Now showing items 811-830 of 1877

    • Icotinib is an active treatment of non-small-cell lung cancer: A retrospective study 

      Chen, X; Zhu, Q; Liu, Y; Liu, P; Yin, Y; Guo, R; Lu, K; Gu, Y; Liu, L; Wang, J; Wang, Z; Røe, Oluf Dimitri; Shu, Y; Zhu, L (Journal article; Peer reviewed, 2014)
      Background Icotinib hydrochloride is a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with preclinical and clinical activity in non-small cell lung cancer (NSCLC). This retrospective ...
    • Identification of genes affecting alginate biosynthesis in Pseudomonas fluorescens by screening a transposon insertion library. 

      Ertesvåg, Helga; Sletta, Håvard; Senneset, Mona; Sun, Yi-Qian; Klinkenberg, Geir; Konradsen, Therese Aursand; Ellingsen, Trond E; Valla, Svein (Journal article; Peer reviewed, 2017)
      BACKGROUND: Polysaccharides often are necessary components of bacterial biofilms and capsules. Production of these biopolymers constitutes a drain on key components in the central carbon metabolism, but so far little is ...
    • Identification of Metabolites from 2D 1H-13C HSQC NMR using Peak Correlation Plots 

      Öman, Tommy; Tessem, May-Britt; Bathen, Tone Frost; Bertilsson, Helena; Angelsen, Anders; Hedenström, Mattias; Andreassen, Trygve (Journal article; Peer reviewed, 2014)
      Background Identification of individual components in complex mixtures is an important and sometimes daunting task in several research areas like metabolomics and natural product studies. NMR spectroscopy is an excellent ...
    • Identification of MicroRNA Expression in Gastrin Stimulated Adenocarcinoma Cells 

      Bergly, Laila H. (Master thesis, 2011)
      The Gastrin System Biology group studies the molecular responses to gastrin using cell line model systems. Recently microRNAs (miRNAs) have been acknowledged as essential participants in the regulation of gene expression, ...
    • Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma 

      Went, Molly; Sud, Amit; Försti, Asta; Halvarsson, Britt-Marie; Weinhold, Niels; Kimber, Scott; van Duin, Mark; Thorleifsson, Gudmar; Holroyd, Amy; Johnson, David C.; Li, Ni; Orlando, Giulia; Law, Philip J.; Ali, Mina; Chen, Bowang; Mitchell, Jonathan S.; Gudbjartsson, Daniel F.; Kuiper, Rowan; Stephens, Owen W.; Bertsch, Uta; Broderick, Peter; Campo, Chiara; Bandapalli, Obul R.; Einsele, Hermann; Gregory, Walter A.; Gullberg, Urban; Hillengass, Jens; Hoffmann, Per; Jackson, Graham H.; Jöckel, Karl-Heinz; Johnsson, Ellinor; Kristinsson, Sigurður Y.; Mellqvist, Ulf-Henrik; Nahi, Hareth; Easton, Douglas; Pharoah, Paul; Dunning, Alison; Peto, Julian; Canzian, Federico; Swerdlow, Anthony; Eeles, Rosalind A.; Kote-Jarai, ZSofia; Muir, Kenneth; Pashayan, Nora; Nickel, Jolanta; Nöthen, Markus M.; Rafnar, Thorunn; Ross, Fiona M.; da Silva Filho, Miguel Inacio; Thomsen, Hauke; Turesson, Ingemar; Vangsted, Annette; Andersen, Niels Frost; Waage, Anders; Walker, Brian A.; Wihlborg, Anna-Karin; Broyl, Annemiek; Davies, Faith E.; Thorsteinsdóttir, Unnur; Langer, Christian; Hansson, Markus; Goldschmidt, Hartmut; Kaiser, Martin; Sonneveld, Pieter; Stefansson, Kari; Morgan, Gareth J.; Hemminki, Kari; Nilsson, Björn; Houlston, Richard S. (Journal article; Peer reviewed, 2018)
      Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous ...
    • Identification of Novel Regulators of Epithelial Polarity and Cell Migration 

      Lobert, Viola Hélène (Doktoravhandlinger ved NTNU, 1503-8181; 2012:281, Doctoral thesis, 2012)
      The ability of cells to form separate apical and basolateral domains of their plasma membranes is an important aspect of epithelial integrity, and loss of epithelial polarity results in the acquisition of mesenchymal ...
    • Identification of the source of elevated hepatocyte growth factor levels in multiple myeloma patients 

      Rampa, Christoph Samuel; Tian, Erming; Våtsveen, Thea Kristin; Buene, Glenn; Slørdahl, Tobias Schmidt; Børset, Magne; Waage, Anders; Sundan, Anders (Journal article; Peer reviewed, 2014)
      Background Hepatocyte growth factor (HGF) is a pleiotropic cytokine which can lead to cancer cell proliferation, migration and metastasis. In multiple myeloma (MM) patients it is an abundant component of the bone marrow. ...
    • IgG and IgG4 antibodies in subjects with irritable bowel syndrome: a case control study in the general population 

      Ligaarden, Solveig Catharina; Lydersen, Stian; Farup, Per Grønaas (Journal article; Peer reviewed, 2012)
      Background Patients with Irritable Bowel Syndrome (IBS) often relate their symptoms to the intake of food and modify their diet. IgE-mediated food allergy is uncommon in IBS, but the role of IgG-mediated food hypersensitivity ...
    • IL-32 and multiple myeloma bone disease 

