Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 171-190 of 1899
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Backbone 1H, 13C and 15N chemical shift assignment of full-length human uracil DNA glycosylase UNG2
(Journal article; Peer reviewed, 2017)Human uracil N-glycosylase isoform 2—UNG2 consists of an N-terminal intrinsically disordered regulatory domain (UNG2 residues 1–92, 9.3 kDa) and a C-terminal structured catalytic domain (UNG2 residues 93–313, 25.1 kDa). ... -
Bacterial Load in Daily Urine Samples of Patients Infected with Mycoplasma genitalium, Mutation Analysis, and Response to Treatment
(Peer reviewed; Journal article, 2016)Objective. Increasing macrolide resistant strains of Mycoplasma genitalium is a challenge, and to differentiate between treatment failure and reinfection a timely test of cure (TOC) is warranted. The aim of this study was ... -
Bacterial secretion systems and regulation of inflammasome activation
(Journal article, 2017)Innate immunity is critical for host defenses against pathogens, but many bacteria display complex ways of interacting with innate immune signaling, as they may both activate and evade certain pathways. Gram‐negative ... -
Bariatric surgery versus lifestyle interventions for severe obesity: 5-year changes in body weight, risk factors and comorbidities
(Journal article; Peer reviewed, 2017)Changes in body weight (BW), risk factors and comorbidities 5 years after Roux-en-Y gastric bypass (RYGB) or different lifestyle interventions are compared. A total of 209 (75% women) severe obese adults were non-randomly ... -
Barriers to and facilitators for implementing quality improvements in palliative care – results from a qualitative interview study in Norway
(Journal article; Peer reviewed, 2016)Background: Implementation of quality improvements in palliative care (PC) is challenging, and detailed knowledge about factors that may facilitate or hinder implementation is essential for success. One part of the ... -
Basal level of autophagy and MAP1LC3B-II as potential biomarkers for DHA-induced cytotoxicity in colorectal cancer cells
(Journal article, 2018)The omega‐3 fatty acid docosahexaenoic acid (DHA) is known as an anticancer agent. Colorectal cancer (CRC) cells exhibit different sensitivity toward DHA, but the mechanisms involved are still unclear. Gene expression ... -
Basal markers and prognosis in luminal breast cancer
(Journal article; Peer reviewed, 2017)Purpose Basal marker expression in triple-negative breast cancers identifies basal-like tumours, and thus separates the TN group into two prognostic groups. However, the expression and prognostic significance of basal ... -
Basic lifestyle advice to individuals at high risk of type 2 diabetes: a 2-year population-based diabetes prevention study. The DE-PLAN intervention in the HUNT Study, Norway
(Journal article; Peer reviewed, 2018)Objective Among individuals at high risk for diabetes identified through a population survey, we performed an intervention study with basic lifestyle advice aiming to prevent diabetes. Research design and methods Among ... -
Beauty and the Beast: The Multifaceted Potential of Mesenchymal Stem Cells in Bone Health and Disease
(Doctoral thesis at NTNU;2015:171, Doctoral thesis, 2015)Mesenkymale stamceller: Biologi og terapeutisk potensiale: Skjelettet er det som holder kroppen vår oppe, beskytter organene våre og det er samtidig en viktig kilde for kalsium og fosfater. Humant beinvev består av en ... -
Bedside dressing changes for open abdomen in the intensive care unit is safe and time and staff efficient
(Journal article; Peer reviewed, 2016)Background Patients with an open abdomen (OA) treated with temporary abdominal closure (TAC) need multiple surgical procedures throughout the hospital stay with repeated changes of the vacuum-assisted closure device (VAC ... -
Behandlingen av ekstremt premature barn - våre dyreste pasienter?: en studie av ressursbruken ved behandlingen av for tidlig fødte barn ved St. Olavs Hospital i perioden 1997-2007
(Master thesis, 2009)Treatment of extremely low birth weight infants – our most expensive patients? Background: Treatment of premature infants is expensive and increasing due to advanced medical technology and rising labour costs. Treatment ... -
Benzoic Acid-Inducible Gene Expression in Mycobacteria
(Journal article; Peer reviewed, 2015)Conditional expression is a powerful tool to investigate the role of bacterial genes. Here, we adapt the Pseudomonas putida-derived positively regulated XylS/Pm expression system to control inducible gene expression in ... -
Better tolerance of preservative-free latanoprost compared to preserved glaucoma eye drops: The 12-month real-life FREE study
(Journal article; Peer reviewed, 2018)Background: Lack of efficacy due to bad compliance caused by intolerance issues is the main reason for a change to a better tolerated ocular treatment, such as using preservative-free (PF) eye drops. Aim: To assess the ... -
Biases in second-trimester ultrasound dating related to prediction models and fetal measurements
(Doktoravhandlinger ved NTNU, 1503-8181; 2012:4, Doctoral thesis, 2012)FEILKILDER VED ULTRALYD-BASERT TERMINFASTSETTELSE I 2. TRIMESTER, RELATERT TIL PREDIKSJONSMETODER OG MÅLINGER Rutineundersøkelsen med ultralyd rundt svangerskapsuke 17–19 har vært en viktig del av norsk svangerskapsomsorg ... -
Bioaktive lipofile stoffer og deres effekt på inflammasjon i SH-SY5Y celler.
(Master thesis, 2019)Bakgrunn: Nevrodegenerative sykdommer (ND) defineres som forstyrrelser i sentrale- og perifere nervesystemet. Kronisk inflammasjon og svikt i mitokondrier er faktorer som er involvert i nevrologiske lidelser. Tetradecylt ... -
Biochemical profiling of diabetes disease progression by multivariate vibrational microspectroscopy of the pancreas
(Journal article; Peer reviewed, 2017)Despite the dramatic increase in the prevalence of diabetes, techniques for in situ studies of the underlying pancreatic biochemistry are lacking. Such methods would facilitate obtaining mechanistic understanding of diabetes ... -
Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism
(Peer reviewed; Journal article, 2016)Cytosine methylation in CpG dinucleotides is an epigenetic DNA modification dynamically established and maintained by DNA methyltransferases and demethylases. Molecular mechanisms of active DNA demethylation began to surface ... -
Biocompatibility and Biotolerability Assessment of Microspheres Using a Whole Blood Model
(Journal article, 2013)The whole blood model is a powerful method to determine the immediate inflammatory reactions towards foreign objects in general. This review focuses on the use of a lepirudin based whole blood model for evaluating microspheres ... -
Biodegradation of Dispersed Oil in natural Seawaters from Western Greenland and a Norwegian fjord
(Journal article; Peer reviewed, 2018)With increasing oil exploration, production and transportation in the Arctic, predictions of the fate of spilled oil become important, including oil compound biodegradation. The use of chemical dispersants may result in ... -
Biomarker discovery in multiple myeloma progression by quantitative proteomics
(Doctoral theses at NTNU;2018:305, Doctoral thesis, 2018)SAMMENDRAG Myelomatose (multipel myelom, benmargskreft) er en krefttype som skyldes ukontrollert vekst av plasmaceller i benmarg. Det er den nest vanligste hematologiske kreftformen og rammer ca. 300 personer i Norge hvert ...