Blar i Institutt for klinisk og molekylær medisin på tittel

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    • Neural correlates of working memory training in HIV patients: Study protocol for a randomized controlled trial 

      Chang, Linda; Løhaugen, Gro; Douet, Vanessa; Miller, Eric N.; Skranes, Jon Sverre; Ernst, Thomas (Peer reviewed; Journal article, 2016)
      Background Potent combined antiretroviral therapy decreased the incidence and severity of HIV-associated neurocognitive disorders (HAND); however, no specific effective pharmacotherapy exists for HAND. Patients with HIV ...

    • Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer. 

      Dubeykovskaya, Z; Si, Y; Chen, X; Worthley, DL; Renz, BW; Urbanska, AM; Hayakawa, Y; Xu, T; Westphalen, CB; Dubeykovskiy, A; Chen, Duan; Friedman, RA; Asfaha, S; Nagar, S; Tailor, Y; Muthupalani, S; Fox, JG; Kitajewski, J; Wang, Timothy C. (Peer reviewed; Journal article, 2016)
      CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory reflex arc involving the vagus nerve and ...

    • Neural signaling modulates metabolism of gastric cancer 

      Rabben, Hanne-Line; Andersen, Gøran Troseth; Olsen, Magnus Kringstad; Øverby, Anders; Ianevski, Aleksandr; Kainov, Denis; Wang, Timothy Cragin; Lundgren, Steinar; Grønbech, Jon Erik; Chen, Duan; Zhao, Chun-Mei (Peer reviewed; Journal article, 2021)
      Tumors comprise cancer cells and the associated stromal and immune/inflammatory cells, i.e., tumor microenvironment (TME). Here, we identify a metabolic signature of human and mouse model of gastric cancer and show that ...

    • Neurocognitive function and associations with mental health in adults born preterm with very low birthweight or small for gestational age at term 

      Weider, Siri; Lærum, Astrid Merete Winsnes; Evensen, Kari Anne Indredavik; Reitan, Solveig Klæbo; Lydersen, Stian; Brubakk, Ann-Mari; Skranes, Jon Sverre; Indredavik, Marit Sæbø (Peer reviewed; Journal article, 2023)
      Objectives: To assess neurocognitive function in adults born with low birthweight compared with controls and to explore associations between neurocognitive function and psychopathology in these groups. Methods: In this ...

    • Neurodevelopmental origins of lifespan changes in brain and cognition 

      Walhovd, Kristine B; Krogsrud, Stine Kleppe; Amlien, Inge Kasbohm; Bartsch, Hauke; Bjørnerud, Atle; Due-Tønnessen, Paulina; Grydeland, Håkon; Hagler, D.; Håberg, Asta; Kremen, William S.; Ferschmann, Lia; Nyberg, Lars; Panizzon, Matthew S; Rohani, Darius; Skranes, Jon Sverre; Storsve, Andreas Berg; Sølsnes, Anne Elisabeth; Tamnes, Christian Krog; Thompson, Wesley K.; Reuter, Chase; Dale, Anders; Fjell, Anders Martin (Journal article; Peer reviewed, 2016)
      Neurodevelopmental origins of functional variation in older age are increasingly being acknowledged, but identification of how early factors impact human brain and cognition throughout life has remained challenging. Much ...

    • Neuroendocrine Aspects of Physiology and Disease 

      Hauso, Øyvind (Doktoravhandlinger ved NTNU, 1503-8181; 2009:93, Doctoral thesis, 2009)
      De nevroendokrine celler står i en mellomstilling mellom nerveceller (nevro-) og hormonproduserende celler (-endokrine). Disse finnes i et helt spekter, spredt i overflaten av kroppens fleste organer. To viktige nevroendokrine ...

    • Neuromodulatory effect of NLRP3 and ASC in neonatal hypoxic ischemic encephalopathy 

      Ystgaard, Martin Bogale; Scheffler, Katja; Suganthan, Rajikala; Bjørås, Magnar; Ranheim, Trine; Sagen, Ellen Lund; Halvorsen, Bente; Saugstad, Ola Didrik; Yndestad, Arne (Journal article; Peer reviewed, 2019)
      Background: Following birth asphyxia there is a robust inflammatory response. NLRP3 is a receptor of the innate immune system. Upon activation, NLRP3 forms an inflammasome together with ASC and procaspase-1 to mediate ...

    • Neuron-astrocyte interactions, pyruvate carboxylation and the pentose phosphate pathway in the neonatal rat brain 

      Morken, Tora Sund; Brekke, Eva Mari Førland; Håberg, Asta; Widerøe, Marius; Brubakk, Ann-Mari; Sonnewald, Ursula (Journal article; Peer reviewed, 2014)
      Glucose and acetate metabolism and the synthesis of amino acid neurotransmitters, anaplerosis, glutamate-glutamine cycling and the pentose phosphate pathway (PPP) have been extensively investigated in the adult, but not ...

    • Neuron-Specific Enolase as an Immunohistochemical Marker Is Better Than Its Reputation 

      Mjønes, Patricia; Sagatun, Liv; Nordrum, Ivar Skjåk; Waldum, Helge (Journal article; Peer reviewed, 2017)
      The diagnosis of neuroendocrine neoplasms (NENs) may be challenging and is based on typical morphological features and positive staining for antibodies of neuroendocrine differentiation. Neuron-specific enolase (NSE) being ...

