• Liposomes - Human phagocytes interplay in whole blood: effect of liposome design 

      Giambelluca, Miriam Soledad; Markova, Elena; Louet, Claire; Steinkjer, Bjørg; Sundset, Rune; Skalko Basnet, Natasa; Hak, Sjoerd (Journal article; Peer reviewed, 2023)
      Nanomedicine holds immense potential for therapeutic manipulation of phagocytic immune cells. However, in vitro studies often fail to accurately translate to the complex in vivo environment. To address this gap, we employed ...
    • Liquid Biopsies in Solid Cancers: Implementation in a Nordic Healthcare System 

      Nordgård, Oddmund; Forthun, Rakel Brendsdal; Lapin, Morten; Grønberg, Bjørn Henning; Kalland, Karl Henning; Kopperud, Reidun Kristin; Thomsen, Liv Cecilie Vestrheim; Tjensvoll, Kjersti; Gilje, Bjørnar; Gjertsen, Bjørn Tore; Hovland, Randi (Peer reviewed; Journal article, 2021)
      Liquid biopsies have emerged as a potential new diagnostic tool, providing detailed information relevant for characterization and treatment of solid cancers. We here present an overview of current evidence supporting the ...
    • Liquid Biopsy in Organ Damage: small extracellular vesicle chip-based assessment of polytrauma 

      Wang, Bingduo; Wöhler, Aliona; Greven, Johannes; Salzmann, Rebekka J. S.; Keller, Cindy M.; Tertel, Tobias; Zhao, Qun; Mert, Ümit; Horst, Klemens; Lupu, Ludmila; Huber-Lang, Markus; van Griensven, Martijn; Mollnes, Tom Erik; Schaaf, Sebastian; Schwab, Robert; Strassburg, Christian P.; Schmidt-Wolf, Ingo G. H.; Giebel, Bernd; Hildebrand, Frank; Lukacs-Kornek, Veronika; Willms, Arnulf G.; Kornek, Miroslaw T. (Journal article; Peer reviewed, 2023)
      Background Despite major advances in medicine, blood-borne biomarkers are urgently needed to support decision-making, including polytrauma. Here, we assessed serum-derived extracellular vesicles (EVs) as potential markers ...
    • Live born recipient of twin-twin transfusion syndrome with anomalous mitral arcade 

      Ødegård, Siv Steinsmo; Kahrs, Birgitte Heiberg; Lang, Astri Maria; Nyrnes, Siri Ann (Peer reviewed; Journal article, 2019)
      We present a case report of anomalous mitral arcade in a live born former recipient of twin-twin transfusion syndrome. At 33+0 week of gestation fetal ultrasound demonstrated that she had a large mitral insufficiency, ...
    • Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile 

      Huang, Kai-Wen; Reebye, Vikash; Czysz, Katherine; Ciriello, Simona; Dorman, Stephanie; Reccia, Isabella; Lai, Hong-Shiee; Peng, Ling; Kostomitsopoulos, Nikos; Nicholls, Joanna; Habib, Robert; Tomalia, Donald A.; Sætrom, Pål; Wilkes, Edmund; Cutillas, Pedro; Rossi, John; Habib, Nagy (Peer reviewed; Journal article, 2020)
      Non-alcoholic fatty liver disease (NAFLD) culminates in insulin resistance and metabolic syndrome. Because there are no approved pharmacological treatment agents for non-alcoholic steatohepatitis (NASH) and NAFLD, different ...
    • LncRNA MORT (ZNF667-AS1) in Cancer—Is There a Possible Role in Gynecological Malignancies? 

      Di Fiore, Riccardo; Suleiman, Sherif; Drago-Ferrante, Rosa; Félix, Ana; O’Toole, Sharon A.; O’Leary, John J.; Ward, Mark P.; Beirne, James; Yordanov, Angel; Vasileva-Slaveva, Mariela; Subbannayya, Yashwanth; Pentimalli, Francesca; Giordano, Antonio; Calleja-Agius, Jean (Peer reviewed; Journal article, 2021)
      Gynecological cancers (GCs) are currently among the major threats to female health. Moreover, there are different histologic subtypes of these cancers, which are defined as ‘rare’ due to an annual incidence of <6 per 100,000 ...
    • Local Postoperative Graft Inflammation in Pancreas Transplant Patients With Early Graft Thrombosis 

