Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 151-170 of 3426
-
Antibiotic Therapy in Integrated Oncology and Palliative Cancer Care: An Observational Study
(Peer reviewed; Journal article, 2022)Simple Summary Approximately one-quarter of the patients with advanced cancer acutely admitted to the Palliative Care Unit at St. Olav’s University Hospital received intravenous antibiotics. We observed that physiological ... -
Antibiotic-induced DNA damage results in a controlled loss of pH homeostasis and genome instability
(Peer reviewed; Journal article, 2020)Extracellular pH has been assumed to play little if any role in how bacteria respond to antibiotics and antibiotic resistance development. Here, we show that the intracellular pH of Escherichia coli equilibrates to the ... -
Antibiotikabehandling ved nedre luftveisinfeksjoner i sykehus; etterlevelse av nasjonal retningslinje
(Master thesis, 2023)Bakgrunn: Antibiotikaresistens er et globalt helseproblem. Selv om forekomsten av resistens ikke er like utbredt i Norge kan dette raskt endre seg. Nasjonal retningslinje for antibiotika i sykehus er i Norge et viktige ... -
Antibiotikaforskrivning ved samfunnservervet pneumoni ved Medisinsk klinikk, Helse Møre og Romsdal
(Master thesis, 2019)Sammendrag Bakgrunn: Samfunnservervet pneumoni (CAP) er en av de vanligste årsakene til hospitalisering og pasienter med CAP assosieres med høy morbiditet og mortalitet, spesielt hos eldre. Det er også en hyppig indikasjon ... -
Antibody cross-linking and target elution protocols used for immunoprecipitation significantly modulate signal-to noise ratio in downstream 2D-PAGE analysis
(Journal article; Peer reviewed, 2011)Background Immunoprecipitation and subsequent 2D-PAGE/mass spectrometry are powerful tools to study post-translational protein modifications. Often disregarded in this workflow is the impact of the chemical cross-linker ... -
Antihistamine use during breastfeeding with focus on breast milk transfer and safety in humans: A systematic literature review
(Journal article; Peer reviewed, 2021)Current data on use of antihistamines during breastfeeding and risks to the breastfed infant are insufficient. The aim of this systematic review was to provide an overview of studies measuring the levels of antihistamines ... -
Antimicrobial peptides targeting the beta-clamp
(Doctoral theses at NTNU;2023:94, Doctoral thesis, 2023) -
Antimicrobial resistance: A challenge awaiting the post-COVID-19 era
(Peer reviewed; Journal article, 2021)Microbe exposure to pharmaceutical and non-pharmaceutical agents plays a role in the development of antibiotic resistance. The risks and consequences associated with extensive disinfectant use during the COVID-19 pandemic ... -
Antimicrobial therapy and adherence to guideline recommendations: Studies on pneumonia and bloodstream infections
(Doctoral theses at NTNU;2023:98, Doctoral thesis, 2023)Effective antimicrobial therapy are a prerequisite for modern medical treatment in all medical specialties. However, overuse of antimicrobial therapy is considered a driver of antimicrobial resistance, which eventually ... -
Antimicrobial therapy of community-acquired pneumonia during stewardship efforts and a coronavirus pandemic: an observational study
(Peer reviewed; Journal article, 2022)Background Community-acquired pneumonia (CAP) is the most frequent infection diagnosis in hospitals. Antimicrobial therapy for CAP is depicted in clinical practice guidelines, but adherence data and effect of antibiotic ... -
Antirheumatic therapy is associated with reduced complement activation in rheumatoid arthritis
(Journal article; Peer reviewed, 2022)Background The complement system plays an important role in pathophysiology of cardiovascular disease (CVD), and might be involved in accelerated atherogenesis in rheumatoid arthritis (RA). The role of complement activation ... -
Antiviral Drug Combinations for Treatment of Emerging and Re-emerging Viral Infections
(Master thesis, 2021)Today, combination antiviral therapy is one of the main methods of treatment of complex diseases, such as HIV, HCV and HBV. Antiviral drug combinations have advantages over monotherapies because of their greater efficacy, ... -
Antiviral Drug Combinations for Viral Infection Treatment
(Master thesis, 2023)Enterovirus, som er en del av Picornaviridae-familien, er ansvarlig for et bredt spekter av sykdommer som varierer fra asymptomatiske til dødelige, inkludert utslett, lammelse, hjernehinnebetennelse, poliomyelitt, forkjølelse, ... -
Antiviral Immunoglobulins of Chicken Egg Yolk for Potential Prevention of SARS-CoV-2 Infection
(Peer reviewed; Journal article, 2022)Background: Some viruses cause outbreaks, which require immediate attention. Neutralizing antibodies could be developed for viral outbreak management. However, the development of monoclonal antibodies is often long, ... -
Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins
(Journal article; Peer reviewed, 2017)Viral diseases remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral diseases, new treatments are urgently needed. Here we show that small-molecules, ... -
Anxiety and depression in pregnant women who have experienced a previous perinatal loss: a case‑cohort study from Scandinavia
(Peer reviewed; Journal article, 2023)Background: Perinatal loss can have long-lasting adverse effects on a woman’s psychosocial health, including during subsequent pregnancies. However, maternal mental health status after perinatal loss during subsequent ... -
Anxiety and depression in pregnant women who have experienced a previous perinatal loss: a case‑cohort study from Scandinavia
(Peer reviewed; Journal article, 2023)Background: Perinatal loss can have long-lasting adverse effects on a woman’s psychosocial health, including during subsequent pregnancies. However, maternal mental health status after perinatal loss during subsequent ... -
Anxiety and depression symptoms, albuminuria and risk of acute myocardial infarction in the Norwegian HUNT cohort study
(Peer reviewed; Journal article, 2022)Background Studies suggest increased risk for an outcome in people with joint exposures that share common causal pathways. The objective of this study was to determine the risk of incident acute myocardial infarction ... -
APIM-Mediated REV3L-PCNA Interaction Important for Error Free TLS Over UV-Induced DNA Lesions in Human Cells
(Journal article; Peer reviewed, 2018)Proliferating cell nuclear antigen (PCNA) is essential for the organization of DNA replication and the bypass of DNA lesions via translesion synthesis (TLS). TLS is mediated by specialized DNA polymerases, which all interact, ... -
APIM-PCNA Interactions in the Regulation of Cellular Stress Responses
(Doktoravhandlinger ved NTNU, 1503-8181; 2013:365, Doctoral thesis, 2013)