Institutt for klinisk og molekylær medisin
Recent Submissions
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Induction of labor in breech presentations - a retrospective cohort study
(Peer reviewed; Journal article, 2021)Background: Recently, there has been an increasing focus among healthcare organisations on implementing patient portals. Previous studies have mainly focussed on the experiences of patient portal use. Few have investigated ... -
Low C-peptide together with a high glutamic acid decarboxylase autoantibody level predicts progression to insulin dependence in latent autoimmune diabetes in adults: The HUNT study
(Journal article; Peer reviewed, 2021)Aim: To search for risk factors that could predict progression in latent autoimmune diabetes in adults (LADA) and compare them with those for type 2 diabetes. Materials and Methods: This study included 175 participants ... -
Novel Peptides Targeting the β-Clamp Rapidly Kill Planktonic and Biofilm Staphylococcus epidermidis Both in vitro and in vivo
(Peer reviewed; Journal article, 2021)Antimicrobial resistance is an increasing threat to global health and challenges the way we treat infections. Peptides containing the PCNA interacting motif APIM (APIM-peptides) were recently shown to bind to the bacterial ... -
Express Team-Based Learning (eTBL): A Time-Efficient TBL Approach in Neuroradiology
(Peer reviewed; Journal article, 2019)Rationale and Objectives Team-based learning (TBL) is a student-centred, teacher-directed instructional method that promotes active learning. The application phase of TBL stimulates group discussion and critical thinking, ... -
Exercise training and high-sensitivity cardiac troponin T in patients with heart failure with reduced ejection fraction
(Journal article; Peer reviewed, 2021)Plasma cell disorders (PCDs) are identified in the clinical lab by detecting the monoclonal immunoglobulin (M-protein) which they produce. Traditionally, serum protein electrophoresis methods have been utilized to detect ... -
The inflammasome components NLRP3 and ASC act in concert with IRGM to rearrange the golgi apparatus during hepatitis C virus infection
(Peer reviewed; Journal article, 2021)Hepatitis C virus (HCV) infection triggers Golgi fragmentation through the Golgi-resident protein immunity-related GTPase M (IRGM). Here, we report the roles of NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) and ... -
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
(Peer reviewed; Journal article, 2021)Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated ... -
A conformational change of complement C5 is required for thrombin-mediated cleavage, revealed by a novel ex vivo human whole blood model preserving full thrombin activity
(Peer reviewed; Journal article, 2021)Thrombin activation of C5 connects thrombosis to inflammation. Complement research in whole blood ex vivo necessitates anticoagulation, which potentially interferes with the inflammatory modulation by thrombin. We challenged ... -
Surgical Complications in Postchemotherapy Retroperitoneal Lymph Node Dissection for Nonseminoma Germ Cell Tumour: A Population-based Study from the Swedish Norwegian Testicular Cancer Group
(Journal article, 2020)Background Reports on perioperative complications after postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) for nonseminoma germ cell tumour (NSGCT) are from experienced single centres, with a lack of ... -
Randomized phase III trial comparing switch-maintenance pemetrexed with observation followed by pemetrexed at progression in advanced NSCLC
(Peer reviewed; Journal article, 2020)Objectives: Two phase III trials show that maintenance pemetrexed therapy after platinum-doublet chemotherapy prolongs overall survival (OS) and progression free survival (PFS) in advanced non-squamous non-small-cell lung ... -
Functional profiling reveals altered metabolic activity in divers’ oral microbiota during commercial heliox saturation diving
(Peer reviewed; Journal article, 2021)Background: The extreme environment in saturation diving affects all life forms, including the bacteria that reside on human skin and mucosa. The oral cavity alone is home to hundreds of different bacteria. In this study, ... -
Past, present and future of zebrafish in epilepsy research
(Journal article; Peer reviewed, 2021)Animal models contribute greatly to our understanding of brain development and function as well as its dysfunction in neurological diseases. Epilepsy research is a very good example of how animal models can provide us with ... -
Rapid systemic surge of IL-33 after severe human trauma: a prospective observational study
(Journal article; Peer reviewed, 2021)Background Alarmins are considered proximal mediators of the immune response after tissue injury. Understanding their biology could pave the way for development of new therapeutic targets and biomarkers in human disease, ... -
Survival and disease recurrence in patients with duodenal neuroendocrine tumours—a single centre cohort
(Journal article; Peer reviewed, 2021)Background: Duodenal neuroendocrine tumours (D-NETs) are rare but increasingly diagnosed. This study aimed to assess the overall survival and recurrence rate among patients treated for D-NETs. Methods: Patients with D-NETs ... -
Intraperitoneal insulin administration - superior choice for an artificial pancreas?
(Doctoral theses at NTNU;2021:334, Doctoral thesis, 2021)The main focus of this thesis is to explore the intraperitoneal (IP) cavity as the location for insulin administration. We hypothesized that IP insulin administration is more physiologic as it mimics endogenous insulin ... -
Examining the educational impact of the mini-CEX: a randomised controlled study
(Journal article; Peer reviewed, 2021)Background: The purpose of this study is to evaluate the mini-Clinical Evaluation Exercise (mini-CEX) as a formative assessment tool among undergraduate medical students, in terms of student perceptions, effects on direct ... -
Increased complement activation 3 to 6 h after trauma is a predictor of prolonged mechanical ventilation and multiple organ dysfunction syndrome: a prospective observational study
(Journal article; Peer reviewed, 2021)Background - Complement activation is a central mechanism in systemic inflammation and remote organ dysfunction following major trauma. Data on temporal changes of complement activation early after injury is largely missing. ... -
Factors associated with the persistence of oral 5-aminosalicylic acid monotherapy in ulcerative colitis: a nationwide Norwegian cohort study
(Journal article; Peer reviewed, 2021)Background: Oral 5-aminosalicylic acid (5-ASA) is the mainstay treatment of ulcerative colitis (UC) and therapy with oral 5-ASA is associated with beneficial outcomes. We have examined factors associated with the persistence ... -
The Tumor Necrosis Factor Alpha and Interleukin 6 Auto-paracrine Signaling Loop Controls Mycobacterium avium Infection via Induction of IRF1/IRG1 in Human Primary Macrophages
(Peer reviewed; Journal article, 2021)Macrophages sense and respond to pathogens by induction of antimicrobial and inflammatory programs to alert other immune cells and eliminate the infectious threat. We have previously identified the transcription factor ... -
Non-coding RNAs in human breast milk: A systematic review
(Peer reviewed; Journal article, 2021)Breast milk is the primary source of nutrition and hydration for the newborn infant but also plays an important role in the child’s first immune defense. Additionally, several breast milk factors have been implicated in ...
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