Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 485-504 av 1899
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E-cadherin cleavage by MT2-MMP regulates apical junctional signaling and epithelial homeostasis in the intestine
(Journal article; Peer reviewed, 2017)Cadherin-based intercellular adhesions are essential players in epithelial homeostasis, but their dynamic regulation during tissue morphogenesis and remodeling remain largely undefined. Herein, we characterize an unexpected ... -
Early BCR-ABL1 transcript decline after 1 month of tyrosine kinase inhibitor therapy as an indicator for treatment response in chronic myeloid leukemia
(Journal article; Peer reviewed, 2017)n chronic myeloid leukemia (CML), early treatment prediction is important to identify patients with inferior overall outcomes. We examined the feasibility of using reductions in BCR-ABL1 transcript levels after 1 month of ... -
Early gut mycobiota and mother-offspring transfer 2017 Aug 24;5(1):107. doi: 10.1186/s40168-017-0319-x.
(Journal article; Peer reviewed, 2017)Background The fungi in the gastrointestinal tract, the gut mycobiota, are now recognised as a significant part of the gut microbiota, and they may be important to human health. In contrast to the adult gut mycobiota, the ... -
Early identification of sepsis in hospital inpatients by ward nurses increases 30-day survival
(Journal article; Peer reviewed, 2016)Background: Systemic inflammatory response syndrome (SIRS) and sepsis are now frequently identified by observations of vital signs and detection of organ failure during triage in the emergency room. However, there is less ... -
Early intervention and follow-up programs among children with cerebral palsy in Moldova: potential impact on impairments?
(Journal article; Peer reviewed, 2020)AIM: To study whether early intervention services (EI) and a follow-up program (FU) influence outcomes of children with cerebral palsy (CP) in Moldova. METHODS: Records from 351 children with CP in Moldova born during 2009 ... -
Early metabolite changes after melatonin treatment in neonatal rats with hypoxic-ischemic brain injury studied by in-vivo 1H MR spectroscopy
(Journal article; Peer reviewed, 2017)Melatonin is a promising neuroprotective agent after perinatal hypoxic-ischemic (HI) brain injury. We used in-vivo 1H magnetic resonance spectroscopy to investigate effects of melatonin treatment on brain metabolism after ... -
Early motor repertoire and longterm motor, cognitive and adaptive function in infants at risk for neurological impairment
(Doctoral thesis at NTNU;2016:21, Doctoral thesis, 2016)Sammendrag: Tidlig motorisk repertoar og seinere motorisk, kognitiv og adaptiv funksjon hos barn med risiko for nevrologiske funksjonsforstyrrelser Spedbarn med risiko for nevrologisk funksjonsforstyrrelse inkluderer ... -
Early motor repertoire in very low birth weight infants in India is associated with motor development at one year
(Journal article; Peer reviewed, 2016)Background: Most studies on Prechtl's method of assessing General Movements (GMA) in young infants originate in Europe. Aim: To determine if motor behavior at an age of 3 months post term is associated with motor ... -
Early postnatal nutrition after preterm birth and cardiometabolic risk factors in young adulthood
(Journal article; Peer reviewed, 2018)Objectives Adults born preterm at very low birthweight (VLBW; <1500 g) have a non-optimal cardiometabolic risk factor profile. Since higher protein intake during the first weeks of life predicted a healthier body ... -
Early self-reported pain in juvenile idiopathic arthritis (JIA) is related to long-term outcomes. Results from the Nordic JIA cohort study.
(Journal article; Peer reviewed, 2018)Objective To study self‐reported pain early in the disease course of juvenile idiopathic arthritis (JIA) as predictor of long‐term disease outcomes. Methods Consecutive cases of JIA with disease onset 1997‐2000 from ... -
Early skin-to-skin contact or incubatorfor very preterm infants: study protocol for a randomized controlled trial
(Journal article; Peer reviewed, 2016)Background Skin-to-skin care immediately following delivery is a common practice for term infants and has been shown to improve cardiorespiratory stability, facilitate early bonding, and promote breastfeeding. Since ... -
Early, accurate diagnosis and early intervention in cerebral palsy: Advances in diagnosis and treatment
(Journal article; Peer reviewed, 2017)Importance Cerebral palsy describes the most common physical disability in childhood and occurs in 1 in 500 live births. Historically, the diagnosis has been made between age 12 and 24 months but now can be made before 6 ... -
Ectonucleotidase CD39 and Checkpoint Signalling Receptor Programmed Death 1 are Highly Elevated in Intratumoral Immune Cells in Non–small-cell Lung Cancer
(Journal article; Peer reviewed, 2019)Lung cancer is the leading cause of cancer death in both sexes worldwide and has a predicted 5-year survival rate of <20%. Immunotherapy targeting immune checkpoints such as the programmed death 1 (PD-1) signaling pathway ... -
Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn
(Journal article; Peer reviewed, 2015)Eculizumab is a humanized IgG2/4 chimeric anti-complement C5 antibody used to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) or atypical hemolytic uremic syndrome. The aim of this study was to evaluate whether ... -
Eculizumab-C5 complexes express a C5a neoepitope in vivo: Consequences for interpretation of patient complement analyses
(Journal article; Peer reviewed, 2017)The complement system has obtained renewed clinical focus due to increasing number of patients treated with eculizumab, a monoclonal antibody inhibiting cleavage of C5 into C5a and C5b. The FDA approved indications are ... -
Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: A double-blind cross-over trial
(Journal article; Peer reviewed, 2018)The increased prevalence of lifestyle diseases, such as the metabolic syndrome and type 2 diabetes mellitus (T2DM), calls for more knowledge on dietary treatments targeting the specific metabolic pathways involved in these ... -
Effect of a multifaceted educational program for care staff concerning fecal incontinence in nursing home patients: Study protocol of a cluster randomized controlled trial
(Journal article; Peer reviewed, 2015)Background Fecal incontinence has a high prevalence in the older population, which cannot be explained by comorbidity or the anatomical or psychological changes of aging alone. Fecal incontinence leads to a high economic ... -
Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial
(Journal article; Peer reviewed, 2016)Aims Interleukin-6 (IL-6) contributes to atherosclerotic plaque destabilization and is involved in myocardial injury during ischaemia–reperfusion. Interleukin-6 is therefore a potential therapeutic target in myocardial ... -
Effect of DHA on growth of two human colon cancer cell lines - the role of ER stress and unfolded protein response
(Master thesis, 2014)Docosahexaenoic acid (DHA; 22:6n-3) is an essential omega-3 polyunsaturated fatty acid important to human health. DHA has been shown to have anticancer properties by reducing cancer cell proliferation, inducing apoptosis ... -
Effect of photodynamic therapy using hexyl aminolevulinate and Amphinex – in vitro and in vivo studies
(Master thesis, 2011)Photodynamic therapy (PDT) is based on administration of photosensitizers (PS) which preferentially accumulates in tumor cells, followed by exposure of light that excites PS molecules and generation of singlet oxygen or ...