• Linguistic and content validation of the translated and culturally adapted PG-SGA, as perceived by Norwegian cancer patients and healthcare professionals 

  Henriksen, Christine; Thoresen, Britt Lene; Fjøseide, Berit; Lorentzen, Sissi C. Stove; Balstad, Trude Rakel; Ottery, Faith; Jager-Wittenaar, Harriet (Peer reviewed; Journal article, 2020)

  Background & aims The Scored Patient-Generated Subjective Global Assessment (PG-SGA©) is a validated nutritional screening, assessment, monitoring, and triage tool. When translated to other languages, the questions and ...

• Physical rehabilitation in patients with head and neck cancer: Impact on health-related quality of life and suitability of a post-treatment program 

  Sandmæl, Jon Arne; Bye, Asta; Solheim, Tora S; Balstad, Trude Rakel; Thorsen, Lene; Skovlund, Eva; Kaasa, Stein; Lund, Jo-Åsmund; Oldervoll, Line Merethe (Peer reviewed; Journal article, 2020)

  Objective: Physical rehabilitation programs hold the potential to mitigate deterioration in health-related quality of life (HRQoL) in patients with head and neck cancer. The objective was to assess development in relevant ...

• Adaptor Template Oligo-Mediated Sequencing (ATOM-Seq) is a new ultra-sensitive UMI-based NGS library preparation technology for use with cfDNA and cfRNA 

  Dunwell, Thomas L.; Dailey, Simon C.; Ottestad, Anine Larsen; Yu, Jihang; Becker, Philipp W.; Scaife, Sarah; Richman, Susan D.; Wood, Henry M.; Slaney, Hayley; Bottomley, Daniel; Yang, Xiangsheng; Xiao, Hui; Wahl, Sissel Gyrid Freim; Grønberg, Bjørn Henning; Dai, Hong Yan; Fu, Guoliang (Peer reviewed; Journal article, 2021)

  Liquid biopsy testing utilising Next Generation Sequencing (NGS) is rapidly moving towards clinical adoption for personalised oncology. However, before NGS can fulfil its potential any novel testing approach must identify ...

• Protocol and description of literature searches for the risk-benefit assessment of fish in the Norwegian diet. The Steering Committee of the Norwegian Scientific Committee for Food and Environment 

  Andersen, Lene Frost; Berstad, Paula; Carlsen, Monica Hauger; Dahl, Lisbeth; Goksøyr, Anders; Knutsen, Helle Katrine; Kvestad, Ingrid; Lillegaard, Inger Therese Laugsand; Mangschou, Bente; Meyer, Haakon E; Nauta, Maarten; Rakkestad, Kirsten Eline; Rasinger, Josef Daniel; Skeie, Guri; Starrfelt, Jostein; Thomsen, Sofie; Ulven, Stine Marie; Agdestein, Angelika; Bodin, Johanna Eva; Elvevoll, Edel O.; Hessen, Dag Olav; Husøy, Trine; Krogdahl, Åshild; Nilsen, Asbjørn Magne; Skjerdal, Olaug Taran; Steffensen, Inger-Lise Karin; Strand, Tor A; Velle, Gaute; Wasteson, Yngvild; Hemre, Gro Ingunn; Vandvik, Vigdis; Alexander, Jan (Research report, 2020)

• Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples 

  Bailey, Matthew H.; Meyerson, William U.; Dursi, L. Jonathan; Wang, Liang-Bo; Dong, Guanlan; Liang, Wen-Wei; Weerasinghe, Amila; Li, Shantao; Li, Yize; Kelso, Sean; Aure, Miriam Ragle; Børresen-Dale, Anne-Lise; Langerød, Anita; Baumhoer, Daniel; Bjerkehagen, Bodil; Garred, Øystein; Lingjærde, Ole Christian; Sauer, Torill; Zaikova, Olga; Myklebost, Ola; Knappskog, Stian; Vazquez, Miguel; Akbani, Rehan; Anur, Pavana; Buchanan, Alex; Chiotti, Kami; Covington, Kyle; Creason, Allison; Niu, Beifang; Bieg, Matthias; Boutros, Paul C.; Buchhalter, Ivo; Butler, Adam P.; Chen, Ken; Chong, Zechen; Drechsel, Oliver; Aaltonen, Lauri; Abascal, Federico; Abeshouse, Adam; Aburatani, H; Adams, David J.; Van Loo, Peter; Saksena, Gordon; Ellrott, Kyle; Wendl, Michael C.; Wheeler, David A.; Getz, Gad; Simpson, Jared T.; Gerstein, Mark B.; Ding, Li (Peer reviewed; Journal article, 2020)

  The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part ...

