Browsing Institutt for klinisk og molekylær medisin by Title
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Low expression levels of ATM may substitute for CHEK2/TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancer
(Journal article; Peer reviewed, 2012)Introduction Mutations affecting p53 or its upstream activator Chk2 are associated with resistance to DNA-damaging chemotherapy in breast cancer. ATM (Ataxia Telangiectasia Mutated protein) is the key activator of p53 ... -
Low fat, low lactose diet used as prophylactic treatment of acute intestinal reactions during pelvic radiotherapy. A prospective randomised study
(Dissertations at the Faculty of Medicine, 0805-7680; 203, Doctoral thesis, 2002)Purpose. The main aim of the present study was to evaluate the effect of a low fat, low lactose diet on acute and late gastrointestinal side effects of pelvic radiotherapy. We also wanted to evaluate if such a treatment ... -
Low frequency cerebral arterial and venous flow oscillations in healthy neonates measured by NeoDoppler
(Peer reviewed; Journal article, 2022)Background: A cerebroprotective effect of low frequency oscillations (LFO) in cerebral blood flow (CBF) has been suggested in adults, but its significance in neonates is not known. This observational study evaluates normal ... -
Low level of MAp44, an inhibitor of the lectin complement pathway, and long-term graft and patient survival; a cohort study of 382 kidney recipients
(Journal article; Peer reviewed, 2016)Background Higher incidence of malignancy and infectious diseases in kidney transplant recipients is related to immunosuppressive treatment after transplantation and the recipient’s native immune system. The complement ... -
Low levels of immunoglobulins and mannose-binding lectin are not associated with etiology, severity, or outcome in community-acquired pneumonia
(Journal article; Peer reviewed, 2018)Background Disease severity and outcome in community-acquired pneumonia (CAP) depend on the host and on the challenge of the causal microorganism(s). We measured levels of immunoglobulins (Igs) and complement in 257 ... -
Low serum lipocalin-2 in pregnant women with systemic lupus erythematosus
(Peer reviewed; Journal article, 2023)OBJECTIVES: Systemic lupus erythematosus (SLE) pregnancies are considered high-risk due to risk of disease flare and pregnancy complications. A more in-depth understanding of the immunological alterations in SLE patients ... -
Low temperature and low UV indexes correlated with peaks of influenza virus activity in Northern Europe during 2010-2018
(Journal article; Peer reviewed, 2019)With the increasing pace of global warming, it is important to understand the role of meteorological factors in influenza virus (IV) epidemics. In this study, we investigated the impact of temperature, UV index, humidity, ... -
Low-contrast detectability and potential for radiation dose reduction using deep learning image reconstruction-A 20-reader study on a semi-anthropomorphic liver phantom
(Peer reviewed; Journal article, 2022)Background A novel deep learning image reconstruction (DLIR) algorithm for CT has recently been clinically approved. Purpose To assess low-contrast detectability and dose reduction potential for CT images reconstructed ... -
Low-contrast detectability and potential for radiation dose reduction using deep learning image reconstruction—A 20-reader study on a semi-anthropomorphic liver phantom
(Peer reviewed; Journal article, 2022)Background A novel deep learning image reconstruction (DLIR) algorithm for CT has recently been clinically approved. Purpose To assess low-contrast detectability and dose reduction potential for CT images reconstructed ... -
Low-grade albuminuria and its implementation in cardiovascular risk assessment: Analyses from the Nord-Trøndelag Heath Studies; HUNT-2 and HUNT-3
(Doctoral theses at NTNU;2017:338, Doctoral thesis, 2017) -
LRRK2 to the rescue of damaged endomembranes
(Peer reviewed; Journal article, 2020)Mutations in several genes encoding for lysosomal proteins are involved in Parkinson's disease (PD). In this issue, Herbst et al (2020) show that PD-related leucine-rich repeat kinase 2 (LRRK2) is activated in response to ... -
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium
(Journal article; Peer reviewed, 2020)Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify regulators of neonatal intestinal epithelial ... -
Lung function in adults born preterm
(Journal article; Peer reviewed, 2018)Very preterm birth, before the gestational age (GA) of 32 weeks, increases the risk of obstructed airflow in adulthood. We examined whether all preterm births (GA<37 weeks) are associated with poorer adult lung function ... -
Lynch syndrome mutation spectrum in New South Wales, Australia, including 55 novel mutations
(Peer reviewed; Journal article, 2016)Background Lynch syndrome, the most frequent hereditary colorectal cancer syndrome, is caused by defects in mismatch repair genes. Genetic testing is important in order to identify mutation carriers who can benefit from ... -
LysoPC and PAF Trigger Arachidonic Acid Release by Divergent Signaling Mechanisms in Monocytes
(Journal article; Peer reviewed, 2011)Oxidized low-density lipoproteins (LDLs) play an important role during the development of atherosclerosis characterized by intimal inflammation and macrophage accumulation. A key component of LDL is lysophosphatidylcholine ... -
M-ficolin: a valuable biomarker to identify leukaemia from juvenile idiopathic arthritis
(Peer reviewed; Journal article, 2021)Objective: Distinction on clinical grounds between acute lymphoblastic leukaemia presenting with arthropathy (ALLarthropathy) and juvenile idiopathic arthritis (JIA) is difficult, as the clinical and paraclinical signs of ... -
M.H. Bjørk og medarbeidere svarer
(Peer reviewed; Journal article, 2020) -
Machine Learning of Infant Spontaneous Movements for the Early Prediction of Cerebral Palsy: A Multi-Site Cohort Study
(Journal article; Peer reviewed, 2019)Background: Early identification of cerebral palsy (CP) during infancy will provide opportunities for early therapies and treatments. The aim of the present study was to present a novel machine-learning model, the ... -
Machine learning-based immune phenotypes correlate with STK11/KEAP1 co-mutations and prognosis in resectable NSCLC: a sub-study of the TNM-I trial
(Peer reviewed; Journal article, 2023)Background We aim to implement an immune cell score model in routine clinical practice for resected non-small-cell lung cancer (NSCLC) patients (NCT03299478 ). Molecular and genomic features associated with immune ... -
Machine-learning analysis of cross-study samples according to the gut microbiome in 12 infant cohorts
(Peer reviewed; Journal article, 2023)Combining and comparing microbiome data from distinct infant cohorts has been challenging because such data are inherently multidimensional and complex. Here, we used an ensemble of machine-learning (ML) models and studied ...