• Prediction of outcome from MRI and general movements assessment after hypoxic-ischaemic encephalopathy in low-income and middle-income countries: data from a randomised controlled trial 

  Aker, Karoline; Thomas, Niranjan; Adde, Lars; Koshy, Beena; Martinez-Biarge, Miriam; Nakken, Ingeborg Elise; Padankatti, Caroline; Støen, Ragnhild (Peer reviewed; Journal article, 2021)

  Objective To evaluate the accuracy of neonatal MRI and general movements assessment (GMA) in predicting neurodevelopmental outcomes in infants with hypoxic-ischaemic encephalopathy (HIE). Design Secondary analyses of a ...

• Patient derived colonoids as drug testing platforms-Critical importance of oxygen concentration 

  Skovdahl, Helene Kolstad; Gopalakrishnan, Shreya; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Bakke, Ingunn; Ginbot, Zekarias; Thorsvik, Silje; Flatberg, Arnar; Sporsheim, Bjørnar; Ostrop, Jenny; Mollnes, Tom Eirik; Sandvik, Arne Kristian; Bruland, Torunn (Peer reviewed; Journal article, 2021)

  Treatment of inflammatory bowel disease (IBD) is challenging, with a series of available drugs each helping only a fraction of patients. Patients may face time-consuming drug trials while the disease is active, thus there ...

• Postponed Withholding: Balanced Decision-Making at the Margins of Viability 

  Syltern, Janicke; Ursin, Lars Øystein; Solberg, Berge; Støen, Ragnhild (Peer reviewed; Journal article, 2021)

  Advances in neonatology have led to improved survival for periviable infants. Immaturity still carries a high risk of short- and long-term harms, and uncertainty turns provision of life support into an ethical dilemma. ...

• Timing of severe toxicity from chemotherapy in patients with lung cancer 

  Sjøgren, Kristina; Jacobsen, Kristian Aalberg; Grønberg, Bjørn Henning; Halvorsen, Tarje Onsøien (Journal article; Peer reviewed, 2020)

  Background/Aim: The aim of this study was to investigate the timing of severe toxicity in lung cancer patients receiving chemotherapy. Patients and Methods: Patients with advanced non-small cell lung cancer or limited ...

• Hvorfor lykkes noen med livsstilsendring? - En kvalitativ studie av tidligere deltagere i Vend-Risk 

  Minde, Elise (Master thesis, 2018)

  Background: Lifestyle interventions to reduce risk of illness related to overweight and obesity, have had limited success. Only a few of those participating in lifestyle interventions are able to maintain changes and keep ...

• Alendronate and omeprazole in combination reduce angiogenic and growth signals from osteoblasts 

  Kruger, Tormod Bjartveit; Herlofson, Bente Brokstad; Lian, Aina-Mari; Syversen, Unni; Reseland, Janne Elin (Peer reviewed; Journal article, 2021)

  Objective: Due to gastrointestinal side effects of oral bisphosphonates (BPs), proton pump inhibitors (PPIs) are often prescribed. PPIs may enhance the risk of osteonecrosis of the jaw, a rare side effect of BPs. Therefore, ...

• Association between habitual sleep duration/quality and appetite markers in individuals with obesity 

  Nymo, Siren; Kleppe, Malin M.; Coutinho, Silvia; Rehfeld, Jens F.; Kulseng, Bård Eirik; Martins, Catia (Peer reviewed; Journal article, 2021)

  Study Objectives: To assess if habitual sleep duration/quality was associated with appetite in individuals with obesity, and if the association was modulated by sex. Methods: Sleep duration/quality was measured with ...

• Application of photodynamic therapy with 5-aminolevulinic acid to extracorporeal photopheresis in the treatment of patients with chronic graft-versus-host disease: A first-in-human study 

  Christensen, Eidi; Foss, Olav A.; Quist-Paulsen, Petter; Staur, Ingrid; Pettersen, Frode; Holien, Toril; Juzenzas, Petras; Qian, Peng (Peer reviewed; Journal article, 2021)

  Extracorporeal photopheresis (ECP), an immunomodulatory therapy for the treatment of chronic graft-versus-host disease (cGvHD), exposes isolated white blood cells to photoactivatable 8-methoxypsoralen (8-MOP) and UVA light ...

