Blar i Institutt for klinisk og molekylær medisin på tittel

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    • Cytotoxicity and repair of uracil and 5-fluorouracil in DNA 

      Pettersen, Henrik Sahlin (Doktoravhandlinger ved NTNU, 1503-8181; 2011:95, Doctoral thesis, 2011)
      Cytotoksisitet og reparasjon av uracil og 5-fluorouracil i DNA Vårt arvemateriale (gener) er organisert i 23 kromosompar, som det finnes fullstendige kopier av i storparten av våre celler. Hvert kromosom består av en lang ...

    • Cytotoxicity of poly(Alkyl cyanoacrylate) nanoparticles 

      Sulheim, Einar; Iversen, Tore Geir; To, Vu; Klinkenberg, Geir; Sletta, Håvard; Schmid, Ruth; Hatletveit, Anne Rein; Wågbø, Ane Marit; Sundan, Anders; Skotland, Tore; Sandvig, Kirsten; Mørch, Ýrr Asbjørg (Journal article; Peer reviewed, 2017)
      Although nanotoxicology has become a large research field, assessment of cytotoxicity is often reduced to analysis of one cell line only. Cytotoxicity of nanoparticles is complex and should, preferentially, be evaluated ...

    • Dansk embryologikompendium 

      Stridsklev, Solhild (Peer reviewed; Journal article, 2021)
      Kompendiet er først og fremst rettet mot medisinstudenter, men kan leses av alle med interesse for feltet eller ønske om en kort repetisjon av embryologien. Det er kortfattet og nærmest stikkordspreget, i A4-størrelse og ...

    • Dasatinib induces fast and deep responses in newly diagnosed chronic myeloid leukaemia patients in chronic phase: Clinical results from a randomised phase-2 study (NordCML006) 

      Hjorth-Hansen, Henrik; Stenke, Leif; Söderlund, Stina; Dreimane, Arta; Ehrencrona, Hans; Gedde-Dahl, Thobias; Gjertsen, Bjørn Tore; Höglund, Martin; Koskenvesa, Perttu; Lotfi, Kourosh; Majeed, Mohammed Waleed; Markevärn, Berit; Ohm, Lotta; Olsson-Strömberg, Ulla; Remes, Kari; Suominen, Merja; Simonsson, Bengt; Porkka, Kimmo; Mustjoki, Satu; Richter, Johan (Journal article, 2015)
      We randomised 46 newly diagnosed patients with chronic myeloid leukaemia (median age 56) to receive dasatinib 100 mg QD or imatinib 400 mg QD and report outcome as an intention-to-treat analysis with 36 months follow-up. ...

    • Decidual and placental NOD1 is associated with inflammation in normal and preeclamptic pregnancies 

      Rakner, Johanne Johnsen; Silva, Gabriela; Mundal, Siv Boon; Thaning, Astrid Josefin; Elschot, Mattijs; Ostrop, Jenny; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Gierman, Lobke; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2021)
      Introduction: Inflammation is a normal physiological process that increases to harmful levels in preeclampsia. It affects the interaction between maternal immune cells and fetal trophoblasts at both sites of the maternal-fetal ...

    • Decidual gene expression analysis: Endoplasmic reticulum stressand oxidative stress asprobable major events in thepatho physiology of preeclampsia 

      Løset, Mari; Mundal, Siv Boon (Master thesis, 2009)

    • Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations 

      Boer, Cindy G.; Hatzikotoulas, Konstantinos; Southam, Lorraine; Stefánsdóttir, Lilja; Almeida, Rodrigo Coutinho de; Zhang, Yanfei; Wu, Tian T.; Zheng, Jie; Hartley, April; Teder-Laving, Maris; Skogholt, Anne Heidi; Terao, Chikashi; Zengini, Eleni; Alexiadis, George; Barysenka, Andrei; Bjornsdottir, Gyda; Gabrielsen, Maiken Elvestad; Gilly, Arthur; Ingvarsson, Thorvaldur; Johnsen, Marianne Bakke; Jonsson, Helgi; Kloppenburg, Margreet; Luetge, Almut; Lund, Sigrun H; Magi, Reedik; Mangino, Massimo; Nelissen, Rob G.H.H.; Shivakumar, Manu; Steinberg, Julia; Takuwa, Hiroshi; Thomas, Laurent; Tuerlings, Margo; Babis, George C.; Cheung, Jason Pui Yin; Kang, Jae Hee; Kraft, Peter; Lietman, Steven A.; Samartzis, Dino; Slagboom, P. Eline; Stefansson, Kari; Thorsteinsdottir, Unnur; Tobias, Jonathan H.; Uitterlinden, André G.; Winsvold, Bendik K S; Zwart, John Anker Henrik; Smith, George Davey; Sham, Pak Chung; Thorleifsson, Gudmar; Hveem, Kristian; Zeggini, Eleftheria (Peer reviewed; Journal article, 2021)
      Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated ...

    • Deciphering role of succinate in metabolic rewiring of innate immunity 

      Sabbir, Ahmed (Master thesis, 2021)
      Succinate is the anionic form of succinic acid, which is produced during adenosine triphosphate (ATP) synthesis via the tricarboxylic acid (TCA) cycle. In a biological system, succinate can be found in two forms. One is ...

    • Deciphering the pathomolecular mechanisms underlying thoracic aortic aneurysm formation in syndromic patients 

      Pulli, Hanna Riina Elina (Master thesis, 2022)
      A thoracic aortic aneurysm (TAA) is local dilatation that occurs in the major blood vessel from which blood flows to the aorta. In the worst case, weakened dilation can lead to rupture. Clinical decision making for the ...

    • Decoding the Metabolic Reprogramming Underlying Toll-like Receptor Signaling 

      Kim, Hera (Doctoral theses at NTNU;2021:297, Doctoral thesis, 2021)

    • Decrease in use of manual vacuum aspiration in postabortion care in Malawi: A cross-sectional study from three public hospitals, 2008-2012 

      Odland, Maria Lisa; Rasmussen, Hanne; Jacobsen, Geir Wenberg; Kafulafula, UK; Chamanga, P; Odland, Jon Øyvind (Journal article; Peer reviewed, 2014)
      Objectives: To investigate the use of manual vacuum aspiration in postabortion care in Malawi between 2008–2012. Methods: A retrospective cross-sectional study was done at the referral hospital Queen Elisabeth Central ...

    • Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity 

      Castela, Inês; Morais, Juliana; Barreiros-Mota, Inês; Silvestre, Marta P.; Marques, Cláudia; Rodrigues, Catarina; Ismael, Shámila; Araújo, João R; Ângelo-Dias, Miguel; Martins, Catarina; Borrego, Luís Miguel; Monteiro, Rosário; dos Santos Ribeiro F. Coutinho, Silvia; Calhau, Conceição; Alho Letra Martins, Catia Patricia; Faria, Ana; Pestana, Diogo; Teixeira, Diana (Journal article; Peer reviewed, 2023)
      Adiponectin/leptin ratio, triacylglycerols, and waist-to-hip ratio explained almost half of HOMA-IR variance in the context of obesity. This study provides evidence to support adipose tissue dysfunction as a central feature ...

    • Decreasing prevalence and severity of cerebral palsy in Norway among children born 1999 to 2010 concomitant with improvements in perinatal health 

      Hollung, Sandra Julsen; Vik, Torstein; Lydersen, Stian; Bakken, Inger Johanne; Andersen, Guro Lillemoen (Journal article; Peer reviewed, 2018)
      Background The aim of our study was to explore if the prevalence and clinical characteristics of cerebral palsy (CP), concomitant with perinatal health indicators in the general population, remained unchanged for children ...

