Nye registreringer

  • Ultrasound and microbubble-enhanced therapy of Gastrointestinal tumors using conventional cytotoxic drugs in preclinical and clinical settings 

    Haram, Margrete (Doctoral theses at NTNU;2024:94, Doctoral thesis, 2024)
    Pancreatic ducal adenocarcinoma (PDAC) remains one of the deadliest cancers, with a very short life expectancy. Together with late diagnosis and aggressive biology, chemoresistance is one important cause of poor survival. ...
  • Healthy ageing from birth to age 84 years in the Helsinki Birth Cohort Study, Finland: a longitudinal study 

    Mikkola, Tuija M; Kautiainen, Hannu; von Bonsdorff, Mikaela B; Wasenius, Niko S; Salonen, Minna K; Haapanen, Markus J; Kajantie, Eero Olavi; Eriksson, Johan G (Peer reviewed; Journal article, 2023)
    Background The true prevalence of healthy ageing on a population level is unknown. In this study we aimed to examine the upper limit for the prevalence of healthy ageing, by quantifying the probability of surviving and ...
  • The effect of BRAFV600E mutation on survival and treatment efficacy in vulnerable older patients with metastatic colorectal cancer – A post-hoc exploratory analysis of the randomized NORDIC9-study 

    Liposits, Gabor; Winther, Stine B.; Ryg, Jesper; Skuladottir, Halla; Möller, Sören; Hofsli, Eva; Shah, Carl-Henrik; Poulsen, Laurids Østergaard; Berglund, Åke; Qvortrup, Camilla; Osterlund, Pia; Glimelius, Bengt; Sorbye, Halfdan; Pfeiffer, Per (Peer reviewed; Journal article, 2023)
  • Protocol of a randomised, controlled trial comparing immediate curative therapy with conservative treatment in men aged ≥75 years with non-metastatic high-risk prostate cancer (SPCG 19/GRand-P) 

    Löffeler, Sven; Bertilsson, Helena Maria; Müller, Christoph Rainer; Aas, Kirsti; Haugnes, Hege Sagstuen; Aksnessæther, Bjørg Yksnøy; Pesonen, Maiju; Thon, Kristian; Tandstad, Torgrim; Murtola, Teemu; Poulsen, Mads Hvid Aaberg; Nordstrøm, Tobias; Vigmostad, Maria Nyre; Ottosson, Fredrik; Holmsten, Karin; Christiansen, Ola B.; Slaaen, Marit; Haug, Erik Skaaheim; Storås, Anne Holck; Asphaug, Lars; Rannikko, Antti; Brasso, Klaus (Peer reviewed; Journal article, 2024)
    Background Older men (aged ≥75 years) with high risk, non-metastatic prostate cancer (PCa) are increasingly treated with curative therapy (surgery or radiotherapy). However, it is unclear if curative therapy prolongs ...
  • No association between disease severity and respiratory syncytial virus subtypes RSV-A and RSV-B in hospitalized young children in Norway 

    Bøås, Håkon; Havdal, Lise Beier; Størdal, Ketil; Døllner, Henrik; Leegaard, Truls Michael; Bekkevold, Terese; Flem, Elmira; Inchley, Christopher; Nordbø, Svein Arne; Rojahn, Astrid Elisabeth; Debes, Sara Molvig; Barstad, Bjørn; Haarr, Elisebet; Kran, Anne-Marte Bakken (Peer reviewed; Journal article, 2024)
    Objective There is conflicting evidence whether subtypes of Respiratory syncytial virus have different seasonality or are differentially associated with clinical severity. We aimed to explore the associations between ...
  • Complement factors B, D, C3bBbP and risk of future venous thromboembolism 

    Skjeflo, Espen Waage; Evensen, Line Holtet; Jensen, Søren Beck; Latysheva, Nadezhda; Michelsen, Annika Elisabet; Ueland, Thor; Brækkan, Sigrid Kufaas; Hindberg, Kristian Dalsbø; Snir, Omri; Mollnes, Tom Eirik; Hansen, John Bjarne (Peer reviewed; Journal article, 2023)
    The complement system appears to be involved in the pathogenesis of venous thromboembolism (VTE). We investigated the association of complement factors (CF) B, D, and the alternative pathway convertase, C3bBbP, measured ...
  • Inflammation and Digestive Cancer 

