• norsk
    • English
  • English 
    • norsk
    • English
  • Login
View Item 
  •   Home
  • Øvrige samlinger
  • Publikasjoner fra CRIStin - NTNU
  • View Item
  •   Home
  • Øvrige samlinger
  • Publikasjoner fra CRIStin - NTNU
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Bronchoalveolar lavage fluid IFN- γ + Th17 cells and regulatory T cells in pulmonary sarcoidosis

Tøndell, Anders; Moen, Torolf; Børset, Magne; Salvesen, Øyvind; Rø, Anne Dorthea; Sue-Chu, Malcolm
Journal article, Peer reviewed
Thumbnail
View/Open
438070.pdf (2.326Mb)
URI
http://hdl.handle.net/11250/296315
Date
2014
Metadata
Show full item record
Collections
  • Institutt for klinisk og molekylær medisin [2067]
  • Institutt for sirkulasjon og bildediagnostikk [1048]
  • Publikasjoner fra CRIStin - NTNU [20842]
Original version
Mediators of Inflammation 2014, 2014   10.1155/2014/438070
Abstract
In sarcoidosis, increased Th17 cell fractions have been reported in bronchoalveolar lavage fluid, and elevated numbers of Th17

cells producing IFN-𝛾 have been observed in peripheral blood. The balance between Th1, Th17, and FoxP3+ CD4+ T cell subsets

in sarcoidosis remains unclear. Bronchoalveolar lavage fluid cells, from 30 patients with sarcoidosis, 18 patients with other diffuse

parenchymal lung diseases, and 15 healthy controls, were investigated with flow cytometry for intracellular expression of FoxP3. In a

subset of the patients, expression of the cytokines IL17A and IFN-𝛾 was investigated.Thefractions of FoxP3+ CD4+ T cells andTh17

cells were both lower in sarcoidosis compared to controls (𝑃 = 0.017 and 𝑃 = 0.011, resp.).The proportion ofTh17 cells positive for

IFN-𝛾 was greater in sarcoidosis than controls (median 72.4% versus 31%, 𝑃 = 0.0005) and increased with radiologic stage (𝑁 = 23,

rho = 0.45, and 𝑃 = 0.03). IFN-𝛾

+ Th17 cells were highly correlated withTh1 cells (𝑁 = 23, rho = 0.64, and 𝑃 = 0.001), and the

ratio of IFN-𝛾

+ Th17/FoxP3+ CD4+ T cells was prominently increased in sarcoidosis. IFN-𝛾

+ Th17 cells may represent a pathogenic

subset of Th17 cells, yet their expression of IFN-𝛾 could be a consequence of aTh1-polarized cytokine milieu. Our results indicate

a possible immune cell imbalance in sarcoidosis.
Publisher
Hindawi Publishing Corporation
Journal
Mediators of Inflammation

Contact Us | Send Feedback

Privacy policy
DSpace software copyright © 2002-2019  DuraSpace

Service from  Unit
 

 

Browse

ArchiveCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsDocument TypesJournalsThis CollectionBy Issue DateAuthorsTitlesSubjectsDocument TypesJournals

My Account

Login

Statistics

View Usage Statistics

Contact Us | Send Feedback

Privacy policy
DSpace software copyright © 2002-2019  DuraSpace

Service from  Unit