• The regulation of neuroinflammation by oxidative DNA base lesion repair 

  Sakshaug, Teri (Master thesis, 2020)

  Current research shows that altered microglia activity and persistent neuroinflammation are underlying factors to neurological diseases such as Alzheimer's, Parkinson's, multiple sclerosis and psychiatric illnesses. ...

• Relevance of transcription regulator MED13 in response of brain tumour cells to the alkylation therapy 

  Aksu, Merdane Ezgi (Master thesis, 2020)

  Glioblastoma multiforme (GBM) is the most frequent and aggressive brain tumour in adults, defined with poor survival, high tumour heterogeneity, and lack of effective treatments. Despite the increasing knowledge in molecular ...

• Effects of hypoxia/reoxygenation and miR-24-3p in human cardiomyocyte models 

  Tran, Anette (Master thesis, 2020)

  Background: Effective cardioprotective therapies targeting the reperfusion phase of ischemia/reperfusion (I/R) injury are lacking, which remain one of the top unmet clinical needs in cardiology. MicroRNAs (miRNAs) are a ...

• Whole exome sequencing analysis of novel rare variants in susceptibility and unprecedented genes of hereditary colorectal cancer 

  Jang, Kijin (Master thesis, 2020)

  High-penetrance mutations lead to predisposition to colorectal cancer (CRC), comprising up to 5% of all colorectal cancer cases, e.g., defects in the DNA mismatch (MMR) genes causing Lynch syndrome. With the advent of ...

• Lipocalin 2 is expressed in MLO-Y4 osteocytes and regulated by the peroxisome proliferator activated receptor α agonist fenofibrate. 

  Syversen, Unni (Master thesis, 2020)

  Background: Lipocalin 2 is highly expressed and secreted from osteoblasts in mice. Lately, bone-derived lipocalin 2 has been shown to suppress appetite by binding to the MC4R in hypothalamus. In the present study we wanted ...

• The role of Fusobacterium nucleatum and the Epstein-Barr virus encoded EBV-miR-BART10-3p in colorectal cancer - focusing on the genes CXCL8, CSF2, SAP18 and CCND1 

  Jerud, Julie Tro (Master thesis, 2020)

  Kolorektal kreft er den tredje mest vanlige krefttypen i verden, og den nest ledende årsaken til dødsfall forårsaket av kreft for begge kjønn. Utviklingen av kolorektal kreft er en prosess som foregår gjennom flere trinn ...

• Toll-like receptor-mediated regulation of IL-32 in multiple myeloma cells 

  Tryggestad, Synne Stokke (Master thesis, 2020)

  Myelomatose, eller beinmargskreft, skyldes ukontrollert vekst av maligne plasmaceller i beinmargen. Pasienter med myelomatose er spesielt utsatt for infeksjoner, som også er en utbredt dødsårsak hos disse pasientene. ...

• In vitro effects of the AMP-activated protein kinase agonist metformin on murine osteocytes MLO-Y4 

  Homstad, Mathilde (Master thesis, 2020)

  Osteoporose er en skjelettsykdom som gir økt risiko for beinbrudd. Sykdommen karakteriseres av nedsatt beinkvalitet og lav beinmasse, og er en økende bekymring grunnet en økt aldrende befolkning. Styrketrening er vist å ...

• Osteogenic properties of human mesenchymal stem cells cultured on additively manufactured Ti-6Al-4V samples 

  Ouyang, Lingzi (Master thesis, 2020)

  Annually, hundreds of thousands of hip replacements are performed in the United States alone. This number is expected to increase with an increasing number of motor vehicle accidents and an increasingly active aging ...

• Use of CRISPR/Cas9-Mediated Genome Editing in Human Induced Pluripotent Stem Cells to Study Oxidative Base Lesion Repair in Cerebral Organoids 

  Núñez Nescolarde, Ana Beatriz (Master thesis, 2020)

  The role of DNA glycosylase OGG1 beyond the base excision repair (BER) pathway involves regulation of brain development and function. However, the molecular mechanisms remain to be unravelled. Here, we describe a reliable ...

