Institutt for klinisk og molekylær medisin
Recent Submissions
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Image-Guided Radiotherapy for Prostate Cancer and Side Effects after Treatment
(Doctoral theses at NTNU;2019:62, Doctoral thesis, 2019)Norsk sammendrag Prostatakreft er den vanligste kreftsykdommen blant norske menn med nesten 5000 nye tilfeller diagnostisert i 2016. Prognosen ved lokalisert sykdom er god og samlet 5-års overlevelse er nå godt over 90%. ... -
Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction
(Journal article; Peer reviewed, 2018)Aim To evaluate the effect of interleukin-6 inhibition with tocilizumab on the cytokine network in patients with acute non-ST-elevation myocardial infarction (NSTEMI). Methods 117 patients with acute NSTEMI were randomised ... -
Anesthesia for Cesarean Delivery: A Cross-Sectional Survey of Provincial, District, and Mission Hospitals in Zimbabwe
(Journal article; Peer reviewed, 2017)Abstract BACKGROUND: Cesarean delivery is the most common surgical procedure in low- and middle-income countries, so provision of anesthesia services can be measured in relation to it. This study aimed to assess the type ... -
Granulocyte and monocyte CD11b expression during plasma separation is dependent on complement factor 5 (C5) – an ex vivo study with blood from a C5‐deficient individual
(Journal article, 2018)The aim of the study was to investigate the role of complement factor 5 (C5) in reactions elicited by plasma separation using blood from a C5‐deficient (C5D) individual, comparing it to C5‐deficient blood reconstituted ... -
Comorbidities in cerebral palsy: a patient registry study
(Journal article; Peer reviewed, 2019)Aim To describe the total burden of disease in individuals with cerebral palsy (CP) in Norway. Method A comprehensive set of disorder categories were extracted from the Norwegian Patient Registry using International ... -
Trans-fatty acids and survival in renal transplantation
(Journal article; Peer reviewed, 2018)Objective High consumption of trans-fatty acids (TFAs) is associated with increased mortality. Design and methods Observational cohort study of 1.988 Norwegian renal transplant recipients with a median follow-up time ... -
Soluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarction
(Journal article; Peer reviewed, 2018)Background The inflammatory response following myocardial infarction (MI) is prerequisite for proper healing of infarcted tissue, but can also have detrimental effects on cardiac function. Interleukin (IL)-1α and IL-1β ... -
Plasma n-6 Polyunsaturated Fatty Acid Levels and Survival in Renal Transplantation
(Journal article; Peer reviewed, 2018)Objective The major n-6 polyunsaturated fatty acids linoleic acid (LA) and arachidonic acid (AA) play a role in inflammation and glucose metabolism, which could affect patient and renal transplant survival. Design and ... -
The APIM-peptide, a novel anti-cancer drug targeting the stress-related roles of PCNA
(Doctoral theses at NTNU;2019:186, Doctoral thesis, 2019) -
Inflammatory biomarkers are associated with aetiology and predict outcomes in community-acquired pneumonia: Results of a 5-year follow-up cohort study
(Journal article; Peer reviewed, 2019)Background Biomarkers may facilitate clinical decisions in order to guide antimicrobial treatment and prediction of prognosis in community-acquired pneumonia (CAP). We measured serum C-reactive protein, procalcitonin (PCT) ... -
Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types: a Mendelian randomization analysis of the HUNT study
(Journal article; Peer reviewed, 2018)We aimed to investigate potential causal associations between serum 25-hydroxyvitamin D [25(OH)D] levels and incidence of lung cancer overall and histologic types. We performed a Mendelian randomization (MR) analysis using ... -
Serum cytokine patterns in first half of pregnancy
(Journal article; Peer reviewed, 2019)Introduction Human pregnancy is a state of elevated maternal systemic inflammation, and pregnancy complications are often associated with a dysfunctional immune response. The network of cytokines reflects this complex ... -
Prenatal exposures and birth indices, and subsequent risk of polycystic ovary syndrome: a national registry-based cohort study
(Journal article; Peer reviewed, 2018)Objective To study the associations between prenatal exposures and risk of developing polycystic ovary syndrome (PCOS). Design National registry‐based cohort study. Setting Sweden. Population Girls born in ... -
Prolactin and breast increase during pregnancy in PCOS: linked to long-term metabolic health?
(Journal article; Peer reviewed, 2019)Objective To explore whether gestational prolactin and breast increase are markers of metabolic health in pregnancy and on long-term, in PCOS. Design Follow-up study. Women with PCOS, according to the Rotterdam criteria ... -
Radiotherapy for prostate cancer – Does daily image guidance with tighter margins improve patient reported outcomes compared to weekly orthogonal verified irradiation? Results from a randomized controlled trial
(Journal article; Peer reviewed, 2018)Background Novel cancer drugs are subject to strict scientific evaluation of safety and efficacy and usually undergo a cost effectiveness analysis before approval for use in clinical practice. For new techniques in ... -
Does Metformin Treatment during Pregnancy Modify the Future Metabolic Profile in Women with PCOS?
(Journal article; Peer reviewed, 2018)Context Worldwide, metformin is prescribed to improve pregnancy outcome in polycystic ovary syndrome (PCOS). Metformin may also benefit future health by modulating increased metabolic stress during pregnancy. Objective To ... -
Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas
(Journal article; Peer reviewed, 2018)Chronic inflammation increases the risk of developing one of several types of cancer. Inflammatory responses are currently thought to be controlled by mechanisms that rely on transcriptional networks that are distinct from ... -
Enhancing knowledge and coordination in obesity treatment: a case study of an innovative educational program
(Journal article; Peer reviewed, 2019)Currently, there is a lack of knowledge, organisation and structure in modern health care systems to counter the global trend of obesity, which has become a major risk factor for noncommunicable diseases. Obesity increases ... -
Factors Associated with Enhanced Gross Motor Progress in children with Cerebral Palsy: A Register-based Study
(Journal article; Peer reviewed, 2018)Aim: To examine associations between interventions and child characteristics; and enhanced gross motor progress in children with cerebral palsy (CP). Methods: Prospective cohort study based on 2048 assessments of 442 ... -
Gynecological cancer patients' attitudes toward follow-up care after cancer treatment: Do preferences reflect patients' experience? A cross-sectional questionnaire study
(Journal article; Peer reviewed, 2018)Introduction Due to an increasing number of cancer patients, new follow‐up models are being debated, among them follow‐up by general practitioners. Before changing surveillance, it is important to explore patients’ views. ...
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