Now showing items 1-20 of 1951

    • 18F-FACBC PET/MRI in diagnostic assessment and neurosurgery of gliomas 

      Karlberg, Anna Maria; Berntsen, Erik Magnus; Johansen, Håkon; Skjulsvik, Anne Jarstein; Reinertsen, Ingerid; Hong, Yan Dai; Xiao, Yiming; Rivaz, Hassan; Borghammer, Per; Solheim, Ole; Eikenes, Live (Journal article; Peer reviewed, 2019)
      Purpose This pilot study aimed to evaluate the amino acid tracer 18F-FACBC with simultaneous PET/MRI in diagnostic assessment and neurosurgery of gliomas. Materials and Methods Eleven patients with suspected primary or ...
    • 18F-Fluciclovine PET/MRI for preoperative lymph node staging in high-risk prostate cancer patients 

      Selnæs, Kirsten Margrete; Krüger-Stokke, Brage; Elschot, Mattijs; Willoch, Frode; Størkersen, Øystein; Sandsmark, Elise; Moestue, Siver Andreas; Tessem, May-Britt; Halvorsen, Dag; Kjøbli, Eirik; Angelsen, Anders; Langørgen, Sverre; Bertilsson, Helena; Bathen, Tone Frost (Journal article; Peer reviewed, 2018)
      Objective To investigate the diagnostic potential of simultaneous 18F-fluciclovine PET/MRI for pelvic lymph node (LN) staging in patients with high-risk prostate cancer. Methods High-risk prostate cancer patients (n=28) ...
    • 3CAPS - A structural AP-site analogue as a tool to investigate DNA base excision repair 

      Schürmann, David; Scheidegger, Simon P.; Weber, Alain R.; Bjørås, Magnar; Leumann, Christian J.; Schär, Primo (Peer reviewed; Journal article, 2016)
      Abasic sites (AP-sites) are frequent DNA lesions, arising by spontaneous base hydrolysis or as intermediates of base excision repair (BER). The hemiacetal at the anomeric centre renders them chemically reactive, which ...
    • 5-hydroxymethylcytosine marks mammalian origins acting as a barrier to replication 

      Prikrylova, Terezia; Robertson, Julia; Ferrucci, Francesca; Konorska, Dorota Joanna; Aanes, Håvard; Manaf, Adeel; Zhang, Beibei; Vågbø, Cathrine Broberg; Kusnierczyk, Anna; Gilljam, Karin Margaretha; Løvkvam-Køster, Caroline; Otterlei, Marit; Dahl, John Arne; Enserink, Jorrit; Klungland, Arne; Robertson, Adam Brian (Journal article; Peer reviewed, 2019)
      In most mammalian cells, DNA replication occurs once, and only once between cell divisions. Replication initiation is a highly regulated process with redundant mechanisms that prevent errant initiation events. In lower ...
    • 53BP1 and BRCA1 control pathway choice for stalled replication restart 

      Xu, Yixi; Ning, Shaokai; Wei, Zheng; Xu, Ran; Xu, Xinlin; Xing, Mengtan; Guo, Rong; Xu, Dongyi (Journal article; Peer reviewed, 2017)
      The cellular pathways that restart stalled replication forks are essential for genome stability and tumor prevention. However, how many of these pathways exist in cells and how these pathways are selectively activated ...
    • 8-oxoguanine DNA glycosylase (Ogg1) controls hepatic gluconeogenesis 

      Scheffler, Katja; Rachek, Lyudmila; You, Panpan; Rowe, Alexander D.; Wang, Wei; Kuśnierczyk, Anna; Kittelsen, Lene Svendsen; Bjørås, Magnar; Eide, Lars (Journal article; Peer reviewed, 2018)
      Mitochondrial DNA (mtDNA) resides in close proximity to metabolic reactions, and is maintained by the 8-oxoguanine DNA glycosylase (Ogg1) and other members of the base excision repair pathway. Here, we tested the hypothesis ...
    • A balanced tissue composition reveals new metabolic and gene expression markers in prostate cancer 

