Browsing Institutt for klinisk og molekylær medisin by Title

Now showing items 1906-1925 of 3426

    • Low-grade albuminuria and its implementation in cardiovascular risk assessment: Analyses from the Nord-Trøndelag Heath Studies; HUNT-2 and HUNT-3 

      Hatlen, Gudrun (Doctoral theses at NTNU;2017:338, Doctoral thesis, 2017)

    • LRRK2 to the rescue of damaged endomembranes 

      Radulovic, Maja; Stenmark, Harald Alfred (Peer reviewed; Journal article, 2020)
      Mutations in several genes encoding for lysosomal proteins are involved in Parkinson's disease (PD). In this issue, Herbst et al (2020) show that PD-related leucine-rich repeat kinase 2 (LRRK2) is activated in response to ...

    • LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium 

      Zwiggelaar, Rosalie; Lindholm, Håvard Takle; Fosslie, Madeleine Lystad; Pedersen, Marianne Terndrup; Ohta, Yuki; Díez-Sánchez, Alberto; Martín-Alonso, Mara; Ostrop, Jenny; Matono, Mami; Parmar, Naveen; Kvaløy, Emilie; Spanjers, Roos; Nazmi, Kamran; Rye, Morten Beck; Drabløs, Finn; Arrowsmith, Cheryl H; Dahl, John Arne; Jensen, Kim B.; Sato, Toshiro; Oudhoff, Menno (Journal article; Peer reviewed, 2020)
      Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify regulators of neonatal intestinal epithelial ...

    • Lung function in adults born preterm 

      Nasanen-Gilmore, Pieta; Sipola-Leppänen, Marika; Tikanma Ki, Marjaana; Matinolli, Hanna-Maria; Eriksson, Johan G; Järvelin, Marjo-Riitta; Vaarasma Ki, Marja; Hovi, Petteri; Kajantie, Eero (Journal article; Peer reviewed, 2018)
      Very preterm birth, before the gestational age (GA) of 32 weeks, increases the risk of obstructed airflow in adulthood. We examined whether all preterm births (GA<37 weeks) are associated with poorer adult lung function ...

    • Lynch syndrome mutation spectrum in New South Wales, Australia, including 55 novel mutations 

      Sjursen, Wenche; McPhillips, Mary; Scott, Rodney J.; Talseth-Palmer, Bente (Peer reviewed; Journal article, 2016)
      Background Lynch syndrome, the most frequent hereditary colorectal cancer syndrome, is caused by defects in mismatch repair genes. Genetic testing is important in order to identify mutation carriers who can benefit from ...

    • LysoPC and PAF Trigger Arachidonic Acid Release by Divergent Signaling Mechanisms in Monocytes 

      Oestvang, Janne; Anthonsen, Marit Walbye; Johansen, Berit (Journal article; Peer reviewed, 2011)
      Oxidized low-density lipoproteins (LDLs) play an important role during the development of atherosclerosis characterized by intimal inflammation and macrophage accumulation. A key component of LDL is lysophosphatidylcholine ...

    • M-ficolin: a valuable biomarker to identify leukaemia from juvenile idiopathic arthritis 

      Brix, Ninna; Glerup, Mia; Thiel, Steffen; Mistegaard, Clara Elbæk; Skals, Regitze Gyldenholm; Berntson, Lillemor; Fasth, Anders; Nielsen, Susan Mary; Nordal, Ellen Berit; Rygg, Marite; Hasle, Henrik; Albertsen, Birgitte Klug; Herlin, Troels (Peer reviewed; Journal article, 2021)
      Objective: Distinction on clinical grounds between acute lymphoblastic leukaemia presenting with arthropathy (ALLarthropathy) and juvenile idiopathic arthritis (JIA) is difficult, as the clinical and paraclinical signs of ...

    • M.H. Bjørk og medarbeidere svarer 

      Bjørk, Marte-Helene; Gerstner, Thorsten Alfons; Taubøll, Erik (Peer reviewed; Journal article, 2020)

    • Machine Learning of Infant Spontaneous Movements for the Early Prediction of Cerebral Palsy: A Multi-Site Cohort Study 

      Ihlen, Espen Alexander F.; Støen, Ragnhild; Boswell, Lynn; de-Regnier, Raye-Ann; Fjørtoft, Toril Larsson; Gaebler-spira, Deborah; Labori, Cathrine; Loennecken, Marianne; Msall, Me; Møinicken, Unn inger; Peyton, Colleen; Schreiber, Me; Silberg, Inger Elisabeth; Songstad, Nils Thomas; Vaagen, Randi; Øberg, Gunn Kristin; Adde, Lars (Journal article; Peer reviewed, 2019)
      Background: Early identification of cerebral palsy (CP) during infancy will provide opportunities for early therapies and treatments. The aim of the present study was to present a novel machine-learning model, the ...

    • Machine learning-based immune phenotypes correlate with STK11/KEAP1 co-mutations and prognosis in resectable NSCLC: a sub-study of the TNM-I trial 

      Rakaee, Mehrdad; Andersen, S.; Giannikou, K.; Paulsen, Erna-Elise; Kilvær, Thomas Karsten; Rasmussen Busund, Lill-Tove; Berg, Thomas; Richardsen, Elin; Lombardi, Ana Paola; Adib, E.; Pedersen, Mona Irene; Tafavvoghi, Masoud; Wahl, Sissel Gyrid Freim; Petersen, R.H.; Bondgaard, A.L.; Yde, C.W.; Baudet, C.; Licht, P.; Lund-Iversen, Marius; Grønberg, Bjørn Henning; Fjellbirkeland, Lars; Helland, Åslaug; Pøhl, M.; Kwiatkowski, D.J.; Dønnem, Tom (Peer reviewed; Journal article, 2023)
      Background We aim to implement an immune cell score model in routine clinical practice for resected non-small-cell lung cancer (NSCLC) patients (NCT03299478 ). Molecular and genomic features associated with immune ...