    • Deep learning-based image analysis reveals significant differences in the number and distribution of mucosal CD3 and γδ T cells between Crohn's disease and ulcerative colitis 

      Røyset, Elin Synnøve; Pettersen, Henrik Sahlin; Xu, Weili; Larbi, Anis; Sandvik, Arne Kristian; Steigen, Sonja Eriksson; Catalan-Serra, Ignacio; Bakke, Ingunn (Peer reviewed; Journal article, 2022)
      Colon mucosae of ulcerative colitis (UC) and Crohn's disease (CD) display differences in the number and distribution of immune cells that are difficult to assess by eye. Deep learning-based analysis on whole slide images ...

    • Deep-inspiration breath-hold - Development and utilization of a deep-inspiration breath-hold system for breast cancer radiotherapy 

      Jensen, Christer André (Doctoral theses at NTNU;2018:315, Doctoral thesis, 2018)
      The purpose of this thesis was to develop a deep-inspiration breath-hold (DIBH) system and study the performance and clinical implications in the treatment of leftsided breast cancer and radiotherapy. This was investigated ...

    • Defining changes in the intestinal epithelium in early life and in response to infections 

      Lindholm, Håvard Takle (Doctoral theses at NTNU;2021:231, Doctoral thesis, 2021)

    • Definitive radiotherapy for prostate cancer in Norway 2006-2015: Temporal trends, performance and survival 

      Fosså, Sophie Dorothea; Aas, Kirsti; Muller, Christoph Rainer; Jerm, Marianne Brenn; Tandstad, Torgrim; Lilleby, Wolfgang; Kvåle, Rune; Gulbrandsen, Johanne; Haug, Erik Skaaheim; Myklebust, Tor Åge (Peer reviewed; Journal article, 2020)
      Background: More studies are needed to document nation-wide use and effectiveness of curative definitive radiotherapy (Def-RT) in the treatment of prostate cancer (PCa). Patients and methods: For 38,960 men diagnosed with ...

    • Degradation and mobility of pesticides in Norwegian soils. Opinion of the Panel on Plant Protection Products of the Norwegian Scientific Committee for Food Safety 

      Eklo, Ole Martin; Almvik, Marit; Hole, Halvard; Nyborg, Åge Arild; Stenrød, Marianne; Borgå, Katrine; Dirven, Hubert; Grung, Merete; Lyche, Jan Ludvig; Låg, Marit; Nilsen, Asbjørn Magne; Sverdrup, Line Emilie; Källqvist, Torsten (VKM Report;, Research report, 2015)
      In this report the following topic of pesticides and fate in Norway has been outlined covering: 1. Factors influencing degradation of pesticides. 2. Description and update of datasets on soil and climate in agricultural ...

    • Deletion of aquaporin-4 improves capillary blood flow distribution in brain edema 

      Bordoni, Luca; Thorén, Anna Elisabeth; Gutiérrez-Jiménez, Eugenio; Åbjørsbråten, Knut Sindre; Bjørnstad, Daniel Marelius; Tang, Wannan; Stern, Mette; Østergaard, Leif; Nagelhus, Erlend Arnulf; Frische, Sebastian; Ottersen, Ole Petter; Enger, Rune (Peer reviewed; Journal article, 2023)
      Brain edema is a feared complication to disorders and insults affecting the brain. It can be fatal if the increase in intracranial pressure is sufficiently large to cause brain herniation. Moreover, accruing evidence ...

    • Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma 

      Kong, Xiang Yi; Vik, Erik Sebastian; Nawaz, Meh Sameen; Berges, Natalia; Dahl, Tuva Børresdatter; Vågbø, Cathrine; Suganthan, Rajikala; Segers, Filip; Holm, Sverre; Quiles-Jimenez, Ana; Gregersen, Ida; Fladeby, Cathrine; Aukrust, Pål; Bjørås, Magnar; Klungland, Arne; Halvorsen, Bente; Alseth, Ingrun (Peer reviewed; Journal article, 2020)
      Endonuclease V (EndoV) is a conserved inosine-specific ribonuclease with unknown biological function. Here, we present the first mouse model lacking EndoV, which is viable without visible abnormalities. We show that ...