      Tessem, May-Britt; Bertilsson, Helena; Angelsen, Anders; Bathen, Tone Frost; Drabløs, Finn Sverre; Rye, Morten Beck (Journal article; Peer reviewed, 2016)
      Molecular analysis of patient tissue samples is essential to characterize the in vivo variability in human cancers which are not accessible in cell-lines or animal models. This applies particularly to studies of tumor ...
    • A ChIP-Seq Benchmark Shows That Sequence Conservation Mainly Improves Detection of Strong Transcription Factor Binding Sites 

      Håndstad, Tony; Rye, Morten Beck; Drabløs, Finn; Sætrom, Pål (Journal article; Peer reviewed, 2011)
      Background: Transcription factors are important controllers of gene expression and mapping transcription factor binding sites (TFBS) is key to inferring transcription factor regulatory networks. Several methods for ...
    • A comparison of CT based measures of skeletal muscle mass and density from the Th4 and L3 levels in patients with advanced non-small-cell lung cancer 

      Grønberg, Bjørn Henning; Sjøblom, Bjørg; Wentzel-Larsen, Tore; Baracos, Vickie Elaine; Hjermstad, Marianne Jensen; Aass, Nina Kathrine; Bremnes, Roy M.; Fløtten, Øystein; Bye, Asta; Jordhøy, Marit Slaaen (Journal article; Peer reviewed, 2018)
      Background: Muscle mass and density assessed from CT-images at the L3 level are prognostic for survival and predict toxicity in cancer patients. However, L3 is not always included on routine CT-scans. We aimed to investigate ...
    • A comprehensive analysis of the structure-function relationship in proteins based on local structure similarity 

      Hvidsten, Torgeir; Lægreid, Astrid; Kryshtafovych, Andriy; Andersson, Gunnar; Fidelis, Krzysztof; Komorowski, J (Peer reviewed, 2009)
      Background:Sequence similarity to characterized proteins provides testable functional hypotheses for less than 50% of the proteins identified by genome sequencing projects. With structural genomics it is believed that ...
    • A Computational Analysis of Motif-Negative VDR-DNA Interaction and Possible Explanations of Its Mechanism of Interaction 

      Hayford, Claude Fiifi (Master thesis, 2014)
      Transcription factor binding to DNA has generally been assumed to be as a result of the recognition of sequence-specific motifs in the transcription factor binding sites. Recent studies have however shown several examples ...
    • A conservative weight loss intervention relieves bowel symptoms in morbidly obese subjects with irritable bowel syndrome: a prospective cohort study 

      Aasbrenn, Martin; Lydersen, Stian; Farup, Per Grønaas (Journal article; Peer reviewed, 2018)
      Background. Irritable bowel syndrome (IBS) is common in subjects with morbid obesity; the effect of weight loss programs on bowel symptoms is largely unknown. Methods. This prospective cohort study explored bowel symptoms, ...
    • A cross-sectional study examining the prevalence of cachexia and areas of unmet need in patients with cancer 

      Vagnildhaug, Ola Magne; Balstad, Trude Rakel; Almberg, Sigrun Saur; Brunelli, Cinzia; Knudsen, Anne Kari; Kaasa, Stein; Thronæs, Morten; Laird, Barry J; Solheim, Tora Skeidsvoll (Journal article; Peer reviewed, 2017)
      Purpose The semantics of defining cancer cachexia over the last decade has resulted in uncertainty as to the prevalence. This has further hindered the recognition and subsequent treatment of this condition. Following the ...
    • A data driven approach reveals disease similarity on a molecular level 

      Lakiotaki, Kleanthi; Georgakopoulos, George; Castanas, Elias; Røe, Oluf Dimitri; Borboudakis, Giorgos; Tsamardinos, Ioannis (Journal article; Peer reviewed, 2019)
      Could there be unexpected similarities between different studies, diseases, or treatments, on a molecular level due to common biological mechanisms involved? To answer this question, we develop a method for computing ...
    • A discrete dopaminergic projection from the incertohypothalamic A13 cell group to the dorsolateral periaqueductal gray in rat 

      Messanvi, F; Eggens-Meijer, E; Roozendaal, B; Van der Want, Johannes (Journal article; Peer reviewed, 2013)
      Several findings have indicated an involvement of dopamine in panic and defensive behaviors. The dorsolateral column of the periaqueductal gray (dlPAG) is crucially involved in the expression of panic attacks in humans and ...
    • A Dual Role of Autophagy in Disease Prevention and Drug Resistance 