    • Machine-learning analysis of cross-study samples according to the gut microbiome in 12 infant cohorts 

      Vänni, Petri; Tejesvi, Mysore V; Paalanne, Niko; Aagaard, Kjersti; Ackermann, Gail; Camargo Jr., Carlos A; Eggesbø, Merete Åse; Hasegawa, Kohei; Hoen, Anne G.; Karagas, Margaret R.; Kolho, Kaija-Leena; Laursen, Martin F.; Ludvigsson, Johnny; Madan, Juliette; Ownby, Dennis; Stanton, Catherine; Stokholm, Jakob; Tapiainen, Terhi (Peer reviewed; Journal article, 2023)
      Combining and comparing microbiome data from distinct infant cohorts has been challenging because such data are inherently multidimensional and complex. Here, we used an ensemble of machine-learning (ML) models and studied ...

    • MACPET: model-based analysis for ChIA-PET 

      Vardaxis, Ioannis; Drabløs, Finn; Rye, Morten Beck; Lindqvist, Bo Henry (Journal article; Peer reviewed, 2019)
      We present model-based analysis for ChIA-PET (MACPET), which analyzes paired-end read sequences provided by ChIA-PET for finding binding sites of a protein of interest. MACPET uses information from both tags of each PET ...

    • Macroeconomic costs of the unmet burden of surgical disease in Sierra Leone: A retrospective economic analysis 

      Grimes, Caris E.; Quaife, Matthew; Kamara, Thaim B.; Lavy, Christopher B.D.; Leather, Andy J.M.; Bolkan, Håkon Angell (Journal article; Peer reviewed, 2018)
      Objectives The Lancet Commission on Global Surgery estimated that low/middle-income countries will lose an estimated cumulative loss of US$12.3 trillion from gross domestic product (GDP) due to the unmet burden of surgical ...

    • Macromolecular maintenance in human cells : repair of uracil in DNA and methylations in DNA and RNA 

      Aas, Per Arne (Dissertations at the Faculty of Medicine, 0805-7680; 243, Doctoral thesis, 2004)
      In all known organisms, except some viruses, genetic information is contained in the form of DNA. Although genetically relatively stable, DNA is subject to continuous damage from the external- and cellular environment. ...

    • Macrophages as a modulator of PLA2G7 and DHRS9 in obesity in a depot dependent manner: implications in energy metabolism and inflammation 

      Nowak, Zuzanna (Master thesis, 2022)
      Mange forskningsstudier har vist at makrofager i fettvev spiller en nøkkelrolle i fedme-indusert inflammasjon. Derfor har samspillet mellom metabolisme og immunsystem (immunometabolisme) blitt grundig undersøkt de siste ...

    • Magnetic Resonance Imaging of Hypoxic-Ischemic Brain Injury Development in the Newborn Rat 

      Widerøe, Marius (Doktoravhandlinger ved NTNU, 1503-8181; 2012:125, Doctoral thesis, 2012)

    • Maintenance pemetrexed therapy in advanced non-smallcell lung cancer 

      Stokke, Kristin (Doctoral theses at NTNU;2023:312, Doctoral thesis, 2023)
      Lung cancer is the most common cancer world-wide, the third most common in Norway after colonand breast cancer, but the most common cause of cancer-related deaths both globally and nationally (1, 2). In 2021, 3499 new cases ...

    • Major durable response of pembrolizumab in chemotherapy refractory small cell bladder cancer: A case report 

      Nguyen, Olav Toai Duc; Sundstrøm, Stein Harald; Westvik, Ganna Surzhykova; Røttereng, Ane Karoline Stræte; Melhus, Mona Røli; Bergseth, Cecilie; Hallem, Elisabeth Kvelstad; Røe, Oluf Dimitri (Peer reviewed; Journal article, 2020)
      Small cell carcinoma of the urinary bladder is a rare subtype (incidence of 1–9/1,000,000), characterized by an aggressive behavior with early metastasis and poor prognosis. Chemotherapy, radiation, and surgery are the ...

    • Major gene expression changes and epigenetic remodelling in Nile tilapia muscle after just one generation of domestication 

      Konstantinidis, Ioannis; Sætrom, Pål; Mjelle, Robin; Nedoluzhko, Artem; Robledo, Diego; Fernandes, Jorge Manuel de Oliveira (Peer reviewed; Journal article, 2020)
      The historically recent domestication of fishes has been essential to meet the protein demands ofa growing human population. Selection for traits of interest during domestication is a complexprocess whose epigenetic basis ...

    • Malignant Mesothelioma: Virus, Biomarkers and Genes- a Translational Approach 

      Røe, Oluf Dimitri (Doktoravhandlinger ved NTNU, 1503-8181; 2008:275, Doctoral thesis, 2008)
      Malignant mesothelioma is an asbestos-related, lethal treatment resistant tumour with increasing incidence worldwide. In four translational studies we have studied the pathogenesis of mesothelioma with regard to the SV40 ...