• Cyclic Arginine–Glycine–Aspartate-Decorated Lipid Nanoparticle Targeting toward Inflammatory Lesions Involves Hitchhiking with Phagocytes 

  Sofias, Alexandros Marios; Bjørkøy, Geir; Ochando, Jordi; Sønstevold, Linda; Hegvik, Maria; Davies, Catharina de Lange; Haraldseth, Olav; Lammers, Twan; Mulder, Willem J. M.; Hak, Sjoerd (Peer reviewed; Journal article, 2021)

  Active-targeting nanomedicine formulations have an intricate in vivo behavior. Nanomedicines developed to target endothelial αvβ3-integrin are recently demonstrated to display extensive uptake by circulating phagocytes. ...

• Democratic and ethical problem of lung cancer screening: Exclusion of true high-risk populations. Can it be fixed? Yes 

  Røe, Oluf Dimitri (Peer reviewed; Journal article, 2020)

  Screening a population for a potentially deadly disease, the ultimate goal must be to prevent morbidity and mortality from this disease for the whole population. Unlike breast cancer or cervical cancer screening, where all ...

• Quality of care for peripheral intravenous catheters (PIVCs) in Nepal: A cross-sectional study on feasibility and inter-rater agreement of the Peripheral Intravenous Catheters-mini Questionnaire (PIVC-miniQ) in a tertiary care hospital 

  Shrestha, Sulekha; Vieler, Johannes; Haug, Nikolai Juliussen; Afset, Jan Egil; Høvik, Lise Husby; Lydersen, Stian; Gustad, Lise Tuset (Peer reviewed; Journal article, 2021)

  Objectives There is a lack of data regarding the quality of peripheral intravenous catheter (PIVC)-related care from low-income and middle-income countries, even though the use of PIVCs may lead to local or severe systemic ...

• Kidney biopsy diagnosis in childhood in the Norwegian Kidney Biopsy Registry and the long-term risk of kidney replacement therapy: a 25-year follow-up 

  Gjerstad, Ann Christin; Skrunes, Rannveig; Tøndel, Camilla; Åsberg, Anders; Leh, Sabine; Klingenberg, Claus Andreas; Døllner, Henrik; Hammarström, Clara Louise; Bjerre, Anna Kristina (Peer reviewed; Journal article, 2022)

  Background There is scarce information on biopsy-verified kidney disease in childhood and its progression to chronic kidney disease stage 5 (CKD 5). This study aims to review biopsy findings in children, and to investigate ...

• DrugVirus.info 2.0: an integrative data portal for broad-spectrum antivirals (BSA) and BSA-containing drug combinations (BCCs) 

  Ianevski, Aleksandr; Simonsen, Ronja Meyer; Myhre, Vegard; Tenson, Tanel; Oksenych, Valentyn; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2022)

  Viruses can cross species barriers and cause unpredictable outbreaks in man with substantial economic and public health burdens. Broad-spectrum antivirals, (BSAs, compounds inhibiting several human viruses), and BSA-containing ...

• SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells 

  Hammer, Quirin; Dunst, Josefine; Christ, Wanda; Picarazzi, Francesca; Wendorff, Mareike; Momayyezi, Pouria; Huhn, Oisín; Netskar, Herman Krogstad; Maleki, Kimia T.; García, Marina; Sekine, Takuya; Sohlberg, Ebba; Azzimato, Valerio; Aouadi, Myriam; Holten, Aleksander Rygh; Kildal, Anders Benjamin; Lind, Andreas; Dyrhol-Riise, Anne Ma; Hoff, Dag Arne Lihaug; Solligård, Erik; Holter, Jan Cato; Afset, Jan Egil; Damås, Jan Kristian; Hov, Johannes Espolin Roksund; Bergan, Jonas; Risnes, Kari; Muller, Karl Erik; Tonby, Kristian; Heggelund, Lars; Gustad, Lise Tuset; Grimsrud, Marit Mæhle; Vadla, May Sissel; Lenning, Ole Bernt; Myhre, Ronny; Haider, Sammra; Dudman, Susanne Gjeruldsen; Karlsen, Tom Hemming; Folseraas, Trine; Skogen, Vegard; Degenhardt, Frauke; Franke, Andre; Spallotta, Francesco; Mori, Mattia; Michaëlsson, Jakob; Björkström, Niklas K.; Rückert, Timo; Romagnani, Chiara; Horowitz, Amir; Klingström, Jonas; Ljunggren, Hans-Gustaf; Malmberg, Karl-Johan (Peer reviewed; Journal article, 2022)

  Natural killer (NK) cells are innate immune cells that contribute to host defense against virus infections. NK cells respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and are activated in ...

