• Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination 

  Eldin, Patrick; Péron, Sophie; Galashevskaya, Anastasia; Denis-Lagache, Nicolas; Cogné, Michel; Slupphaug, Geir; Briant, Laurence (Peer reviewed; Journal article, 2020)

  Background HIV-1 Vpr encodes a 14 kDa protein that has been implicated in viral pathogenesis through modulation of several host cell functions. In addition to pro-apoptotic and cytostatic properties, Vpr can redirect ...

• The Gene Ontology resource: enriching a GOld mine 

  Carbon, Seth J.; Douglass, Eric; Good, Benjamin M; Unni, Deepak R; Harris, Nomi L.; Mungall, Christopher J.; Basu, Siddartha; Chisholm, Rex L.; Dodson, Robert J.; Hartline, Eric; Fey, Petra; Thomas, Paul D.; Albou, Laurent-Philippe; Ebert, Dustin; Kesling, Michael J; Mi, Huaiyu; Muruganujan, Anushya; Huang, Xiaosong; Mushayahama, Tremayne; LaBonte, Sandra A.; Siegele, Deborah A.; Antonazzo, Giulia; Attrill, Helen; Brown, Nick H.; Garapati, Phani; Marygold, Steven J.; Trovisco, Vitor; dos Santos, Gil; Falls, Kathleen; Tabone, Christopher; Zhou, Pinglei; Goodman, Joshua L.; Strelets, Victor B.; Thurmond, Jim; Garmiri, Penelope; Ishtiaq, Rizwan; Rodríguez-López, Milagros; Acencio, Marcio Luis; Kuiper, Martin; Lægreid, Astrid; Logie, Colin; Lovering, Ruth C.; Kramarz, Barbara; Saverimuttu, Shirin C.C.; Pinheiro, Sandra M.; Gunn, Heather; Su, Renzhi; Thurlow, Katherine E.; Chibucos, Marcus; Giglio, Michelle; Nadendla, Suvarna; Munro, James; Jackson, Rebecca; Duesbury, Margaret J.; del-Toro, Noemi; Meldal, Birgit H.M.; Paneerselvam, Kalpana; Perfetto, Livia; Porras, Pablo; Orchard, Sandra; Shrivastava, Anjali (Peer reviewed; Journal article, 2021)

  The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene products. Here, we report the advances of the consortium ...

• Corticosteroids Prior to Embryo Transfer in Assisted Reproduction in Women with Crohn’s Disease and Ulcerative Colitis – A Nationwide Cohort Study 

  Nørgård, Bente Mertz; Larsen, Michael Due; Freidman, Sonia; Fedder, Jens (Peer reviewed; Journal article, 2020)

  Purpose: Former studies have suggested that women with Crohn’s disease (CD) and ulcerative colitis (UC) have a decreased chance of a live born child after assisted reproductive technology (ART) treatment. It is debated ...

• Discovery and development of safe-in-man broad-spectrum antiviral agents 

  Anderssen, Petter Inge; Ianevski, Aleksandr; Lysvand, Hilde; Vitkauskiene, Astra; Oksenych, Valentyn; Bjørås, Magnar; Telling, Kaidi; Lutsar, Irja; Dumpis, Uga; Irie, Yasuhiko; Tenson, Tanel; Kantele, Anu; Kainov, Denis (Peer reviewed; Journal article, 2020)

  Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases. However, broad-spectrum antiviral ...

• Sperm counts and endocrinological markers of spermatogenesis in long-term survivors of testicular cancer 

  Brydøy, Marianne; Fosså, Sophie Dorothea; Klepp, Olbjørn; Bremnes, Roy M.; Wist, Erik; Bjøro, Trine; Wentzel-Larsen, Tore; Dahl, Olav (Peer reviewed; Journal article, 2012)

  Background: The objective of this study was to assess markers of spermatogenesis in long-term survivors of testicular cancer (TC) according to treatment, and to explore correlations between the markers and associations ...

• Use of peripheral venous catheters in two Norwegian hospitals. 

  Høvik, Lise Husby; Gjeilo, Kari Hanne; Lydersen, Stian; Solligård, Erik; Damås, Jan Kristian; Gustad, Lise Tuset (Peer reviewed; Journal article, 2020)

  BAKGRUNN De fleste pasienter ved norske sykehus får rutinemessig ett eller flere perifere venekatetre. Et perifert venekateter regnes som ufarlig, men kan gi lokal infeksjon, med blodstrømsinfeksjon og sepsis som følge. ...

