Institutt for klinisk og molekylær medisin
Recent Submissions
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Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTorc2 activation
(Peer reviewed; Journal article, 2020)Parp3 is a member of the Poly(ADP-ribose) polymerase (Parp) family that has been characterized for its functions in strand break repair, chromosomal rearrangements, mitotic segregation and tumor aggressiveness. Yet its ... -
Inhibition of O-GlcNAc transferase activates tumor-suppressor gene expression in tamoxifen-resistant breast cancer cells
(Peer reviewed; Journal article, 2020)In this study, we probed the importance of O-GlcNAc transferase (OGT) activity for the survival of tamoxifen-sensitive (TamS) and tamoxifen-resistant (TamR) breast cancer cells. Tamoxifen is an antagonist of estrogen ... -
Cognitive impairment in minor Stroke An observational study of the prevalence of cognitive impairment and emotional symptoms and consequences for social functioning and employment
(Doctoral theses at NTNU;2020:320, Doctoral thesis, 2020)Hjerneslag rammer årlig ca 12 000 personer i Norge og er en av de hyppigste årsaker til invaliditet. Data fra Norsk hjerneslagregister viser at 2/3 av pasientene blir selvhjulpne etter et hjerneslag. En betydelig andel av ... -
CT Derived Muscle Measures, Inflammation, and Frailty in a Cohort of Older Cancer Patients
(Peer reviewed; Journal article, 2020)Background/Aim: Muscle loss, inflammation, and frailty are prevalent among older cancer patients. We aimed to evaluate whether inflammatory markers could identify muscle loss, and if muscle measures differed between frail ... -
Clinical phenotypes and long-term prognosis in white patients with biopsy-verified hypertensive nephrosclerosis
(Peer reviewed; Journal article, 2020)Introduction Hypertensive nephrosclerosis is considered the second most common cause of end-stage renal disease (ESRD), but it is still an insufficiently studied and controversial disease entity. More information on the ... -
T1 bladder cancer in Norway: treatment and survival
(Peer reviewed; Journal article, 2020)Aim: Evaluation of treatment and survival of pT1 stage (T1) bladder cancer (BC) patients diagnosed with transitional cell carcinoma of the urinary bladder in Norway. Material and methods: According to the Cancer Registry ... -
Long-term outcomes of patients treated with rituximab as second-line treatment for adult immune thrombocytopenia – Follow-up of the RITP study
(Peer reviewed; Journal article, 2020)RITP was a double‐blind randomized, 78‐week follow‐up trial in which 109 adults with immune thrombocytopenias (ITP) who failed to achieve adequate response to steroids, were randomized to receive rituximab or placebo. Here, ... -
Vulnerability and risk among victims and suspects in sexual assault and rape
(Doctoral theses at NTNU;2020:325, Doctoral thesis, 2020) -
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
(Peer reviewed; Journal article, 2020)Respiratory failure in the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is hypothesized to be driven by an overreacting innate immune response, where the complement system is a key player. In this prospective ... -
Associations between muscle measures, survival and toxicity in patients with limited disease small cell lung cancer receiving concurrent chemoradiotherapy
(Peer reviewed; Journal article, 2020)Background Standard treatment for patients with limited stage small cell lung cancer (LS SCLC) is concurrent platinum– etoposide chemotherapy and thoracic radiotherapy (TRT). Up to 30% of patients are cured, but severe ... -
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma
(Peer reviewed; Journal article, 2020)Endonuclease V (EndoV) is a conserved inosine-specific ribonuclease with unknown biological function. Here, we present the first mouse model lacking EndoV, which is viable without visible abnormalities. We show that ... -
Circulating and Adipose Tissue miRNAs in Women With Polycystic Ovary Syndrome and Responses to High-Intensity Interval Training
(Peer reviewed; Journal article, 2020)MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally. In women with polycystic ovary syndrome (PCOS), several miRNAs are differentially expressed compared to women without PCOS, ... -
Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection
(Peer reviewed; Journal article, 2020)Mycobacterium tuberculosis is a global health problem in part as a result of extensive cytotoxicity caused by the infection. Here, we show how M. tuberculosis causes caspase-1/NLRP3/gasdermin D-mediated pyroptosis of human ... -
The short-term impact of methylprednisolone on patient-reported sleep in patients with advanced cancer in a randomized, placebo-controlled, double-blind trial
(Peer reviewed; Journal article, 2020)Purpose: Although corticosteroids are frequently used in patients with advanced cancer, few studies have examined the impact of these drugs on patient-reported sleep. We aimed to examine the short-term impact of ... -
Insight to Functional Conformation and Noncovalent Interactions of Protein-Protein Assembly Using MALDI Mass Spectrometry
(Peer reviewed; Journal article, 2020)Noncovalent interactions are the keys to the structural organization of biomolecule e.g., proteins, glycans, lipids in the process of molecular recognition processes e.g., enzyme-substrate, antigen-antibody. Protein ... -
NMR-Based Prostate Cancer Metabolomics
(Journal article; Peer reviewed, 2018)Prostate cancer is the second most common malignancy, and the fifth leading cause of cancer-related death among men, worldwide. A major unsolved clinical challenge in prostate cancer is the ability to accurately distinguish ... -
Serum 25-hydroxyvitamin D level in relation to weight change and the risk of weight gain in adults of normal weight at baseline: the Norwegian HUNT cohort study
(Peer reviewed; Journal article, 2020)Objective We sought to investigate the relationship of serum 25-hydroxyvitamin D (25(OH)D) level with weight change and the risk of weight gain in an adult population who had normal weight at baseline and were followed up ... -
Serum 25-hydroxyvitamin D level in relation to weight change and the risk of weight gain in adults of normal weight at baseline: the Norwegian HUNT cohort study
(Peer reviewed; Journal article, 2020)Objective We sought to investigate the relationship of serum 25-hydroxyvitamin D (25(OH)D) level with weight change and the risk of weight gain in an adult population who had normal weight at baseline and were followed up ... -
Gut microbiota-dependent trimethylamine N-oxide associates with inflammation in common variable immunodeficiency
(Peer reviewed; Journal article, 2020)A substantial proportion of patients with common variable immunodeficiency (CVID) have inflammatory and autoimmune complications of unknown etiology. We have previously shown that systemic inflammation in CVID correlates ... -
A qualitative study of the work experiences of midwives performing obstetric ultrasound in Norway
(Peer reviewed; Journal article, 2020)Background Performing obstetric ultrasound is part of midwifery practice in Norway. Knowledge of these midwives’ working situation can enhance understanding of what their work involves and the challenges they encounter ...
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