Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 2530-2549 av 3434
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Previous life experiences and social relations affecting individuals wish for support when establishing healthy habits – a qualitative study of Norwegian Healthy Life Centre participants
(Peer reviewed; Journal article, 2021)Background: Interventions to reduce and prevent overweight, obesity and T2D has been advocated worldwide. In Norway, Healthy Life Centres have been established to help individuals to reduce and prevent diseases, offering ... -
Primary Open-Angle Glaucoma & Exfoliative Glaucoma: Survival, Comorbidity and Genetics
(Doktoravhandlinger ved NTNU, 1503-8181; 2008:141, Doctoral thesis, 2008) -
Primary Porcine Brain Endothelial Cells as In Vitro Model to Study Effects of Ultrasound and Microbubbles on Blood-Brain Barrier Function
(Journal article; Peer reviewed, 2017)Focused ultrasound in the presence of microbubbles transiently and reversibly opens the blood-brain barrier (BBB) in rodents and humans thereby providing a time window for increased drug delivery into brain tissue. To get ... -
Primary Treatment Effects for High-Grade Serous Ovarian Carcinoma Evaluated by Changes in Serum Metabolites and Lipoproteins
(Peer reviewed; Journal article, 2023)High-grade serous ovarian carcinoma (HGSOC) is the most common and deadliest ovarian cancer subtype. Despite advances in treatment, the overall prognosis remains poor. Regardless of efforts to develop biomarkers to predict ... -
Prior statin use and 90-day mortality in Gram-negative and Gram-positive bloodstream infection: a prospective observational study
(Journal article; Peer reviewed, 2014)n several studies on patients with bloodstream infection (BSI), prior use of statins has been associated with improved survival. Gram-positive and Gram-negative bacteria alert the innate immune system in different ways. ... -
PRL-3 induces a positive signaling circuit between glycolysis and activation of STAT1/2
(Peer reviewed; Journal article, 2021)Multiple myeloma (MM) is an incurable hematologic malignancy resulting from the clonal expansion of plasma cells. MM cells are interacting with components of the bone marrow microenvironment such as cytokines to survive ... -
PRL-3–a signaling hub in Multiple Myeloma
(Doctoral theses at NTNU;2017:131, Doctoral thesis, 2017)PRL-3 -en sentral aktør i myelomatsoecellens signalformidling: Myelomatose er en kreftform som oppstår i plasmaceller, den ferdig differensierte formen for B lymfocytter. Et kjennetegn på myelomatose er dens lokalisasjon ... -
The pro-tumorigenic cytokine IL-32 has a high turnover in multiple myeloma cells due to proteolysis regulated by oxygen-sensing cysteine dioxygenase and deubiquitinating enzymes
(Peer reviewed; Journal article, 2023)IL-32 is a pro-inflammatory cytokine expressed by several types of cancer cells and immune cells. Currently, no treatment targeting IL-32 is available, and its intracellular and exosomal localization make IL-32 less ... -
Proactive versus standard support of labour in nulliparous women; study protocol for a randomized, controlled trial
(Peer reviewed; Journal article, 2020)Background Prolonged latent phase of labour often results in a traumatic birth experience. Prolonged labour is associated with more operative deliveries, haemorrhage, fetal asphyxia and poor birth experience. Women with ... -
Probiotics, Symptoms, and Gut Microbiota: What Are the Relations? A Randomized Controlled Trial in Subjects with Irritable Bowel Syndrome
(Journal article; Peer reviewed, 2012)Introduction. Knowledge of the mechanism of action of probiotics in subjects with irritable bowel syndrome (IBS) is imperfect. Objective. This trial aimed at discriminating between a direct effect on the gut wall and an ... -
Proceedings of the 3rd European Workshop on Practical Aspects of Health Informatics (PAHI 2015)
(CEUR Workshop Proceedings;, Research report, 2016) -
Processing of genomic uracil in man and mouse
(Doktoravhandlinger ved NTNU, 1503-8181; 2012:83, Doctoral thesis, 2012)Prosessering av genomisk uracil i menneske og mus Grunnlaget for alt liv ligger i arvestoffet vårt, DNA. Den genetiske informasjonen overføres nærmest uendret gjennom generasjoner til tross for at DNA-molekylet er kjemisk ... -
Producing ultrapure wood cellulose nanofibrils and evaluating the cytotoxicity using human skin cells
(Journal article; Peer reviewed, 2016)Wood cellulose nanofibrils (CNF) have been suggested as a potential wound healing material, but its utilization is limited by FDA requirements regarding endotoxin levels. In this study a method using sodium hydroxide ... -
Profile of children referred to primary health care physiotherapy: a longitudinal observational study in Norway
(Peer reviewed; Journal article, 2021)Background Physiotherapy services are an important part of the primary health care services for children, serving a broad spectrum of children referred from different sources and for a variety of reasons. There is limited ... -
Profiling of immune-related gene expression in children with familial hypercholesterolaemia
(Journal article; Peer reviewed, 2019)Background Innate and adaptive immune responses are pivotal in atherosclerosis, but their association with early‐stage atherosclerosis in humans is incompletely understood. In this regard, untreated children with familial ... -
Profound gene expression changes in the epithelial monolayer of active ulcerative colitis and Crohn's disease
(Peer reviewed; Journal article, 2022)In recent years it has become apparent that the epithelium is highly involved in inflammatory bowel disease (IBD) pathophysiology. The majority of gene expression studies of IBD are generated from heterogeneous biopsies, ... -
Prognostic and predictive factors in limited disease small-cell lung cancer
(Doctoral theses at NTNU;2020:203, Doctoral thesis, 2020)Lung cancer is the most common type of cancer and the leading cause of cancer related deaths. Small cell lung cancer (SCLC) is one of two main types of lung cancer. Concurrent chemoradiotherapy is recommended for SCLC if ... -
The prognostic effect of KRAS mutations in non-small cell lung carcinoma revisited: A norwegian multicentre study
(Peer reviewed; Journal article, 2021)Background: due to emerging therapeutics targeting KRAS G12C and previous reports with conflicting results regarding the prognostic impact of KRAS and KRAS G12C in non-small cell lung cancer (NSCLC), we aimed to investigate ... -
Prognostic role of microscopically positive margins for primary gastrointestinal stromal tumors: a systematic review and meta-analysis
(Peer reviewed; Journal article, 2016)The impact and management of microscopically positive margins in gastrointestinal stromal tumors (GISTs) remain unclear. The aim of this study is to estimate the prognostic value of surgical margins for disease-free survival ... -
Prognostic value of absolute quantification of mutated KRAS in circulating tumour DNA in lung adenocarcinoma patients prior to therapy
(Peer reviewed; Journal article, 2021)Droplet digital polymerase chain reaction (ddPCR) is a highly sensitive and accurate method for quantication of nucleic acid sequences. We used absolute quantication of mutated v-Ki-ras2 Kirsten rat sarcoma viral oncogene ...