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Diverse functions of DNA glycosylases processing oxidative base lesions in brain

Scheffler, Katja; Bjørås, Karine Øian; Bjørås, Magnar
Peer reviewed, Journal article
Published version
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Magnar+Bj%C3%B8r%C3%A5s+2019-Diverse+functions+of+DNA+glycosylases+processing+oxidative+base+lesions+in.pdf (Locked)
URI
https://hdl.handle.net/11250/2677933
Date
2019
Metadata
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  • Institutt for klinisk og molekylær medisin [2067]
  • Publikasjoner fra CRIStin - NTNU [20842]
Original version
DNA Repair. 2019, 81   10.1016/j.dnarep.2019.102665
Abstract
Endogenous and exogenous oxidative agents continuously damage genomic DNA, with the brain being particularly vulnerable. Thus, preserving genomic integrity is key for brain health and neuronal function. Accumulation of DNA damage is one of the causative factors of ageing and increases the risk of a wide range of neurological disorders. Base excision repair is the major pathway for removal of oxidized bases in the genome and initiated by DNA glycosylases. Emerging evidence suggest that DNA glycosylases have non-canonical functions important for genome regulation. Understanding canonical and non-canonical functions of DNA glycosylases processing oxidative base lesions modulating brain function will be crucial for the development of novel therapeutic strategies.
Publisher
Elsevier
Journal
DNA Repair

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