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Impaired verbal learning is associated with larger caudate volumes in early onset schizophrenia spectrum disorders

Juuhl-Langseth, Monica; Hartberg, Cecilie Bhandari; Holmen, Aina; Thormodsen, Rune; Groote, Inge Rasmus; Rimol, Lars Morten; Emblem, Kyrre Eeg; Agartz, Ingrid; Rund, Bjørn Rishovd
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URI
http://hdl.handle.net/11250/2372570
Date
2015
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  • Institutt for klinisk og molekylær medisin [3827]
  • Publikasjoner fra CRIStin - NTNU [41867]
Original version
PLoS ONE 2015, 10:e0130435(7)   10.1371/journal.pone.0130435
Abstract
Background:

Both brain structural abnormalities and neurocognitive impairments are core features of

schizophrenia. We have previously reported enlargements in subcortical brain structure volumes

and impairment of neurocognitive functioning as measured by the MATRICS Cognitive

Consensus Battery (MCCB) in early onset schizophrenia spectrum disorders (EOS). To

our knowledge, no previous study has investigated whether neurocognitive performance

and volumetric abnormalities in subcortical brain structures are related in EOS.

Methods:

Twenty-four patients with EOS and 33 healthy controls (HC) were included in the study.

Relationships between the caudate nucleus, the lateral and fourth ventricles volumes and

neurocognitive performance were investigated with multivariate linear regression analyses.

Intracranial volume, age, antipsychotic medication and IQ were included as independent

predictor-variables.

Results:

The caudate volume was negatively correlated with verbal learning performance uniquely in

the EOS group (r=-.454, p = .034). There were comparable positive correlations between

the lateral ventricular volume and the processing speed, attention and reasoning and problem

solving domains for both the EOS patients and the healthy controls. Antipsychotic medication

was related to ventricular enlargements, but did not affect the brain structure-function

relationship.

Conclusion:

Enlargement of the caudate volume was related to poorer verbal learning performance in

patients with EOS. Despite a 32% enlargement of the lateral ventricles in the EOS group,

associations to processing speed, attention and reasoning and problem solving were similar

for both the EOS and the HC groups.
Publisher
Public Library of Science
Journal
PLoS ONE

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