• Novel insights on human-virus interactions through genome-wide approaches 

  Bösl, Korbinian (Doctoral theses at NTNU;2019:113, Doctoral thesis, 2019)

  Virus er en viktig årsak til sykdom og død blant mennesker over hele verden. Symptomer påvirusinfeksjoner spenner fra lett forkjølelse til livstruende sykdomstilstand. Virale patogener som Human Immunodeficiency Virus ...

• Biomarker discovery using NMR based metabolomics of tissue 

  Grinde, Maria Tunset; Giskeødegård, Guro F.; Andreassen, Trygve; Tessem, May-Britt; Bathen, Tone Frost; Moestue, Siver Andreas (Journal article; Peer reviewed, 2019)

  NMR-based metabolomics has shown promise in the diagnosis of diseases as it enables identification and quantification of metabolic biomarkers. Using high-resolution magic-angle-spinning (HR-MAS) NMR spectroscopy, metabolic ...

• Moderately increased albuminuria, chronic kidney disease and incident dementia: the HUNT study 

  Gabin, Jessica Mira; Romundstad, Solfrid; Saltvedt, Ingvild; Holmen, Jostein (Journal article; Peer reviewed, 2019)

  Background Epidemiologic studies has shown an association of albuminuria and low estimated glomerular filtration rate (eGFR) with dementia, but the findings are inconsistent. This study examines the association between ...

• Lung function in adults born preterm 

  Nasanen-Gilmore, Pieta; Sipola-Leppänen, Marika; Tikanma Ki, Marjaana; Matinolli, Hanna-Maria; Eriksson, Johan G; Järvelin, Marjo-Riitta; Vaarasma Ki, Marja; Hovi, Petteri; Kajantie, Eero (Journal article; Peer reviewed, 2018)

  Very preterm birth, before the gestational age (GA) of 32 weeks, increases the risk of obstructed airflow in adulthood. We examined whether all preterm births (GA<37 weeks) are associated with poorer adult lung function ...

• Lenalidomide versus lenalidomide + dexamethasone prolonged treatment after second-line lenalidomide + dexamethasone induction in multiple myeloma 

  Lund, Johan; Gruber, Astrid; Lauri, Birgitta; Duru, Adil Doganay; Blimark, Cecilie; Swedin, Agneta; Hansson, Markus; Forsberg, Karin; Ahlberg, Lucia; Carlsson, Conny; Waage, Anders; Gimsing, Peter; Vangsted, Annette Juul; Frølund, Ulf; Holmberg, Erik; Gahrton, Gösta C.A.; Alici, Evren; Hardling, Mats; Mellqvist, Ulf-Henrik; Nahi, Hareth (Journal article; Peer reviewed, 2018)

  Lenalidomide (Len) plus dexamethasone (Dex) is approved for the treatment of relapsed or refractory multiple myeloma (RRMM). It is possible that single‐agent Len may be effective as prolonged treatment regimen in RRMM once ...

• Feasibility of early meal detection based on abdominal sound. 

  Kölle, Konstanze; Fougner, Anders Lyngvi; Ellingsen, Reinold; Carlsen, Sven Magnus; Stavdahl, Øyvind (Journal article; Peer reviewed, 2019)

  Background In classical approaches for an artificial pancreas, continuous glucose monitoring (CGM) is the only measured variable used for insulin dosing and additional control functions. The CGM values are subject to time ...

• Do laws impact opioids consumption? A breakpoint analysis based on italian sales data 

  Musazzi, Umberto Maria; Rocco, Paolo; Brunelli, Cinzia; Bisaglia, Luisa; Caraceni, Augusto Tomasso Giovanni; Minghetti, Paola (Journal article; Peer reviewed, 2018)

  Purpose: In Italy, where the adoption of opioid analgesics in pain management has been historically poor, an increase in opioids consumption occurred between 2000 and 2015. The aim of this study is to assess, through ...

• MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP 

  Jemth, Ann-Sofie; Gustafsson, Robert; Bräutigam, Lars; Henriksson, Linda; Vallin, Karl S.A.; Sarno, Antonio; Almlöf, Ingrid; Homan, Evert; Rasti, Azita; Warpman Berglund, Ulrika; Stenmark, Pål; Helleday, Thomas (Journal article; Peer reviewed, 2018)

  Nucleotides in the free pool are more susceptible to nonenzymatic methylation than those protected in the DNA double helix. Methylated nucleotides like O6-methyl-dGTP can be mutagenic and toxic if incorporated into DNA. ...

• The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression 

  Ali, Mina; Ajore, Ram; Wihlborg, Anna-Karin; Niroula, Abhishek; Swaminathan, Bhairavi; Johnsson, Ellinor; Stephens, Owen W; Morgan, Gareth; Meissner, Tobias; Turesson, Ingemar; Goldschmidt, Hartmut; Mellqvist, Ulf-Henrik; Gullberg, Urban; Hansson, Markus; Hemminki, Kari; Nahi, Hareth; Waage, Anders; Weinhold, Niels; Nilsson, Björn (Journal article; Peer reviewed, 2018)

  Recently, we identified ELL2 as a susceptibility gene for multiple myeloma (MM). To understand its mechanism of action, we performed expression quantitative trait locus analysis in CD138+ plasma cells from 1630 MM patients ...

• Early postnatal nutrition after preterm birth and cardiometabolic risk factors in young adulthood 

  Suikkanen, Julia; Matinolli, Hanna-Maria; Eriksson, Johan G; Jarvenpaa, Anna-Liisa; Andersson, Sture; Kajantie, Eero; Hovi, Petteri (Journal article; Peer reviewed, 2018)

  Objectives Adults born preterm at very low birthweight (VLBW; <1500 g) have a non-optimal cardiometabolic risk factor profile. Since higher protein intake during the first weeks of life predicted a healthier body ...