• Hypergastrinemia Expands Gastric ECL Cells Through CCK2R Progenitor Cells via ERK Activation 

  Sheng, Weiwei; Ermanno, Malagola,; Henrik, Nienhüser; Zhengyu, Zhang; Woosook, Kim; Leah, Zamechek; Antonia, Sepulveda; Masahiro, Hata; Yoku, Hayakawa; Zhao, Chun-Mei; Chen, Duan; Timothy C., Wang (Peer reviewed; Journal article, 2020)

  Background & Aims Enterochromaffin-like (ECL) cells in the stomach express gastrin/cholecystokinin 2 receptor CCK2R and are known to expand under hypergastrinemia, but whether this results from expansion of existing ECL ...

• Testicular cancer in the cisplatin era: Causes of death and mortality rates in a population-based cohort 

  Hellesnes, Ragnhild; Myklebust, Tor Åge; Fosså, Sophie Dorothea; Bremnes, Roy M.; Karlsdottir, Åsa; Kvammen, Øivind; Tandstad, Torgrim; Wilsgaard, Tom; Negaard, Helene Francisca Stigter; Haugnes, Hege Sagstuen (Peer reviewed; Journal article, 2021)

  PURPOSE Using complete information regarding testicular cancer (TC) treatment burden, this study aimed to investigate cause-specific non-TC mortality with impact on previous treatment with platinum-based chemotherapy (PBCT) ...

• A user guide for the online exploration and visualization of PCAWG data 

  Goldman, Mary J.; Zhang, Junjun; Fonseca, Nuno A.; Cortés-Ciriano, Isidro; Xiang, Qian; Craft, Brian; Piñeiro-Yáñez, Elena; O’Connor, Brian D.; Bazant, Wojciech; Barrera, Elisabet; Muñoz-Pomer, Alfonso; Petryszak, Robert; Füllgrabe, Anja; Al-Shahrour, Fatima; Keays, Maria; Haussler, David; Weinstein, John N.; Huber, Wolfgang; Valencia, Alfonso; Park, Peter J.; Papatheodorou, Irene; Zhu, Jingchun; Ferretti, Vincent; Vazquez Garcia, Miguel (Peer reviewed; Journal article, 2020)

  The Pan-Cancer Analysis of Whole Genomes (PCAWG) project generated a vast amount of whole-genome cancer sequencing resource data. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which ...

• Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile 

  Huang, Kai-Wen; Reebye, Vikash; Czysz, Katherine; Ciriello, Simona; Dorman, Stephanie; Reccia, Isabella; Lai, Hong-Shiee; Peng, Ling; Kostomitsopoulos, Nikos; Nicholls, Joanna; Habib, Robert; Tomalia, Donald A.; Sætrom, Pål; Wilkes, Edmund; Cutillas, Pedro; Rossi, John; Habib, Nagy (Peer reviewed; Journal article, 2020)

  Non-alcoholic fatty liver disease (NAFLD) culminates in insulin resistance and metabolic syndrome. Because there are no approved pharmacological treatment agents for non-alcoholic steatohepatitis (NASH) and NAFLD, different ...

• Origin and role of the cerebrospinal fluid bidirectional flow in the central canal 

  Thouvenin, Olivier; Keiser, Ludovic; Cantaut-Belarif, Yasmine; Carbo-Tano, Martin; Verweij, Frederik J.; Jurisch-Yaksi, Nathalie; Bardet, Pierre-Luc; Van Niel, Guillaume; Gallaire, Francois; Wyart, Claire (Peer reviewed; Journal article, 2020)

  Circulation of the cerebrospinal fluid (CSF) contributes to body axis formation and brain development. Here, we investigated the unexplained origins of the CSF flow bidirectionality in the central canal of the spinal cord ...

• Establishment of an in vivo rat model for chronic musculoskeletal implant infection 

  Witsø, Eivind; Hoang, Linh; Løseth, Kirsti; Bergh, Kåre (Peer reviewed; Journal article, 2020)

  Background The aim of the study was to establish an experimental chronic musculoskeletal infection model in vivo characterized by (a) a small bacterial inoculum, (b) no general or local signs of infection, (c) several ...

