Institutt for klinisk og molekylær medisin
Recent Submissions
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The fungal cell wall component b-1,3-glucan has an adjuvant effect on the allergic response to ovalbumin in mice
(Peer reviewed; Journal article, 2010)The polyglucose b -1,3-D-glucan is a major structural component of the cell wall of yeasts and fungi. In the present study, the adjuvant activity of b-1,3-glucan from the fungus Sclerotinia sclerotiorum (SSG) on the response ... -
Innate immune signalling genetics of pain, cognitive dysfunction and sickness symptoms in cancer pain patients treated with transdermal fentanyl
(Peer reviewed; Journal article, 2015)Common adverse symptoms of cancer and chemotherapy are a major health burden; chief among these is pain, with opioids including transdermal fentanyl the mainstay of treatment. Innate immune activation has been implicated ... -
Targeted next-generation sequencing of 22 mismatch repair genes identifies Lynch syndrome families
(Peer reviewed; Journal article, 2016)Causative germline mutations in mismatch repair (MMR ) genes can only be identified in ~50% of families with a clinical diagnosis of the inherited colorectal cancer (CRC ) syndrome hereditary nonpolyposis colorectal cancer ... -
EpiFactors: A comprehensive database of human epigenetic factors and complexes
(Peer reviewed; Journal article, 2015)Epigenetics refers to stable and long-term alterations of cellular traits that are not caused by changes in the DNA sequence per se . Rather, covalent modifications of DNA and histones affect gene expression and genome ... -
Efficient and Reliable Production of Vectors for the Study of the Repair, Mutagenesis, and Phenotypic Consequences of Defined DNA Damage Lesions in Mammalian Cells
(Peer reviewed; Journal article, 2016)Mammalian cells are constantly and unavoidably exposed to DNA damage from endogenous and exogenous sources, frequently to the detriment of genomic integrity and biological function. Cells acquire a large number of chemically ... -
Life after adolescent and adult moderate and severe traumatic brain injury: self-reported executive, emotional, and behavioural function 2-5 years after injury
(Peer reviewed; Journal article, 2015)Survivors of moderate-severe Traumatic Brain Injury (TBI) are at risk for long-term cognitive, emotional, and behaviouralproblems. This prospective cohort study investigated self-reported executive, emotional, and behavioural ... -
The Norwegian preeclampsia family cohort study: a new resource for investigating genetic aspects and heritability of preeclampsia and related phenotypes
(Peer reviewed; Journal article, 2015)Background:Preeclampsia is a major pregnancy complication without curative treatment available. A NorwegianPreeclampsia Family Cohort was established to provide a new resource for genetic and molecular studies aiming ... -
A randomized study of the effect of patient positioning on setup reproducibility and dose distribution to organs at risk in radiotherapy of rectal cancer patients
(Peer reviewed; Journal article, 2015)Background:The patient positioning in pelvic radiotherapy (RT) should be decided based on both reproducibilityand on which position that yields the lowest radiation dose to the organs at risk (OAR), and thereby less ... -
Explaining variation in cancer survival between 11 jurisdictions in the International Cancer Benchmarking Partnership: a primary care vignette survey
(Peer reviewed; Journal article, 2015)Objectives The International Cancer Benchmarking Partnership (ICBP) is a collaboration between 6 countries and 12 jurisdictions with similar primary care-led health services. This study investigates primary care physician ... -
The expression of the long NEAT1_2 isoform is associated with human epidermal growth factor receptor 2-positive breast cancers
(Peer reviewed; Journal article, 2020)The long non-coding RNA NEAT1 locus is transcribed into two overlapping isoforms, NEAT1_1 and NEAT1_2, of which the latter is essential for the assembly of nuclear paraspeckles. NEAT1 is abnormally expressed in a wide ... -
Mycobacterium smegmatis Vaccine Vector Elicits CD4+ Th17 and CD8+ Tc17 T Cells With Therapeutic Potential to Infections With Mycobacterium avium
(Peer reviewed; Journal article, 2020)Mycobacterium avium (Mav) complex is increasingly reported to cause non-tuberculous infections in individuals with a compromised immune system. Treatment is complicated and no vaccines are available. Previous studies have ... -
Long-term results after surgical treatment for severe obesity
(Doctoral theses at NTNU;2020:199, Doctoral thesis, 2020)Ny kunnskap om utvikling av alvorlig fedme har erstattet oppfatningen av at av fedme er en individuell selvforskyldt tilstand med en forståelse av at fedme er en kronisk progressiv sykdom med sammensatte årsaksfaktorer. ... -
Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer.
(Peer reviewed; Journal article, 2016)CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory reflex arc involving the vagus nerve and ... -
Progressive multifocal leukoencephalopathy in an immunocompetent patient?
(Peer reviewed; Journal article, 2013)Background: Progressive multifocal leukoencephalopathy (PML) is a rapidly progressive, potentially fatal, demyelinating disease affecting immunosuppressed patients. PML is rarely reported in cases with no underlying disease ... -
Helicobacter pylori and gastric acid: An intimate and reciprocal relationship
(Peer reviewed; Journal article, 2016)Helicobacter pylori (Hp) is the main cause of gastritis, peptic ulcer disease and gastric cancer. There are still unanswered questions related to the interaction between Hp and man, like what determines the susceptibility ... -
An ensemble framework for identifying essential proteins
(Peer reviewed; Journal article, 2016)Many centrality measures have been proposed to mine and characterize the correlations between network topological properties and protein essentiality. However, most of them show limited prediction accuracy,and the number ... -
Placental inflammation by HMGB1 activation of TLR4 at the syncytium
(Peer reviewed; Journal article, 2018)Introduction: Normal pregnancy is characterized by an elevated inflammatory state involving the placenta. The placental inflammation is further increased in preeclampsia, resulting in release of harmful danger signals to ... -
Lynch syndrome mutation spectrum in New South Wales, Australia, including 55 novel mutations
(Peer reviewed; Journal article, 2016)Background Lynch syndrome, the most frequent hereditary colorectal cancer syndrome, is caused by defects in mismatch repair genes. Genetic testing is important in order to identify mutation carriers who can benefit from ... -
Impact of acetyltransferases in B cell development
(Master thesis, 2020)Abstract Histone acetylation is a crucial mechanism involved in several cellular functions, including embryogenesis, DNA repair, cell cycle regulation, neurogenesis, and lymphocyte development. Acetyltransferases are the ... -
Comparison of iron acquisition mechanisms and growth characteristics of Escherichia coli from bloodstream infection in patients with low and normal iron status
(Master thesis, 2019)Sepsis is a systemic inflammatory response to infection which is one of the major public health issues with significant mortality and morbidity. Bloodstream infections are infectious diseases characterised by the presence ...
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