      Rydenfelt, Kristina Elisabeth; Kjøsen, Gisle; Horneland, Rune; Ludviksen, Judith K; Jenssen, Trond; Line, Pål Dag; Tønnessen, Tor Inge; Mollnes, Tom Eirik; Haugaa, Håkon; Pischke, Soeren (Peer reviewed; Journal article, 2023)
      Background. Graft thrombosis is the main cause of early graft loss following pancreas transplantation, and is more frequent in pancreas transplant alone (PTA) compared with simultaneous pancreas-kidney (SPK) recipients. ...
    • Localization of NG2 immunoreactive neuroglia cells in the rat locus coeruleus and their plasticity in response to stress 

      Seifi, M; Corteen, NL; Van der Want, Johannes; Metzger, F; Swinny, JD (Journal article; Peer reviewed, 2014)
      The locus coeruleus (LC) nucleus modulates adaptive behavioral responses to stress and dysregulation of LC neuronal activity is implicated in stress-induced mental illnesses. The LC is composed primarily of noradrenergic ...
    • The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans 

      Agarwal, Shiuli; Vierbuchen, Tim; Ghosh, Sreya; Chan, Jennie; Jiang, Zhaozhao; Kandasamy, Richard Kumaran; Ricci, Emiliano; Fitzgerald, Katherine A. (Peer reviewed; Journal article, 2020)
      Long non-coding RNAs are important regulators of biological processes including immune responses. The immunoregulatory functions of lncRNAs have been revealed primarily in murine models with limited understanding of lncRNAs ...
    • Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial 

      Vaidya, Jayant S; Bulsara, Max; Baum, Michael; Wenz, Frederik; Massarut, Samuele; Pigorsch, Steffi; Alvarado, Michael; Douek, Michael; Saunders, Christobel; Flyger, Henrik; Eiermann, Wolfgang; Brew-Graves, Chris; Williams, Norman R; Potyka, Ingrid; Roberts, Nicholas; Bernstein, Marcelle; Brown, Douglas; Sperk, Elena; Laws, Siobhan; Sütterlin, Marc; Corica, Tammy; Lundgren, Steinar; Holmes, Dennis; Vinante, Lorenzo; Bozza, Fernando; Pazos, Montserrat; Le Blanc-Onfroy, Magali; Gruber, Günther; Polkowski, Wojciech; Dedes, Konstantin J; Niewald, Marcus; Blohmer, Jens; McCready, David; Hoefer, Richard; Kelemen, Pond; Petralia, Gloria; Falzon, Mary; Joseph, David J; Tobias, Jeffrey S (Journal article; Peer reviewed, 2020)
    • Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial 

      Vaidya, Jayant S; Bulsara, Max; Baum, Michael; Wenz, Frederik; Massarut, Samuele; Pigorsch, Steffi; Alvarado, Michael; Douek, Michael; Saunders, Christobel; Flyger, Henrik; Eiermann, Wolfgang; Brew-Graves, Chris; Williams, Norman R; Potyka, Ingrid; Roberts, Nicholas; Bernstein, Marcelle; Brown, Douglas; Sperk, Elena; Laws, Siobhan; Sütterlin, Marc; Corica, Tammy; Lundgren, Steinar; Holmes, Dennis; Vinante, Lorenzo; Bozza, Fernando; Pazos, Montserrat; Le Blanc-Onfroy, Magali; Gruber, Günther; Polkowski, Wojciech; Dedes, Konstantin J; Niewald, Marcus; Blohmer, Jens; McCready, David; Hoefer, Richard; Kelemen, Pond; Petralia, Gloria; Falzon, Mary; Joseph, David J; Tobias, Jeffrey S (Peer reviewed; Journal article, 2020)
      Objective To determine whether risk adapted intraoperative radiotherapy, delivered as a single dose during lumpectomy, can effectively replace postoperative whole breast external beam radiotherapy for early breast ...
    • Long term trends of breast cancer incidence according to proliferation status 

      Klæstad, Elise; Opdahl, Signe; Raj, Sunil Xavier; Valla, Marit; Bofin, Anna M. (Peer reviewed; Journal article, 2022)
      Background Long-term breast cancer incidence trends according to proliferation status are poorly described. We studied time-trends in breast cancer incidence, using mitotic count and Ki-67 as markers of proliferation. ...
    • Long-term consequences of prematurity: Motor skills, mental health, health-related quality of life and white matter microstructure in young adults born preterm with very low birth weight 

      Hollund, Ingrid Marie Husby (Doctoral theses at NTNU;2017:207, Doctoral thesis, 2017)
      LANGTIDSKONSEKVENSER AV FOR TIDLIG FØDSEL Motoriske ferdigheter, psykisk helse, livskvalitet og integritet av hjernens hvite substans hos unge voksne født for tidlig med veldig lav fødselsvekt Barn som er født for ...
    • Long-Term Exposure to Nanosized TiO2 Triggers Stress Responses and Cell Death Pathways in Pulmonary Epithelial Cells 

