• Genome editing in food and feed production – implications for risk assessment 

  Bodin, Johanna Eva; Thorstensen, Tage; Alsheikh, Muath K; Basic, Dean; Edvardsen, Rolf Brudvik; Dalen, Knut Tomas; das Neves, Carlos Gonçalo; Duale, Nur; Eklo, Ole Martin; Ergon, Åshild Gunilla; Jevnaker, Anne-Marthe Ganes; Hindar, Kjetil; Håvarstein, Leiv Sigve; Malmstrøm, Martin; Nielsen, Kaare Magne; Olsen, Siri Lie; Rueness, Eli Knispel; Sanden, Monica; Sipinen, Ville Erling; Vikse, Rose; von Krogh, Kristine; Våge, Dag Inge; Wargelius, Anna; Wendell, Micael; Yazdankhah, Siamak Pour; Alexander, Jan; Bruzell, Ellen Merete; Hemre, Gro Ingunn; Vandvik, Vigdis; Agdestein, Angelika; Elvevoll, Edel O.; Hessen, Dag Olav; Hofshagen, Merete; Husøy, Trine; Knutsen, Helle Katrine; Krogdahl, Åshild; Nilsen, Asbjørn Magne; Rafoss, Trond; Skjerdal, Olaug Taran; Steffensen, Inger-Lise Karin; Strand, Tor Arne; Velle, Gaute; Wasteson, Yngvild (Peer reviewed; Journal article, 2021)

  The Norwegian Scientific Committee for Food and Environment (VKM) initiated this work to examine the extent to which organisms developed by genome-editing technologies pose new challenges in terms of risk assessment. This ...

• Assessing the Role of TDG in the Hippocampus-dependent Memory using Transgenic Mouse Models and rAAV Viral Tools 

  Døskeland, Dagny Sanden (Master thesis, 2022)

  Tymin DNA-glykosylase (TDG) er et enzym med viktige roller i genomisk reperasjon og epigenetisk regulering. Tiltredende bevis indikerer en viktig rolle for TDG i aktiv DNA-demetylering. DNA-methylering har en regulerende ...

• The functional role of NEIL3 DNA glycosylase in the hippocampus 

  Heggedal, Mina (Master thesis, 2022)

  Tiltagende bevis tyder på at NEIL3 har viktige funksjoner i hjernen. Studier med gnagere har avslørt et diskret ekspresjonsmønster av NEIL3 i den subgranulære sonen av dentate gyrus og i den subventrikulære sonen av de ...

• Co-medication among patients diagnosed with Crohn’s disease – an observational health register study. 

  Al-Azawi, Marwan Shakir (Master thesis, 2022)

  Abstract will be available on 2027-05-31

• Changes in comedication use among patients with ulcerous colitis - an observational register study 

  Mikalsen, Simon. (Master thesis, 2022)

  Abstract will be available on 2027-05-31

• Development of an improved pathway analysis - The FunHop story 

  Rise, Kjersti (Doctoral theses at NTNU;2022:212, Doctoral thesis, 2022)

  Norsk sammendrag Arbeidet som presenteres i denne avhandlingen omhandler metabolisme i prostatakreft, hovedsakelig i form av bruk og forbedring av analyse av biologiske spor. En stor del av oppgaven handler om utvikling ...

• Cardiorespiratory fitness and mortality in rheumatoid arthritis 

  Liff, Marthe Halsan (Doctoral theses at NTNU;2022:128, Doctoral thesis, 2022)

  Background Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that affects synovial joints and internal organs. It affects around 1% of the population, and the disease is associated with increased all-cause ...

• Saliva as a biological material in research and diagnostics. Comparative analysis of inflammatory biomarkers in saliva and blood. 

  Langvik, Toril (Master thesis, 2022)

  Abstract will be available on 2024-11-01

• Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination 

  Eldin, Patrick; Péron, Sophie; Galashevskaya, Anastasia; Denis-Lagache, Nicolas; Cogné, Michel; Slupphaug, Geir; Briant, Laurence (Peer reviewed; Journal article, 2020)

  Background HIV-1 Vpr encodes a 14 kDa protein that has been implicated in viral pathogenesis through modulation of several host cell functions. In addition to pro-apoptotic and cytostatic properties, Vpr can redirect ...

