Blar i Institutt for klinisk og molekylær medisin på tittel

Viser treff 1293-1312 av 3428

    • Genetic Susceptibility to Preeclampsia: Studies on the Nord-Trøndelag Health Study (HUNT) Cohort, an Australian/New Zealand Family Cohort and Decidua Basalis Tissue 

      Fenstad, Mona Høysæter (Doktoravhandlinger ved NTNU, 1503-8181; 2011:63, Doctoral thesis, 2011)
      Genetisk disposisjon for utvikling av svangerskapsforgiftning : Studier fra Helseundersøkelsen i Nord-Trøndelag, en familiekohort fra Australia/New Zealand og decidua basalis vev Svangerskapsforgiftning er en alvorlig ...

    • Genetic variants associated with cardiometabolic abnormalities during treatment with selective serotonin reuptake inhibitors: a genome-wide association study 

      Fjukstad, Katrine Kveli; Athanasiu, Lavinia; Bahrami, Shahram; O`Connell, Kevin; van der Meer, Dennis; Bettella, Francesco; Dieset, Ingrid; Steen, Nils Eiel; Djurovic, Srdjan; Spigset, Olav; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2021)
      Selective serotonin reuptake inhibitors (SSRIs) are prescribed both to patients with schizophrenia and bipolar disorder. Previous studies have shown associations between SSRI treatment and cardiometabolic alterations. The ...

    • Genetic variants related to physical activity or sedentary behaviour: a systematic review 

      Aasdahl, Lene; Nilsen, Tom Ivar Lund; Meisingset, Ingebrigt; Nordstoga, Anne Lovise; Evensen, Kari Anne Indredavik; Paulsen, Julie; Mork, Paul Jarle; Skarpsno, Eivind S. (Peer reviewed; Journal article, 2021)
      Background Research shows that part of the variation in physical activity and sedentary behaviour may be explained by genetic factors. Identifying genetic variants associated with physical activity and sedentary behaviour ...

    • Genetic variation and cognitive dysfunction in opioid-treated patients with cancer 

      Kurita, Geana Paula; Ekholm, Ola; Kaasa, Stein; Klepstad, Pål; Skorpen, Frank; Sjøgren, Per (Peer reviewed; Journal article, 2016)
      Background and purpose The effects of single‐nucleotide polymorphisms (SNPs) on the cognitive function of opioid‐treated patients with cancer until now have not been explored, but they could potentially be related to ...

    • Genetic Variation/Evolution and Differential Host Responses Resulting from In-Patient Adaptation of Mycobacterium avium 

      Kannan, Nisha; Lai, Yi-Pin; Haug, Markus; Lilleness, M.K.; Bakke, Siril Skaret; Marstad, Anne; Hov, Håkon; Naustdal, Thor; Afset, Jan Egil; Ioerger, Thomas R.; Flo, Trude Helen; Steigedal, Magnus (Journal article; Peer reviewed, 2019)
      Members of the Mycobacterium avium complex (MAC) are characterized as nontuberculosis mycobacteria and are pathogenic mainly in immunocompromised individuals. MAC strains show a wide genetic variability, and there is growing ...

    • Genmodifisert maislinje MON810. Uttalelse fra Faggruppe for genmodifiserte organismer i Vitenskapskomiteen for mattrygghet 09.11.07 

      Berdal, Knut G; Clarke, Jihong; Klemsdal, Sonja; Klungland, Helge; Lid, Elin Thingnæs; Linnestad, Casper; Mikalsen, Arne; Myhr, Anne Ingeborg; Nerland, Audun Helge; Nes, Ingolf; Nielsen, Kaare Magne; Sorteberg, Hilde-Gunn Opsahl; Stabbetorp, Odd Egil; Thrane, Vibeke (VKM Report;, Research report, 2007)

