Blar i Institutt for klinisk og molekylær medisin på tittel

Viser treff 2106-2125 av 3426

    • Multiple layers of gene regulation: the cell cycle, epigenetics and microRNAs 

      Mjelle, Robin (Doctoral thesis at NTNU;2015:73, Doctoral thesis, 2015)

    • Multiple myeloma : the interplay between malignant plasma cells and the bonemarrow microenvironment 

      Standal, Therese (Dissertations at the Faculty of Medicine, 0805-7680; 2006:26272, Doctoral thesis, 2006)
      The overall objective of this work was to study how myeloma cells influence the bone marrow microenvironment in which they reside, focusing on the cells that resorb or synthesize bone. More specifically we wanted to ...

    • Multiple myeloma cells and cytokines from the bone marrow environment; aspects of growth regulation and migration 

      Fagerli, Unn-Merete (Doktoravhandlinger ved NTNU, 1503-8181; 2009:177, Doctoral thesis, 2009)

    • Multiple myeloma in Norway - Population-based studies on incidence, survival, familial risk, and associated malignancies 

      Langseth, Øystein Olstad (Doctoral theses at NTNU;2022:110, Doctoral thesis, 2022)
      Norsk sammendrag Myelomatose utgjør omtrent 10% av all hematologisk kreft og karakteriseres av klonal proliferasjon av maligne plasmaceller i benmargen. Myelomatose utvikles fra et forstadium som kalles monoklonal gammopati ...

    • Multiple Myeloma-study of cellular sensitivity to proteasome inhibitors 

      Baranowska, Katarzyna Anna (Doctoral theses at NTNU;2018:273, Doctoral thesis, 2018)
      Myelomatose (benmargskreft) – en studie av kreftcellenes følsomhet for kreftmedisiner i gruppen proteasomhemmere Myelomatose er en kreftform som utvikler seg i beinmargen og karakteriseres av ukontrollert vekst av de ...

    • Multiple Myeloma: Cancer Cell Intrinsic- and Tumor Microenvironmental Factors 

      Nedal, Tonje Marie Vikene (Doctoral theses at NTNU;2024:33, Doctoral thesis, 2024)
      Myelomatose (MM) er en hematologisk kreftsykdom som skyldes ukontrollert vekst av maligne plasmaceller i beinmargen. Myelomatose utvikler seg via to asymptomatiske forstadier: monoklonal gammopati av usikker betydning ...

    • Multippel erythema migrans, borrelialymfocytom og nevroborreliose hos eit barn 

      Schei, Kasper; Modalsli, Ellen Heilmann; Nag, Torbjørn (Peer reviewed; Journal article, 2023)

    • Multippel sklerose i Møre og Romsdal 1950-2007: Prevalens og insidens - en oppdatering 

      Kirkeland, Ellen; Støen, Kjersti Opøien (Master thesis, 2009)

    • Muscle mass and association to quality of life in non-small cell lung cancer patients 

      Bye, Asta; Sjøblom, Bjørg; Wentzel-Larsen, Tore; Grønberg, Bjørn Henning; Baracos, Vickie E.; Hjermstad, Marianne Jensen; Aass, Nina Kathrine; Bremnes, Roy M.; Fløtten, Øystein; Jordhøy, Marit Slaaen (Journal article; Peer reviewed, 2017)
      Background Cancer wasting is characterized by muscle loss and may contribute to fatigue and poor quality of life (QoL). Our aim was to investigate associations between skeletal muscle index (SMI) and skeletal muscle ...