      Alswady-Hoff, Mayes; Erdem, Johanna Maria Samulin; Phuyal, Santosh; Knittelfelder, Oskar; Sharma, Animesh; Fonseca, Davi de Miranda; Skare, Øivind; Slupphaug, Geir; Zienolddiny, Shanbeh (Peer reviewed; Journal article, 2021)
      There is little in vitro data available on long-term effects of TiO2 exposure. Such data are important for improving the understanding of underlying mechanisms of adverse health effects of TiO2 . Here, we exposed pulmonary ...
    • Long-term follow-up of mental health, health-related quality of life and associations with motor skills in young adults born preterm with very low birth weight 

      Husby, Ingrid Marie; Stray, Kaia; Olsen, Alexander; Lydersen, Stian; Indredavik, Marit Sæbø; Brubakk, Ann-Mari; Skranes, Jon Sverre; Evensen, Kari Anne Indredavik (Journal article; Peer reviewed, 2016)
      Background: Being born with very low birth weight(VLBW:≤1500 g) is related to long-term disability and neurodevelopmental problems, possibly affecting mental health and health-related quality of life (HRQoL). However, ...
    • Long-Term Incidence of Venous Thromboembolism in Cancer: The Scandinavian Thrombosis and Cancer Cohort 

      Gade, Inger Lise; Brækkan, Sigrid Kufaas; Næss, Inger Anne; Hansen, John-Bjarne; Cannegieter, Suzanne C.; Rosendaal, Frits Richard; Overvad, Kim; Hindberg, Kristian; Hammerstrøm, Jens; Gran, Olga Vikhammer; Tjønneland, Anne; Severinsen, Marianne T.; Kristensen, Søren R (Journal article; Peer reviewed, 2018)
      The risk of venous thromboembolism (VTE) in patients who survive the first years after a cancer diagnosis after the acute effects of disease and treatment in comparison to a similar background population has been sparsely ...
    • Long-term motor outcomes of very preterm and/or very low birth weight individuals without cerebral palsy: A review of the current evidence 

      Evensen, Kari Anne Indredavik; Ustad, Tordis; Tikanmäki, Marjaana; Haaramo, Peija; Kajantie, Eero Olavi (Peer reviewed; Journal article, 2020)
      We reviewed literature on long-term motor outcomes of individuals aged five years or older born very preterm (VP: ≤32 weeks of gestation) or with very low birth weight (VLBW: ≤1500g), without cerebral palsy (CP). PubMed ...
    • Long-term outcomes in juvenile idiopathic arthritis: 18 years of follow-up in the population-based Nordic Juvenile Idiopathic Arthritis (JIA) cohort. 

      Glerup, Mia; Rypdal, Veronika Gjertsen; Arnstad, Ellen Dalen; Ekelund, Maria; Peltoniemi, Suvi; Aalto, Kristiina; Rygg, Marite; Toftedal, Peter; Nielsen, Susan; Fasth, Anders; Berntson, Lillemor; Nordal, Ellen Berit; Herlin, Troels (Journal article; Peer reviewed, 2019)
      Objectives This study assessed the long‐term course, remission rate and disease burden in juvenile idiopathic arthritis (JIA) 18 years after disease onset in a population‐based setting from the early biologic era. Methods A ...
    • Long-term outcomes of patients treated with rituximab as second-line treatment for adult immune thrombocytopenia – Follow-up of the RITP study 

      Tjønnfjord, Eirik; Holme, Pål Andre; Darne, Bernadette; Khelif, Abderrahim; Waage, Anders; Michel, Marc; Romdhan, Neila Ben; Ghanima, Waleed Khalid (Peer reviewed; Journal article, 2020)
      RITP was a double‐blind randomized, 78‐week follow‐up trial in which 109 adults with immune thrombocytopenias (ITP) who failed to achieve adequate response to steroids, were randomized to receive rituximab or placebo. Here, ...
    • Long-term results after surgical treatment for severe obesity 

      Sandvik, Jorunn (Doctoral theses at NTNU;2020:199, Doctoral thesis, 2020)
      Ny kunnskap om utvikling av alvorlig fedme har erstattet oppfatningen av at av fedme er en individuell selvforskyldt tilstand med en forståelse av at fedme er en kronisk progressiv sykdom med sammensatte årsaksfaktorer. ...