• Maternal pre-pregnancy overweight and gestational diabetes and dietary intakes among young adult offspring 

  Kaseva, Nina; Vääräsmäki, Marja; Matinolli, Hanna-Maria; Sipola, Marika; Tikanmäki, Marjaana; Kanerva, Noora; Heinonen, Kati; Lano, Aulikki; Wolke, Dieter; Andersson, Sture; Järvelin, Marjo-Riitta; Räikkönen, Katri; Eriksson, Johan G.; Männistö, Satu; Kajantie, Eero Olavi (Peer reviewed; Journal article, 2020)

  Background/Objectives Maternal pre-pregnancy overweight/obesity and gestational diabetes (GDM) are associated with increased fat deposition in adult offspring. The purpose of this study was to identify if maternal ...

• Inherited Genetic Mutations and Polymorphisms in Malignant Mesothelioma: A Comprehensive Review 

  Panou, Vasiliki; Røe, Oluf Dimitri (Peer reviewed; Journal article, 2020)

  Malignant mesothelioma (MM) is mainly caused by air-born asbestos but genetic susceptibility is also suspected to be a risk factor. Recent studies suggest an increasing number of candidate genes that may predispose to MM ...

• Bruk av botulinumtoksin A til barn med cerebral parese 

  Ross Raftemo, Anne Elisabeth; Mahendran, Arani; Hollung, Sandra Julsen; Jahnsen, Reidun; Lydersen, Stian; Vik, Torstein; Andersen, Guro Lillemoen (Peer reviewed; Journal article, 2019)

  BAKGRUNN Intramuskulære injeksjoner med botulinumtoksin A har i over 20 år vært en etablert behandling av spastisitet hos barn med cerebral parese. Vi undersøkte hvor mange barn med cerebral parese i Norge som får slik ...

• Non-occupational exposure to asbestos is the main cause of malignant mesothelioma in women in North Jutland, Denmark 

  Panou, Vasiliki; Vyberg, Mogens; Meristoudis, Christos; Hansen, Johnni; Bøgsted, Martin; Omland, Øyvind; Weinreich, Ulla Møller; Røe, Oluf Dimitri (Peer reviewed; Journal article, 2019)

  Objectives Diffuse malignant mesothelioma (MM) is mainly caused by asbestos inhalation. The malignancy is rare among women and studies of the prevalence and causative role of non-occupational asbestos exposure among women ...

• En kvinne i 40-årene som brukte vanedannende legemidler i svært høye doser 

  Heldal, Anne Taraldsen; Aamo, Trond Oskar; Frost, Joachim (Peer reviewed; Journal article, 2020)

  En kvinne i 40-årene fikk forskrevet opioider i forbindelse med et operativt inngrep. Forskrivningen eskalerte i etterkant til enorme doser som viste seg å skape utfordringer i det videre behandlingsforløpet.

• Baseline identification of clonal V(D)J sequences for DNA-based minimal residual disease detection in multiple myeloma 

  Rustad, Even Holth; Hultcrantz, Malin; Yellapantula, Venkata D; Akhlaghi, Theresia; Ho, Caleb; Arcila, Maria E; Roshal, Mikhail; Patel, Akshar; Chen, Denise; Devlin, Sean M; Jacobsen, Austin; Huang, Ying; Miller, Jeffrey E; Papaemmanuil, Elli; Landgren, Ola (Peer reviewed; Journal article, 2019)

  Tracking of clonal immunoglobulin V(D)J rearrangement sequences by next generation sequencing is highly sensitive for minimal residual disease in multiple myeloma. However, previous studies have found variable rates of ...

• Content of endothelial progenitor cells in autologous stem cellgrafts predict survival after transplantation for multiplemyeloma 

  Blix, Egil Støre; Kildal, Anders Benjamin; Bertelsen, Eirin Listau; Waage, Anders; Myklebust, June; Kolstad, Arne; Husebekk, Anne (Peer reviewed; Journal article, 2015)

  Multiple myeloma (MM) is considered an incurable B cell malignancy, although many patients can benefit from high-dose therapy with autologous stem cell transplantation (ASCT) as a first-line treatment. In non-Hodgkin ...

• Perinatal asphyxia in a global perspective: How can we improve outcomes? 

  Aker, Karoline (Doctoral theses at NTNU;2022:137, Doctoral thesis, 2022)

  Norsk sammendrag Fødselsasfyksi er en tilstand der mangelfull gassutveksling og/eller blodstrøm fører til oksygenmangel til fosteret i tiden omkring fødsel. Dette kan påvirke alle organer, men skade på hjernen, hypoksisk ...

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