• A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres 

  Mentegari, Elisa; Bertoletti, Federica; Kissova, Miroslava; Zucca, Elisa; Galli, Silvia; Tagliavini, Giulia; Garbelli, Anna; Maffia, Antonio; Bione, Silvia; Ferrari, Elena; d'Adda di Fagagna, Fabrizio; Francia, Sofia; Sabbioneda, Simone; Chen, Liuh-Yow; Lingner, Joachim; Bergoglio, Valerie; Hoffmann, Jean-Sebastien; Hübscher, Ulrich; Crespan, Emmanuele; Maga, Giovanni (Peer reviewed; Journal article, 2021)

  Telomerase negative cancer cell types use the Alternative Lengthening of Telomeres (ALT) pathway to elongate telomeres ends. Here, we show that silencing human DNA polymerase (Pol λ) in ALT cells represses ALT activity and ...

• High-dose thoracic radiation therapy for non-small cell lung cancer: a novel grading scale of radiation-induced lung injury for symptomatic radiation pneumonitis 

  Szejniuk, Weronika Maria; Nielsen, Martin Skovmos; Takács-Szabó, Zsuzsanna; Pawlowski, Jacek; Al-Saadi, Sahar Sulaiman; Maidas, Panagiotis; Bøgsted, Martin; McCulloch, Tine; Frøkjær, Jens Brøndum; Falkmer, Ursula Gerda; Røe, Oluf Dimitri (Peer reviewed; Journal article, 2021)

  Background Symptomatic radiation pneumonitis (RP) may be a serious complication after thoracic radiation therapy (RT) for non-small cell lung cancer (NSCLC). This prospective observational study sought to evaluate the ...

• Ascorbic acid supports ex vivo generation of plasmacytoid dendritic cells from circulating hematopoietic stem cells 

  Laustsen, Anders; van der Sluis, Renée M.; Gris-Oliver, Albert; Hernández, Sabina Sánchez; Cemalovic, Ena; Tang, Hai Q.; Pedersen, Lars Henning; Uldbjerg, Niels; Jakobsen, Martin R.; Bak, Rasmus O. (Peer reviewed; Journal article, 2021)

  Plasmacytoid dendritic cells (pDCs) constitute a rare type of immune cell with multifaceted functions, but their potential use as a cell-based immunotherapy is challenged by the scarce cell numbers that can be extracted ...

• RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis 

  Zelic, Matija; Pontarelli, Fabrizio; Woodworth, Lisa; Zhu, Cheng; Mahan, Amy; Ren, Yi; LaMorte, Michael; Gruber, Ross; Keane, Aislinn; Loring, Pequita; Guo, Lilu; Xia, Tai-he; Zhang, Boyao; Ørning, Mathias Pontus; Lien, Egil; Degterev, Alexei; Hammond, Timothy; Ofengeim, Dimitry (Peer reviewed; Journal article, 2021)

• Syntese av fenylpropanoider ved bruk av trekomponentsyntese med Bestmann-ylid 

  Ryjoan Karwan Ahmed Ahmed (Master thesis, 2022)

  Fenylpropanoider er plante sekundærmetabolitter og har i de siste årene fått oppmerksomhet da de har vist forskjellige biologiske effekter. Målet for dette master prosjektet var å danne et kjemisk bibliotek av fenylpropanoid ...

• Et apatisk barn med hallusinasjoner 

  Teigen, Ingrid Anna; Berg, Jon Andsnes; Brodwall, Kristoffer (Peer reviewed; Journal article, 2021)

• SARS-CoV-2 antibody persistence after five and twelve months: A cohort study from South-Eastern Norway 

  Sarjomaa, Marjut Anneli; Diep, Lien My; Zhang, Chi; Tveten, Yngvar; Reiso, Harald; Thilesen, Carina; Nordbø, Svein Arne; Berg, Kristine Karlsrud; Aaberge, Ingeborg Aase S.; Pearce, Neil; Kersten, Hege; Vandenbroucke, Jan Paul; Eikeland, Randi; Fell, Anne Kristin M. (Peer reviewed; Journal article, 2022)

  Objectives: To assess total antibody levels against Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS CoV-2) spike protein up to 12 months after Coronavirus Disease (COVID-19) infection in non-vaccinated individuals ...

• Longitudinal minimal residual disease assessment in multiple myeloma patients in complete remission - results from the NMSG flow-MRD substudy within the EMN02/HO95 MM trial 

  Schmitz, Alexander; Brøndum, Rasmus Froberg; Johnsen, Hans Erik; Mellqvist, Ulf-Henrik; Waage, Anders; Gimsing, Peter; Op Bruinink, Davine Hofste; van der Velden, Vincent; van der Holt, Bronno; Hansson, Markus; Andersen, Niels Frost; Frølund, Ulf Christian; Helleberg, Carsten; Schjesvold, Fredrik Hellem; Ahlberg, Lucia; Gulbrandsen, Nina; Andreasson, Bjorn; Lauri, Birgitta; Haukås, Einar; Bødker, Julie Støve; Roug, Anne Stidsholt; Bøgsted, Martin; Severinsen, Marianne T.; Gregersen, Henrik; Abildgaard, Niels; Sonneveld, Pieter; Dybkær, Karen (Peer reviewed; Journal article, 2022)

  Background Multiple myeloma remains an incurable disease with multiple relapses due to residual myeloma cells in the bone marrow of patients after therapy. Presence of small number of cancer cells in the body after cancer ...

• Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway 

  Helland, Åslaug; Russnes, Hege Elisabeth Giercksky; Fagereng, Gro Live; Al-Shibli, Khalid Ibrahim; Andersson, Yvonne; Berg, Thomas; Bjørge, Line; Blix, Egil Støre; Bjerkehagen, Bodil; Brabrand, Sigmund; CAMERON, MARTE; Dalhaug, Astrid; Dietzel, Dalia; Dønnem, Tom; Enerly, Espen; Flobak, Åsmund; Fluge, Sverre; Gilje, Bjørnar; Gjertsen, Bjørn Tore; Grønberg, Bjørn Henning; Grønås, Kari; Guren, Tormod Kyrre; Hamre, Hanne Mari; Haug, Åse; Heinrich, Daniel; Hjortland, Geir Olav; Hovig, Eivind; Hovland, Randi; Iversen, Ann-Charlotte; Janssen, Emiel; Kyte, Jon A; Gythfeldt, Hedda; Lothe, Ragnhild Adelheid; Lund, Jo-Åsmund; Meza, Leonardo Zepeda; Munthe-Kaas, Monica Cheng; Nguyen, Olav Toai Duc; Niehusmann, Pitt; Nilsen, Hilde; Puco, Katarina; Ree, Anne Hansen; Riste, Tonje Bøyum; Semb, Karin; Steinskog, Eli Sihn Samdal; Stensvold, Andreas; Suhrke, Pål; Tennøe, Øyvind Krohn; Tjønnfjord, Geir Erland; Vassbotn, Liv Jorunn; Aas, Eline; Aasebø, Kristine Øverås; Tasken, Kjetil; Smeland, Sigbjørn (Peer reviewed; Journal article, 2022)

  Background Matching treatment based on tumour molecular characteristics has revolutionized the treatment of some cancers and has given hope to many patients. Although personalized cancer care is an old concept, renewed ...

• The development and validation of a high-capacity serological assay for celiac disease 

  Klaasen, Rolf; Warren, David; Iversen, Rasmus; Bolstad, Nils; Andersen, Ina Lervåg; Mjønes, Patricia; Rønne, Elin; Lundin, Knut; Sollid, Ludvig Magne; Ness-Jensen, Eivind (Peer reviewed; Journal article, 2022)

  Background The aim of the present study was to develop and clinically validate a high-throughput assay for serum IgA and IgG antibodies against transglutaminase-2 (TG2) and to determine appropriate assay cut-offs for ...

• Establishing Methodology and Best Practices for Metagenomic and Metatranscriptomic Study of the Human Gut Microbiome 

  Desiati, Indri (Master thesis, 2022)

  Due to its fundamental impact on overall health, the gut microbiome has emerged as one of the most popular research subjects over the last decade. It is believed that there are associations between gut microbial perturbation ...

• Increased incidence of inflammatory bowel disease on etanercept in juvenile idiopathic arthritis regardless of concomitant methotrexate use 

  van Straalen, Joeri W.; Krol, Roline; Giancane, Gabriella; Panaviene, Violeta; Ailioaie, Laura Marinela; Dolezalova, Pavla; Cattalini, Marco; Susic, Gordana; Sztajnbok, Flavio; Maritsi, Despoina; Constantin, Tamas; Sawhney, Sujata; Rygg, Marite; Oliveira, Sheila K.; Nordal, Ellen Berit; Saad-Magalhaes, C; Rubio-Perez, Nadina; Jelusic, Marija; de Roock, Sytze; Wulffraat, Nico; Ruperto, Nicolino; Swart, Joost Frans; International Trials Org, Paediatric Rheumatology (Peer reviewed; Journal article, 2021)

  Objectives: To describe risk factors for inflammatory bowel disease (IBD) development in a cohort of children with juvenile idiopathic arthritis (JIA). Methods: JIA patients who developed IBD were identified from the ...

• Electron Beam Sterilization of Poly(Methyl Methacrylate)—Physicochemical and Biological Aspects 

  Sharifi, Sina; Islam, Mohammad Mirazul; Sharifi, Hannah; Islam, Rakibul; Huq, Tahmida N.; Nilsson, Per; Mollnes, Tom Eirik; Tran, Khoa D.; Patzer, Corrina; Dohlman, Claes H.; Patra, Hirak K.; Paschalis, Eleftherios I.; Gonzalez-Andrades, Miguel; Chodosh, James (Peer reviewed; Journal article, 2021)

  Electron beam (E-beam) irradiation is an attractive and efficient method for sterilizing clinically implantable medical devices made of natural and/or synthetic materials such as poly(methyl methacrylate) (PMMA). As ionizing ...

• Genotyping of human adenovirus C by tiled amplicon sequencing 

  Toftemo, Anna Matilde (Master thesis, 2022)

  adenovirus (HAdV) er et vanlig humanpatogent virus som vanligvis forårsaker milde og selvbegrensende sykdommer i øvre luftveier eller i gastrointestinaltraktus. Alvorlige og livstruende infeksjoner kan imidlertid oppstå, ...

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