• In vitro effects of radiation and mechanical load on murine osteocytes MLO-Y4 

  Jongen, Vincent Alexander (Master thesis, 2020)

  The increased survival rates for cancer as a result of improved diagnosis and treatment has come with the drawback that cancer treatment side effects are becoming more frequent as well. Cancer treatment induced bone loss ...

• Lipid droplets in hepatitis C virus-infected hepatocytes – exploring the role of TANK-binding kinase 1 and autophagy 

  Fürst Bright, Mentowa (Master thesis, 2020)

  Hepatisk steatose defineres som opphoping av lipider i lipiddråper i hepatocytter, og er en betydelig årsak til levercirrhose og alvorlig leversykdom. Hepatitt C-virus (HCV) forårsaker steatose, men mekanismene som regulerer ...

• Endogenous ligands secreted by multiple myeloma cell lines activate TLRs 7, 8, and 9 

  Vatn, Susanne (Master thesis, 2020)

• Fusobacterium nucleatum and the Epstein-Barr virus-encoded microRNA miR-BART10-3p in colorectal cancer - validating the role of the genes CSF2, CCL20, MAT2B and ELL2 

  Sognnes, Vibeke (Master thesis, 2020)

  Kreft i tykktarm- og endetarm, kolorektal kreft (CRC), er den tredje hyppigste diagnostiserte og den nest mest dødelige kreftformen i verden med over 1.8 millioner nye tilfeller og 800,000 nye dødsfall i 2018. Nyere forskning ...

• The Metastatic Intestinal Epithelial cell line SW620 produce neutrophil-attracting chemokines and extracellular matrix associated components in a Toll-Like Receptor 3 dependent manner 

  Skauge, Nadia Huse (Master thesis, 2020)

  Toll-lik reseptor 3 (TLR) er en mønstergjenkjennende reseptor (PRR) som kan indusere immunresponser når de gjenkjenner dsRNA, endogent mRNA oog den syntetiske TLR3 liganden Poly(I:C). Tiidligere har den metastatiske ...

• Genetic Engineering for Revealing Underlying Mechanisms of Inflammatory Bowel Diseases 

  Roseth, Ingrid Aass (Master thesis, 2020)

  Inflammatorisk tarmsykdom, også kalt IBD, er en samlebetegnelse på kronisk betennelse i tarmen. IBD består i hovedsak av ulcerøs kolitt og Crohns sykdom. De underliggende årsakene er i stor grad ukjent, men både genetikk, ...

• Exploring the role of IKKε during hepatitis C virus infection with focus on lipid accumulation 

  Helene Heskestad (Master thesis, 2020)

  Hepatitis C virus (HCV) targets the hepatocytes in the liver. HCV develops a chronic infection in 85% of infected patients which develops over decades and have different outcomes, for example hepatic steatosis (accumulation ...

• Elucidating the gene encoding the R3 surface protein in Streptococcus agalactiae 

  Basson, Adelle (Master thesis, 2020)

  Introduction: S. agalactiae, Lancefield’s group B Streptococcus (GBS), occurs as part of the normal microbial flora of the gastrointestinal and genital tract and can cause critical invasive disease in neonates, including ...

• Detecting Toll-Like Receptor 8 

  Mevatne, Sebastian (Master thesis, 2020)

  Toll-lignende reseptorer (TLR)er er reseptorer i det iboende immunsystemet som kan binde et bredt utvalg av mikrobe-tilknyttede molekylære mønstre (MAMP)s. Ved deres aktivering, utløses et bredt spekter av cellulære ...

• BRD4 degradation by PROTAC technology in carfilzomib-treated multiple myeloma cells 

  Maisiuk, Aliaksandr (Master thesis, 2020)

  Multiple myeloma is the second most common cancer of the blood, characterized by clonal expansion of plasma cells. Targeting MYC in multiple myeloma may be promising. However, it is not likely that MYC could be a single ...

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