Browsing Institutt for klinisk og molekylær medisin by Title

Now showing items 1744-1763 of 3430

    • Investigating novel biomarkers of immune activation and modulation in the context of sedentary behaviour: a multicentre prospective ischemic stroke cohort study 

      Alme, Katinka Nordheim; Askim, Torunn; Assmus, Jörg; Mollnes, Tom Eirik; Naik, Mala; Næss, Halvor; Saltvedt, Ingvild; Ueland, Per-Magne; Ulvik, Arve; Knapskog, Anne-Brita (Peer reviewed; Journal article, 2021)
      Background Sedentary behaviour is associated with disease, but the molecular mechanisms are not understood. Valid biomarkers with predictive and explanatory properties are required. Therefore, we have investigated traditional ...

    • Investigating optimal β-cell-preserving treatment in latent autoimmune diabetes in adults: Results from a 21-month randomized trial 

      Hals, Ingrid Kathrin; Fleiner, Hanne Fiskvik; Reimers, Nina; Astor, Marianne; Filipsson, Karin; Ma, Zuheng; Grill, Valdemar Erik Robert; Björklund, Anneli (Peer reviewed; Journal article, 2019)
      Aims To compare outcomes of glucagon‐stimulated C‐peptide tests (GSCTs) in people with latent autoimmune diabetes in adults (LADA) after a 21‐month intervention with either insulin or the dipeptidyl peptidase‐4 inhibitor ...

    • Investigating survival, quality of life and cognition in PROton versus photon therapy for IDH- mutated diffuse grade 2 and 3 GLIOmas (PRO-GLIO): a randomised controlled trial in Norway and Sweden 

      Heggebø, Liv Cathrine; Borgen, Ida Maria Henriksen; Rylander, Hillevi; Kiserud, Cecilie E.; Nordenmark, Tonje Kristin Haug; Hellebust, Taran Annette Paulsen; Evensen, Morten Egeberg; Gustavsson, Magnus; Ramberg, Christina; Sprauten, Mette; Magelssen, Henriette; Blakstad, Hanne; Moorthy, Janani; Andersson, Karin; Raunert, Ingela; Henry, Thomas; Moe, Cecilie; Granlund, Carin; Goplen, Dorota; Brekke, Jorunn; Johannessen, Tor-Christian Aase; Solheim, Tora S; Marienhagen, Kirsten; Humberset, Øyvind; Bergström, Per; Agrup, Måns; Dahl, Ludvig; Gubanski, Michael; Gojon, Helene; Brahme, Carl-Johan; Rydén, Isabelle; Jakola, Asgeir Store; Vik-Mo, Einar O.; Lie, Hanne Cathrine; Asphaug, Lars; Hervani, Maziar; Kristensen, Ingrid; Rüegg, Corina Silvia; Olsen, Inge Christoffer; Ledal, Rolf J; Degsell, Eskil; Werlenius, Katja; Blomstrand, Malin; Brandal, Petter (Peer reviewed; Journal article, 2023)
      Abstract Introduction The use of proton therapy increases globally despite a lack of randomised controlled trials demonstrating its efficacy and safety. Proton therapy enables sparing of non-neoplastic tissue from ...

    • Investigating the causal effect of smoking on hay fever and asthma: A Mendelian randomization meta-analysis in the CARTA consortium 

      Skaaby, Tea; Taylor, Amy E; Jacobsen, Rikke K.; Paternoster, Lavinia; Thuesen, Betina H.; Ahluwalia, Tarunveer S.; Larsen, Sofus C.; Zhou, Ang; Wong, Andrew; Gabrielsen, Maiken Elvestad; Bjørngaard, Johan Håkon; Flexeder, Claudia; Männistö, Satu; Hardy, Rebecca; Kuh, Diana; Barry, Sarah J.; Møllehave, Line Tang; Cerqueira, Charlotte; Friedrich, Nele; Bonten, Tobias N.; Noordam, Raymond; Mook-Kanamori, Dennis O.; Taube, Christian; Jessen, Leon E.; McConnachie, Alex; Sattar, Naveed; Upton, Mark N.; McSharry, Charles; Bønnelykke, Klaus; Bisgaard, Hans; Schulz, Holger; Strauch, Konstantin; Meitinger, Thomas; Peters, Annette; Grallert, Harald; Nohr, Ellen A.; Kivimäki, Mika; Kumari, Meena; Völker, Uwe; Nauck, Matthias; Völzke, Henry; Power, Chris; Hyppönen, Elina; Hansen, Torben; Jørgensen, Torben; Pedersen, Oluf; Salomaa, Veikko; Grarup, Niels; Langhammer, Arnulf; Romundstad, Pål Richard; Skorpen, Frank; Kaprio, Jaakko; Munafò, Marcus R.; Linneberg, Allan (Journal article; Peer reviewed, 2017)
      Observational studies on smoking and risk of hay fever and asthma have shown inconsistent results. However, observational studies may be biased by confounding and reverse causation. Mendelian randomization uses genetic ...