• Validation and development of models using clinical, biochemical and ultrasound markers for predicting pre-eclampsia: an individual participant data meta-analysis 

  Allotey, John; Snell, Kym I.E.; Smuk, Melanie; Hooper, Richard; Chan, Claire; Ahmed, Asif; Chappell, Lucy C.; von Dadelszen, Peter; Dodds, Julie; Green, Marcus; Kenny, Louise; Khalil, Asma; Khan, Khalid S.; Mol, Ben W.; Myers, Jenny; Poston, Lucilla; Thilaganathan, Basky; Staff, Anne Cathrine; Smith, Gordon C.S.; Ganzevoort, Wessel; Laivuori, Hannele; Odibo, Anthony O.; Ramírez, Javier A.; Kingdom, John; Daskalakis, George; Farrar, Diane; Baschat, AA; Seed, PT; Prefumo, F; da Silva Costa, F; Groen, H; Audibert, F; Masse, J; Skråstad, Ragnhild Bergene; Salvesen, Kjell Å; Haavaldsen, Camilla; Nagata, C; Rumbold, Alice R.; Heinonen, Seppo; Askie, LM; Smits, LJ; Vinter, CA; Magnus, Per; Kajantie, Eero Olavi; Villa, PM; Jenum, Anne Karen; Andersen, LB; Norman, JE; Ohkuchi, A; Eskild, Anne; Bhattacharya, Sohinee; McAuliffe, Fionnuala M.; Galindo, Alberto; Herraiz, Ignacio; Carbillon, , Lionel; Klipstein-Grobusch, Kerstin; Yeo, SeonAe; Teede, Helena J.; Browne, Joyce L; Moons, Karel G.M.; Riley, Richard D; Thangaratinam, Shakila (Peer reviewed; Journal article, 2020)

  Background: Pre-eclampsia is a leading cause of maternal and perinatal mortality and morbidity. Early identification of women at risk is needed to plan management. Objectives: To assess the performance of existing pre-eclampsia ...

• Choice of immunoassay to evaluate porcine cytokine levels 

  Ueland, Nora Lamark; Ludvigsen, Judith K.; Hellerud, Bernt C; Mollnes, Tom Eirik; Skjeflo, Espen Waage (Peer reviewed; Journal article, 2020)

  Background In order to adequately monitor cytokines in experimental models, currently available methods and commercially available kits should be compared. Aim To compare the plasma and tissue concentrations of IL-1β, ...

• A complement C3–Specific nanobody for modulation of the alternative cascade identifies the C-Terminal domain of C3b as functional in C5 convertase activity 

  Pedersen, Henrik; Jensen, Rasmus K.; Jensen, Jens Magnus B.; Fox, Rachel; Pedersen, Dennis V.; Olesen, Heidi G.; Hansen, Annette G.; Christiansen, Dorte; Mazarakis, Sofia M.M.; Lojek, Neal; Hansen, Pernille; Gadeberg, Trine A.F.; Zarantonello, Alessandra; Laursen, Nick S.; Mollnes, Tom Eirik; Johnson, Matthew B.; Stevens, Beth; Thiel, Steffen; Andersen, Gregers R. (Peer reviewed; Journal article, 2020)

  The complement system is an intricate cascade of the innate immune system and plays a key role in microbial defense, inflammation, organ development, and tissue regeneration. There is increasing interest in developing ...

• CD14 inhibition improves survival and attenuates thrombo-inflammation and cardiopulmonary dysfunction in a baboon model of Escherichia coli sepsis 

  Keshari, Ravi Shankar; Silasi, Robert; Popescu, Narcis Ioan; Regmi, Girija; Chaaban, Hala; Lambris, John D.; Lupu, Cristina; Mollnes, Tom Eirik; Lupu, Florea (Peer reviewed; Journal article, 2020)

  Background During sepsis, gram‐negative bacteria induce robust inflammation primarily via lipopolysacharride (LPS) signaling through TLR4, a process that involves the glycosylphosphatidylinositol (GPI)‐anchored receptor ...

• Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction – a prospective observational study 

  Anstensrud, Anne Kristine; Molden, Espen; Haug, Hans Jørgen; Qazi, Rehman; Muriq, Hysen; Fosshaug, Linn Elisabeth Lillerud; Spigset, Olav; Øie, Erik (Peer reviewed; Journal article, 2020)

  Purpose The β-1 adrenergic receptor blocker metoprolol is primarily metabolized by the polymorphic enzyme cytochrome P 450 2D6 (CYP2D6), an enzyme with substantial genetic heterogeneity. Our purpose was to investigate the ...

• Osimertinib in T790M-positive and -negative patients with EGFR-mutated advanced non-small cell lung cancer (the TREM-study) 

  Eide, Inger Johanne; Helland, Åslaug; Ekman, Simon; Mellemgaard, Anders; Hansen, Karin Holmskov; Cicenas, Saulius; Koivunen, Jussi; Grønberg, Bjørn Henning; Brustugun, Odd Terje (Peer reviewed; Journal article, 2020)

  Objectives In non-small cell lung cancer patients with acquired resistance to first- or second-generation EGFR-TKIs, osimertinib is approved in the presence of the T790 M resistance mutation. We assessed the efficacy of ...

• Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement 

  Zhang, Jie; Song, Lihong; Pedersen, Dennis V.; Li, Anna; Lambris, John D.; Andersen, Gregers Rom; Mollnes, Tom Eirik; Ma, Ying Jie; Garred, Peter (Peer reviewed; Journal article, 2020)

  Properdin stabilizes the alternative C3 convertase (C3bBb), whereas its role as pattern-recognition molecule mediating complement activation is disputed for decades. Previously, we have found that soluble collectin-12 ...

• Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction 

  Louwe, Maria Cornelia; Olsen, Maria Belland; Kaasbøll, Ole Jørgen; Yang, Kuan; Fosshaug, Linn Elisabeth Lillerud; Alfsnes, Katrine; Øgaard, Jonas; Rashidi, Azita; Skulberg, Vidar Magne; Yang, Mingyi; Fonseca, Davi de Miranda; Sharma, Animesh; Aronsen, Jan Magnus; Schrumpf, Elisabeth; Ahmed, Muhammad Shakil; Dahl, Christen Peder; Nyman, Tuula Anneli; Ueland, Thor; Melum, Espen; Halvorsen, Bente; Bjørås, Magnar; Attramadal, Håvard; Sjaastad, Ivar; Aukrust, Pål; Yndestad, Arne (Peer reviewed; Journal article, 2020)

  An inflammatory response is required for tissue healing after a myocardial infarction (MI), but the process must be balanced to prevent maladaptive remodeling. This study shows that improved survival and cardiac function ...

• Trace Elements in the Large Population-Based HUNT3 Survey 

  Syversen, Tore; Evje, Lars Gjermund; Wolf-Grosse, Susann; Flaten, Trond Peder; Lierhagen, Syverin; Simic, Anica (Peer reviewed; Journal article, 2020)

  The Nord-Trøndelag Health Study (The HUNT Study) is a large health survey population study in the county of Trøndelag, Norway. The survey has been repeated four times in about 10-year intervals. In the HUNT3 survey ...

• Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation 

  Rolinski, Milosz; Montaldo, Nicola Pietro; Aksu, Merdane Ezgi; Martin, Sarah Fordyce; Brambilla, Alessandro; Kunath, Nicolas; Johansen, Jostein; Erlandsen, Sten Even; Liabakk, Nina-Beate; Rian, Kristin; Bjørås, Magnar; Sætrom, Pål; van Loon, Barbara (Peer reviewed; Journal article, 2020)

  Alkylating drugs are among the most often used chemotherapeutics. While cancer cells frequently develop resistance to alkylation treatments, detailed understanding of mechanisms that lead to the resistance is limited. Here, ...

• Tumour texture features from preoperative CT predict high-risk disease in endometrial cancer 

  Ytre-Hauge, Sigmund; Salvesen, Øyvind; Krakstad, Camilla; Trovik, Jone; Haldorsen, Ingfrid S. (Peer reviewed; Journal article, 2020)

  BACKGROUND To enable more individualised treatment of endometrial cancer, improved methods for preoperative tumour characterization are warranted. Texture analysis is a method for quantification of heterogeneity in images, ...

• Changes in muscle measures during chemoradiotherapy in patients with limited stage small cell lung cancer 

  Valan, Christine Damgaard; Halvorsen, Tarje Onsøien; Jordhøy, Marit Slaaen; Grønberg, Bjørn Henning (Peer reviewed; Journal article, 2020)

  Background: Concurrent chemoradiotherapy is the recommended treatment for limited stage small cell lung cancer. Severe side‐effects, which might cause loss of muscle mass, are frequent. Low skeletal muscle index (SMI) and ...

• Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the α-D-phosphohexomutase superfamily 

  Backe, Paul Hoff; Lærdahl, Jon Kristen; Kittelsen, Lene Svendsen; Dalhus, Bjørn; Mørkrid, Lars; Bjørås, Magnar (Peer reviewed; Journal article, 2020)

  Human phosphoglucomutase 1 (PGM1) is an evolutionary conserved enzyme that belongs to the ubiquitous and ancient α-D-phosphohexomutases, a large enzyme superfamily with members in all three domains of life. PGM1 catalyzes ...

• Vitamin D and stress urinary incontinence in pregnancy: a cross-sectional study 

  Stafne, Signe Nilssen; Mørkved, Siv; Gustafsson, Miriam Katarina; Syversen, Unni; Stunes, Astrid Kamilla; Salvesen, Kjell Å; Johannessen, Hege Hølmo (Peer reviewed; Journal article, 2020)

  Objective To assess the association between levels of vitamin D and urinary incontinence (UI) in pregnancy. Design A cross‐sectional study. Secondary analysis of a randomised controlled trial. Setting Two university ...

• Relationship between hippocampal subfield volumes and memory function in adults born preterm with very low birth weight (VLBW) 

  Aanes, Synne; Bjuland, Knut Jørgen; Lærum, Astrid M Winsnes; Weider, Siri; Evensen, Kari Anne I; Indredavik, Marit; Brubakk, Ann-Mari; Håberg, Asta; Løhaugen, Gro C; Skranes, Jon Sverre (Journal article, 2020)

  Background: Being born preterm with very low birth weight (VLBW) is related to aberrant brain development. Hippocampus is a brain region particularly vulnerable to injury, for instance from consequences following preterm ...

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