the burden of HBoV1 respiratory tract infections (RTI) has been unknown. Using HBoV1-mRNA ... -
The Burden of Human Coronavirus in Norwegian Children hospitalized with Respiratory Tract Infections
(Doctoral theses at NTNU;2022:359, Doctoral thesis, 2022) -
The burden of respiratory syncytial virus in children under 5 years of age in Norway
(Peer reviewed; Journal article, 2021)Abstract Objectives To estimate age-specific incidence of medically attended respiratory syncytial virus (RSV) infections in hospitalised Norwegian children and describe disease epidemiology. Methods Active prospective ... -
The burden of rheumatoid arthritis - physical fitness, function, and mortality
(Doctoral theses at NTNU;2023:243, Doctoral thesis, 2023)Patients with rheumatoid arthritis (RA) have higher mortality rates than the general population as well as lower cardiorespiratory fitness. They also have an increased risk of myocardial infarction of similar magnitudes ... -
Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes
(Journal article, 2017)Intravenously injected nanopharmaceuticals, including PEGylated nanoparticles, induce adverse cardiopulmonary reactions in sensitive human subjects, and these reactions are highly reproducible in pigs. Although the underlying ... -
Bystander memory T cells and IMiD/checkpoint therapy in multiple myeloma: A dangerous tango?
(Peer reviewed; Journal article, 2021)In this review article we discuss the role of the memory T cells in multiple myeloma (MM) and how they may influence immune responses in patients that received immunomodulating drugs and check point therapy