Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 1273-1292 av 3426
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Genetic and Non-genetic Factors Associated WithConstipation in Cancer Patients Receiving Opioids
(Journal article; Peer reviewed, 2015)Objectives: To examine whether the inter-individual variation in constipation among patients receiving opioids for cancer pain is associated with genetic or non-genetic factors. Methods: Cancer patients receiving ... -
Genetic biomarkers in multiple myeloma
(Doctoral theses at NTNU;2019: 223, Doctoral thesis, 2019)Multiple myeloma is a cancer of plasma cells in the bone marrow that accounts for 2 % of cancer cases globally. Improved understanding of the molecular basis of this disease has resulted in new treatment options and prolonged ... -
Genetic diversity and drug resistance pattern of Mycobacterium tuberculosis strains isolated from pulmonary tuberculosis patients in the Benishangul Gumuz region and its surroundings, Northwest Ethiopia
(Peer reviewed; Journal article, 2020)Introduction Tuberculosis (TB) remains a major global public health problem and is the leading cause of death from a single bacterium, Mycobacterium tuberculosis (MTB) complex. The emergence and spread of drug-resistant ... -
Genetic diversity of rotavirus strains circulating in Norway before and after the introduction of rotavirus vaccination in children
(Peer reviewed; Journal article, 2021)Globally, rotavirus (RV) is the leading cause of acute gastroenteritis (AGE) in young children under 5 years of age. Implementation of RV vaccination is expected to result in fewer cases of RV in the target population, but ... -
Genetic Engineering for Revealing Underlying Mechanisms of Inflammatory Bowel Diseases
(Master thesis, 2020)Inflammatorisk tarmsykdom, også kalt IBD, er en samlebetegnelse på kronisk betennelse i tarmen. IBD består i hovedsak av ulcerøs kolitt og Crohns sykdom. De underliggende årsakene er i stor grad ukjent, men både genetikk, ... -
Genetic interaction between accessory non-homologous end joining factors in B and T lymphocyte development
(Master thesis, 2020)DNA dobbeltstrengsbrudd (DSB) induseres av eksogene og endogene faktorer. Ikke-homolog endeforbindelse (NHEJ) -vei er et reparasjonssystem som omhandler DSB-er over hele cellesyklusen. NHEJ er nødvendig for V (D) J-rekombinasjon ... -
Genetic Interaction Between DNA Repair Factors in Lymphocyte Development
(Master thesis, 2019)Dobbeltråd-brudd (DSB) på DNA-tråden er den mest cytotoksiske skaden i cellene våre. I løpet av utviklingen av B- og T-celler introduseres DSBs med vilje i løpet av V(D)J rekombinasjonen, og repareres av den ikke-homologe ... -
Genetic interaction between DNA repair factors PAXX, XLF, XRCC4 and DNA-PKcs in human cells
(Journal article; Peer reviewed, 2019)DNA double‐strand breaks (DSBs) are highly cytotoxic lesions, and unrepaired or misrepaired DSBs can lead to various human diseases, including immunodeficiency, neurological abnormalities, growth retardation, and cancer. ... -
Genetic interaction between the non-homologous end joining factors in mice and humans
(Doctoral theses at NTNU;2019:117, Doctoral thesis, 2019) -
Genetic interaction between the non‐homologous end joining factors during B and T lymphocyte development: in vivo mouse models
(Peer reviewed; Journal article, 2020)Non-homologous end joining (NHEJ) is the main DNA repair mechanism for the repair of double-strand breaks (DSBs) throughout the course of the cell cycle. DSBs are generated in developing B and T lymphocytes during V(D)J ... -
Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies
(Peer reviewed; Journal article, 2022)Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies ... -
Genetic predisposition for development of preeclampsia: Candidate gene studies in the HUNT(Nord-Trøndelag Health Study) population
(Doktoravhandlinger ved NTNU, 1503-8181; 2009:157, Doctoral thesis, 2009)Preeclampsia is a major cause of maternal morbidity and mortality in the western world, and approximately 63,000 women dye yearly of the disease worldwide. This disorder is characterized by increased maternal blood pressure ... -
Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
(Peer reviewed; Journal article, 2020)Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate ... -
Genetic Predisposition to Preeclampsia: Genetic Association Studies on Population-Based Cohorts and Transcriptional Studies on Decidua Basalis Tissue
(Doktoravhandlinger ved NTNU, 1503-8181; 2014:47, Doctoral thesis, 2014) -
Genetic Rescue of the Highly Inbred Norwegian Lundehund
(Journal article; Peer reviewed, 2022)Augmenting the genetic diversity of small, inbred populations by the introduction of new individuals is often termed “genetic rescue“. An example is the Norwegian Lundehund, a small spitz dog with inbreeding-related health ... -
Genetic Risk Factors for Lung Cancer: Relationship to Smoking Habits and Nicotine Addiction: The Nord-Trøndelag (HUNT) and Tromsø Health Studies
(Doktoravhandlinger ved NTNU, 1503-8181; 2013:87, Doctoral thesis, 2013) -
Genetic risk score associations for myocardial infarction are comparable in persons with and without rheumatoid arthritis: the population-based HUNT study
(Peer reviewed; Journal article, 2020)Persons with rheumatoid arthritis (RA) have increased risk of myocardial infarction (MI). Overlapping associations with MI of weighted genetic risk scores (wGRS) for coronary artery disease (CAD) and RA is unknown in a ... -
Genetic studies of candidate genes in Parkinson’s disease
(Doktoravhandlinger ved NTNU, 1503-8181; 2008:324, Doctoral thesis, 2008)The genetics of Parkinson’s disease (PD) have been extensively studied during recent years. This thesis presents an investigation of genetic causes of Parkinson’s disease in differently structured population samples using ... -
Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache
(Peer reviewed; Journal article, 2021)Objective Identifying common genetic variants that confer genetic risk for cluster headache. Methods We conducted a case–control study in the Dutch Leiden University Cluster headache neuro-Analysis program (LUCA) study ... -
Genetic Susceptibility to Preeclampsia: Studies on the Nord-Trøndelag Health Study (HUNT) Cohort, an Australian/New Zealand Family Cohort and Decidua Basalis Tissue
(Doktoravhandlinger ved NTNU, 1503-8181; 2011:63, Doctoral thesis, 2011)Genetisk disposisjon for utvikling av svangerskapsforgiftning : Studier fra Helseundersøkelsen i Nord-Trøndelag, en familiekohort fra Australia/New Zealand og decidua basalis vev Svangerskapsforgiftning er en alvorlig ...