    • Investigating the effect of sex and ketosis on weight-loss-induced changes in appetite 

      Lyngstad, Anna; Nymo, Siren; Coutinho, Silvia; Rehfeld, Jens F.; Truby, Helen; Kulseng, Bård Eirik; Martins, Catia (Peer reviewed; Journal article, 2019)
      Background Diet-induced weight loss (WL) is usually accompanied by increased appetite, a response that seems to be absent when ketogenic diets are used. It remains unknown if sex modulates the appetite suppressant effect ...

    • Investigating the immunomodulatory effects of SARS-CoV-2 proteins ORF3a, ORF6 and ORF9b on the inflammatory response of human lung epithelial cells 

      Margarido Galán, Daniel (Master thesis, 2022)
      The COVID-19 pandemic has taken an unprecedented number of lives and brought incredibly high social costs across the globe. The disease severity is associated with a strong innate immune dysregulation characterised by low ...

    • Investigating the missing data mechanism in quality of life outcomes: a comparison of approaches 

      Fielding, S; Fayers, Peter; Ramsay, CR (Journal article; Peer reviewed, 2009)
      Background: Missing data is classified as missing completely at random (MCAR), missing at random (MAR) or missing not at random (MNAR). Knowing the mechanism is useful in identifying the most appropriate analysis. The ...

    • Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium 

      Taylor, Amy E; Fluharty, Meg; Bjørngaard, Johan Håkon; Gabrielsen, Maiken Elvestad; Skorpen, Frank; Marioni, Riccardo R.; Campbell, A.; Engmann, J; Mirza, Saira Saeed; Loukola, A.; Laatikainen, Tiina; Partonen, Timo; Kaakinen, Marika; Ducci, Francesca; Cavadino, Alana; Husemoen, Lise Lotte N; Ahluwalia, Tarunveer Singh; Jacobsen, Rikke Kart; Skaaby, Tea; Ebstrup, Jeanette Frost; Mortensen, Erik Lykke; Minica, Camelia C; Vink, Jacqueline; Willemsen, Gonneke; Marques-Vidal, Pedro; Dale, Caroline E; Amuzu, Antoinette; Lennon, Lucy; Lahti, J; Palotie, Aarno; Räikkönen, K; Wong, Andrew; Paternoster, Lavinia; Wong, Angelita Pui-Yee; Horwood, L John; Murphy, Michael; Johnstone, Elaine; Kennedy, Martin A; Pausova, Zdenka; Paus, Tomas; Ben-Shlomo, Yoav; Nohr, Ellen A; Kuh, Diana; Kivimaki, Mika; Eriksson, Johan G; Morris, Richard W; Casas, Juan Pablo; Preisig, Martin; Boomsma, Dorret I; Linneberg, Allan; Power, Chris; Hypponen, Elina; Veijola, J; Järvelin, Marjo-Riitta; Korhonen, T.; Tiemeier, H; Kumari, Meena; Porteous, David J.; Hayward, Caroline; Romundstad, Pål Richard; Smith, George Davey; Munafo, Marcus R (Journal article; Peer reviewed, 2014)
      Objectives: To investigate whether associations of smoking with depression and anxiety are likely to be causal, using a Mendelian randomisation approach. Design: Mendelian randomisation meta-analyses using a genetic ...

    • Investigating the Role of PRL-3 and Targeting PHGDH in Multiple Myeloma 

      Elsaadi, Samah (Doctoral theses at NTNU;2020:378, Doctoral thesis, 2020)
      Myelomatose er en hematologisk kreftsykdom som skyldes klonal ekspansjon av plasmaceller som infiltrerer beinmargen. Til tross for fremskritt innen behandlingen av myelomatose, er sykdommen fortsatt uhelbredelig. Artiklene ...

    • Investigation into the cardiovascular effects of the 2nd generation reverse transcriptase inhibitors Rilpivirine and Dapivirine
 

      Bergin, Yvonne. (Master thesis, 2021)
      Humant immunsviktvirus (HIV) er et virus som angriper immunsystemet og uten behandling fører til immunsviktsykdommen, ervervet immunsviktsyndrom (AIDS). Tidligere var behandlingen for denne gruppe pasienter dårlig, men ...

