Institutt for klinisk og molekylær medisin
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Phenylalanine Hydroxylase RNAi Knockdown Negatively Affects Larval Development, Molting and Swimming Performance of Salmon Lice
(Peer reviewed; Journal article, 2020)Phenylalanine hydroxylase (PAH) is a crucial enzyme involved in tyrosine biosynthesis, having roles in neurological and physiological processes. The purpose of PAH has received little attention in crustaceans despite ... -
The effect of supplementation with low doses of a cod protein hydrolysate on satiety hormones and inflammatory biomarkers in adults with metabolic syndrome: A randomized, double-blind study
(Peer reviewed; Journal article, 2020)Metabolic syndrome (MetS) is characterised by metabolic abnormalities that increase the risk of developing type 2 diabetes mellitus and cardiovascular disease. Altered levels of circulating ghrelin, several adipokines and ... -
Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTorc2 activation
(Peer reviewed; Journal article, 2020)Parp3 is a member of the Poly(ADP-ribose) polymerase (Parp) family that has been characterized for its functions in strand break repair, chromosomal rearrangements, mitotic segregation and tumor aggressiveness. Yet its ... -
Inhibition of O-GlcNAc transferase activates tumor-suppressor gene expression in tamoxifen-resistant breast cancer cells
(Peer reviewed; Journal article, 2020)In this study, we probed the importance of O-GlcNAc transferase (OGT) activity for the survival of tamoxifen-sensitive (TamS) and tamoxifen-resistant (TamR) breast cancer cells. Tamoxifen is an antagonist of estrogen ... -
Cognitive impairment in minor Stroke An observational study of the prevalence of cognitive impairment and emotional symptoms and consequences for social functioning and employment
(Doctoral theses at NTNU;2020:320, Doctoral thesis, 2020)Hjerneslag rammer årlig ca 12 000 personer i Norge og er en av de hyppigste årsaker til invaliditet. Data fra Norsk hjerneslagregister viser at 2/3 av pasientene blir selvhjulpne etter et hjerneslag. En betydelig andel av ... -
CT Derived Muscle Measures, Inflammation, and Frailty in a Cohort of Older Cancer Patients
(Peer reviewed; Journal article, 2020)Background/Aim: Muscle loss, inflammation, and frailty are prevalent among older cancer patients. We aimed to evaluate whether inflammatory markers could identify muscle loss, and if muscle measures differed between frail ... -
Clinical phenotypes and long-term prognosis in white patients with biopsy-verified hypertensive nephrosclerosis
(Peer reviewed; Journal article, 2020)Introduction Hypertensive nephrosclerosis is considered the second most common cause of end-stage renal disease (ESRD), but it is still an insufficiently studied and controversial disease entity. More information on the ... -
T1 bladder cancer in Norway: treatment and survival
(Peer reviewed; Journal article, 2020)Aim: Evaluation of treatment and survival of pT1 stage (T1) bladder cancer (BC) patients diagnosed with transitional cell carcinoma of the urinary bladder in Norway. Material and methods: According to the Cancer Registry ... -
Long-term outcomes of patients treated with rituximab as second-line treatment for adult immune thrombocytopenia – Follow-up of the RITP study
(Peer reviewed; Journal article, 2020)RITP was a double‐blind randomized, 78‐week follow‐up trial in which 109 adults with immune thrombocytopenias (ITP) who failed to achieve adequate response to steroids, were randomized to receive rituximab or placebo. Here, ... -
Vulnerability and risk among victims and suspects in sexual assault and rape
(Doctoral theses at NTNU;2020:325, Doctoral thesis, 2020) -
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
(Peer reviewed; Journal article, 2020)Respiratory failure in the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is hypothesized to be driven by an overreacting innate immune response, where the complement system is a key player. In this prospective ... -
Associations between muscle measures, survival and toxicity in patients with limited disease small cell lung cancer receiving concurrent chemoradiotherapy
(Peer reviewed; Journal article, 2020)Background Standard treatment for patients with limited stage small cell lung cancer (LS SCLC) is concurrent platinum– etoposide chemotherapy and thoracic radiotherapy (TRT). Up to 30% of patients are cured, but severe ... -
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma
(Peer reviewed; Journal article, 2020)Endonuclease V (EndoV) is a conserved inosine-specific ribonuclease with unknown biological function. Here, we present the first mouse model lacking EndoV, which is viable without visible abnormalities. We show that ... -
Circulating and Adipose Tissue miRNAs in Women With Polycystic Ovary Syndrome and Responses to High-Intensity Interval Training
(Peer reviewed; Journal article, 2020)MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally. In women with polycystic ovary syndrome (PCOS), several miRNAs are differentially expressed compared to women without PCOS, ... -
Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection
(Peer reviewed; Journal article, 2020)Mycobacterium tuberculosis is a global health problem in part as a result of extensive cytotoxicity caused by the infection. Here, we show how M. tuberculosis causes caspase-1/NLRP3/gasdermin D-mediated pyroptosis of human ... -
The short-term impact of methylprednisolone on patient-reported sleep in patients with advanced cancer in a randomized, placebo-controlled, double-blind trial
(Peer reviewed; Journal article, 2020)Purpose: Although corticosteroids are frequently used in patients with advanced cancer, few studies have examined the impact of these drugs on patient-reported sleep. We aimed to examine the short-term impact of ... -
Insight to Functional Conformation and Noncovalent Interactions of Protein-Protein Assembly Using MALDI Mass Spectrometry
(Peer reviewed; Journal article, 2020)Noncovalent interactions are the keys to the structural organization of biomolecule e.g., proteins, glycans, lipids in the process of molecular recognition processes e.g., enzyme-substrate, antigen-antibody. Protein ... -
NMR-Based Prostate Cancer Metabolomics
(Journal article; Peer reviewed, 2018)Prostate cancer is the second most common malignancy, and the fifth leading cause of cancer-related death among men, worldwide. A major unsolved clinical challenge in prostate cancer is the ability to accurately distinguish ... -
Serum 25-hydroxyvitamin D level in relation to weight change and the risk of weight gain in adults of normal weight at baseline: the Norwegian HUNT cohort study
(Peer reviewed; Journal article, 2020)Objective We sought to investigate the relationship of serum 25-hydroxyvitamin D (25(OH)D) level with weight change and the risk of weight gain in an adult population who had normal weight at baseline and were followed up ... -
Serum 25-hydroxyvitamin D level in relation to weight change and the risk of weight gain in adults of normal weight at baseline: the Norwegian HUNT cohort study
(Peer reviewed; Journal article, 2020)Objective We sought to investigate the relationship of serum 25-hydroxyvitamin D (25(OH)D) level with weight change and the risk of weight gain in an adult population who had normal weight at baseline and were followed up ...
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