Blar i Institutt for klinisk og molekylær medisin på tittel

Viser treff 2146-2165 av 3426

    • Nedregulering av urokinase ved hjelp av RNA-interferens 

      Hammervold, Kristen Kåre Rembar (Master thesis, 2009)

    • NEFA Dynamics in Adults With Severe Obesity and Insulin Resistance: No Coupling to the rs9939609 FTO Risk Allele 

      Mostad, Ingrid Løvold; Grill, Valdemar Erik Robert (Peer reviewed; Journal article, 2023)
      Context: The FTO gene is highly expressed in adipose tissues; however, whether nonesterified fatty acids (NEFA) dynamics are impacted by FTO has not been rigorously tested for in a uniformly obese study population comprising ...

    • NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice 

      Hildrestrand, Gunn Annette; Rolseth, Veslemøy; Kunath, Nicolas; Suganthan, Rajikala; Jensen, Vidar; Bugaj, Anna Maria; Fernandez Berrocal, Marion Silvana; SIkko, Sunniva Bøe; Vetlesen, Susanne; Kusnierczyk, Anna; Olsen, Ann-Karin Hardie; Gutzkow, Kristine Bjerve; Rowe, Alexander D.; Wang, Wei; Moldestad, Olve; Syrstad, Monika; Slupphaug, Geir; Eide, Lars; Klungland, Arne; Sætrom, Pål; Luna, Luisa; Ye, Jing; Scheffler, Katja; Bjørås, Magnar (Peer reviewed; Journal article, 2021)
      Oxidative DNA damage in the brain has been implicated in neurodegeneration and cognitive decline. DNA glycosylases initiate base excision repair (BER), the main pathway for oxidative DNA base lesion repair. NEIL1 and NEIL3 ...

    • Neil3 induced neurogenesis protects against prion disease during the clinical phase 

      Jalland, Clara Maria Osnes; Scheffler, Katja; Benestad, Sylvie Lafond; Moldal, Torfinn; Ersdal, Cecilie; Gunnes, Gjermund; Suganthan, Rajikala; Bjørås, Magnar; Tranulis, Michael A. (Journal article; Peer reviewed, 2016)
      Base excision repair (BER) is the major pathway for repair of oxidative DNA damage. Mice with genetic knockout of the BER enzyme Neil3 display compromised neurogenesis in the sub-ventricular zone of the lateral ventricle ...

    • NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype 

      Karlsen, Tom Rune; Kong, Xiang Yi; Holm, Sverre; Quiles-Jiménez, Ana M T; Dahl, Tuva Børresdatter; Yang, Kuan; Sagen, Ellen Lund; Skarpengland, Tonje; Øgaard, Jonas; Holm, Kristian; Vestad, Beate; Olsen, Maria Belland; Aukrust, Pål; Bjørås, Magnar; Hov, Johannes Espolin Roksund; Halvorsen, Bente; Gregersen, Ida (Journal article; Peer reviewed, 2021)
      Atherosclerosis and its consequences cause considerable morbidity and mortality world-wide. We have previously shown that expression of the DNA glycosylase NEIL3 is regulated in human atherosclerotic plaques, and that ...

    • NEIL3-deficient bone marrow displays decreased hematopoietic capacity and reduced telomere length 

      Karlsen, Tom Rune; Olsen, Maria Belland; Kong, Xiang Yi; Yang, Kuan; Quiles-Jiménez, Ana M T; Kroustallaki, Pinelopi; Holm, Sverre; Lines, Glenn Terje; Aukrust, Pål; Skarpengland, Tonje; Bjørås, Magnar; Dahl, Tuva Børresdatter; Nilsen, Hilde; Gregersen, Ida; Halvorsen, Bente (Peer reviewed; Journal article, 2022)
      Deficiency of NEIL3, a DNA repair enzyme, has significant impact on mouse physiology, including vascular biology and gut health, processes related to aging. Leukocyte telomere length (LTL) is suggested as a marker of ...

    • Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice 

      Skarpengland, Tonje; Holm, Sverre; Scheffler, Katja; Gregersen, Ida; Dahl, Tuva Børresdatter; Suganthan, Rajikala; Segers, Filip; Østlie, Ingunn; Otten, Jeroen J.T.; Gomez, Luisa Fernanda Luna; Ketelhuth, Daniel F.J.; Lundberg, Anna M.; Neurauter, Christine Gran; Hildrestrand, Gunn Annette; Skjelland, Mona; Bjørndal, Bodil; Svardal, Asbjørn M.; Iversen, Per Ole; Hedin, Ulf; Nygård, Ståle; Olstad, Ole Kristoffer; Krohg-Sørensen, Kirsten; Slupphaug, Geir; Eide, Lars; Kusnierczyk, Anna; Folkersen, Lasse; Ueland, Thor; Berge, Rolf Kristian; Hansson, Göran K.; Biessen, Erik A.L.; Halvorsen, Bente; Bjørås, Magnar; Aukrust, Pål (Peer reviewed; Journal article, 2016)
      Increasing evidence suggests that oxidative DNA damage accumulates in atherosclerosis. Recently, we showed that a genetic variant in the human DNA repair enzyme NEIL3 was associated with increased risk of myocardial ...

    • NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture 

      Olsen, Maria Belland; Hildrestrand, Gunn Annette; Scheffler, Katja; Vinge, Leif Erik; Alfsnes, Katrine; Palibrk, Vuk; Wang, Junbai; Neurauter, Christine Gran; Gomez, Luisa Fernanda Luna; Johansen, Jostein; Øgaard, Jonas; Ohm, Ingrid Kristine; Slupphaug, Geir; Kusnierczyk, Anna; Fiane, Arnt E; Brorson, Sverre Henning; Zhang, Lili; Gullestad, Lars; Louch, William Edward; Iversen, Per Ole; Østlie, Ingunn; Klungland, Arne; Christensen, Geir Arve; Sjaastad, Ivar; Sætrom, Pål; Yndestad, Arne; Aukrust, Pål; Bjørås, Magnar; Finsen, Alexandra (Journal article; Peer reviewed, 2017)
      Myocardial infarction (MI) triggers a reparative response involving fibroblast proliferation and differentiation driving extracellular matrix modulation necessary to form a stabilizing scar. Recently, it was shown that a ...

    • Neoadjuvant chemotherapy versus surgery first for resectable pancreatic cancer (Norwegian Pancreatic Cancer Trial - 1 (NorPACT-1)) – study protocol for a national multicentre randomized controlled trial 

      Labori, Knut Jørgen; Lassen, Kristoffer; Hoem, Dag; Grønbech, Jon Erik; Søreide, Jon Arne; Mortensen, Kim Erlend; Smaaland, Rune; Sorbye, Halfdan; Verbeke, Caroline Sophie; Dueland, Svein (Journal article; Peer reviewed, 2017)
      Background: Pancreatic cancer is the fourth leading cause of cancer-related death. While surgical resection remains the foundation for potentially curative treatment, survival benefit is achieved with adjuvant oncological ...

    • NeoDoppler: New ultrasound technology for continous cerebral circulation monitoring in neonates. 

      Vik, Sigrid Dannheim; Torp, Hans; Follestad, Turid; Støen, Ragnhild; Nyrnes, Siri Ann (Journal article; Peer reviewed, 2019)
      BACKGROUND: There is a strong need for continuous cerebral circulation monitoring in neonatal care, since suboptimal cerebral blood flow may lead to brain injuries in preterm infants and other critically ill neonates. ...

    • The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9 

      Bayly-Jones, Charles; Ho, Bill H. T.; Lau, Corinna; Leung, Eleanor W. W.; D’Andrea, Laura; Lupton, Christopher J.; Ekkel, Susan M.; Venugopal, Hariprasad; Whisstock, James C.; Mollnes, Tom Eirik; Spicer, Bradley A.; Dunstone, Michelle A. (Peer reviewed; Journal article, 2023)
      The Membrane Attack Complex (MAC) is responsible for forming large β-barrel channels in the membranes of pathogens, such as gram-negative bacteria. Off-target MAC assembly on endogenous tissue is associated with inflammatory ...

    • Neonatal biomarkers and morbidity as risk factors for visual impairment in extremely low gestational age newborns 

      Holm, Mari (Doctoral theses at NTNU;2017:183, Doctoral thesis, 2017)
      Being born preterm imposes a risk of increased mortality and numerous morbidities on the infant. Preterm newborns carry their "birth history" with them throughout life; this implies an increased risk of problems related ...

    • Neonatal withdrawal syndrome following in utero exposure to antidepressants: a disproportionality analysis of VigiBase, the WHO spontaneous reporting database. 