• Parechovirus A in Hospitalized Children With Respiratory Tract Infections: A 10-Year-Long Study From Norway 

  Skanke, Lars Høsøien; Lysvand, Hilde; Heimdal, Inger; Moe, Nina; Krokstad, Sidsel; Christensen, Andreas; Risnes, Kari; Nordbø, Svein Arne; Døllner, Henrik (Peer reviewed; Journal article, 2021)

  Background. The role of Parechovirus A (PeV-A) in hospitalized children with respiratory tract infections (RTIs) is unclear. We studied the occurrence and impact of PeV-A over 10 years. Methods. Children from Sør-Trøndelag ...

• Patterns of previous and secondary malignancies in patients with multiple myeloma 

  Langseth, Øystein Olstad; Myklebust, Tor Åge; Johannessen, Tom Børge; Hjertner, Øyvind; Waage, Anders (Peer reviewed; Journal article, 2021)

  Objectives: In contrast to secondary primary malignancies (SPM) following multiple myeloma (MM), less is known about previous malignancies. We therefore conducted a population-based study to assess the patterns of previous ...

• Induction of labor in breech presentations - a retrospective cohort study 

  Welle-Strand, Johanne Augusta Horn; Tappert, Christian; Eggebø, Torbjørn Moe (Peer reviewed; Journal article, 2021)

  Background: Recently, there has been an increasing focus among healthcare organisations on implementing patient portals. Previous studies have mainly focussed on the experiences of patient portal use. Few have investigated ...

• Low C-peptide together with a high glutamic acid decarboxylase autoantibody level predicts progression to insulin dependence in latent autoimmune diabetes in adults: The HUNT study 

  Sørgjerd, Elin P.; Åsvold, Bjørn O.; Grill, Valdemar (Journal article; Peer reviewed, 2021)

  Aim: To search for risk factors that could predict progression in latent autoimmune diabetes in adults (LADA) and compare them with those for type 2 diabetes. Materials and Methods: This study included 175 participants ...

• Novel Peptides Targeting the β-Clamp Rapidly Kill Planktonic and Biofilm Staphylococcus epidermidis Both in vitro and in vivo 

  Ræder, Synnøve Brandt; Sandbakken, Erik Thorvaldsen; Nepal, Anala; Løseth, Kirsti; Bergh, Kåre; Witsø, Eivind; Otterlei, Marit (Peer reviewed; Journal article, 2021)

  Antimicrobial resistance is an increasing threat to global health and challenges the way we treat infections. Peptides containing the PCNA interacting motif APIM (APIM-peptides) were recently shown to bind to the bacterial ...

• Express Team-Based Learning (eTBL): A Time-Efficient TBL Approach in Neuroradiology 

  Smeby, Susanne Skjervold; Lillebo, Børge; Slørdahl, Tobias Schmidt; Berntsen, Erik Magnus (Peer reviewed; Journal article, 2019)

  Rationale and Objectives Team-based learning (TBL) is a student-centred, teacher-directed instructional method that promotes active learning. The application phase of TBL stimulates group discussion and critical thinking, ...

• Exercise training and high-sensitivity cardiac troponin T in patients with heart failure with reduced ejection fraction 

  Koppen, Elias; Omland, Torbjørn; Larsen, Alf Inge; Karlsen, Trine; Linke, Axel; Prescott, Eva Irene Bossano; Halle, Martin; Dalen, Håvard; Delagardelle, Charles; Hole, Torstein; van Craenenbroeck, Emeline M.; Beckers, Paul; Ellingsen, Øyvind; Feiereisen, Patrick; Valborgland, Torstein; Videm, Vibeke (Journal article; Peer reviewed, 2021)

  Plasma cell disorders (PCDs) are identified in the clinical lab by detecting the monoclonal immunoglobulin (M-protein) which they produce. Traditionally, serum protein electrophoresis methods have been utilized to detect ...

• The inflammasome components NLRP3 and ASC act in concert with IRGM to rearrange the golgi apparatus during hepatitis C virus infection 

  Daussy, Coralie F.; Monard, Sarah C.; Guy, Coralie; Muñoz-González, Sara; Chazal, Maxime; Anthonsen, Marit Walbye; Jouvenet, Nolwenn; Henry, Thomas; Dreux, Marlène; Meurs, Eliane F.; Hansen, Marianne Dore (Peer reviewed; Journal article, 2021)

  Hepatitis C virus (HCV) infection triggers Golgi fragmentation through the Golgi-resident protein immunity-related GTPase M (IRGM). Here, we report the roles of NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) and ...

• Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations 

  Boer, Cindy G.; Hatzikotoulas, Konstantinos; Southam, Lorraine; Stefánsdóttir, Lilja; Almeida, Rodrigo Coutinho de; Zhang, Yanfei; Wu, Tian T.; Zheng, Jie; Hartley, April; Teder-Laving, Maris; Skogholt, Anne Heidi; Terao, Chikashi; Zengini, Eleni; Alexiadis, George; Barysenka, Andrei; Bjornsdottir, Gyda; Gabrielsen, Maiken Elvestad; Gilly, Arthur; Ingvarsson, Thorvaldur; Johnsen, Marianne Bakke; Jonsson, Helgi; Kloppenburg, Margreet; Luetge, Almut; Lund, Sigrun H; Magi, Reedik; Mangino, Massimo; Nelissen, Rob G.H.H.; Shivakumar, Manu; Steinberg, Julia; Takuwa, Hiroshi; Thomas, Laurent; Tuerlings, Margo; Babis, George C.; Cheung, Jason Pui Yin; Kang, Jae Hee; Kraft, Peter; Lietman, Steven A.; Samartzis, Dino; Slagboom, P. Eline; Stefansson, Kari; Thorsteinsdottir, Unnur; Tobias, Jonathan H.; Uitterlinden, André G.; Winsvold, Bendik K S; Zwart, John Anker Henrik; Smith, George Davey; Sham, Pak Chung; Thorleifsson, Gudmar; Hveem, Kristian; Zeggini, Eleftheria (Peer reviewed; Journal article, 2021)

  Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated ...

• A conformational change of complement C5 is required for thrombin-mediated cleavage, revealed by a novel ex vivo human whole blood model preserving full thrombin activity 

  Nilsson, Per; Johnson, Christina; Quach, Huy Quang; Macpherson, Alex; Durrant, Oliver; Pischke, Soeren; Fure, Hilde; Landsem, Anne; Bergseth, Grete; Schjalm, Camilla; Haugaard-Kedström, Linda M.; Huber-Lang, Markus; van den Elsen, Jean; Brekke, Ole-Lars; Mollnes, Tom Eirik (Peer reviewed; Journal article, 2021)

  Thrombin activation of C5 connects thrombosis to inflammation. Complement research in whole blood ex vivo necessitates anticoagulation, which potentially interferes with the inflammatory modulation by thrombin. We challenged ...

• Surgical Complications in Postchemotherapy Retroperitoneal Lymph Node Dissection for Nonseminoma Germ Cell Tumour: A Population-based Study from the Swedish Norwegian Testicular Cancer Group 

  Gerdtsson, Axel; Håkansson, Ulf; Törnblom, Magnus; Jancke, George; Negaard, Helene Francisca Stigter; Glimelius, Ingrid; Halvorsen, Dag; Karlsdottir, Åsa; Haugnes, Hege Sagstuen; Andreassen, Kristine Engen; Larsen, Signe Melsen; Holmberg, Göran; Wahlqvist, Rolf; Tandstad, Torgrim; Cohn-Cedermark, Gabriella; Ståhl, Olof; Kjellmann, Anders (Journal article, 2020)

  Background Reports on perioperative complications after postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) for nonseminoma germ cell tumour (NSGCT) are from experienced single centres, with a lack of ...

• Randomized phase III trial comparing switch-maintenance pemetrexed with observation followed by pemetrexed at progression in advanced NSCLC 

  Halvorsen, Tarje Onsøien; Stokke, Kristin; Killingberg, Kristin Toftaker; Raj, Sunil Xavier; Sørhaug, Sveinung; Brustugun, Odd Terje; Fløtten, Øystein; Helbekkmo, Nina; Hornslien, Kjersti; Madebo, Tesfaye; Fluge, Sverre; Grønberg, Bjørn Henning (Peer reviewed; Journal article, 2020)

  Objectives: Two phase III trials show that maintenance pemetrexed therapy after platinum-doublet chemotherapy prolongs overall survival (OS) and progression free survival (PFS) in advanced non-squamous non-small-cell lung ...

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