      Johansson, Ida (Doctoral thesis at NTNU;2015:310, Doctoral thesis, 2015)
      Aging is associated with various diseases, such as neurodegenerative diseases. However, individual risk of developing these age-related diseases clearly varies due to differences in both genetic and environmental factors. ...
    • A European multi-centre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts 

      Hayes, Alexander G.; Nguyen, Dung; Andersson, Monique I; Anton, Andrés; Bailly, Jean-Luc; Beard, S.; Benschop, K.S.M..; Berginc, N; Blomqvist, S; Cunningham, E; Davis, D; Dembinski, Jennifer Lynn; Didrich, S; Dudman, Susanne Gjeruldsen; Eltringham, G.J.K.; Gonzales‐Goggia, S; Gunson, R; Howson‐Wells, H.C..; Jääskeläinen, A.J.; López‐Labrador, F.X.; Maier, M.; Majumbar, M; Midgley, S.; Mirand, A.; Morley, U.; Nordbø, Svein Arne; Oikarinen, S; Osman, H; Papa, A; Pellegrinelli, L; Piralla, A; Rabella, N; Richter, J.; Smith, M.; Söderlund Stran, A; Templeton, K; Vipond, B; Vuorinen, T; Williams, C.; Wollants, E; Zakikhany, K; Fischer, T. K.; Harvala, H; Simmonds, Peter (Journal article; Peer reviewed, 2019)
      Polymerase chain reaction (PCR) detection has become the gold standard for diagnosis and typing of enterovirus (EV) and human parechovirus (HPeV) infections. Its effectiveness depends critically on using the appropriate ...
    • A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts 

      Hayes, A; Nguyen, Dung; Andersson, Monique; Antón, Andres; Bailly, Jean-Luc; Beard, Stuart; Benschop, Kimberley; Berginc, Natasa; Blomqvist, Soile; Cunningham, Emma; Davis, D; Dembinski, Jennifer Lynn; Diedrich, Sabine; Dudman, Susanne Marie Rogne Gjeruldsen; Dyrdak, R; Eltringham, G. J. A.; Gonzales-Goggia, S; Gunson, R; Howson-Wells, H. C.; Jääskeläinen, A. J.; López-Labrador, F. Xavier; Maier, M.; Majumdar, M.; Midgley, S.; Mirand, A.; Morley, U.; Nordbø, Svein Arne; Oikarinen, S; Osman, H; Papa, A; Pellegrinelli, L; Piralla, A; Rabella, N; Richter, J; Smith, M; Söderlund Strand, A; Templeton, K; Vipond, B; Vuorinen, T; Williams, C; Wollants, E; Zakikhany, K; Fischer, T. K.; Harvala, H; Simmonds, P (Journal article; Peer reviewed, 2019)
      Polymerase chain reaction (PCR) detection has become the gold standard for diagnosis and typing of enterovirus (EV) and human parechovirus (HPeV) infections. Its effectiveness depends critically on using the appropriate ...
    • A Functional Polymorphism C-509T in TGFβ-1 Promoter Contributes to Susceptibility and Prognosis of Lone Atrial Fibrillation in Chinese Population 

      Cao, Hailong; Zhou, Qing; Lan, Rongfang; Røe, Oluf Dimitri; Chen, Xin; Chen, Yijiang; Wang, Dongjin (Journal article; Peer reviewed, 2014)
      Transforming growth factor-β1 (TGF-β1) is an important mediator of atrial fibrosis and atrial fibrillation (AF). But the involved genetic mechanism is unknown. Herein, the TGF-β1 C-509T polymorphism (rs1800469) was genotyped ...
    • A high precision method for quantitative measurements of reactive oxygen species in frozen biopsies 

      Berg, Kirsti; Ericsson, Madelene; Lindgren, Mikael; Gustafsson, Håkan (Journal article; Peer reviewed, 2014)
      Objective: An electron paramagnetic resonance (EPR) technique using the spin probe cyclic hydroxylamine 1-hydroxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine (CMH) was introduced as a versatile method for high ...