    • Mutasjonstesting ved ikke-småcellet lungekreft 

      Brustugun, Odd Terje; Helland, Åslaug; Fjellbirkeland, Lars; Kleinberg, Lilach; Ariansen, Sarah Louise; Jebsen, Peter Wilhelm; Scott, Helge; Dønnem, Tom; Bremnes, Roy M.; Berg, Thomas; Grønberg, Bjørn Henning; Dai, Hong Yan; Wahl, Sissel Gyrid Freim; Mangseth, Kjersti; Helgeland, Lars (Peer reviewed; Journal article, 2012)
      BAKGRUNN. Epidermal vekstfaktor-reseptor (EGFR) tyrosinkinasehemmere (EGFR-TKI) er en relativt ny klasse legemidler til behandling av ikke-småcellet lungekreft. Den nasjonale faggruppen for lungekreft, Norsk Lunge Cancer ...

    • Mutation Spectrum in Liquid Versus Solid Biopsies From Patients With Advanced astroenteropancreatic Neuroendocrine Carcinoma 

      Knappskog, Stian; Grob, Tobias; Venizelos, Andreas; Amstutz, Ursula; Hjortland, Geir Olav; Lothe, Inger Marie Bowitz; Kersten, Christian; Hofsli, Eva; Sundlöv, Anna; Elvebakken, Hege; Garresori, Herish; Couvelard, Anne; Svensson, Johanna; Sorbye, Halfdan; Perren, Aurel (Peer reviewed; Journal article, 2023)
      Purpose Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are rare and have a poor prognosis. Most GEP-NEC are diagnosed with metastatic disease, with only minor biopsies available for molecular diagnostics. We ...

    • Mutational analysis and protein profiling predict drug sensitivity in multiple myeloma cell lines 

      Giliberto, Mariaserena; Miranda Santana, Leonardo; Holien, Toril; Misund, Kristine; Nakken, Sigve; Vodak, Daniel; Hovig, Eivind; Meza, Leonardo Zepeda; Coward, Eivind; Waage, Anders; Tasken, Kjetil; Skånland, Sigrid S (Peer reviewed; Journal article, 2022)
      Introduction: Multiple myeloma (MM) is a heterogeneous disease where cancer-driver mutations and aberrant signaling may lead to disease progression and drug resistance. Drug responses vary greatly, and there is an unmet ...

    • Mutational signature analysis reveals NTHL1 deficiency to cause a multi-tumor phenotype 

      Grolleman, Judith E.; de Voer, Richarda M.; Elsayed, Fadwa A.; Nielsen, Maartje; Weren, Robbert D.A.; Palles, Claire; Ligtenberg, Marjolijn J.L.; Vos, Janet R.; ten Broeke, Sanne W.; de Miranda, Noel F.C.C.; Kuiper, Renske A.; Kamping, Eveline J.; Jansen, Erik A.M.; Vink-Börger, M. Elisa; Popp, Isabell; Lang, Alois; Spier, Isabel; Hüneburg, Robert; James, Paul A.; Li, Na; Staninova, Marija; Lindsay, Helen; Cockburn, David; Spasic-Boskovic, Olivera; Clendenning, Mark; Sweet, Kevin; Capellá, Gabriel; Sjursen, Wenche; Vetti, Hildegunn Høberg; Jongmans, Marjolijn C.; Neveling, Kornelia; van Kessel, Ad Geurts; Morreau, Hans; Hes, Frederik J.; Sijmons, Rolf H.; Schackert, Hans K.; Ruiz-Ponte, Clara; Dymerska, Dagmara; Lubiñski, Jan; Rivera, Barbara; Foulkes, William D.; Tomlinson, Ian P.; Valle, Laura; Buchanan, Daniel D.; Kenwrick, Sue; Adlard, Julian; Dimovski, Aleksandar J.; Campbell, Ian G.; Aretz, Stefan; Schindler, Detlev; van Wezel, Tom; Hoogerbrugge, Nicoline; Kuiper, Roland P. (Peer reviewed; Journal article, 2019)
      Biallelic germline mutations affecting NTHL1 predispose carriers to adenomatous polyposis and colorectal cancer, but the complete phenotype is unknown. We describe 29 individuals carrying biallelic germline NTHL1 mutations ...

