Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 1551-1570 of 3426
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Impact of KRAS, BRAF and microsatellite instability status after cytoreductive surgery and HIPEC in a national cohort of colorectal peritoneal metastasis patients
(Peer reviewed; Journal article, 2021)Patients with metastatic colorectal cancer (mCRC) carrying BRAF (mutBRAF) or KRAS mutation (mutKRAS) have an inferior prognosis after liver or lung surgery, whereas the prognostic role in the context of peritoneal metastasis ... -
The impact of longitudinal surveillance of individuals with cerebral palsy in Norway; a 20-year quality registry and follow-up program perspective
(Peer reviewed; Journal article, 2023)The Norwegian Quality and Surveillance Registry for Cerebral Palsy (NorCP) has systematically collected data on individuals with cerebral palsy (CP) and been a driver of knowledge dissemination for over 20 years. NorCP ... -
Impact of maternal education on response to lifestyle interventions to reduce gestational weight gain: individual participant data meta-analysis
(Journal article; Peer reviewed, 2019)Objectives: To identify if maternal educational attainment is a prognostic factor for gestational weight gain (GWG), and to determine the differential effects of lifestyle interventions (diet based, physical activity based ... -
Impact of NEIL3 on neuronal maturation and organization in the hippocampal formation (HF) and medial entorhinal cortex (MEC)
(Master thesis, 2019)DNA damage is proposed to be the reason for mutations to occur. Base excision repair (BER) is the main pathway utilized by the brain to repair oxidative DNA damage. Defects in BER have been linked to the development of ... -
The Impact of Post-bariatric Abdominoplasty on Secondary Weight Regain After Roux-en-Y Gastric Bypass
(Peer reviewed; Journal article, 2020)Roux-en-Y gastric bypass (RYGB), implies a considerable weight loss during the first two years after surgery. Excess skin due to rapid weight loss might affect self-esteem, decrease quality of life and be a hindrance to ... -
The impact of proton pump inhibitors on the course of ulcerative colitis: a cohort study of over 10,000 newly diagnosed patients in Norway
(Peer reviewed; Journal article, 2023)Background and Aims Proton pump inhibitors (PPI) affect the gastrointestinal microbiota, which is thought to play a role in the pathogenesis of ulcerative colitis (UC). Previous studies suggest an association between ... -
Impact of psychotherapy in psychosis: A retrospective case control study
(Journal article; Peer reviewed, 2019)Background: The need for psychological therapies for psychosis has become apparent since long-term antipsychotic drug treatment has a range of adverse side effects, with moderate therapeutic effects at best. Aims: To ... -
Impact of selective serotonin reuptake inhibitors on cardiometabolic factors in patients with schizophrenia or bipolar disorder
(Doctoral theses at NTNU;2019:208, Doctoral thesis, 2019) -
The impact of the COVID-19 pandemic on hospital utilisation in Sierra Leone
(Peer reviewed; Journal article, 2021)Introduction The COVID-19 pandemic has adversely affected health systems in many countries, but little is known about effects on health systems in sub-Saharan Africa. This study examines the effects of COVID-19 on hospital ... -
The impact of the DNA glycosylase NEIL3 on neural coding of spatial learning and memory
(Doctoral theses at NTNU;2021:1, Doctoral thesis, 2021) -
Impact of the Rotavirus Vaccination Program in Norway After Four Years With High Coverage
(Peer reviewed; Journal article, 2020)Background: Use of rotavirus vaccines worldwide since 2006 has led to a significant impact on the burden of rotavirus disease. However, only a third of European countries have introduced rotavirus vaccination in their ... -
Impact of thyrotropin receptor antibody levels on fetal development in two successive pregnancies in a woman with Graves' Disease
(Peer reviewed; Journal article, 2013)Background: Treatment with radioiodine for Graves’ disease regularly increases the level of antithyroid antibodies, and transplacental passage of stimulating thyrotropin receptor antibodies (TRAb) may cause fetal ... -
Impact of transient versus sustained gastrin mediated gene expression in adenocarcinoma cells
(Doktoravhandlinger ved NTNU, 1503-8181; 2013:265, Doctoral thesis, 2013) -
Impact of weight loss achieved through a very-low calorie diet on compensatory mechanisms activated during weight reduction in obese individuals
(Master thesis, 2014)Background: Diet-induced weight loss is accompanied by compensatory mechanisms, with increased drive to eat, and reduced energy expenditure, which try to restore energy balance. Ketosis has been shown to modulate ... -
Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice
(Peer reviewed; Journal article, 2022)Increased astrocytic Ca2+ signaling has been shown in Alzheimer’s disease mouse models, but to date no reports have characterized behaviorally induced astrocytic Ca2+ signaling in such mice. Here, we employ an event-based ... -
Impaired HDL function amplifies systemic inflammation in common variable immunodeficiency
(Journal article; Peer reviewed, 2019)Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency, characterized by inadequate antibody responses and recurrent bacterial infections. Paradoxically, a majority of CVID patients ... -
Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability
(Journal article; Peer reviewed, 2017)Mutations in the HECT, UBA and WWE domain-containing 1 (HUWE1) E3 ubiquitin ligase cause neurodevelopmental disorder X-linked intellectual disability (XLID). HUWE1 regulates essential processes such as genome integrity ... -
Impaired skeletal health and neuromuscular function among amphetamine users in clinical treatment
(Journal article; Peer reviewed, 2016)Summary This study examined musculoskeletal health in amphetamine users, compared with healthy age-matched controls. We show that amphetamine users have reduced bone mass at several skeletal sites and attenuated maximal ... -
Impaired verbal learning is associated with larger caudate volumes in early onset schizophrenia spectrum disorders
(Journal article, 2015)Background: Both brain structural abnormalities and neurocognitive impairments are core features of schizophrenia. We have previously reported enlargements in subcortical brain structure volumes and impairment of ... -
Implementation and evaluation of new surgical methods for treatment of abdominal compartment syndrome, open abdomen and entero-atmospheric fistulas: A clinical study
(Doctoral theses at NTNU;2017:118, Doctoral thesis, 2017)