Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 1457-1476 of 1966
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R2* Relaxation Affects Pharmacokinetic Analysis of Dynamic Contrast-Enhanced MRI in Cancer and Underestimates Treatment Response at 7 T
(Journal article, 2019)Effective transverse relaxivity of gadolinium-based contrast agents is often neglected in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Here, we assess time and tissue dependence of R2* enhancement and ... -
Rab11a GTPase controls Toll-like receptor 4 trafficking and signaling
(Master thesis, 2010)Rab GTPases are involved in controlling the endosomal pathway, and we have developed an expression system allowing us to study the expression and trafficking of these molecules in live cells. Toll-like receptor 4 (TLR4) ... -
Radiological and epidemiological aspects of mammographic screening
(Doktoravhandlinger ved NTNU, 1503-8181; 2013:298, Doctoral thesis, 2013)Breast cancer is the most frequent cancer and the most frequent cause of cancer death in women worldwide. Service screening programs have been implemented in many countries in the western world, with the intention to reduce ... -
Radiologisk vekstmåling av glioblastomer
(Master thesis, 2016)Bakgrunn: Anbefalt metode for bedømming av vekst av glioblastomer er i dag todimensjonale mål i henhold til RANO-kriteriene. En viktig svakhet ved denne metoden er at den bruker todimensjonale mål på en irregulær tredimensjonal ... -
Radiotherapy for prostate cancer – Does daily image guidance with tighter margins improve patient reported outcomes compared to weekly orthogonal verified irradiation? Results from a randomized controlled trial
(Journal article; Peer reviewed, 2018)Background Novel cancer drugs are subject to strict scientific evaluation of safety and efficacy and usually undergo a cost effectiveness analysis before approval for use in clinical practice. For new techniques in ... -
Radiotherapy in anal carcinoma and prostate cancer
(Doktoravhandlinger ved NTNU, 1503-8181; 2008:318, Doctoral thesis, 2008)Moderne kreftbehandling har medført at flere pasienter blir friske og flere lever i mange år etter diagnose. Behandlingen består ofte av en kombinasjon av flere behandlingsformer, hvilket medfører en økt risiko for ... -
Radiotherapy in patients with bone metastases; treatment schedules and evaluations
(Doktoravhandlinger ved NTNU, 1503-8181; 2014:162, Doctoral thesis, 2014)Strålebehandling til pasienter med spredning til skjelett; strålefraksjoner og evalueringer Spredning av kreft til skjelett (skjelettmetastaser) den vanligste årsaken til krefsmerte. Strålebehandling gir en effektiv ... -
Raised serum levels of syndecan-1 (CD138), in a case of acute idiopathic systemic capillary leak syndrome (SCLS) (Clarkson's disease)
(Journal article; Peer reviewed, 2018)BACKGROUND: Systemic capillary leak syndrome (SCLS) (Clarkson’s disease) is a rare disorder of unknown etiology, characterized by transient episodes of hypotension, and the microvascular leak of fluids into the peripheral ... -
Randomized clinical trial of topical tranexamic acid after reduction mammoplasty
(Journal article; Peer reviewed, 2015)Background The antifibrinolytic drug tranexamic acid is currently being rediscovered for both trauma and major surgery. Intravenous administration reduces the need for blood transfusion and blood loss by about one-third, ... -
Randomized phase II trial comparing twice daily hyperfractionated with once daily hypofractionated thoracic radiotherapy in limited disease small cell lung cancer
(Journal article; Peer reviewed, 2016)Background: Concurrent chemotherapy and thoracic radiotherapy (TRT) is recommended for limited disease small cell lung cancer (LD SCLC). Twice daily TRT is well documented, but not universally implemented – probably mainly ... -
A randomized study of the effect of patient positioning on setup reproducibility and dose distribution to organs at risk in radiotherapy of rectal cancer patients
(Peer reviewed; Journal article, 2015)Background:The patient positioning in pelvic radiotherapy (RT) should be decided based on both reproducibilityand on which position that yields the lowest radiation dose to the organs at risk (OAR), and thereby less ... -
Ranking of substances for monitoring in foods, drinks and dietary supplements - based on risk and knowledge gaps
(VKM Report;, Research report, 2019)The Norwegian Food Safety Authority (NFSA) requested the Norwegian Scientific Committee for Food and Environment (VKM) to provide an overview of substances in foods, drinks and dietary supplements that may constitute a ... -
Rapid acting fentanyl formulations in breakthrough pain in cancer. Drug selection by means of the System of Objectified Judgement Analysis
(Journal article; Peer reviewed, 2017)Drug selection of rapid acting fentanyl formulations in the treatment of breakthrough pain in patients with cancer is performed by the System of Objectified Judgement Analysis method. All seven available formulations were ... -
Rationale for the ASSAIL-MI-trial: a randomised controlled trial designed to assess the effect of tocilizumab on myocardial salvage in patients with acute ST-elevation myocardial infarction (STEMI).
(Journal article; Peer reviewed, 2019)Introduction Interleukin-6 (IL-6) may be involved in ischaemia-reperfusion injury and myocardial remodelling after myocardial infarction (MI). We have recently shown that IL-6 inhibition by tocilizumab attenuates systemic ... -
Re-assessment of the plant protection product PROMAN – with the active ingredient metobromuron. Opinion of the Panel on Plant Protection Products of the Norwegian Scientific Committee for Food Safety
(VKM Report;, Research report, 2015)Proman is a broad spectrum selective herbicide for potatoes grown outdoors, containing the active substance metobromuron. VKM’s Panel on Plant Protection Products has previously discussed questions concerning Proman raised ... -
Real-time analysis of endogenous protoporphyrin IX fluorescence from δ-aminolevulinic acid and its derivatives reveals distinct time- and dose-dependent characteristics in vitro
(Journal article; Peer reviewed, 2014)Abstract. Photodynamic therapy (PDT) and photodiagnosis based on the intracellular production of the photosensitizer protoporphyrin IX (PPIX) by administration of its metabolic precursor δ-aminolevulinic acid (ALA) achieved ... -
Reasons for prolonged time for diagnostic workup for stage I-II lung cancer and estimated effect of applying an optimized pathway for diagnostic procedures
(Journal article; Peer reviewed, 2019)Background:Minimizing the time until start of cancer treatment is a political goal. In Norway, the target time forlung cancer is 42 days. The aim of this study was to identify reasons for delays and estimate the effect on ... -
Recessive Truncating Mutations in ALKBH8 Cause Intellectual Disability and Severe Impairment of Wobble Uridine Modification
(Journal article; Peer reviewed, 2019)The wobble hypothesis was proposed to explain the presence of fewer tRNAs than possible codons. The wobble nucleoside position in the anticodon stem-loop undergoes a number of modifications that help maintain the efficiency ... -
Reconstituted High-Density Lipoprotein Attenuates Cholesterol Crystal-Induced Inflammatory Responses by Reducing Complement Activation
(Journal article; Peer reviewed, 2015)Chronic inflammation of the arterial wall is a key element in the development of atherosclerosis, and cholesterol crystals (CC) that accumulate in plaques are associated with initiation and progression of the disease. We ... -
Rectal cancer surgery: Prognostic Factors Related to Treatment
(Doktoravhandlinger ved NTNU, 1503-8181; 2012:284, Doctoral thesis, 2012)Background Towards the end of the 80-ties, 28 % of the rectal cancer patients treated for cure developed local recurrence, and only 55 % survived five years. Since 1993, intensified focus on the rectal cancer patients has ...