Institutt for klinisk og molekylær medisin
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Increased glycolysis and higher lactate production in hyperglycemic myotubes
(Journal article; Peer reviewed, 2019)Previous studies have shown that chronic hyperglycemia impairs glucose and fatty acid oxidation in cultured human myotubes. To further study the hyperglycemia-induced suppression of oxidation, lactate oxidation, mitochondrial ... -
Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression
(Journal article; Peer reviewed, 2019)Base excision repair (BER) initiated by alkyladenine DNA glycosylase (AAG) is essential for removal of aberrantly methylated DNA bases. Genome instability and accumulation of aberrant bases accompany multiple diseases, ... -
A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts
(Journal article; Peer reviewed, 2019)Polymerase chain reaction (PCR) detection has become the gold standard for diagnosis and typing of enterovirus (EV) and human parechovirus (HPeV) infections. Its effectiveness depends critically on using the appropriate ... -
Mixed evidence for the relationship between periodontitis and Alzheimer’s disease: A bidirectional Mendelian randomization study
(Journal article; Peer reviewed, 2020)Recent experimental studies indicated that a periodontitis-causing bacterium might be a causal factor for Alzheimer’s disease (AD). We applied a two-sample Mendelian randomization (MR) approach to examine the potential ... -
Experimental-Computational Approaches to Identify Synergistic Effects of Anti-Cancer Drugs
(Doctoral theses at NTNU;2019:384, Doctoral thesis, 2019) -
Nutritional experiences in head and neck cancer patients
(Journal article; Peer reviewed, 2019)Objective Extensive research has documented the negative nutritional impact of head neck cancer (HNC) treatment, but few studies have addressed the patients' experiences. The purpose of this study was to describe how ... -
Effects of supervised exercise training during pregnancy on psychological well-being among overweight and obese women: secondary analyses of the ETIP-trial, a randomised controlled trial
(Journal article; Peer reviewed, 2019)Objectives Women with high body mass index (BMI) have increased risk for symptoms of anxiety and depression during pregnancy and postpartum. In this prespecified secondary analysis from the exercise training in pregnancy ... -
Sensing of HIV-1 by TLR8 activates human T cells and reverses latency
(Journal article; Peer reviewed, 2020)During HIV infection, cell-to-cell transmission results in endosomal uptake of the virus by target CD4+ T cells and potential exposure of the viral ssRNA genome to endosomal Toll-like receptors (TLRs). TLRs are instrumental ... -
Timelines in Lung Cancer Diagnostic Workup
(Doctoral theses at NTNU;2019:241, Doctoral thesis, 2019)Lange ventetider for å starte kreftutredning eller -behandling fører til bekymring og oppfattes som en medisinsk risiko som kan påvirke mulighetene til å få effektiv behandling. Derfor er det innført krav til ventetider i ... -
Associations between severe co-morbidity and muscle measures in advanced non-small cell lung cancer patients
(Journal article; Peer reviewed, 2019)Introduction Several studies show that low skeletal muscle index (SMI) and low skeletal muscle density (SMD) are negative prognostic factors and associated with more toxicity from systemic therapy in cancer patients. ... -
Additive manufacturing of laminar flow cells for single-molecule experiments
(Journal article; Peer reviewed, 2019)A microfluidic laminar flow cell (LFC) forms an indispensable component in single-molecule experiments, enabling different substances to be delivered directly to the point under observation and thereby tightly controlling ... -
An in-hospital clinical care pathway with integrated decision support for cancer pain management reduced pain intensity and needs for hospital stay
(Journal article; Peer reviewed, 2019)Purpose A clinical care pathway for pain management in a palliative care unit was studied with outcomes related to patients, physicians, and health care service. Mandatory use of patient-reported outcome measures (PROMs) ... -
Impact of a FTO gene risk variant on variables of energy metabolism in adults with obesity class 2 and 3
(Journal article; Peer reviewed, 2019)Purpose The metabolic consequences of carrying a FTO obesity-promoting risk allele have not been fully elucidated and may be confounded by obesity per se. Against this background, we investigated the impact of FTO allele ... -
Survivors' knowledge of their diagnosis, treatment and possible late adverse effects after autologous stem cell transplantation for lymphoma
(Journal article; Peer reviewed, 2019)Purpose: Lymphoma survivors after high dose therapy with autologous stem cell therapy (HD-ASCT) are at high risk for late adverse effects (AEs). Information patients receive and collect throughout their cancer trajectory ... -
Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy
(Journal article, 2019)Receptor tyrosine kinases (RTKs), such as HER2 and/or EGFR are important therapeutic targets in multiple cancer cells. Low and/or short response to targeted therapies are often due to activation of compensatory signaling ... -
Causes of inferior relative survival after testicular germ cell tumor diagnosed 1953–2015: A population-based prospective cohort study
(Journal article; Peer reviewed, 2019)Background Testicular germ cell tumor (TGCT) patients and survivors have excess mortality compared to the general male population, but relative survival (RS) has been scarcely studied. We investigated causes of excess ... -
Academic detailing as a method of continuing medical education
(Journal article; Peer reviewed, 2019)Introduction: Academic detailing is an interactive educational outreach to prescribers to present unbiased, non-commercial, evidence-based information, mostly about medications, with the goal of improving patient care. ... -
The effect of antenatal depression and antidepressant treatment on placental tissue: a protein-validated gene expression study
(Journal article; Peer reviewed, 2019) -
Continuing increased risk of second cancer in long-term testicular cancer survivors after treatment in the cisplatin era
(Journal article; Peer reviewed, 2019)Using complete information on total treatment burden, this population‐based study aimed to investigate second cancer (SC) risk in testicular cancer survivors (TCS) treated in the cisplatin era. The Cancer Registry of Norway ... -
Diversity in changes of HRQoL over a one-year period after radiotherapy in Norwegian breast cancer survivors – results of cluster analyses
(Journal article; Peer reviewed, 2019)Purpose The diversity in long-term changes in health-related quality of life (HRQoL) among breast cancer (BC) survivors is poorly understood. The aim of this study was to identify clusters of trajectories (subgroups of ...
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