    • Genome editing in food and feed production – implications for risk assessment 

      Bodin, Johanna Eva; Thorstensen, Tage; Alsheikh, Muath K; Basic, Dean; Edvardsen, Rolf Brudvik; Dalen, Knut Tomas; das Neves, Carlos Gonçalo; Duale, Nur; Eklo, Ole Martin; Ergon, Åshild Gunilla; Jevnaker, Anne-Marthe Ganes; Hindar, Kjetil; Håvarstein, Leiv Sigve; Malmstrøm, Martin; Nielsen, Kaare Magne; Olsen, Siri Lie; Rueness, Eli Knispel; Sanden, Monica; Sipinen, Ville Erling; Vikse, Rose; von Krogh, Kristine; Våge, Dag Inge; Wargelius, Anna; Wendell, Micael; Yazdankhah, Siamak Pour; Alexander, Jan; Bruzell, Ellen Merete; Hemre, Gro Ingunn; Vandvik, Vigdis; Agdestein, Angelika; Elvevoll, Edel O.; Hessen, Dag Olav; Hofshagen, Merete; Husøy, Trine; Knutsen, Helle Katrine; Krogdahl, Åshild; Nilsen, Asbjørn Magne; Rafoss, Trond; Skjerdal, Olaug Taran; Steffensen, Inger-Lise Karin; Strand, Tor Arne; Velle, Gaute; Wasteson, Yngvild (Peer reviewed; Journal article, 2021)
      The Norwegian Scientific Committee for Food and Environment (VKM) initiated this work to examine the extent to which organisms developed by genome-editing technologies pose new challenges in terms of risk assessment. This ...

    • Genome editing in food and feed production – implications for risk assessment. Scientific Opinion of the Scientific Steering Committee of the Norwegian Scientific Committee for Food and Environment 

      Bodin, Johanna Eva; Thorstensen, Tage; Alsheikh, Muath K; Basic, Dean; Edvardsen, Rolf Brudvik; Dalen, Knut Tomas; Duale, Nur; Eklo, Ole Martin; Ergon, Åshild Gunilla; Jevnaker, Anne-Marthe Ganes; Hindar, Kjetil; Håvarstein, Leiv Sigve; Malmstrøm, Martin; Nielsen, Kaare Magne; Olsen, Siri Lie; Rueness, Eli Knispel; Sanden, Monica; Sipinen, Ville Erling; von Krogh, Kristine; Våge, Dag Inge; Wargelius, Anna; Wendell, Per Hans Micael; Yazdankhah, Siamak Pour; Alexander, Jan; Bruzell, Ellen Merete; Hemre, Gro Ingunn; Vandvik, Vigdis; Agdestein, Angelika; Elvevoll, Edel O.; Hessen, Dag Olav; Hofshagen, Merete; Husøy, Trine; Knutsen, Helle Katrine; Krogdahl, Åshild; Nilsen, Asbjørn Magne; Rafoss, Trond; Skjerdal, Olaug Taran; Steffensen, Inger-Lise Karin; Strand, Tor Arne; Velle, Gaute; Wasteson, Yngvild (Journal article; Peer reviewed, 2021)
      The Norwegian Scientific Committee for Food and Environment (VKM) initiated this work to examine the extent to which organisms developed by genome-editing technologies pose new challenges in terms of risk assessment. This ...

    • Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions 

      Khoury, Samar; Parisien, Marc; Thompson, Scott J.; Vachon-Presseau, Etienne; Roy, Mathieu; Mitchell, Amy; Winsvold, Bendik K S; Skogholt, Anne Heidi; Brumpton, Ben Michael; Willer, Cristen J.; Fors, Egil Andreas; Heuch, Ingrid; Nielsen, Jonas Bille; Storheim, Kjersti; Hagen, Knut; Nilsen, Kristian Bernhard; Hveem, Kristian; Fritsche, Lars; Thomas, Laurent; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Johnsen, Marianne Bakke; Lie, Marie; Holmen, Oddgeir; Børte, Sigrid; Stensland, Synne; Zhou, Wei; Mundal, Ingunn Pernille; Zwart, John Anker Henrik; Kania, Artur; Mogil, Jeffrey S.; Diatchenko, Luda (Peer reviewed; Journal article, 2021)
      Chronic pain is often present at more than one anatomical location, leading to chronic overlapping pain conditions (COPC). Whether COPC represents a distinct pathophysiology from the occurrence of pain at only one site is ...

    • Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles 

      Hautakangas, Heidi; Winsvold, Bendik K S; Ruotsalainen, Sanni; Bjornsdottir, Gyda; Harder, Aster V. E.; Kogelman, Lisette J. A.; Thomas, Laurent; Noordam, Raymond; Benner, Christian; Gormley, Padhraig; Artto, Ville; Banasik, Karina; Bjornsdottir, Anna; Boomsma, Dorret I.; Brumpton, Ben Michael; Burgdorf, Kristoffer Sølvsten; Buring, Julie E.; Chalmer, Mona Ameri; de Boer, Irene; Dichgans, Martin; Erikstrup, Christian; Färkkilä, Markus; Gabrielsen, Maiken Elvestad; Ghanbari, Mohsen; Hagen, Knut; Häppölä, Paavo; Hottenga, Jouke-Jan; Hrafnsdottir, Maria G.; Hveem, Kristian; Johnsen, Marianne Bakke; Kähönen, Mika; Kristoffersen, Espen Saxhaug; Kurth, Tobias; Lehtimäki, Terho; Lighart, Lannie; Magnusson, Sigurdur H.; Malik, Rainer; Pedersen, Ole Birger; Pelzer, Nadine; Penninx, Brenda W. J. H.; Ran, Caroline; Ridker, Paul M.; Rosendaal, Frits Richard; Sigurdardottir, Gudrun R.; Skogholt, Anne Heidi; Sveinsson, Olafur A.; Thorgeirsson, Thorgeir E.; Ullum, Henrik; Zwart, John Anker Henrik (Peer reviewed; Journal article, 2022)
      Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified ...

    • Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease 

      Zheng, Thenghao; Skogholt, Anne Heidi; Gabrielsen, Maiken Elvestad; Hveem, Kristian; Thomas, Laurent; Ness-Jensen, Eivind (Peer reviewed; Journal article, 2021)
      Objective Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the population but its aetiology, including suspected genetic predisposition, is poorly understood. We report the first genome-wide ...

    • Genome-wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker overexpressed in cancer. 

      Vange, Pål; Bruland, Torunn; Beisvag, Vidar; Erlandsen, Sten Even; Flatberg, Arnar; Doseth, Berit; Sandvik, Arne Kristian; Bakke, Ingunn (Journal article; Peer reviewed, 2015)
      The oxyntic proliferative isthmus zone contains the main stem/progenitor cells that provide for physiological renewal of the distinct mature cell lineages in the oxyntic epithelium of the stomach. These cells are also ...

    • Genome-wide association meta-analysis identifies 29 new acne susceptibility loci 

      Mitchell, Brittany L.; Saklatvala, Jake R.; Dand, Nick; Hagenbeek, Fiona A.; Li, Xin; Min, Josine L.; Thomas, Laurent; Bartels, Meike; Jan Hottenga, Jouke; Lupton, Michelle K.; Boomsma, Dorret I.; Dong, Xianjun; Hveem, Kristian; Løset, Mari; Martin, Nicholas G.; Barker, Jonathan N.; Han, Jiali; Smith, Catherine H.; Rentería, Miguel E.; Simpson, Michael A. (Peer reviewed; Journal article, 2022)
      Acne vulgaris is a highly heritable skin disorder that primarily impacts facial skin. Severely inflamed lesions may leave permanent scars that have been associated with long-term psychosocial consequences. Here, we perform ...

    • Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene 

      Johnson, Matthew P; Brennecke, Shaun P.; East, Christine; Göring, Harald H H; Kent, Jack W; Dyer, Thomas D.; Said, Joanne M; Roten, Linda Tømmerdal; Iversen, Ann-Charlotte; Abraham, Lawrence J; Heinonen, Seppo; Kajantie, Eero; Kere, Juha; Kivinen, Katja; Pouta, Anneli; Laivuori, Hannele; Austgulen, Rigmor; Blangero, John; Moses, Eric K (Journal article; Peer reviewed, 2012)
      Elucidating the genetic architecture of preeclampsia is a major goal in obstetric medicine. We have performed a genome-wide association study (GWAS) for preeclampsia in unrelated Australian individuals of Caucasian ancestry ...

    • Genome-wide association study identifies multiple susceptibility loci for multiple myeloma 

      Mitchell, Jonathan S; Li, Ni; Weinhold, Niels; Försti, Asta; Ali, Mina; Van Duin, Mark; Thorleifsson, Gudmar; Johnson, David C; Chen, Bowang; Halvarsson, Britt-Marie; Gudbjartsson, Daniel F.; Kuiper, Rowan; Stephens, Owen W; Bertsch, Uta; Broderick, Peter; Campo, Chiara; Einsele, Hermann; Gregory, Walter A; Gullberg, Urban; Henrion, Marc; Hillengass, Jens; Hoffmann, Per; Jackson, Graham H.; Johnsson, Ellinor; Jöud, Magnus; Kristinsson, Sigurdur Y; Lenhoff, Stig; Lenive, Oleg; Mellqvist, Ulf-Henrik; Migliorini, Gabriele; Nahi, Hareth; Nelander, Sven; Nickel, Jolanta; Nothen, Markus M; Rafnar, Thorunn; Ross, Fiona M; Da Silva Filho, Miguel Inacio; Swaminathan, Bhairavi; Thomsen, Hauke; Turesson, Ingemar; Vangsted, Annette; Vogel, Ulla; Waage, Anders; Walker, Brian A; Wihlborg, Anna-Karin; Broyl, Annemiek; Davies, Faith E; Thorsteinsdottir, Unnur; Langer, Christian; Hansson, Markus; Kaiser, Martin; Sonneveld, Pieter; Stefansson, Kari; Morgan, Gareth J; Goldschmidt, Hartmut; Hemminki, Kari; Nilsson, Björn; Houlston, Richard S. (Peer reviewed; Journal article, 2016)
      Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power ...

    • Genome-wide association study of cardiac troponin i in the general population 

      Moksnes, Marta Riise; Røsjø, Helge; Richmond, Anne; Lyngbakken, Magnus N; Graham, Sarah E; Wolford, Brooke N; Hansen, Ailin Falkmo; Gagliano Taliun, Sarah A; Lefaive, Jonathon; Rasheed, Humaira; Thomas, Laurent; Zhou, Wei; Aung, Nay; Surakka, Ida; Douville, Nicholas J; Campbell, Archie; Porteous, David J; Petersen, Steffen E; Munroe, Patricia B; Welsh, Paul; Sattar, Naveed; Smith, George Davey; Fritsche, Lars G; Nielsen, Jonas Bille; Åsvold, Bjørn Olav; Hveem, Kristian; Hayward, Caroline; Willer, Cristen J; Brumpton, Ben M; Omland, Torbjørn (Peer reviewed; Journal article, 2021)
      Circulating cardiac troponin proteins are associated with structural heart disease and predict incident cardiovascular disease in the general population. However, the genetic contribution to cardiac troponin I (cTnI) ...

    • Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth 

      Beaumont, Robin N.; Flatley, Christopher; Vaudel, Marc; Wu, Xiaoping; Chen, Jing; Moen, Gunn-Helen Øiseth; Skotte, Line; Helgeland, Øyvind; Solé-Navais, Pol; Banasik, Karina; Albiñana, Clara; Ronkainen, Justiina; Fadista, João; Stinson, Sara Elizabeth; Trajanoska, Katerina; Wang, Carol A.; Westergaard, David; Srinivasan, Sundararajan; Sánchez-Soriano, Carlos; Bilbao, Jose Ramon; Allard, Catherine; Groleau, Marika; Kuulasmaa, Teemu; Leirer, Daniel J.; White, Frédérique; Jacques, Pierre-Étienne; Cheng, Haoxiang; Hao, Ke; Andreassen, Ole; Åsvold, Bjørn Olav; Atalay, Mustafa; Bhatta, Laxmi; Bouchard, Luigi; Brumpton, Ben Michael; Brunak, Søren; Bybjerg-Grauholm, Jonas; Ebbing, Cathrine; Elliott, Paul; Engelbrechtsen, Line; Erikstrup, Christian; Estarlich, Marisa; Franks, Stephen; Gaillard, Romy; Geller, Frank; Grove, Jakob; Hougaard, David M.; Kajantie, Eero Olavi; Morgen, Camilla S.; Nøhr, Ellen Aagaard; Nyegaard, Mette; Palmer, Colin N. A.; Pedersen, Ole Birger; Rivadeneira, Fernando; Sebert, Sylvain; Shields, Beverley M.; Stoltenberg, Camilla; Surakka, Ida; Thørner, Lise Wegner; Ullum, Henrik; Vaarasmaki, Marja; Vilhjalmsson, Bjarni J.; Willer, Cristen J.; Lakka, Timo A.; Gybel-Brask, Dorte; Bustamante, Mariona; Hansen, Torben; Pearson, Ewan R.; Reynolds, Rebecca M.; Ostrowski, Sisse R.; Pennell, Craig E.; Jaddoe, Vincent W. V.; Felix, Janine F.; Hattersley, Andrew T.; Melbye, Mads; Lawlor, Deborah A.; Hveem, Kristian; Werge, Thomas; Nielsen, Henriette Svarre; Magnus, Per Minor; Evans, David M.; Jacobsson, Bo; Järvelin, Marjo-Riitta; Zhang, Ge; Hivert, Marie-France; Johansson, Stefan; Freathy, Rachel M.; Feenstra, Bjarke; Njølstad, Pål Rasmus (Peer reviewed; Journal article, 2023)
      A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), ...

    • Genome-Wide Copy Number Variant and High-Throughput Transcriptomics Analyses of Placental Tissues Underscore Persisting Child Susceptibility in At-Risk Pregnancies Cleared in Standard Genetic Testing 

      Czamara, Darina; Cruceanu, Cristiana; Lahti-Pulkkinen, Marius; Dieckmann, Linda; Ködel, Maik; Sauer, Susann; Rex-Haffner, Monika; Sammallahti, Sara; Kajantie, Eero Olavi; Laivuori, Hannele; Lahti, Jari; Räikkönen, Katri; Binder, Elisabeth B. (Peer reviewed; Journal article, 2022)
      Several studies have shown that children from pregnancies with estimated first-trimester risk based on fetal nuchal translucency thickness and abnormal maternal serum pregnancy protein and hormone levels maintain a higher ...

    • Genome-wide hydroxymethylation profiles in liver of female Nile tilapia with distinct growth performance 

      Konstantinidis, Ioannis; Sætrom, Pål; Fernandes, Jorge Manuel de Oliveira (Peer reviewed; Journal article, 2023)
      The mechanisms underlying the fast genome evolution that occurs during animal domestication are poorly understood. Here, we present a genome-wide epigenetic dataset that quantifies DNA hydroxymethylation at single nucleotide ...

    • Genome-wide microRNA screening in Nile tilapia reveals pervasive isomiRs’ transcription, sex-biased arm switching and increasing complexity of expression throughout development 

      Pinhal, Danillo; Bovolenta, Luiz Augusto; Moxon, Simon; Oliveira, Arthur; Nachtigall, Pedro; Acencio, Marcio Luis; Patton, James; Hilsdorf, Alexandre; Lemke, Ney; Martins, Cesar (Journal article; Peer reviewed, 2018)
      MicroRNAs (miRNAs) are key regulators of gene expression in multicellular organisms. The elucidation of miRNA function and evolution depends on the identification and characterization of miRNA repertoire of strategic ...