Browsing Institutt for klinisk og molekylær medisin by Title

Now showing items 2181-2200 of 3434

    • A new high-content screening assay of the entire hepatitis B virus life cycle identifies novel antivirals 

      Yang, Jaewon; König, Alexander; Park, Soonju; Jo, Eunji; Sung, Pil Soo; Yoon, Seung Kew; Zusinaite, Eva; Kainov, Denis; Shum, David; Windisch, Marc Peter (Peer reviewed; Journal article, 2021)
      Background & Aims: Chronic hepatitis B is an incurable disease. Addressing the unmet medical need for therapies has been hampered by a lack of suitable cell culture models to investigate the HBV life cycle in a single ...

    • New players in an old game: Role of immunoglobulins in the pathogenesis of multiple myeloma 

      Kovcic, Vlado (Doctoral theses at NTNU;2020:124, Doctoral thesis, 2020)
      Multiple myeloma is a haematological malignancy characterized by uncontrolled proliferation of malignant plasma cells. The myeloma cells secrete immunoglobulins, which leads to the presence of high levels of monoclonal ...

    • New reference intervals for cortisol, cortisol binding globulin and free cortisol index in women using ethinyl estradiol 

      Panton, Kristine Kollerøs; Mikkelsen, Gustav; Irgens, Wenche Elna Øiestad; Hovde, Ann Kristin; Killingmo, Marte Wien; Øien, Monja Airin; Thorsby, Per Medbøe; Åsberg, Arne (Peer reviewed; Journal article, 2019)
      Healthy women using contraceptives containing a low dose of an estrogen may have a higher serum concentration of cortisol (s-cortisol) and cortisol binding globulin (s-CBG) than the commonly used upper reference limits. ...

    • New relative intensity ambulatory accelerometer thresholds for elderly men and women: The Generation 100 study 

      Zisko, Nina; Carlsen, Trude; Salvesen, Øyvind; Aspvik, Nils Petter; Ingebrigtsen, Jan Erik; Wisløff, Ulrik; Stensvold, Dorthe (Journal article; Peer reviewed, 2015)
      Background Public health initiatives world-wide recommend increasing physical activity (PA) to improve health. However, the dose and the intensity of PA producing the most benefit are still debated. Accurate assessment ...

    • Next Generation Sequencing based methods in genetic disease diagnostics 

      Singh, Ashish Kumar (Doctoral theses at NTNU 2023:222, Doctoral thesis, 2023)
      Background: Identification of a germline pathogenic variant that increases risk of getting diseases in a family is important for the clinical management of the family members. DNA sequencing is an important molecular ...

    • NHDL, a recombinant VL/VH hybrid antibody control for IgG2/4 antibodies. 

      Lau, Corinna; McAdam, MB; Bergseth, G; Grevys, Algirdas; Bruun, JA; Ludviksen, Judith K; Fure, Hilde; Espevik, Terje; Moen, A; Andersen, Jan Terje; Mollnes, Tom Eirik (Journal article; Peer reviewed, 2020)
      The mechanism of action of recombinant IgG2/4 antibodies involves blocking of their target without the induction of effector functions. Examples are eculizumab (Soliris®), which is used clinically to block complement factor ...

    • NICU dialects: Understanding Norwegian practice variation 

      Syltern, Janicke Marita; Markestad, Trond Jacob; Saugstad, Ola Didrik; Støen, Ragnhild (Journal article; Peer reviewed, 2018)
      In Norway, a national consensus-based guideline used to address thresholds for offering life support at extreme preterm birth was issued in 1998. Since then, therapeutic advances may have changed attitudes and expectations ...

    • NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis 

      Varghese, Paramel G; Folkersen, Lasse; Strawbridge, Rona J.; Halvorsen, Bente; Yndestad, Arne; Ranheim, Trine; Krogh-Sørensen, Kristin; Skjelland, Mona; Espevik, Terje; Aukrust, Pål; Lengquist, Mariette; Hedin, Ulf; Jansson, Jan-Håkan; Fransen, Karin; Hansson, Göran K.; Eriksson, Per; Sirsjø, Allan (Journal article; Peer reviewed, 2016)
      Background The NLR family, pyrin domain containing 3 (NLRP3) inflammasome is an interleukin (IL)‐1β and IL‐18 cytokine processing complex that is activated in inflammatory conditions. The role of the NLRP3 inflammasome in ...

    • NLRP3 inflammasome promotes myocardial remodeling during diet-induced obesity 

      Sokolova, Marina; Sjaastad, Ivar; Louwe, Maria Cornelia; Alfsnes, Katrine; Aronsen, Jan Magnus; Zhang, Lili; Haugstad, Solveig Bjærum; Bendiksen, Bård Andre; Øgaard, Jonas; Bliksøen, Marte; Lien, Egil; Berge, Rolf Kristian; Aukrust, Pål; Ranheim, Trine; Yndestad, Arne (Journal article; Peer reviewed, 2019)
      Background: Obesity is an increasingly prevalent metabolic disorder in the modern world and is associated with structural and functional changes in the heart. The NLRP3 inflammasome is an innate immune sensor that can be ...

    • NMR-based metabolomics of biofluids in cancer 

      Giskeødegård, Guro F.; Madssen, Torfinn Støve; Euceda, Leslie R.; Tessem, May-Britt; Moestue, Siver Andreas; Bathen, Tone Frost (Journal article; Peer reviewed, 2018)
      Metabolomics is the branch of “omics” technologies that involves high‐throughput identification and quantification of small‐molecule metabolites in the metabolome. NMR‐based spectroscopy of biofluids represents a potential ...

    • NMR-Based Prostate Cancer Metabolomics 

      Euceda, Leslie R.; Andersen, Maria Karoline; Tessem, May-Britt; Moestue, Siver Andreas; Grinde, Maria Tunset; Bathen, Tone Frost (Journal article; Peer reviewed, 2018)
      Prostate cancer is the second most common malignancy, and the fifth leading cause of cancer-related death among men, worldwide. A major unsolved clinical challenge in prostate cancer is the ability to accurately distinguish ...

    • No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT Study 

      Hagen, Knut; Pettersen, Elin; Stovner, Lars Jacob; Skorpen, Frank; Zwart, John-Anker (Journal article; Peer reviewed, 2006-05-04)
      Background: The Catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception. In one study fibromyalgia was less likely among those with ...

    • No association between disease severity and respiratory syncytial virus subtypes RSV-A and RSV-B in hospitalized young children in Norway 

      Bøås, Håkon; Havdal, Lise Beier; Størdal, Ketil; Døllner, Henrik; Leegaard, Truls Michael; Bekkevold, Terese; Flem, Elmira; Inchley, Christopher; Nordbø, Svein Arne; Rojahn, Astrid Elisabeth; Debes, Sara Molvig; Barstad, Bjørn; Haarr, Elisebet; Kran, Anne-Marte Bakken (Peer reviewed; Journal article, 2024)
      Objective There is conflicting evidence whether subtypes of Respiratory syncytial virus have different seasonality or are differentially associated with clinical severity. We aimed to explore the associations between ...

    • No association of tobacco use and disease activity in multiple sclerosis 

      Kvistad, Silje; Myhr, Kjell-Morten; Holmøy, Trygve; Saltyte Benth, Jurate; Løken-Amsrud, Kristin Ingeleiv; Wergeland, Stig; Beiske, Antonie Giæver; Bjerve, Kristian S; Hovdal, Harald Olav; Lilleås, Finn; Midgard, Rune; Pedersen, Tom; Bakke, Søren Jacob; Torkildsen, Øivind (Journal article; Peer reviewed, 2016)
      Objective: To study whether tobacco use is associated with MRI and clinical disease activity in patients with multiple sclerosis (MS). Methods: Prospective cohort study of 87 patients with relapsing-remitting MS originally ...