      Gastaldon, Chiara; Arzenton, Elena; Raschi, Emanuel; Spigset, Olav; Papola, Davide; Ostuzzi, Giovanni; Moretti, Ugo; Trifirò, Gianluca; Barbui, Corrado; Schoretsanitis, Georgios (Peer reviewed; Journal article, 2022)
      Background Evidence on neonatal withdrawal syndrome following antidepressant intrauterine exposure is limited, particularly for antidepressants other than selective serotonin reuptake inhibitor (SSRIs). Methods In ...

    • Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke 

      Alme, Katinka Nordheim; Ulvik, Arve; Askim, Torunn; Assmus, Jörg; Mollnes, Tom Eirik; Naik, Mala; Næss, Halvor; Saltvedt, Ingvild; Ueland, Per-Magne; Knapskog, Anne Brita (Peer reviewed; Journal article, 2021)
      Background Chronic low-grade inflammation is associated with both ischemic stroke and sedentary behaviour. The aim of this study was to investigate the predictive abilities of biomarkers of inflammation and immune modulation ...

    • Nephronectin as a matrix effector in cancer 

      Norvoll Magnussen, Synnøve; Toraskar, Jimita Prashant; Hadler-Olsen, Elin Synnøve; Steigedal, Tonje S.; Svineng, Gunbjørg (Peer reviewed; Journal article, 2021)
      The extracellular matrix protein nephronectin plays an important regulatory role during embryonic development, controlling renal organogenesis through integrin α8β1 association. Nephronectin has three main domains: five ...

    • Nephronectin in breast cancer progression and metastasis 

      Toraskar, Jimita Prashant (Doctoral theses at NTNU;2018:390, Doctoral thesis, 2018)
      Breast cancer is life threatening due to its ability to spread and invade other tissues. The best approach in solving a problem of this sort is to be able to reason backwards. Tumors appear chaotic as they are composed of ...

    • Nephronectin mediates p38 MAPK‐induced cell viability via its integrin binding enhancer motif 

      Toraskar, Jimita Prashant; Magnussen, Synnøve; Chawla, Konika; Svineng, Gunbjørg; Steigedal, Tonje S. (Journal article; Peer reviewed, 2018)
      Nephronectin (NPNT) is an extracellular matrix (ECM) protein involved in kidney development. We recently reported intracellular NPNT as a potential prognostic marker in breast cancer and that NPNT promotes metastasis in ...

    • Network and Systems Medicine: Position Paper of the European Collaboration on Science and Technology Action on Open Multiscale Systems Medicine 

      Comte, Blandine; Baumbach, Jan; Benis, Arriel; Basílio, José; Debeljak, Nataša; Flobak, Åsmund; Franken, Christian; Harel, Nissim; He, Feng; Kuiper, Martin; Juan Albino Méndez, Pérez; Pujos-Guillot, Estelle; Režen, Tadeja; Rozman, Damjana; Schmid, Johannes A; Scerri, Jeanesse; Tieri, Paolo; Van Steen, Kristel; Sona, Vasudevan; Watterson, Steven; Schmidt, Harald H H W (Journal article; Peer reviewed, 2020)
      Introduction: Network and systems medicine has rapidly evolved over the past decade, thanks to computational and integrative tools, which stem in part from systems biology. However, major challenges and hurdles are still ...

    • Neural correlates of working memory training in HIV patients: Study protocol for a randomized controlled trial 

      Chang, Linda; Løhaugen, Gro; Douet, Vanessa; Miller, Eric N.; Skranes, Jon Sverre; Ernst, Thomas (Peer reviewed; Journal article, 2016)
      Background Potent combined antiretroviral therapy decreased the incidence and severity of HIV-associated neurocognitive disorders (HAND); however, no specific effective pharmacotherapy exists for HAND. Patients with HIV ...

    • Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer. 

      Dubeykovskaya, Z; Si, Y; Chen, X; Worthley, DL; Renz, BW; Urbanska, AM; Hayakawa, Y; Xu, T; Westphalen, CB; Dubeykovskiy, A; Chen, Duan; Friedman, RA; Asfaha, S; Nagar, S; Tailor, Y; Muthupalani, S; Fox, JG; Kitajewski, J; Wang, Timothy C. (Peer reviewed; Journal article, 2016)
      CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory reflex arc involving the vagus nerve and ...