Institutt for klinisk og molekylær medisin
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HDACi Mediate UNG2 Depletion, Dysregulated Genomic Uracil and Altered Expression of Oncoproteins and Tumor Suppressors in B- And T-cell Lines
(Peer reviewed; Journal article, 2020)Background HDAC inhibitors (HDACi) belong to a new group of chemotherapeutics that are increasingly used in the treatment of lymphocyte-derived malignancies, but their mechanisms of action remain poorly understood. Here ... -
Physicians’ Recognition and Management of Kidney Disease: A Randomized Vignette Study Evaluating the Impact of the KDIGO 2012 CKD Classification System
(Peer reviewed; Journal article, 2020)Rationale & Objective The Kidney Disease Outcome Quality Initiative (KDOQI) and Kidney Disease: Improving Global Outcomes (KDIGO) chronic kidney disease (CKD) classification systems published in 2002 and 2012, respectively, ... -
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium
(Journal article; Peer reviewed, 2020)Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify regulators of neonatal intestinal epithelial ... -
Spatial distribution of malignant transformation in patients with low-grade glioma
(Journal article; Peer reviewed, 2020)Background Malignant transformation represents the natural evolution of diffuse low-grade gliomas (LGG). This is a catastrophic event, causing neurocognitive symptoms, intensified treatment and premature death. However, ... -
Mitochondrial genome-wide association study of migraine – the HUNT Study
(Peer reviewed; Journal article, 2020)Background Variation in mitochondrial DNA (mtDNA) has been indicated in migraine pathogenesis, but genetic studies to date have focused on candidate variants, with sparse findings. We aimed to perform the first mitochondrial ... -
Correct Identification of Cell of Origin may Explain Many Aspects of Cancer: The role of Neuroendocrine Cells as Exemplfied from the Stomach
(Peer reviewed; Journal article, 2020)Cancers are believed to originate from stem cells. Previously, the hypothesis was that tumors developed due to dedifferentiation of mature cells. We studied the regulation of gastric acid secretion and showed that gastrin ... -
Strategies to Enhance Logic Modeling-Based Cell Line-Specific Drug Synergy Prediction
(Journal article; Peer reviewed, 2020)Discrete dynamical modeling shows promise in prioritizing drug combinations for screening efforts by reducing the experimental workload inherent to the vast numbers of possible drug combinations. We have investigated ... -
emba: R package for analysis and visualization of biomarkers in boolean model ensembles
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High-throughput screening reveals higher synergistic effect of MEK inhibitor combinations in colon cancer spheroids
(Peer reviewed; Journal article, 2020)Drug combinations have been proposed to combat drug resistance, but putative treatments are challenged by low bench-to-bed translational efficiency. To explore the effect of cell culture format and readout methods on ... -
DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease
(Peer reviewed; Journal article, 2020)The DNA glycosylase Neil2 is a member of the base excision repair (BER) family of enzymes, which are important for repair of oxidative DNA damage. Specifically, Neil2 participates in repair of oxidized bases in single-stranded ... -
Differential Effects of Dietary Supplementation of Krill Meal, Soybean Meal, Butyrate, and Bactocell® on the Gene Expression of Atlantic Salmon Head Kidney
(Peer reviewed; Journal article, 2020)The head kidney is a key organ that plays a fundamental role in the regulation of the fish immune response and in the maintenance of endocrine homeostasis. Previous studies indicate that the supplementation of exogenous ... -
Does caesarean delivery in the first pregnancy increase the risk for adverse outcome in the second? A registry-based cohort study on first and second singleton births in Norway
(Peer reviewed; Journal article, 2020)Objective To explore if newborns in the second pregnancy following a previous caesarean delivery (CD) have higher risk of perinatal mortality or cerebral palsy than newborns in pregnancies following a previous vaginal ... -
Network and Systems Medicine: Position Paper of the European Collaboration on Science and Technology Action on Open Multiscale Systems Medicine
(Journal article; Peer reviewed, 2020)Introduction: Network and systems medicine has rapidly evolved over the past decade, thanks to computational and integrative tools, which stem in part from systems biology. However, major challenges and hurdles are still ... -
Peptides containing the PCNA interacting motif APIM bind to the beta-clamp and inhibit bacterial growth and mutagenesis
(Journal article; Peer reviewed, 2020)In the fight against antimicrobial resistance, the bacterial DNA sliding clamp, β-clamp, is a promising drug target for inhibition of DNA replication and translesion synthesis. The β-clamp and its eukaryotic homolog, PCNA, ... -
Intraperitoneal and subcutaneous glucagon delivery in anaesthetized pigs: effects on circulating glucagon and glucose levels
(Journal article; Peer reviewed, 2020)Glucagon is a pancreatic hormone and increases the blood glucose levels. It may be incorporated in a dual hormone artificial pancreas, a device to automatically and continuously control blood glucose levels of individuals ... -
Breakthrough cancer pain in 2020
(Peer reviewed; Journal article, 2020)Purpose of review An overview on breakthrough cancer pain (BTCP), including inherent limitations of the terminology, assessment, clinical presentation, and treatment options. Recent findings The estimated prevalence ... -
Diverse functions of DNA glycosylases processing oxidative base lesions in brain
(Peer reviewed; Journal article, 2019)Endogenous and exogenous oxidative agents continuously damage genomic DNA, with the brain being particularly vulnerable. Thus, preserving genomic integrity is key for brain health and neuronal function. Accumulation of DNA ... -
Anti-inflammatory effects of non-statin low-density lipoprotein cholesterol-lowering drugs: an unused potential?
(Peer reviewed; Journal article, 2020)Objectives. Inflammatory responses are closely knit with low-density lipoprotein (LDL)-cholesterol in driving atherosclerosis. Even if LDL-cholesterol is causative to atherosclerotic diseases and LDL-cholesterol lowering ... -
Translational Research in Personalized Medicine with Special References to Gastric Cancer and Obesity
(Doctoral theses at NTNU;2020:285, Doctoral thesis, 2020)Translational research in personalized medicine with special references to gastric cancer and obesity Background: Translational research in medical science is essential because the rapid progression of science and technology ... -
Health-related quality of life in Norwegian adolescent living with chronic fatigue syndrome
(Peer reviewed; Journal article, 2020)Purpose The primary aim was to measure health related quality of life (HRQoL) in a Norwegian cohort of adolescents with Chronic Fatigue Syndrome (CFS/ME). A secondary aim was to identify factors before diagnosis, at time ...
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