    • Investigation of an outbreak caused by antibiotic susceptible Klebsiella oxytoca in a neonatal intensive care unit in Norway 

      Rønning, Torunn Gresdal; Ås, Christina Gabrielsen; Støen, Ragnhild; Bergh, Kåre; Afset, Jan Egil; Holte, Mari Sagli; Radtke, Andreas (Journal article; Peer reviewed, 2018)
      Abstract Aim Klebsiella spp. have been stated to be the most frequent cause of neonatal intensive care unit (NICU) outbreaks. We report an outbreak of Klebsiella oxytoca in a NICU at a tertiary care hospital in Norway ...

    • Investigation of changes in immunostimulatory properties of clinical Mycobacterium avium strains over time of infection 

      Dietrich, Markus (Master thesis, 2013)

    • Investigation of Pattern Recognition Receptor Expression and Cytokine Responses in CAL-1 and PMDC05 cell lines and human Plasmacytoid Dendritic Cells (pDCs) 

      Lau, Eileen (Master thesis, 2022)
      Abstract will be available on 2027-06-30

    • Investigation of properties and classification of human transcription factors 

      Bahrami, Shahram (Doctoral theses at NTNU;2016:243, Doctoral thesis, 2016)
      Studier av egenskaper og klassifisering av humane transkripsjonsfaktorer Egenskaper og funksjonen av ulike celler bestemmes gjennom regulering av genuttrykket, og en rekke ulike mekanismer er aktive i den enkelte ...

    • Investigation of single cells in tumor tissue and microRNAs in serum of colorectal cancer patients 

      Kjemperud, Hanna Sofie (Master thesis, 2022)
      Kolorektal kreft er en sykdom som påvirker nesten 2 millioner mennesker hvert år, og omtrent 20% av pasientene blir diagnostisert ved avanserte kreftstadier hvor behandling har dårlig effekt, som følge av mangel på symptomer ...

    • Investigation of the long-term sustainability of changes in appetite after weight loss 

      Nymo, Siren; Coutinho, Silvia dos Santos Ribeiro F; Vestbostad, I.; Kulseng, Bård Eirik; Martins, Catia; Truby, Helen; Rehfeld, Jens Frederik (Journal article; Peer reviewed, 2018)
      Background/Objective Diet-induced weight loss (WL) leads to a compensatory increase in appetite and changes in the plasma concentration of appetite-regulating hormones are likely to play a role. Whether these changes are ...

    • Investigations of immunogenic, allergenic and adjuvant properties of Cry1Ab protein after intragastric exposure in a food allergy model in mice 

      Andreassen, Monica; Bøhn, Thomas; Wikmark, Odd-Gunnar; Bodin, Johanna; Traavik, Terje; Løvik, Martinus; Nygaard, Unni Cecilie (Journal article; Peer reviewed, 2016-05-04)
      Background: In genetically modified (GM) crops there is a risk that the inserted genes may introduce new allergens and/or adjuvants into the food and feed chain. The MON810 maize, expressing the insecticidal Cry1Ab toxin, ...

    • Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice 

      Yang, Hang; Qi, Haili; Ren, Jingli; Cui, Jing; Li, Zhenfeng; Waldum, Helge; Guanglin, Cui (Journal article; Peer reviewed, 2014)
      Nuclear factor-kappaB (NF-κB)/interleukin (IL-6) pathway links chronic inflammation to colitis associated cancer (CAC). In this study, we examined the dynamic temporal changes of the NF-κB/IL-6 pathway during the procession ...

    • Involvement of the ASC-1 complex in processing of methylated DNA and RNA 

      Rabe, Renana (Doctoral theses at NTNU;2018:83, Doctoral thesis, 2018)
      Den grunnleggende informasjon om organismene ligger lagret i DNA, som er en polymer sammensatt av fire ulike nitrogenbaser bundet til en sukkerfosfat ryggrad. Langs DNA-tråden ligger ulike gener, og baserekkefølgen innen ...

    • Iodine status and iodised salt consumption in portuguese school-aged children: The iogeneration study 

      Leite, Joao Costa; Keating, Elisa; Pestana, Diogo; Fernandes, Virginia Cruz; Maia, Maria Luz; Norberto, Sonia; Pinto, Edgar; Moreira-Rosario, Andre; Sintra, Diana; Moreira, Barbara; Costa, Ana; Silva, Sofia; Costa, Vera; Martins, Ines; Mendes, Francisca Castro; Queiros, Pedro; Peixoto, Bruno; Caldas, Jose Carlos; Guerra, Antonio; Fontoura, Manuel; Leal, Sandra; Moreira, Roxana; Carvalho, Irene Palmares; Lima, Rui Matias; Martins, Catia; Delerue-Matos, Cristina; Almeida, Agostinho; Azevedo, Luís; Calhau, Conceição (Journal article; Peer reviewed, 2017)
      The World Health Organization promotes salt iodisation to control iodine deficiency. In Portugal, the use of iodised salt in school canteens has been mandatory since 2013. The present study aimed to evaluate iodine status ...