    • Neuropsychological functioning and quantitative cerebral MRI in young adults born Small-for-Gestational-Age at term 

      Østgård, Heidi Furre (Doktoravhandlinger ved NTNU, 1503-8181; 2014:185, Doctoral thesis, 2014)
      Fetal growth restriction (FGR) is said to occur in 3-10% of fetuses. The term small-for-gestational-age (SGA) is used as a proxy for FGR in epidemiological studies, and is defined as a birth weight cut-off, adjusted for ...

    • Neutrophil activation in a roller pump model of cardiopulmonary bypass:  Influence of biomaterial, platelets and complement 

      Åsberg, Ann Elisabeth (Doktoravhandlinger ved NTNU, 1503-8181; 2008:104, Doctoral thesis, 2008)
        Background: In cardiac surgery with cardiopulmonary bypass a complex systemic inflammatory response can arise postoperatively, causing serious complications such as the development of multi-organ dysfunction. ...

    • Neutrophil gelatinase-associated lipocalin in inflammatory bowel disease 

      Thorsvik, Silje (Doctoral theses at NTNU;2019:108, Doctoral thesis, 2019)
      Nøytrofil gelatinase-assosiert lipocalin i inflammatorisk tarmsykdom Inflammatorisk tarmsykdom (IBD) er kroniske betennelsestilstander i mage-tarmsystemet. De to hovedformene er Crohns sykdom (CD) og ulcerøs kolitt (UC). ...

    • New genetic signatures associated with cancer cachexia as defined by low skeletal muscle index and weight loss. 

      Johns, Neil; Stretch, C; Tan, BH; Solheim, Tora Skeidsvoll; Sørhaug, Sveinung; Stephens, NA; Gioulbasanis, Ioannis; Skipworth, RJ; Deans, DA; Vigano, Antonio A.L.; Ross, JA; Bathe, OF; Tremblay, ML; Kaasa, Stein; Strasser, Florian; Gagnon, B; Baracos, VE; Damaraju, S; Fearon, KC (Peer reviewed; Journal article, 2017)
      Background Cachexia affects the majority with advanced cancer. Based on current demographic and clinical factors, it is not possible to predict who will develop cachexia or not. Such variation may, in part, be due to ...

    • A new high-content screening assay of the entire hepatitis B virus life cycle identifies novel antivirals 

      Yang, Jaewon; König, Alexander; Park, Soonju; Jo, Eunji; Sung, Pil Soo; Yoon, Seung Kew; Zusinaite, Eva; Kainov, Denis; Shum, David; Windisch, Marc Peter (Peer reviewed; Journal article, 2021)
      Background & Aims: Chronic hepatitis B is an incurable disease. Addressing the unmet medical need for therapies has been hampered by a lack of suitable cell culture models to investigate the HBV life cycle in a single ...

    • New players in an old game: Role of immunoglobulins in the pathogenesis of multiple myeloma 

      Kovcic, Vlado (Doctoral theses at NTNU;2020:124, Doctoral thesis, 2020)
      Multiple myeloma is a haematological malignancy characterized by uncontrolled proliferation of malignant plasma cells. The myeloma cells secrete immunoglobulins, which leads to the presence of high levels of monoclonal ...

    • New reference intervals for cortisol, cortisol binding globulin and free cortisol index in women using ethinyl estradiol 

      Panton, Kristine Kollerøs; Mikkelsen, Gustav; Irgens, Wenche Elna Øiestad; Hovde, Ann Kristin; Killingmo, Marte Wien; Øien, Monja Airin; Thorsby, Per Medbøe; Åsberg, Arne (Peer reviewed; Journal article, 2019)
      Healthy women using contraceptives containing a low dose of an estrogen may have a higher serum concentration of cortisol (s-cortisol) and cortisol binding globulin (s-CBG) than the commonly used upper reference limits. ...

    • New relative intensity ambulatory accelerometer thresholds for elderly men and women: The Generation 100 study 

      Zisko, Nina; Carlsen, Trude; Salvesen, Øyvind; Aspvik, Nils Petter; Ingebrigtsen, Jan Erik; Wisløff, Ulrik; Stensvold, Dorthe (Journal article; Peer reviewed, 2015)
      Background Public health initiatives world-wide recommend increasing physical activity (PA) to improve health. However, the dose and the intensity of PA producing the most benefit are still debated. Accurate assessment ...

    • Next Generation Sequencing based methods in genetic disease diagnostics 

      Singh, Ashish Kumar (Doctoral theses at NTNU 2023:222, Doctoral thesis, 2023)
      Background: Identification of a germline pathogenic variant that increases risk of getting diseases in a family is important for the clinical management of the family members. DNA sequencing is an important molecular ...

    • NHDL, a recombinant VL/VH hybrid antibody control for IgG2/4 antibodies. 

      Lau, Corinna; McAdam, MB; Bergseth, G; Grevys, Algirdas; Bruun, JA; Ludviksen, Judith K; Fure, Hilde; Espevik, Terje; Moen, A; Andersen, Jan Terje; Mollnes, Tom Eirik (Journal article; Peer reviewed, 2020)
      The mechanism of action of recombinant IgG2/4 antibodies involves blocking of their target without the induction of effector functions. Examples are eculizumab (Soliris®), which is used clinically to block complement factor ...

    • NICU dialects: Understanding Norwegian practice variation 

      Syltern, Janicke Marita; Markestad, Trond Jacob; Saugstad, Ola Didrik; Støen, Ragnhild (Journal article; Peer reviewed, 2018)
      In Norway, a national consensus-based guideline used to address thresholds for offering life support at extreme preterm birth was issued in 1998. Since then, therapeutic advances may have changed attitudes and expectations ...