Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 1704-1723 of 1966
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T cell subsets in bronchoalveolar lavage fluid in sarcoidosis and other diffuse parenchymal lung diseases
(Doctoral thesis at NTNU;2015:49, Doctoral thesis, 2015)Slimhinnen i luftveiene og lungene er kontinuerlig eksponert for partikler, støv og en stor mengde mikrober fra omgivelsene. Ufarlige mikrober og partikler fjernes med minst mulig betennelsesreaksjon i vevet, slik at ... -
T1 bladder cancer in Norway: treatment and survival
(Peer reviewed; Journal article, 2020)Aim: Evaluation of treatment and survival of pT1 stage (T1) bladder cancer (BC) patients diagnosed with transitional cell carcinoma of the urinary bladder in Norway. Material and methods: According to the Cancer Registry ... -
Tailored microfluidic platforms for advanced neurobiology, neuroengineering and electrophysiology
(Doctoral theses at NTNU;2019:135, Doctoral thesis, 2019) -
Tar pasienter legemidler som forskrevet?
(Master thesis, 2009) -
Targeted correlative light and electron microscopy in the study of host-pathogen interactions
(Doktoravhandlinger ved NTNU;2018:89, Doctoral thesis, 2018)Abstract Tuberculosis (TB) and HIV are the two deadliest infectious diseases in the world today. 1,8 million people died from TB in 2015, 400.000 of which were HIV positive. Drug resistant TB strains are rapidly spreading, ... -
Targeted Next Generation sequencing identified novel gene variants involved in hereditary colorectal cancer
(Master thesis, 2015)cancer (CRC) is one of the most common types of cancer both worldwide and in Norway. Risk factors and mechanisms contributing to the disease are among dietary and lifestyle and somatic and inherited mutations. CRC is ... -
Targeted next-generation sequencing identified novel mismatch repair risk-variants involved in hereditary colorectal cancer
(Master thesis, 2015)Colorectal cancer (CRC) is the third most common malignancy worldwide, with over 1 million new cases annually. Around 30% of cases are believed to be familial with causal genetic alterations. However, fewer than 10% of ... -
Targeted next-generation sequencing of 22 mismatch repair genes identifies Lynch syndrome families
(Peer reviewed; Journal article, 2016)Causative germline mutations in mismatch repair (MMR ) genes can only be identified in ~50% of families with a clinical diagnosis of the inherited colorectal cancer (CRC ) syndrome hereditary nonpolyposis colorectal cancer ... -
Targeted sequencing of genes associated with the mismatch repair pathway in patients with endometrial cancer
(Peer reviewed; Journal article, 2020)Germline variants inactivating the mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2 cause Lynch syndrome that implies an increased cancer risk, where colon and endometrial cancer are the most frequent. Identification ... -
Targeting FKBP12 potentiates bone morphogenetic protein signaling in multiple myeloma cells
(Master thesis, 2019)Abstract Background Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells. Although new treatments approved in the last decades have improved patient outcomes considerably, most patients relapse ... -
Targeting Proliferating Cell Nuclear Antigen and Its Protein Interactions Induces Apoptosis in Multiple Myeloma Cells
(Journal article; Peer reviewed, 2013)Multiple myeloma is a hematological cancer that is considered incurable despite advances in treatment strategy during the last decade. Therapies targeting single pathways are unlikely to succeed due to the heterogeneous ... -
Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy
(Journal article, 2019)Receptor tyrosine kinases (RTKs), such as HER2 and/or EGFR are important therapeutic targets in multiple cancer cells. Low and/or short response to targeted therapies are often due to activation of compensatory signaling ... -
Targeting translesion synthesis by inhibiting protein interactions of the DNA sliding clamps
(Doctoral theses at NTNU;2019:354, Doctoral thesis, 2019) -
Tarmfloraen - på helsa løs
(Journal article, 2015) -
Teambasert læring - en studentaktiviserende og lærerstyrt undervisningsform
(Journal article; Peer reviewed, 2017)Bakgrunn: Studentaktiviserende undervisning er viktig for å oppnå god læring. I teambasert læring (TBL) aktiviseres studentene individuelt, gruppevis og i plenum under ledelse av faglærer. TBL er i liten grad prøvd ut og ... -
Test retest reliability of computer-based video analysis for the assessment of postural control in individuals with cerebral palsy
(Master thesis, 2017)BACKGROUND: Deficits in the control of posture is an important aspect of CP, as defined by SCPE and children with CP often exhibit activity limitations that are associated with postural control problems. However, there is ... -
Testing the flexibility of mitochondrial functioning in insulin-producing β-cells under diabetes like conditions in vitro
(Master thesis, 2019)Bakgrunn: Kronisk hyperglykemi er skadelig for de insulinproduserende β-cellene i pankreas. Mitokondrienes funksjon i disse cellene er helt essensiell for at β-cellene skal fungere optimalt. Mitokondriene påvirkes trolig ... -
Tetradecylthioacetic acid inhibits proliferation of human SW620 colon cancer cells - gene expression profiling implies endoplasmic reticulum stress
(Journal article; Peer reviewed, 2011)Background Previous reports have shown an antiproliferative effect of the synthetic, 3-thia fatty acid tetradecylthioacetic acid (TTA) on different cancer cells in vitro and in vivo. The mechanisms behind the observed ... -
TGF-β contamination of purified recombinant GDF15
(Journal article; Peer reviewed, 2017)Purified recombinant proteins for use in biomedical research are invaluable to investigate protein function. However, purity varies in protein batches made in mammalian expression systems, such as CHO-cells or HEK293-cells. ... -
The alternative complement pathway is dysregulated in patients with chronic heart failure
(Journal article; Peer reviewed, 2017)The complement system, an important arm of the innate immune system, is activated in heart failure (HF). We hypothesized that HF patients are characterized by an imbalance of alternative amplification loop components; ...