    Waldum, Helge; Fossmark, Reidar (Journal article; Peer reviewed, 2023)
    Chronic inflammation is linked to carcinogenesis, particularly in the digestive organs, i.e., the stomach, colon, and liver. The mechanism of this effect has, however, only partly been focused on. In this review, we focus ...
  • APOE Polymorphism Is Associated with Changes in the Kynurenine Pathway 

    Farup, Per Grønaas; Rootwelt, Helge; Hestad, Knut (Peer reviewed; Journal article, 2023)
    Abstract: Background: APOE polymorphism and the Kynurenine pathway (KP) are associated with many disorders, but little is known about associations between APOE polymorphism and the KP. This study explored the associations ...
  • Methplotlib: Analysis of modified nucleotides from nanopore sequencing 

    De Coster, Wouter; Stovner, Endre Bakken; Strazisar, Mojca (Journal article; Peer reviewed, 2020)
    Summary Modified nucleotides play a crucial role in gene expression regulation. Here, we describe methplotlib, a tool developed for the visualization of modified nucleotides detected from Oxford Nanopore Technologies ...
  • Gestational diabetes is associated with the risk of offspring's congenital anomalies: a register-based cohort study 

    Kinnunen, Jenni; Nikkinen, Hilkka; Keikkala, Elina; Mustaniemi, Sanna; Gissler, Mika; Laivuori, Hannele; Eriksson, Johan G.; Kaaja, Risto; Pouta, Anneli; Kajantie, Eero Olavi; Vääräsmäki, Marja (Peer reviewed; Journal article, 2023)
    Background Gestational diabetes mellitus (GDM) is a common pregnancy-related disorder and a well-known risk factor for adverse pregnancy outcomes. There are conflicting findings on the association of GDM with the risk of ...
  • Støtte til fallforebygging hos eldre 

    Ruths, Sabine; Bakken, Marit Stordal; Ranhoff, Anette Hylen; Granås, Anne Gerd; Spigset, Olav (Journal article; Peer reviewed, 2023)
  • Liquid Biopsy in Organ Damage: small extracellular vesicle chip-based assessment of polytrauma 

    Wang, Bingduo; Wöhler, Aliona; Greven, Johannes; Salzmann, Rebekka J. S.; Keller, Cindy M.; Tertel, Tobias; Zhao, Qun; Mert, Ümit; Horst, Klemens; Lupu, Ludmila; Huber-Lang, Markus; van Griensven, Martijn; Mollnes, Tom Erik; Schaaf, Sebastian; Schwab, Robert; Strassburg, Christian P.; Schmidt-Wolf, Ingo G. H.; Giebel, Bernd; Hildebrand, Frank; Lukacs-Kornek, Veronika; Willms, Arnulf G.; Kornek, Miroslaw T. (Journal article; Peer reviewed, 2023)
    Background Despite major advances in medicine, blood-borne biomarkers are urgently needed to support decision-making, including polytrauma. Here, we assessed serum-derived extracellular vesicles (EVs) as potential markers ...
  • Effectiveness of a group-based Diabetes Prevention Education Program (DiPEP) in a population with pre-diabetes: a cluster randomised controlled trial in Nepal 

    Shakya, Pushpanjali; Shrestha, Archana; Bajracharya, Monish; Shrestha, Abha; Kulseng, Bård Eirik; Karmacharya, Biraj Man; Shrestha, Smriti; Das, Seema; Shrestha, Ishwori Byanju; Barun, Krishnaa; Shrestha, Nistha; Skovlund, Eva; Sen, Abhijit (Journal article; Peer reviewed, 2023)
    Background Although several lifestyle intervention studies have been conducted in low/middle-income countries, there were no such studies in Nepal. Therefore, a group-based culturally tailored Diabetes Prevention Education ...
  • Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity 

