• Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation 

      Bakke, Siril Skaret; Aune, Marie Hjelmseth; Niyonzima, Nathalie; Pilely, Katrine; Ryan, Liv; Skjelland, Mona; Garred, Peter; Aukrust, Pål; Halvorsen, Bente; Latz, Eicke; Damås, Jan Kristian; Mollnes, Tom Eirik; Espevik, Terje (Journal article, 2017)
      Cholesterol crystals (CC) are abundant in atherosclerotic plaques and promote inflammatory responses via the complement system and inflammasome activation. Cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin (BCD) is a ...
    • Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation 

      Bakke, Siril Skaret; Aune, Marie Hjelmseth; Niyonzima, Nathalie; Pilely, Katrine; Ryan, Liv; Skjelland, Mona; Garred, Peter; Aukrust, Pål; Halvorsen, Bente; Latz, Eicke; Damås, Jan Kristian; Mollnes, Tom Eirik; Espevik, Terje (Journal article; Peer reviewed, 2017)
      Cholesterol crystals (CC) are abundant in atherosclerotic plaques and promote inflammatory responses via the complement system and inflammasome activation. Cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin (BCD) is a ...
    • The Cyclooxygenase 2 inhibitor etoricoxib as adjunctive therapy in tuberculosis impairs macrophage control of mycobacterial growth 

      Nore, Kristin Grotle; Louet, Claire; Bugge, Marit; Gidon, Alexandre; Jørgensen, Marthe Jøntvedt; Jenum, Synne; Dyrhol-Riise, Anne Ma; Tonby, Kristian; Flo, Trude Helen (Peer reviewed; Journal article, 2023)
      Background Current tuberculosis treatment regimens could be improved by adjunct host-directed therapies (HDT) targeting host responses. We investigated the antimycobacterial capacity of macrophages from patients with ...
    • Cytochrome P-450 (CYP) inhibition by commercial Rhodiola rosea products in vitro and in humans 

      Thu, Ole Kristian Forstrønen (Doctoral theses at NTNU;2017:244, Doctoral thesis, 2017)
      Cytokrom P-450 (CYP) inhibering av kommersielle Rhodiola rosea produkter in vitro og i mennesker. Rosenrot (Rhodiola rosea) er et populært naturprodukt med en global utbredelse. Tidligere studier har vist at naturprodukter ...
    • Cytokine Network in Scrub Typhus: High Levels of Interleukin-8 Are Associated with Disease Severity and Mortality 

      Astrup, Elisabeth; Janardhanan, J; Otterdal, Kari; Ueland, Thor; Prakash, JAJ; Lekva, Tove; Strand, Øystein Anders; Abraham, OC; Thomas, K; Damås, Jan Kristian; Mathews, P; Mathai, D; Aukrust, Pål; Varghese, GM (Journal article; Peer reviewed, 2014)
      Background: Scrub typhus, caused by Orientia tsutsugamushi, is endemic in the Asia-Pacific region. Mortality is high if untreated, and even with treatment as high as 10–20%, further knowledge of the immune response during ...
    • Cytokine pattern in patients with ST-elevation myocardial infarction treated with the interleukin-6 receptor antagonist tocilizumab 

      Woxholt, Sindre; Ueland, Thor; Aukrust, Pål; Anstensrud, Anne Kristine; Broch, Kaspar; Tøllefsen, Ingvild Maria; Ryan, Liv; Bendz, Bjørn; Hopp, Einar; Kløw, Nils-Einar; Seljeflot, Ingebjørg; Halvorsen, Bente; Dahl, Tuva Børresdatter; Huse, Camilla; Andersen, Geir Øystein; Gullestad, Lars; Wiseth, Rune; Amundsen, Brage H.; Damås, Jan Kristian; Kleveland, Ola (Peer reviewed; Journal article, 2023)
      Background Tocilizumab improves myocardial salvage index (MSI) in patients with ST-elevation myocardial infarction (STEMI), but its mechanisms of action are unclear. Here, we explored how cytokines were affected by tocilizumab ...
    • Cytokine Patterns in Maternal Serum From First Trimester to Term and Beyond 

      Jarmund, Anders Hagen; Giskeødegård, Guro F.; Ryssdal, Mariell; Steinkjer, Bjørg; Stokkeland, Live Marie; Madssen, Torfinn Støve; Stafne, Signe Nilssen; Stridsklev, Solhild; Moholdt, Trine; Heimstad, Runa Kristine; Vanky, Eszter; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2021)
      Pregnancy implies delicate immunological balance between two individuals, with constant changes and adaptions in response to maternal capacity and fetal demands. We performed cytokine profiling of 1149 longitudinal serum ...
    • Cytokine profiles and diagnoses in elderly, hospitalised psychiatric patients 

      Bugge, Erlend; Wynn, Rolf; Mollnes, Tom Eirik; Reitan, Solveig Merete Klæbo; Grønli, Ole Kristian (Journal article; Peer reviewed, 2018)
      Background There is a paucity of studies on inflammatory markers in elderly psychiatric patients. Hence, our study was undertaken to investigate cytokines as biomarkers in diagnostically unselected elderly patients admitted ...
    • Cytokine profiles in human metapneumovirus infected children: Identification of genes involved in the antiviral response and pathogenesis 

      Malmo, Jostein; Moe, Nina; Krokstad, Sidsel; Ryan, Liv; Loevenich, Simon; Johnsen, Ingvild Bjellmo; Espevik, Terje; Nordbø, Svein Arne; Døllner, Henrik; Anthonsen, Marit Walbye (Journal article; Peer reviewed, 2016)
      Human metapneumovirus (hMPV) causes severe airway infection in children that may be caused by an unfavorable immune response. The nature of the innate immune response to hMPV in naturally occurring infections in children ...
    • Cytokine profiling and post-transfusion haemoglobin increment in patients with haematological diseases 

