Institutt for klinisk og molekylær medisin
Recent Submissions
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Cold agglutinin disease revisited: a multinational, observational study of 232 patients
(Peer reviewed; Journal article, 2020)We retrospectively studied 232 patients with cold agglutinin disease (CAD) at 24 centers in 5 countries. In Norway and a northern region of Italy, the study was close to being population-based. For the first time, we ... -
Development and validation of a prediction model for incident hand osteoarthritis in the HUNT study
(Peer reviewed; Journal article, 2020)Objective To develop and externally validate prediction models for incident hand osteoarthritis (OA) in a large population-based cohort of middle aged and older men and women. Design We included 17,153 men and 18,682 ... -
Physiological effects of intraperitoneal versus subcutaneous insulin infusion in patients with diabetes mellitus type 1: A systematic review and meta-analysis
(Peer reviewed; Journal article, 2021)The intraperitoneal route of administration accounts for less than 1% of insulin treatment regimes in patients with diabetes mellitus type 1 (DM1). Despite being used for decades, a systematic review of various physiological ... -
Analysis of Intra-Tumoral Macrophages and T Cells in Non-Small Cell Lung Cancer (NSCLC) Indicates a Role for Immune Checkpoint and CD200-CD200R Interactions
(Peer reviewed; Journal article, 2021)Lung cancer is the leading cause of cancer-related death worldwide, accounting for nearly one-fifth of all cancer-related deaths. Immunotherapy with immune checkpoint inhibitors has become one of the most promising approaches ... -
Continuous subcutaneous infusion for pain control in dying patients: experiences from a tertiary palliative care center
(Peer reviewed; Journal article, 2020)Background Continuous subcutaneous infusion (CSCI) via ambulatory infusion pump (AIP) is a valuable method of pain control in palliative care. When using CSCI, low-dose methadone as add-on to other opioids might be an ... -
Effect of Aerobic Exercise Intensity on Energy Expenditure and Weight Loss in Severe Obesity-A Randomized Controlled Trial
(Peer reviewed; Journal article, 2021)Objective This study aimed to compare the effects of two aerobic exercise programs of different intensities on energy expenditure. Methods This was a single‐center randomized controlled trial of patients with severe obesity ... -
Identification of genetic polymorphisms modulating nausea and vomiting in two series of opioid-treated cancer patients
(Peer reviewed; Journal article, 2020)Nausea and vomiting are often associated with opioid analgesia in cancer patients; however, only a subset of patients develop such side effects. Here, we tested the hypothesis that the occurrence of nausea and vomiting is ... -
Bystander memory T cells and IMiD/checkpoint therapy in multiple myeloma: A dangerous tango?
(Peer reviewed; Journal article, 2021)In this review article we discuss the role of the memory T cells in multiple myeloma (MM) and how they may influence immune responses in patients that received immunomodulating drugs and check point therapy -
Sustained Maternal Hyperandrogenism During PCOS Pregnancy Reduced by Metformin in Non-obese Women Carrying a Male Fetus
(Peer reviewed; Journal article, 2020)Context Large, longitudinal studies on androgen levels in pregnant women with polycystic ovary syndrome (PCOS) are lacking. While metformin has a mild androgen-lowering effect in non-pregnant women with PCOS, its effects ... -
Post mortem tissue distribution of quetiapine in forensic autopsies
(Peer reviewed; Journal article, 2020)The antipsychotic drug quetiapine is widely used, and increasingly prescribed off-label. Furthermore, quetiapine use has been linked to increased mortality rates, most likely due to a range of cardiovascular and metabolic ... -
Impact of thyrotropin receptor antibody levels on fetal development in two successive pregnancies in a woman with Graves' Disease
(Peer reviewed; Journal article, 2013)Background: Treatment with radioiodine for Graves’ disease regularly increases the level of antithyroid antibodies, and transplacental passage of stimulating thyrotropin receptor antibodies (TRAb) may cause fetal ... -
The pen, the receiver and the pump: Exploring young children's experiences of having a parent with type 1 diabetes
(Peer reviewed; Journal article, 2021)In this article, we explore young children's experiences of having a parent with type 1 diabetes (T1D). In our research we found that the children's knowledge about T1D was not age related, and that some had more in‐depth ... -
Nephronectin as a matrix effector in cancer
(Peer reviewed; Journal article, 2021)The extracellular matrix protein nephronectin plays an important regulatory role during embryonic development, controlling renal organogenesis through integrin α8β1 association. Nephronectin has three main domains: five ... -
Computational Drug Repositioning and Experimental Validation of Ivermectin in Treatment of Gastric Cancer
(Peer reviewed; Journal article, 2021)Objective: The aim of the present study was repositioning of ivermectin in treatment of gastric cancer (GC) by computational prediction based on gene expression profiles of human and mouse model of GC and validations with ... -
Initial experience with positron emission tomography/computed tomography in addition to computed tomography and magnetic resonance imaging in preoperative risk assessment of endometrial cancer patients
(Peer reviewed; Journal article, 2021)Objective: Improved preoperative evaluation of lymph node status could potentially replace lymphadenectomy in women with endometrial cancer. PET/CT was routinely implemented in the preoperative workup of endometrial cancer ... -
Decidual and placental NOD1 is associated with inflammation in normal and preeclamptic pregnancies
(Peer reviewed; Journal article, 2021)Introduction: Inflammation is a normal physiological process that increases to harmful levels in preeclampsia. It affects the interaction between maternal immune cells and fetal trophoblasts at both sites of the maternal-fetal ... -
Assessing the role of genome-wide DNA methylation between smoking and risk of lung cancer using repeated measurements: the HUNT Study
(Peer reviewed; Journal article, 2021)Background: It is unclear if smoking-related DNA methylation represents a causal pathway between smoking and risk of lung cancer. We sought to identify novel smoking-related DNA methylation sites in blood, with repeated ... -
Intraperitoneal insulin administration in pigs: Effect on circulating insulin and glucose levels
(Peer reviewed; Journal article, 2021)Introduction The effect of intraperitoneal insulin infusion has limited evidence in the literature. Therefore, the aim of the study was to investigate the pharmacokinetics and pharmacodynamics of different intraperitoneal ... -
Claims for compensation from women with cervical cancer in Norway-A retrospective, descriptive study of a 12-year period
(Peer reviewed; Journal article, 2020)Introduction: In Norway, all patient-reported claims for compensation are evaluated by The Norwegian System of Patient Injury Compensation (NPE). The number of claims from women with cervical cancer is rising, and the ... -
T.M. Gundem og medarbeidere svarer
(Journal article; Peer reviewed, 2020)
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