• The Gene Ontology resource: enriching a GOld mine 

  Carbon, Seth J.; Douglass, Eric; Good, Benjamin M; Unni, Deepak R; Harris, Nomi L.; Mungall, Christopher J.; Basu, Siddartha; Chisholm, Rex L.; Dodson, Robert J.; Hartline, Eric; Fey, Petra; Thomas, Paul D.; Albou, Laurent-Philippe; Ebert, Dustin; Kesling, Michael J; Mi, Huaiyu; Muruganujan, Anushya; Huang, Xiaosong; Mushayahama, Tremayne; LaBonte, Sandra A.; Siegele, Deborah A.; Antonazzo, Giulia; Attrill, Helen; Brown, Nick H.; Garapati, Phani; Marygold, Steven J.; Trovisco, Vitor; dos Santos, Gil; Falls, Kathleen; Tabone, Christopher; Zhou, Pinglei; Goodman, Joshua L.; Strelets, Victor B.; Thurmond, Jim; Garmiri, Penelope; Ishtiaq, Rizwan; Rodríguez-López, Milagros; Acencio, Marcio Luis; Kuiper, Martin; Lægreid, Astrid; Logie, Colin; Lovering, Ruth C.; Kramarz, Barbara; Saverimuttu, Shirin C.C.; Pinheiro, Sandra M.; Gunn, Heather; Su, Renzhi; Thurlow, Katherine E.; Chibucos, Marcus; Giglio, Michelle; Nadendla, Suvarna; Munro, James; Jackson, Rebecca; Duesbury, Margaret J.; del-Toro, Noemi; Meldal, Birgit H.M.; Paneerselvam, Kalpana; Perfetto, Livia; Porras, Pablo; Orchard, Sandra; Shrivastava, Anjali (Peer reviewed; Journal article, 2021)

  The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene products. Here, we report the advances of the consortium ...

• Corticosteroids Prior to Embryo Transfer in Assisted Reproduction in Women with Crohn’s Disease and Ulcerative Colitis – A Nationwide Cohort Study 

  Nørgård, Bente Mertz; Larsen, Michael Due; Freidman, Sonia; Fedder, Jens (Peer reviewed; Journal article, 2020)

  Purpose: Former studies have suggested that women with Crohn’s disease (CD) and ulcerative colitis (UC) have a decreased chance of a live born child after assisted reproductive technology (ART) treatment. It is debated ...

• Discovery and development of safe-in-man broad-spectrum antiviral agents 

  Anderssen, Petter Inge; Ianevski, Aleksandr; Lysvand, Hilde; Vitkauskiene, Astra; Oksenych, Valentyn; Bjørås, Magnar; Telling, Kaidi; Lutsar, Irja; Dumpis, Uga; Irie, Yasuhiko; Tenson, Tanel; Kantele, Anu; Kainov, Denis (Peer reviewed; Journal article, 2020)

  Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases. However, broad-spectrum antiviral ...

• Sperm counts and endocrinological markers of spermatogenesis in long-term survivors of testicular cancer 

  Brydøy, Marianne; Fosså, Sophie Dorothea; Klepp, Olbjørn; Bremnes, Roy M.; Wist, Erik; Bjøro, Trine; Wentzel-Larsen, Tore; Dahl, Olav (Peer reviewed; Journal article, 2012)

  Background: The objective of this study was to assess markers of spermatogenesis in long-term survivors of testicular cancer (TC) according to treatment, and to explore correlations between the markers and associations ...

• Use of peripheral venous catheters in two Norwegian hospitals. 

  Høvik, Lise Husby; Gjeilo, Kari Hanne; Lydersen, Stian; Solligård, Erik; Damås, Jan Kristian; Gustad, Lise Tuset (Peer reviewed; Journal article, 2020)

  BAKGRUNN De fleste pasienter ved norske sykehus får rutinemessig ett eller flere perifere venekatetre. Et perifert venekateter regnes som ufarlig, men kan gi lokal infeksjon, med blodstrømsinfeksjon og sepsis som følge. ...

