Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 41-60 of 3430
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A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling
(Journal article; Peer reviewed, 2015)Toll-like receptors (TLRs) are involved in sensing invading microbes by host innate immunity. TLR2 recognizes bacterial lipoproteins/lipopeptides, and lipopolysaccharide activates TLR4. TLR2 and TLR4 signal via the ... -
A short-activating RNA oligonucleotide targeting the islet β-cell transcriptional factor MafA in CD34(+) cells
(Journal article; Peer reviewed, 2013)Upon functional loss of insulin producing islet β-cells, some patients with diabetes become dependent on life-long insulin supplementation therapy. Bioengineering surrogate insulin producing cells is an alternative replacement ... -
A study of the transcriptional repressor ICER: Regulatory networks in gastrin-induced gene expression
(Doktoravhandlinger ved NTNU, 1503-8181; 2009:117, Doctoral thesis, 2009)En studie av transkripsjonsrepressoren ICER. Regulatoriske nettverk i gastrin-indusert genuttrykk. Nar et hormon eller en vekstfaktor binder til spesifikke mottagere pa celleoverflaten, vil dette fore til en intracellular ... -
A Study of Toll-like Receptors in Trophoblasts, and the Influence of Cytomegalovirus Infection
(Master thesis, 2012)Toll-like receptors (TLRs) act as sensors against invading pathogens and endogenous danger signals, and are critical mediators of inflammatory immune responses. During pregnancy, intrauterine activation of TLRs might evoke ... -
A Study of Urothelial Carcinoma: Gene Expression Profiling, Tumorigenesis and Therapies in Orthotopic Animal Models
(Doktoravhandlinger ved NTNU, 1503-8181; 2011:27, Doctoral thesis, 2011)En studie om urothelial karsinom: Genekspresjonsprofilering, tumorutvikling og terapi i ortotopiskiske dyremodeller. Urinblærekreft er en hyppig forekommende kreftform som i noen tilfeller har dårlig prognose. Dette arbeide ... -
A systematic review of maternal smoking during pregnancy and fetal measurements with meta-analysis
(Journal article; Peer reviewed, 2017)Background Maternal smoking during pregnancy is linked to reduced birth weight but the gestation at onset of this relationship is not certain. We present a systematic review of the literature describing associations between ... -
A systematic review on the role of vitamins, minerals, proteins, and other supplements for the treatment of cachexia in cancer: a European Palliative Care Research Centre cachexia project
(Journal article; Peer reviewed, 2017)We provide a systematic review to support the European Palliative Care Research Collaboration development of clinical guidelines for cancer patients suffering from cachexia. CENTRAL, MEDLINE, PsycINFO, ClinicalTrials.gov, ... -
A systems approach to study immuno- and neuro-modulatory properties of antiviral agents
(Journal article; Peer reviewed, 2018)There are dozens of approved, investigational and experimental antiviral agents. Many of these agents cause serious side effects, which can only be revealed after drug administration. Identification of the side effects ... -
A targeted mass spectrometry immunoassay to quantify osteopontin in fresh-frozen breast tumors and adjacent normal breast tissues
(Journal article; Peer reviewed, 2019)Osteopontin (OPN) is a multifunctional protein that can activate cell-signaling pathways and lead to cancer development and metastasis. Elevated OPN expression was reported in different cancer types, including breast tumors. ... -
A Toll-like receptor 7/8 ligand secreted by a myeloma cell line induces primary bone marrow stromal cells to produce survival promoting cytokines
(Master thesis, 2015)Multiple myeloma (MM) is a cancer of plasma cells, which accumulate in the bone marrow (BM). The BM milieu provides MM cells with survival and proliferation signals. Toll-like receptors (TLRs) are immune receptors that ... -
A transgenic minipig model of Huntington’s disease shows early signs of behavioral and molecular pathologies
(Journal article; Peer reviewed, 2018)Huntington's disease (HD) is a monogenic, progressive, neurodegenerative disorder with currently no available treatment. The Libechov transgenic minipig model for HD (TgHD) displays neuroanatomical similarities to humans ... -
A translational medicine approach to hypertensive nephropathy: Prevalence, diagnosis, and pathophysiology
(Doctoral theses at NTNU;2018:400, Doctoral thesis, 2018)NORSK SAMMENDRAG Translasjonsmedisinske studier av hypertensiv nefropati: Prevalens, diagnose og patofysiologi Kronisk nyresjukdom defineres som nedsatt nyrefunksjon (estimert glomerulær filtrasjonsrate (eGFR) <60 ... -
A two-step site and mRNA-level model for predicting microRNA targets
(Journal article; Peer reviewed, 2010)Background: Despite experiments showing that the number of microRNA (miRNA) target sites is critical for miRNA targeting, most existing methods focus on identifying individual miRNA target sites and do not model contributions ... -
A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair
(Journal article; Peer reviewed, 2017)DNA repair is essential to prevent the cytotoxic or mutagenic effects of various types of DNA lesions, which are sensed by distinct pathways to recruit repair factors specific to the damage type. Although biochemical ... -
A Validated Clinical Risk Prediction Model for Lung Cancer in Smokers of All Ages and Exposure Types: A HUNT Study
(Journal article; Peer reviewed, 2018)Lung cancer causes >1·6 million deaths annually, with early diagnosis being paramount to effective treatment. Here we present a validated risk assessment model for lung cancer screening. The prospective HUNT2 population ... -
abc4pwm: affinity based clustering for position weight matrices in applications of DNA sequence analysis
(Peer reviewed; Journal article, 2022)Background Transcription factor (TF) binding motifs are identified by high throughput sequencing technologies as means to capture Protein-DNA interactions. These motifs are often represented by consensus sequences in form ... -
Abdominal adipose tissue and liver fat imaging in very low birth weight adults born preterm: birth cohort with sibling-controls
(Peer reviewed; Journal article, 2022)Preterm birth at very low birth weight (VLBW, < 1500 g) is associated with an accumulation of cardiovascular and metabolic risk factors from childhood at least to middle age. Small-scale studies suggest that this could ... -
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction
(Peer reviewed; Journal article, 2020)An inflammatory response is required for tissue healing after a myocardial infarction (MI), but the process must be balanced to prevent maladaptive remodeling. This study shows that improved survival and cardiac function ... -
Academic detailing as a method of continuing medical education
(Journal article; Peer reviewed, 2019)Introduction: Academic detailing is an interactive educational outreach to prescribers to present unbiased, non-commercial, evidence-based information, mostly about medications, with the goal of improving patient care. ... -
Academic detailing as a method to improve general practitioners’ drug prescribing in type 2 diabetes: evaluation of changes in prescribing
(Peer reviewed; Journal article, 2023)Objective To investigate the effect of an academic detailing intervention on the utilisation of type 2 diabetes medication among general practitioners. Design We developed an academic detailing campaign based on the ...