    • No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice 

      Rolseth, Veslemøy; Luna, Luisa; Olsen, Ann-Karin; Suganthan, Rajikala; Scheffler, Katja; Neurauter, Christine Gran; Esbensen, Qin Ying; Kusnierczyk, Anna; Hildrestrand, Gunn Annette; Graupner, Anne; Andersen, Jill Mari; Slupphaug, Geir; Klungland, Arne; Nilsen, Hilde; Bjørås, Magnar (Journal article; Peer reviewed, 2017)
      Base excision repair (BER) is a major pathway for removal of DNA base lesions and maintenance of genomic stability, which is essential in cancer prevention. DNA glycosylases recognize and remove specific lesions in the ...

    • No impact of gestational diabetes mellitus on pregnancy complications in women with PCOS, regardless of GDM criteria used 

      Fougner, Stine Lyngvi; Vanky, Eszter; Løvvik, Tone Shetelig; Carlsen, Sven Magnus (Journal article; Peer reviewed, 2021)
      Polycystic ovary syndrome (PCOS) is characterized by the presence of insulin resistance, and women with PCOS have high prevalence of gestational diabetes (GDM). Both conditions have been associated with increased risk for ...

    • A nomogram to predict survival probability of gastric cancer patients undergoing radical surgery and adjuvant chemotherapy 

      Ma, Ling; Chen, Guosheng; Wang, Deqiang; Zhang, Kai; Zhao, Fengjiao; Tang, Jie; Zhao, Jianyi; Røe, Oluf Dimitri; He, Shaohua; Liao, Dongcheng; Gu, Yanhong; Tao, Min; Shu, Yongqian; Li, Wei; Chen, Xiaofeng (Peer reviewed; Journal article, 2022)
      Gastric cancer (GC) is the third-leading cause of cancer mortality worldwide. The aim of this study was to develop a nomogram that estimates 1-year, 3-year, and 5-year survival probability of GC patients after D2 gastrectomy ...

    • Non-coding RNAs in human breast milk: A systematic review 

      Tingö, Lina; Ahlberg, Emelie; Johansson, Lovisa; Pedersen, Sindre Andre; Chawla, Konika; Sætrom, Pål; Cione, Erika; Simpson, Melanie Rae (Peer reviewed; Journal article, 2021)
      Breast milk is the primary source of nutrition and hydration for the newborn infant but also plays an important role in the child’s first immune defense. Additionally, several breast milk factors have been implicated in ...

    • Non-Homologous End Joining Factors XLF, PAXX and DNA-PKcs Maintain the Neural Stem and Progenitor Cell Population 

      Gago-Fuentes, Raquel; Oksenych, Valentyn (Peer reviewed; Journal article, 2020)
      Non-homologous end-joining (NHEJ) is a major DNA repair pathway in mammalian cells that recognizes, processes and fixes DNA damage throughout the cell cycle and is specifically important for homeostasis of post-mitotic ...

    • Non-Invasive Prostate Cancer Characterization with Diffusion-Weighted MRI: Insight from In silico Studies of a Transgenic Mouse Model 

      Hill, Deborah Katherine; Heindl, Andreas; Zormpas-Petridis, Konstantinos; Collins, David J.; Euceda, Leslie R.; Rodrigues, Daniel; Moestue, Siver Andreas; Jamin, Yann; Koh, Dow-Mu; Yuan, Yinyin; Bathen, Tone Frost; Leach, Martin O; Blackledge, Matthew D. (Journal article; Peer reviewed, 2017)
      Diffusion-weighted magnetic resonance imaging (DWI) enables non-invasive, quantitative staging of prostate cancer via measurement of the apparent diffusion coefficient (ADC) of water within tissues. In cancer, more advanced ...