• Mapping nanoparticles in hydrogels: A comparison of preparation methods for electron microscopy 

  Muri, Harald Ian; Hoang, Linh; Hjelme, Dag Roar (Journal article; Peer reviewed, 2018)

  The distribution of noble metal nanoparticles (NMNPs) in hydrogels influences their nanoplasmonic response and signals used for biosensor purposes. By controlling the particle distribution in NMNP-nanocomposite hydrogels, ...

• Better tolerance of preservative-free latanoprost compared to preserved glaucoma eye drops: The 12-month real-life FREE study 

  Economou, Mario A; Laukeland, Helene Kolstad; Grabska-Liberek, Iwona; Rouland, Jean-Francois (Journal article; Peer reviewed, 2018)

  Background: Lack of efficacy due to bad compliance caused by intolerance issues is the main reason for a change to a better tolerated ocular treatment, such as using preservative-free (PF) eye drops. Aim: To assess the ...

• Simultaneous 18F-fluciclovine Positron Emission Tomography and Magnetic Resonance Spectroscopic Imaging of Prostate Cancer 

  Esmaeili, Morteza; Tayari, Nassim; Scheenen, Tom WJ; Elschot, Mattijs; Sandsmark, Elise; Bertilsson, Helena; Heerschap, Arend; Selnæs, Kirsten Margrete; Bathen, Tone Frost (Journal article; Peer reviewed, 2018)

  Purpose: To investigate the associations of metabolite levels derived from magnetic resonance spectroscopic imaging (MRSI) and 18F-fluciclovine positron emission tomography (PET) with prostate tissue characteristics. Methods: ...

• Recessive Truncating Mutations in ALKBH8 Cause Intellectual Disability and Severe Impairment of Wobble Uridine Modification 

  Vågbø, Cathrine Broberg; Monies, Dorota; Al-Owain, Mohammad; Alhomaidi, Suzan; Alkuraya, Fowzan S. (Journal article; Peer reviewed, 2019)

  The wobble hypothesis was proposed to explain the presence of fewer tRNAs than possible codons. The wobble nucleoside position in the anticodon stem-loop undergoes a number of modifications that help maintain the efficiency ...

• Impaired HDL function amplifies systemic inflammation in common variable immunodeficiency 

  Macpherson, Magnhild Eide; Halvorsen, Bente; Yndestad, Arne; Ueland, Thor; Mollnes, Tom Eirik; Berge, Rolf Kristian; Rashidi, Azita; Otterdal, Kari; Gregersen, Ida; Kong, Xiang Yi; Holven, Kirsten Bjørklund; Aukrust, Pål; Fevang, Børre; Jørgensen, Silje Fjellgård (Journal article; Peer reviewed, 2019)

  Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency, characterized by inadequate antibody responses and recurrent bacterial infections. Paradoxically, a majority of CVID patients ...

• Plasma levels of mannose-binding lectin and future risk of venous thromboembolism 

  Liang, Robin Amanda; Høiland, Ina Isabella; Ueland, Thor; Aukrust, Pål; Snir, Omri; Hindberg, Kristian; Brækkan, Sigrid Kufaas; Garred, Peter; Mollnes, Tom Eirik; Hansen, John-Bjarne (Journal article; Peer reviewed, 2019)

  Background Animal and observational studies have suggested a pathophysiological role for complement in venous thromboembolism (VTE), but the initiating mechanisms are unknown. Mannose‐binding lectin (MBL) bound to altered ...

• Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity 

  Souza, Rodrigo W. A.; Alves, Christiano R. R.; Medeiros, Alessandra; Rolim, Natale Pinheiro Lage; Silva, Gustavo Jose Justo; Moreira, Jose Bianco Nascimento; Alves, Marcia Netto Magalhaes; Wohlwend, Martin; Gebriel, Mohammed; Hagen, Lars; Sharma, Animesh; Koch, Lauren G.; Britton, Steven L.; Slupphaug, Geir; Wisløff, Ulrik; Brum, Patricia C. (Journal article; Peer reviewed, 2018)

  Given the association between high aerobic capacity and the prevention of metabolic diseases, elucidating the mechanisms by which high aerobic capacity regulates whole-body metabolic homeostasis is a major research challenge. ...

• Uterine artery Doppler in pregnancy: Women with PCOS compared to healthy controls 

  Stridsklev, Solhild; Salvesen, Øyvind; Salvesen, Kjell Å; Carlsen, Sven Magnus; Vanky, Eszter (Journal article; Peer reviewed, 2018)

  The objective of this study was to investigate possible differences in uterine artery pulsatility index (UtAPI) between pregnant women with PCOS and healthy controls and to explore possible effects of metformin on UtAPI. ...

• Comparison of surgical skill acquisition by UK surgical trainees and Sierra Leonean associate clinicians in a task-sharing programme 

  Liu, Ben; Hunt, Lesley; Lonsdale, Robert J; Narula, Harjeet; Manasrey, Alieu; Bundu, Ibrahim; Bolkan, Håkon Angell (Journal article; Peer reviewed, 2018)

  Background Task‐sharing in surgery is well established, with associate clinicians performing successful surgery in many countries. Little is known about the process of surgical skill acquisition by associate clinicians, ...

• Mechanical properties of 67NR tumours are broadly independent of the immune status of the host mouse 

  Nordgård, Catherine Taylor; Rao, Shalini Vasudev; Dille, Morten Johnsen; Steigedal, Tonje S.; Draget, Kurt Ingar (Journal article; Peer reviewed, 2017)

  Tumour stiffness is increasingly seen as a clinically relevant parameter, with increased stiffness being linked to poorer prognosis, but it is also one that is not inherently easy to measure either in vivo or ex vivo. We ...

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