    Castela, Inês; Morais, Juliana; Barreiros-Mota, Inês; Silvestre, Marta P.; Marques, Cláudia; Rodrigues, Catarina; Ismael, Shámila; Araújo, João R; Ângelo-Dias, Miguel; Martins, Catarina; Borrego, Luís Miguel; Monteiro, Rosário; dos Santos Ribeiro F. Coutinho, Silvia; Calhau, Conceição; Alho Letra Martins, Catia Patricia; Faria, Ana; Pestana, Diogo; Teixeira, Diana (Journal article; Peer reviewed, 2023)
    Adiponectin/leptin ratio, triacylglycerols, and waist-to-hip ratio explained almost half of HOMA-IR variance in the context of obesity. This study provides evidence to support adipose tissue dysfunction as a central feature ...
  • Mutation Spectrum in Liquid Versus Solid Biopsies From Patients With Advanced astroenteropancreatic Neuroendocrine Carcinoma 

    Knappskog, Stian; Grob, Tobias; Venizelos, Andreas; Amstutz, Ursula; Hjortland, Geir Olav; Lothe, Inger Marie Bowitz; Kersten, Christian; Hofsli, Eva; Sundlöv, Anna; Elvebakken, Hege; Garresori, Herish; Couvelard, Anne; Svensson, Johanna; Sorbye, Halfdan; Perren, Aurel (Peer reviewed; Journal article, 2023)
    Purpose Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are rare and have a poor prognosis. Most GEP-NEC are diagnosed with metastatic disease, with only minor biopsies available for molecular diagnostics. We ...
  • Antenatal corticosteroid treatment and infectious diseases in children: a nationwide observational study 

    Räikkönen, Katri; Gissler, Mika; Kajantie, Eero Olavi; Tapiainen, Terhi (Peer reviewed; Journal article, 2023)
    Background Antenatal Corticosteroid Treatment (ACT) improves the outcome of preterm infants, but may influence immune system development and risk of immune-related diseases. We investigated whether ACT is associated ...
  • Quality learning in undergraduate medical education - Improving teaching and assessment practices 

    Martinsen, Susanne Skjervold Smeby (Doctoral theses at NTNU;2024:88, Doctoral thesis, 2024)
    Although there have been significant advancements in our understanding of human learning over the last century, many educational practices within the medical field have not integrated educational research findings. ...
  • A 39 kb structural variant causing Lynch Syndrome detected by optical genome mapping and nanopore sequencing 

    Bjørnstad, Pål Marius; Aaløkken, Ragnhild Margrethe; Åsheim, June; Sundaram, Arvind; Nangota Felde, Caroline; Østby, Gina Henriette; Dalland, Marianne; Sjursen, Wenche; Carrizosa, Christian; Vigeland, Magnus Dehli; Sorte, Hanne Sørmo; Sheng, Ying; Ariansen, Sarah Louise; Grindedal, Eli Marie; Gilfillan, Gregor (Peer reviewed; Journal article, 2023)
    Lynch Syndrome (LS) is a hereditary cancer syndrome caused by pathogenic germline variants in one of the four mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2. It is characterized by a significantly increased risk of ...
  • TFCheckpoint database update, a cross-referencing system for transcription factors from human, mouse and rat 

    Acencio, Marcio Luis; Vázquez, Miguel; Chawla, Konika; Lægreid, Astrid Renner; Kuiper, Martin (Journal article; Peer reviewed, 2023)
    Prior knowledge about DNA-binding transcription factors (dbTFs), transcription co-regulators (coTFs) and general transcriptional factors (GTFs) is crucial for the study and understanding of the regulation of transcription. ...
  • Established and novel methods and biomarkers in breast cancer 

    Skjervold, Anette Hansen (Doctoral theses at NTNU;2024:80, Doctoral thesis, 2024)
    The present thesis is based on three published papers. The work arises from three cohorts of women from Trøndelag county in Norway. These were women born between 1886 and 1977, that were diagnosed with breast cancer (BC). ...

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