      Aass, Kristin Roseth (Master thesis, 2016)
      Multiple myeloma is a malignancy of plasma cells characterized by multiple tumors in the bone marrow and progressive osteolytic bone disease. The bone lesions are caused by increased bone resorption by osteoclasts and ...
    • IL-6 receptor inhibition by tocilizumab attenuated expression of C5a receptor 1 and 2 in non-ST-elevation myocardial infarction 

      Orrem, Hilde Lang; Nilsson, Per; Pischke, Søren Erik; Kleveland, Ola; Yndestad, Arne; Ekholt, Karin; Damås, Jan Kristian; Espevik, Terje; Bendz, Bjørn; Halvorsen, Bente; Gregersen, Ida; Wiseth, Rune; Andersen, Geir Øystein; Ueland, Thor; Gullestad, Lars; Aukrust, Pål; Barratt-Due, Andreas; Mollnes, Tom Eirik (Journal article; Peer reviewed, 2018)
      Background: Elevated interleukin-6 (IL-6) and complement activation are associated with detrimental effects of inflammation in coronary artery disease (CAD). The complement anaphylatoxins C5a and C3a interact with their ...
    • Ileal Pouches 

      Wasmuth, Hans H. (Doktoravhandlinger ved NTNU, 1503-8181; 2012:10, Doctoral thesis, 2012)
      Background The conventional ileostomy can be avoided. Many attempts have been performed. The first successful solution was the continent ileostomy- Kock pouch. The high rate of complications and revisions some experienced ...
    • Image-Guided Radiotherapy for Prostate Cancer and Side Effects after Treatment 

      Tøndel, Hanne (Doctoral theses at NTNU;2019:62, Doctoral thesis, 2019)
      Norsk sammendrag Prostatakreft er den vanligste kreftsykdommen blant norske menn med nesten 5000 nye tilfeller diagnostisert i 2016. Prognosen ved lokalisert sykdom er god og samlet 5-års overlevelse er nå godt over 90%. ...
    • Immune and inflammatory responses to freediving calculated from leukocyte gene expression profiles 

      Eftedal, Ingrid; Flatberg, Arnar; Drvis, Ivan; Dujic, Zeljko (Journal article; Peer reviewed, 2016)
      Freedivers hold their breath while diving, causing blood oxygen levels to decrease (hypoxia) while carbon dioxide increases (hypercapnia). Whereas blood gas changes are presumably involved in the progression of respiratory ...
    • Immune cell self-organization towards ongoing immune reactions on a tissue-mimicking microdevice 

      Perinetti Casoni, Giovanna (Master thesis, 2015)
      A tissue mimicking micro-device has been developed by our microfluidics group. The device has been designed in order to mimic complex in vivo scenarios of immune cell recruitment, where cells sense and are directed by ...
    • IMMUNITY-ON-A-CHIP Microfluidic Devices for Immunoengineering 

      Moura Rosa, Patrícia (Doctoral theses at NTNU;2017:357, Doctoral thesis, 2017)
      Immunitet-på-mikrobrikke Mikrofluidiske innretninger for immunologisk forskning og utvikling Sammendrag: Det siste tiåret har mikrofluidteknologi, dvs væskestrømmer i mikroskala basert på prosesser fra halvlederindustrien, ...
    • Immunomodulatory effects of iron oxide nanoparticles in two human biological model systems 

      Wolf-Grosse, Susann (Doctoral theses at NTNU;2017:368, Doctoral thesis, 2017)
    • Impact of 2015 Earthquakes on a local hospital in Nepal: A Prospective Hospital-based Study 

      Giri, Samita; Risnes, Kari Ravndal; Uleberg, Oddvar; Rogne, Tormod; Shrestha, Sanu Krishna; Nygaard, Øystein Petter; Koju, Rajendra; Solligård, Erik (Journal article; Peer reviewed, 2018)
      Introduction Natural disasters pose a great challenge to the health systems and individual health facilities. In low-resource settings, disaster preparedness systems are often limited and not been well described. Two ...
    • Impact of a FTO gene risk variant on variables of energy metabolism in adults with obesity class 2 and 3 

      De Soysa, Ann Kristin Hjelle; Klevjer, Marie; Grill, Valdemar Erik Robert; Mostad, Ingrid Løvold (Journal article; Peer reviewed, 2019)
      Purpose The metabolic consequences of carrying a FTO obesity-promoting risk allele have not been fully elucidated and may be confounded by obesity per se. Against this background, we investigated the impact of FTO allele ...
    • Impact of acetyltransferases in B cell development 

      Kalaiyarasi Ragunathan (Master thesis, 2020)
      Abstract Histone acetylation is a crucial mechanism involved in several cellular functions, including embryogenesis, DNA repair, cell cycle regulation, neurogenesis, and lymphocyte development. Acetyltransferases are the ...
    • Impact of dietary fat quantity and quality in type 2 diabetes with emphasis on marine n-3 fatty acids 

      Mostad, Ingrid Løvold (Doktoravhandlinger ved NTNU, 1503-8181; 2007:83, Doctoral thesis, 2007)
      Doktoravhandlingen bygger på tre kliniske studier av personer med type 2 diabetes. Artikkel 1. Hensikten var å undersøke effekter av en 3-dagers intervensjon med fettfattig kost. Blodsukker, insulinfølsomhet, fettstoffer ...