    • Mutations in the substrate binding site of human heat-shock protein 70 indicate specific interaction with HLA-DR outside the peptide binding groove 

      Rohrer, Karin; Haug, Markus; Schwoerer, Daniela; Kalbacher, Hubert; Holzer, Ursula (Journal article; Peer reviewed, 2014)
      Heat-shock protein 70 (Hsp70)–peptide complexes are involved in MHC class I- and II-restricted antigen presentation, enabling enhanced activation of T cells. As shown previously, mammalian cytosolic Hsp70 (Hsc70) molecules ...

    • MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP 

      Jemth, Ann-Sofie; Gustafsson, Robert; Bräutigam, Lars; Henriksson, Linda; Vallin, Karl S.A.; Sarno, Antonio; Almlöf, Ingrid; Homan, Evert; Rasti, Azita; Warpman Berglund, Ulrika; Stenmark, Pål; Helleday, Thomas (Journal article; Peer reviewed, 2018)
      Nucleotides in the free pool are more susceptible to nonenzymatic methylation than those protected in the DNA double helix. Methylated nucleotides like O6-methyl-dGTP can be mutagenic and toxic if incorporated into DNA. ...

    • MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool 

      Scaletti, Emma Rose; Vallin, Karl S.A.; Bräutigam, Lars; Sarno, Antonio; Berglund, Ulrika Warpman; Helleday, Thomas; Stenmark, Pål; Jemth, Ann-Sofie (Peer reviewed; Journal article, 2020)
      MutT homologue 1 (MTH1) removes oxidized nucleotides from the nucleotide pool and thereby prevents their incorporation into the genome and thereby reduces genotoxicity. We previously reported that MTH1 is an efficient ...

    • MYC amplifications in myeloma cell lines; correlation with MYC-inhibitor efficacy 

      Holien, Toril; Misund, Kristine; Olsen, Oddrun Elise; Baranowska, Katarzyna Anna; Buene, Glenn; Børset, Magne; Waage, Anders; Sundan, Anders (Journal article; Peer reviewed, 2015)
      In multiple myeloma, elevated MYC expression is related to disease initiation and progression. We found that in myeloma cell lines, MYC gene amplifications were common and correlated with MYC mRNA and protein. In primary ...

    • MYC dysregulation in the progression of multiple myeloma 

      Misund, Kristine; Keane, Niamh; Stein, Caleb; Asmann, Yan; Day, GM; Welsh, Seth; Van Wier, Scott; Riggs, Daniel; Ahmann, Gregory; Chesi, Marta; Viswanatha, DS; Kumar, SK; Dispenzieri, Angela; Gonzalez-Calle, V; Kyle, RA; O'Dwyer, Michael; Rajkumar, SV; Kortüm, KM; Keats, JJ; Fonseca, R; Stewart, A.Keith; Kuehl, WM; Braggio, Esteban; Bergsagel, PL (Journal article; Peer reviewed, 2019)

    • Mycobacterial Esx-3 Requires Multiple Components for Iron Acquisition 

      Siegrist, M. Sloan; Steigedal, Magnus; Ahmad, Rushdy; Mehra, Alka; Dragset, Marte Singsås; Schuster, Brian M.; Phillips, Jennifer A.; Carr, Steven A.; Rubin, Eric J (Journal article; Peer reviewed, 2014)
      The type VII secretion systems are conserved across mycobacterial species and in many Gram-positive bacteria. While the well-characterized Esx-1 pathway is required for the virulence of pathogenic mycobacteria and conjugation ...

    • Mycobacterium smegmatis Vaccine Vector Elicits CD4+ Th17 and CD8+ Tc17 T Cells With Therapeutic Potential to Infections With Mycobacterium avium 

      Kannan, Nisha; Haug, Markus; Steigedal, Magnus; Flo, Trude Helen (Peer reviewed; Journal article, 2020)
      Mycobacterium avium (Mav) complex is increasingly reported to cause non-tuberculous infections in individuals with a compromised immune system. Treatment is complicated and no vaccines are available. Previous studies have ...