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MYC amplifications in myeloma cell lines; correlation with MYC-inhibitor efficacy

Holien, Toril; Misund, Kristine; Olsen, Oddrun Elise; Baranowska, Katarzyna Anna; Buene, Glenn; Børset, Magne; Waage, Anders; Sundan, Anders
Journal article, Peer reviewed
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4245-59175-1-PB.pdf (1.373Mb)
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http://hdl.handle.net/11250/284777
Utgivelsesdato
2015
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  • Institutt for klinisk og molekylær medisin [1998]
  • Publikasjoner fra CRIStin - NTNU [19694]
Originalversjon
OncoTarget 2015   10.18632/oncotarget.4245
Sammendrag
In multiple myeloma, elevated MYC expression is related to disease initiation

and progression. We found that in myeloma cell lines, MYC gene amplifications were

common and correlated with MYC mRNA and protein. In primary cell samples MYC

mRNA levels were also relatively high; however gene copy number alterations were

uncommon. Elevated levels of MYC in primary myeloma cells have been reported

to arise from complex genetic aberrations and are more common than previously

thought. Thus, elevated MYC expression is achieved differently in myeloma cell lines

and primary cells. Sensitivity of myeloma cell lines to the MYC inhibitor 10058-F4

correlated with MYC expression, supporting that the activity of 10058-F4 was through

specific inhibition of MYC.
Tidsskrift
OncoTarget

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