LRRK2 to the rescue of damaged endomembranes
Peer reviewed, Journal article
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Original versionEMBO Journal. 2020, 39 (18), 1-3. 10.15252/embj.2020106162
Mutations in several genes encoding for lysosomal proteins are involved in Parkinson's disease (PD). In this issue, Herbst et al (2020) show that PD-related leucine-rich repeat kinase 2 (LRRK2) is activated in response to pathogen or membranolytic drug-induced damage of phagolysosomes and lysosomes in macrophages, and regulates endolysosomal homeostasis by controlling the balance between membrane repair and degradation.