Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 1833-1852 av 3426
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Laying the foundations for Gastrin Systems Biology: Conceptual models and knowledge resources to enhance research on gastrin mediated intracellular signaling and gene regulation
(Doktoravhandlinger ved NTNU, 1503-8181; 2013:222, Doctoral thesis, 2013)Behovet for å forstå biologisk kompleksitet har vært en sterk pådriver for utvikling av ny teknologi og nye kunnskapsressurser. Avanserte og kvantitative storskalateknologier har gjort det nærmest trivielt å framstille ... -
Leaky severe combined immunodeficiency in mice lacking non-homologous end joining factors XLF and MRI
(Peer reviewed; Journal article, 2020)Non-homologous end-joining (NHEJ) is a DNA repair pathway required to detect, process, and ligate DNA double-stranded breaks (DSBs) throughout the cell cycle. The NHEJ pathway is necessary for V(D)J recombination in ... -
Learning deep abdominal CT registration through adaptive loss weighting and synthetic data generation
(Peer reviewed; Journal article, 2023)Purpose This study aims to explore training strategies to improve convolutional neural network-based image-to-image deformable registration for abdominal imaging. Methods Different training strategies, loss functions, and ... -
Learning habits of medical students at the Norwegian University of Science and Technology, and the application of Serious Games in learning dermatovenereology
(Master thesis, 2017)Introduction The interest in so called “Serious Games” (SGs) in education has increased, with several new RCTs in just the last few years, but there is not yet a clear consensus as to the potential benefit of using Serious ... -
Learning the effects of psychotropic drugs during pregnancy using real-world safety data: a paradigm shift toward modern pharmacovigilance
(Peer reviewed; Journal article, 2018)The growing evidence on psychotropic drug safety in pregnancy has been possible thanks to the increasing availability of real-world data, i.e. data not collected in conventional randomised controlled trials. Use of these ... -
Legemiddelavvik hos pasienter innlagt i sykehus.
(Peer reviewed; Journal article, 2021)BAKGRUNN Avvik i bruk og håndtering av legemidler er ikke uvanlig. Det finnes lite oppdatert informasjon om legemiddelavvik i norske sykehus. MATERIALE OG METODE Alle uønskede hendelser ved St. Olavs hospital er pålagt ... -
Legemiddelmangel i apotek: Håndtering og kommunikasjon Et prosjekt med bruk av simulert pasient
(Master thesis, 2022)Bakgrunn: Legemiddelmangel er et økende problem, både globalt og nasjonalt. Årsakene er ofte komplekse og multifaktorielle. For apotekene medfører legemiddelmangel store økonomiske og tidsmessige konsekvenser. ... -
Legemiddelrelaterte problemer (LRP) hos pasienter med atrieflimmer, avdekket på en hjerteavdeling
(Master thesis, 2020)Hensikt Hensikten med denne studien var å kartlegge hvilke legemiddelrelaterte problemer (LRP) man avdekker ved legemiddelgjennomgang av pasienter som behandles for atrieflimmer, innlagt ved en hjertemedisinsk avdeling. ... -
Legers erfaringer og vurderinger om hvordan kommunikasjon påvirker pasienters etterlevelse av legemiddelbruk
(Master thesis, 2019)Bakgrunn: Feilbruk av legemidler kan gi unødvendige bivirkninger, nedsatt livskvalitet og dødsfall. WHO rapporterte at 30-50 % av legemidler brukt ved kroniske sykdommer ikke tas som anbefalt. Å ha flere forskrivere har ... -
Legers påvirkning på pasienters etterlevelse av legemiddelbehandling - En spørreundersøkelse
(Master thesis, 2019)Bakgrunn: Lav etterlevelse av legemiddelbehandling er en stor utfordring og det kan føre til store utgifter for samfunnet ved at pasienter ikke opplever bedring av sin sykdomstilstand. Videre kan det føre til økt morbiditet ... -
Legumain is upregulated in acute cardiovascular events and associated with improved outcome – potentially related to anti-inflammatory effects on macrophages
(Peer reviewed; Journal article, 2019)Background and aims We have previously found increased levels of the cysteine protease legumain in plasma and plaques from patients with carotid atherosclerosis. This study further investigated legumain during acute ... -
Lenalidomide versus lenalidomide + dexamethasone prolonged treatment after second-line lenalidomide + dexamethasone induction in multiple myeloma
(Journal article; Peer reviewed, 2018)Lenalidomide (Len) plus dexamethasone (Dex) is approved for the treatment of relapsed or refractory multiple myeloma (RRMM). It is possible that single‐agent Len may be effective as prolonged treatment regimen in RRMM once ... -
Levator ani muscle injury and risk for urinary and fecal incontinence in parous women from a normal population, a cross-sectional study
(Journal article; Peer reviewed, 2019)Aims To study possible associations between levator ani muscle (LAM) injury and urinary incontinence (UI) and fecal incontinence (FI) and possible associations between bladder neck descent (BND), urethral funneling, and ... -
Levator ani muscle morphology and function in women with obstetric anal sphincter injury
(Peer reviewed; Journal article, 2019)Objectives To estimate the prevalence of, and explore the risk factors for, levator ani muscle (LAM) injury in women with clinically diagnosed obstetric anal sphincter injury (OASI). The secondary aim was to assess the ... -
Life after adolescent and adult moderate and severe traumatic brain injury: self-reported executive, emotional, and behavioural function 2-5 years after injury
(Peer reviewed; Journal article, 2015)Survivors of moderate-severe Traumatic Brain Injury (TBI) are at risk for long-term cognitive, emotional, and behaviouralproblems. This prospective cohort study investigated self-reported executive, emotional, and behavioural ... -
Lifestyle behavior among lymphoma survivors after high-dose therapy with autologous hematopoietic stem cell transplantation, assessed by patient-reported outcomes
(Journal article; Peer reviewed, 2019)Introduction: High-dose therapy with autologous stem cell transplantation (HD-ASCT) is associated with an increased risk of late effects. Our aim was to assess lifestyle behavior and factors associated with unhealthy ... -
Lifestyle modification for weight loss: Effects on cardiorespiratory capacity in patients with class II and class III obesity
(Journal article; Peer reviewed, 2021)Background: The prevalence of obesity has increased worldwide. Obesity affectsthe lungs and airways, limits peak oxygen uptake, and hampers physical perfor-mance; however, objective data are scarce. Does lifestyle modification ... -
Limited effect of red blood cell transfusion on long-term mortality among anaemic cardiac surgery patients
(Peer reviewed; Journal article, 2020)OBJECTIVES Our goal was to investigate long-term mortality associated with red blood cell (RBC) transfusion among patients with anaemia undergoing cardiac surgery when adjusting for known risk factors. METHODS Adults with ... -
Limited microstructural and connectivity deficits despite subcortical volume reductions in school-aged children born preterm with very low birth weight.
(Journal article; Peer reviewed, 2015)Preterm birth and very low birth weight (VLBW, ≤ 1500 g) are worldwide problems that burden survivors with lifelong cognitive, psychological, and physical challenges. In this multimodal structural magnetic resonance imaging ... -
Linguistic and content validation of the translated and culturally adapted PG-SGA, as perceived by Norwegian cancer patients and healthcare professionals
(Peer reviewed; Journal article, 2020)Background & aims The Scored Patient-Generated Subjective Global Assessment (PG-SGA©) is a validated nutritional screening, assessment, monitoring, and triage tool. When translated to other languages, the questions and ...