Institutt for klinisk og molekylær medisin
Recent Submissions
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Elucidating antibiotic mode of action through multi-omics analysis of bacterial stress responses
(Doctoral theses at NTNU;2024:385, Doctoral thesis, 2024)In 2023, the World Health Organization stated that antimicrobial resistance (AMR) remains one of the top ten threats to global health. In 2019, an estimated 4.95 million deaths were associated with antibiotic-resistant ... -
Sample Preparation for Metabolite Detection in Mass Spectrometry Imaging
(Peer reviewed; Journal article, 2023) -
Visualization of Small Intact Proteins in Breast Cancer FFPE Tissue
(Peer reviewed; Journal article, 2023) -
Self-reported health, function, and use of health care services in older prostate cancer survivors compared to matched controls: a cross-sectional study
(Journal article; Peer reviewed, 2024)Purpose: Information about outcomes of particular relevance to older prostate cancer survivors is limited. This study aimed to compare health, activities of daily living (ADL), and use of health care services between ... -
LSD1 drives intestinal epithelial maturation and controls small intestinal immune cell composition independent of microbiota in a murine model
(Journal article; Peer reviewed, 2024)Postnatal development of the gastrointestinal tract involves the establishment of the commensal microbiota, the acquisition of immune tolerance via a balanced immune cell composition, and maturation of the intestinal ... -
Polygenic interactions with environmental exposures in blood pressure regulation: the HUNT study
(Journal article; Peer reviewed, 2024)Background: The essential hypertension phenotype results from an interplay between genetic and environmental factors. The influence of lifestyle exposures such as excess adiposity, alcohol consumption, tobacco use, diet, ... -
Investigating the Role of TRIM37 and CD5L in Osteoarthritis: A Study on Chondrocyte Dysfunction
(Master thesis, 2023)Osteoarthritis (OA) is a chronic joint disease that affects millions of people worldwide. OA represents a substantial burden, not only in terms of patient quality of life but also in healthcare costs. Despite its high ... -
Dynamic Boolean modeling of molecular and cellular interactions in psoriasis predicts drug target candidates
(Journal article; Peer reviewed, 2024)Psoriasis arises from complex interactions between keratinocytes and immune cells, leading to uncontrolled inflammation, immune hyperactivation, and a perturbed keratinocyte life cycle. Despite the availability of drugs ... -
Impact of inflammatory signals in multiple myeloma – the role of interleukin-32 and toll-like receptors
(Doctoral theses at NTNU;, Doctoral thesis, 2024)En studie av inflammatoriske signaler i myelomatose: fokus på rollen til interleukin-32 og toll-liknende reseptorer Myelomatose, også kalt beinmargkreft, skyldes ukontrollert vekst av plasmaceller i beinmargen. Plasmaceller ... -
Executive Functions in the Chronic Phase of Pediatric Acquired Brain Injury: A randomized controlled trial investigating the efficacy of pediatric Goal Management Training and Associations with Long-term Outcome
(Doctoral theses at NTNU;2024:304, Doctoral thesis, 2024)Pediatric acquired brain injury (pABI), both traumatic and non-traumatic such as brain tumor or stroke, result in more diffuse and enduring impairments compared to adult ABI. These injuries, occurring during ongoing ... -
Phosphatidylethanol (PEth) as a marker of alcohol consumption with particular focus on women: Could there be a future for increased use?
(Doctoral theses at NTNU;2024:312, Doctoral thesis, 2024)English summary Alcohol is the most commonly abused substance and it carries significant harm to the fetus. It not only leads to psychological, physical, and familial issues for the individual, but also imposes a substantial ... -
Enhancing Palliative Care in Primary Healthcare for Patients with Cancer: Integrating Advance Care Planning to Support Home-Based Care at the End-of-Life
(Doctoral theses at NTNU;2024:295, Doctoral thesis, 2024)According to the World Health Organization (WHO), cancer is a significant global health issue and one of the leading causes of death worldwide. An increasing number of cancer patients, live longer with modern oncology ... -
Sleep Disturbances, Epilepsy, EEG findings and Clinical function in Norwegian Children with Fetal Alcohol Spectrum Disorder
(Doctoral theses at NTNU;2024:285, Doctoral thesis, 2024)Søvnforstyrrelser, epilepsi, EEG-funn og klinisk funksjon hos norske barn med føtalt alkohol spektrumforstyrrelse (FASD) Vi har utført en omfattende undersøkelse av barn og ungdom med diagnosen FASD som har vært til ... -
Child Maltreatment: To Report or Not to Report? It’s More Complex than That
(Journal article; Peer reviewed, 2024)Child maltreatment (CM) is a widespread problem, contributing to health and societal difficulties often throughout the lifespan. Healthcare professionals (HCPs) who see potential warning signs for CM are responsible for ... -
Neutrophil Extracellular Traps in ST-Segment Elevation Myocardial Infarction: Reduced by Tocilizumab and Associated With Infarct Size
(Peer reviewed; Journal article, 2024) -
Impaired awareness of hypoglycemia in adults with type 1 diabetes is not associated with autonomic dysfunction or peripheral neuropathy
(Peer reviewed; Journal article, 2015)OBJECTIVE: Impaired awareness of hypoglycemia (IAH) is a risk factor for severe hypoglycemia in people with insulin-treated diabetes; autonomic neuropathy has been suggested to underlie its development. The aim was to ... -
Return to Work after Surgical Clipping versus Endovascular Treatment of Unruptured Intracranial Aneurysms: A Nationwide Registry–Based Study
(Peer reviewed; Journal article, 2023) -
A 1-year pilot study of intralymphatic injections of GAD-alum in individuals with latent autoimmune diabetes in adults (LADA) with signs of high immunity: No safety concerns and resemblance to juvenile type 1 diabetes
(Peer reviewed; Journal article, 2023)Aims To test, for the first time in latent autoimmune diabetes in adults (LADA), the effects of autoantigen-specific immunotherapy by intralymphatic administration of aluminium-formulated recombinant human glutamic acid ... -
Histomolecular Validation of [<sup>18</sup>F]-FACBC in Gliomas Using Image-Localized Biopsies
(Journal article; Peer reviewed, 2024)Background: Gliomas have a heterogeneous nature, and identifying the most aggressive parts of the tumor and defining tumor borders are important for histomolecular diagnosis, surgical resection, and radiation therapy ... -
SLAMF1-derived peptide exhibits cardio protection after permanent left anterior descending artery ligation in mice
(Peer reviewed; Journal article, 2024)