Blar i Institutt for klinisk og molekylær medisin på tittel
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Divergent Regulation of Decidual Oxidative-Stress Response by NRF2 and KEAP1 in Preeclampsia with and without Fetal Growth Restriction
(Peer reviewed; Journal article, 2022)Utero-placental development in pregnancy depends on direct maternal–fetal interaction in the uterine wall decidua. Abnormal uterine vascular remodeling preceding placental oxidative stress and placental dysfunction are ... -
Diverse functions of DNA glycosylases processing oxidative base lesions in brain
(Peer reviewed; Journal article, 2019)Endogenous and exogenous oxidative agents continuously damage genomic DNA, with the brain being particularly vulnerable. Thus, preserving genomic integrity is key for brain health and neuronal function. Accumulation of DNA ... -
Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain
(Peer reviewed; Journal article, 2021)Motile cilia defects impair cerebrospinal fluid (CSF) flow and can cause brain and spine disorders. The development of ciliated cells, their impact on CSF flow, and their function in brain and axial morphogenesis are not ... -
Diversity in changes of HRQoL over a one-year period after radiotherapy in Norwegian breast cancer survivors – results of cluster analyses
(Journal article; Peer reviewed, 2019)Purpose The diversity in long-term changes in health-related quality of life (HRQoL) among breast cancer (BC) survivors is poorly understood. The aim of this study was to identify clusters of trajectories (subgroups of ... -
Divulging a Pleiotropic Role of Succinate Receptor SUCNR1 in Renal Cell Carcinoma Microenvironment
(Peer reviewed; Journal article, 2022)The succinate receptor, SUCNR1, has been attributed to tumor progression, metastasis, and immune response modulation upon its activation via the oncometabolite succinate. Nonetheless, little is known about the prognostic ... -
DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates
(Journal article; Peer reviewed, 2016)Well-known epigenetic DNA modifications in mammals include the addition of a methyl group and a hydroxyl group to cytosine, resulting in 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) respectively. In contrast, ... -
DNA damage tolerance in human cells mediated by the APIM-containing proteins REV3L, HLTF, and SHPRH
(Doctoral theses at NTNU;2020:108, Doctoral thesis, 2020) -
DNA excision repair of uracil and 5-fluorouracil in human cancercell lines
(Doktoravhandlinger ved NTNU, 1503-8181; Doktoravhandlinger ved NTNU, 2009:260, Doctoral thesis, 2009)DNA er et tilsynelatende stabilt molekyl, som overføres så å si uten endringer fra unnfangelse til alderdom og fra generasjon til generasjon. Men arvestoffet vårt er ikke så uforanderlig som det kan se ut som. DNA kan ... -
DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease
(Peer reviewed; Journal article, 2020)The DNA glycosylase Neil2 is a member of the base excision repair (BER) family of enzymes, which are important for repair of oxidative DNA damage. Specifically, Neil2 participates in repair of oxidized bases in single-stranded ... -
DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development
(Peer reviewed; Journal article, 2021)Background and aims Atherogenesis involves a complex interaction between immune cells and lipids, processes greatly influenced by the vascular smooth muscle cell (VSMC) phenotype. The DNA glycosylase NEIL3 has previously ... -
DNA hypermethylation associated with upregulated gene expression in prostate cancer demonstrates the diversity of epigenetic regulation
(Journal article; Peer reviewed, 2020)Background Prostate cancer (PCa) has the highest incidence rates of cancers in men in western countries. Unlike several other types of cancer, PCa has few genetic drivers, which has led researchers to look for additional ... -
DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival
(Peer reviewed; Journal article, 2022)Background Locally advanced breast cancer is a heterogeneous disease with respect to response to neoadjuvant chemotherapy (NACT) and survival. It is currently not possible to accurately predict who will benefit from the ... -
DNA methylation data by sequencing: experimental approaches and recommendations for tools and pipelines for data analysis
(Journal article; Peer reviewed, 2019)Sequencing technologies have changed not only our approaches to classical genetics, but also the field of epigenetics. Specific methods allow scientists to identify novel genome-wide epigenetic patterns of DNA methylation ... -
DNA methylation-based age acceleration observed in IDH wild-type glioblastoma is associated with better outcome-including in elderly patients
(Peer reviewed; Journal article, 2022)Elderly patients represent a growing proportion of individuals with glioblastoma, who however, are often excluded from clinical trials owing to poor expected prognosis. We aimed at identifying age-related molecular differences ... -
DNA repair enzyme NEIL3 enables a stable neural representation of space by shaping transcription in hippocampal neurons
(Peer reviewed; Journal article, 2021)DNA repair enzymes are essential for the maintenance of the neuronal genome and thereby proper brain functions. Emerging evidence links DNA repair to epigenetic gene regulation; however, its contribution to different ... -
DNA Repair Mechanisms are Activated in Circulating Lymphocytes of Hospitalized Covid-19 Patients
(Peer reviewed; Journal article, 2022)Purpose: Reactive oxygen species (ROS) are an important part of the inflammatory response during infection but can also promote DNA damage. Due to the sustained inflammation in severe Covid-19, we hypothesized that ... -
DNA repair protein complexes, functionality and significance for repair efficiency and cell survival
(Doktoravhandlinger ved NTNU, 1503-8181; 2010:146, Doctoral thesis, 2010)DNA‐reparasjons‐protein‐komplekser, funksjonalitet og signifikans for reparasjonseffektivitet og skadetoleranse All informasjon om en organisme er lagret i vår arvestoff, DNA. DNA er et relativt ustabilt makromolekyl som ... -
DNA topoisomerase IIα and mitosin expression predict meningioma recurrence better than histopathological grade and MIB-1 after initial surgery
(Journal article; Peer reviewed, 2017)Background: The 2016 WHO histopathological grade or conventional biomarker MIB-1 is insufficient for predicting meningioma recurrence after initial treatment and alternative strategies are required. In this study, we ... -
DNA-basert overvåking av den skandinaviske jervbestanden 2008-2011
(NINI rapport;843, Research report, 2012)Genetiske analyser er de siste årene blitt implementert som et viktig verktøy i rovviltovervåkingen i Skandinavia. I særlig grad har antallet DNA-analyser av ekskrementer økt betydelig. Det siste tiåret er det gjennomført ... -
Do changes in persistent organic pollutants after bariatric surgery cause endocrine disruption?
(Peer reviewed; Journal article, 2022)Do changes in persistent organic pollutants after bariatric surgery cause endocrine disruption?