      Wendelbo, Øystein; Opheim, Elin Netland; Hervig, Tor; Lunde, Turid Helen Felli; Bruserud, Øystein; Mollnes, Tom Eirik; Reikvam, Håkon (Journal article; Peer reviewed, 2018)
    • Cytokine profiling as a measure of immunological development and deviation throughout pregnancy in healthy women and women with PCOS 

      Stokkeland, Live Marie Tobiesen (Doctoral theses at NTNU;2022:183, Doctoral thesis, 2022)
      Norsk sammendrag Cytokinprofilering som mål på immunologiske forandringer gjennom svangerskapet hos friske kvinner og kvinner med PCOS Mors immunsystem tilpasser seg gjennom de ulike fasene av svangerskapet for å sikre ...
    • Cytokine responses, microbial aetiology and short-term outcome in community-acquired pneumonia 

      Siljan, William Ward; Holter, Jan Cato; Nymo, Ståle Haugset; Husebye, Einar; Ueland, Thor; Aukrust, Pål; Mollnes, Tom Eirik; Heggelund, Lars (Journal article; Peer reviewed, 2017)
      Background The inflammatory response to community-acquired pneumonia (CAP) is orchestrated through activation of cytokine networks and the complement system. We examined the association of multiple cytokines and the ...
    • Cytokines in Relation to Motor Activity in an Acute Psychiatric Population 

      Larsen, Jeanette Brun; Stunes, Astrid Kamilla; Iversen, Valentina Cabral; Vaaler, Arne; Reitan, Solveig Merete Klæbo (Peer reviewed; Journal article, 2019)
      Background: Deviations in motor activity are important clinical features of several psychiatric disorders in an acute state. Immune activity is associated with several psychiatric disorders and may affect motor activity. ...
    • Cytomegalovirus antibody status at 17 - 18 weeks of gestation and preeclampsia: a case-control study of pregnant women in Norway 

      Strand, Kristin Melheim; Odland, Maria Lisa; Iversen, Ann-Charlotte; Nordbø, Svein Arne; Vik, Torstein; Austgulen, Rigmor (Journal article; Peer reviewed, 2012)
      Objective To assess the association between maternal cytomegalovirus (CMV) antibodies in mid-pregnancy and preeclampsia. Design Nested case–control study. Setting Pregnancies registered in the Norwegian Mother and ...
    • Cytosolic Phospholipase A2 Alpha Regulates TLR Signaling and Migration in Metastatic 4T1 Cells 

      Tunset, Hanna Maja; Feuerherm, Astrid Jullumstrø; Selvik, Linn-Karina M.; Johansen, Berit; Moestue, Siver Andreas (Journal article; Peer reviewed, 2019)
      Metastatic disease is the leading cause of death in breast cancer patients. Disrupting the cancer cell’s ability to migrate may be a strategy for hindering metastasis. Cytosolic phospholipase A2 α (cPLA2α), along with ...
    • Cytosolic scaffold functions of PCNA 

      Olaisen, Camilla (Doctoral theses at NTNU;2017:203, Doctoral thesis, 2017)
      PCNA som et plattform-protein i cytosol Kroppen vår består av millioner av celler som alle stammer fra en enkelt celle. For hver celledeling må arvestoffet, DNA-et, kopieres feilfritt i et samarbeid mellom mange ulike ...
    • Cytotoxic Effect on Human Myeloma Cells and Leukemic Cells by the Agaricus blazei Murill Based Mushroom Extract, Andosan™ 

      Tangen, Jon-Magnus; Holien, Toril; Mirlashari, Mohammad Reza; Misund, Kristine; Hetland, Geir (Journal article; Peer reviewed, 2017)
      Agaricus blazei Murill is an edible mushroom of the Basidiomycetes family, which has been found to contain a number of compounds with antitumor properties, such as proteoglycans and ergosterol. In the present investigation, ...
    • Cytotoxicity and effect on wound re-epithelialization after topical administration of tranexamic acid 

      Eikebrokk, Tuva; Vassmyr, Brita; Ausen, Kjersti; Gravastrand, Caroline S.; Spigset, Olav; Pukstad, Brita (Journal article; Peer reviewed, 2019)
      Background Topical administration of tranexamic acid (TXA) reduces bleeding from surgical wounds similarly to intravenous use, but with negligible risk of adverse systemic events. Topical use is expanding, but is ...
    • Cytotoxicity and repair of uracil and 5-fluorouracil in DNA 

      Pettersen, Henrik Sahlin (Doktoravhandlinger ved NTNU, 1503-8181; 2011:95, Doctoral thesis, 2011)
      Cytotoksisitet og reparasjon av uracil og 5-fluorouracil i DNA Vårt arvemateriale (gener) er organisert i 23 kromosompar, som det finnes fullstendige kopier av i storparten av våre celler. Hvert kromosom består av en lang ...
    • Cytotoxicity of poly(Alkyl cyanoacrylate) nanoparticles 

      Sulheim, Einar; Iversen, Tore Geir; To, Vu; Klinkenberg, Geir; Sletta, Håvard; Schmid, Ruth; Hatletveit, Anne Rein; Wågbø, Ane Marit; Sundan, Anders; Skotland, Tore; Sandvig, Kirsten; Mørch, Ýrr Asbjørg (Journal article; Peer reviewed, 2017)
      Although nanotoxicology has become a large research field, assessment of cytotoxicity is often reduced to analysis of one cell line only. Cytotoxicity of nanoparticles is complex and should, preferentially, be evaluated ...