• Hypergastrinemia Expands Gastric ECL Cells Through CCK2R Progenitor Cells via ERK Activation 

  Sheng, Weiwei; Ermanno, Malagola,; Henrik, Nienhüser; Zhengyu, Zhang; Woosook, Kim; Leah, Zamechek; Antonia, Sepulveda; Masahiro, Hata; Yoku, Hayakawa; Zhao, Chun-Mei; Chen, Duan; Timothy C., Wang (Peer reviewed; Journal article, 2020)

  Background & Aims Enterochromaffin-like (ECL) cells in the stomach express gastrin/cholecystokinin 2 receptor CCK2R and are known to expand under hypergastrinemia, but whether this results from expansion of existing ECL ...

• Testicular cancer in the cisplatin era: Causes of death and mortality rates in a population-based cohort 

  Hellesnes, Ragnhild; Myklebust, Tor Åge; Fosså, Sophie Dorothea; Bremnes, Roy M.; Karlsdottir, Åsa; Kvammen, Øivind; Tandstad, Torgrim; Wilsgaard, Tom; Negaard, Helene Francisca Stigter; Haugnes, Hege Sagstuen (Peer reviewed; Journal article, 2021)

  PURPOSE Using complete information regarding testicular cancer (TC) treatment burden, this study aimed to investigate cause-specific non-TC mortality with impact on previous treatment with platinum-based chemotherapy (PBCT) ...

• A user guide for the online exploration and visualization of PCAWG data 

  Goldman, Mary J.; Zhang, Junjun; Fonseca, Nuno A.; Cortés-Ciriano, Isidro; Xiang, Qian; Craft, Brian; Piñeiro-Yáñez, Elena; O’Connor, Brian D.; Bazant, Wojciech; Barrera, Elisabet; Muñoz-Pomer, Alfonso; Petryszak, Robert; Füllgrabe, Anja; Al-Shahrour, Fatima; Keays, Maria; Haussler, David; Weinstein, John N.; Huber, Wolfgang; Valencia, Alfonso; Park, Peter J.; Papatheodorou, Irene; Zhu, Jingchun; Ferretti, Vincent; Vazquez Garcia, Miguel (Peer reviewed; Journal article, 2020)

  The Pan-Cancer Analysis of Whole Genomes (PCAWG) project generated a vast amount of whole-genome cancer sequencing resource data. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which ...

• Inherited Genetic Mutations and Polymorphisms in Malignant Mesothelioma: A Comprehensive Review 

  Panou, Vasiliki; Røe, Oluf Dimitri (Peer reviewed; Journal article, 2020)

  Malignant mesothelioma (MM) is mainly caused by air-born asbestos but genetic susceptibility is also suspected to be a risk factor. Recent studies suggest an increasing number of candidate genes that may predispose to MM ...

• Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile 

  Huang, Kai-Wen; Reebye, Vikash; Czysz, Katherine; Ciriello, Simona; Dorman, Stephanie; Reccia, Isabella; Lai, Hong-Shiee; Peng, Ling; Kostomitsopoulos, Nikos; Nicholls, Joanna; Habib, Robert; Tomalia, Donald A.; Sætrom, Pål; Wilkes, Edmund; Cutillas, Pedro; Rossi, John; Habib, Nagy (Peer reviewed; Journal article, 2020)

  Non-alcoholic fatty liver disease (NAFLD) culminates in insulin resistance and metabolic syndrome. Because there are no approved pharmacological treatment agents for non-alcoholic steatohepatitis (NASH) and NAFLD, different ...

• Origin and role of the cerebrospinal fluid bidirectional flow in the central canal 

  Thouvenin, Olivier; Keiser, Ludovic; Cantaut-Belarif, Yasmine; Carbo-Tano, Martin; Verweij, Frederik J.; Jurisch-Yaksi, Nathalie; Bardet, Pierre-Luc; Van Niel, Guillaume; Gallaire, Francois; Wyart, Claire (Peer reviewed; Journal article, 2020)

  Circulation of the cerebrospinal fluid (CSF) contributes to body axis formation and brain development. Here, we investigated the unexplained origins of the CSF flow bidirectionality in the central canal of the spinal cord ...

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