Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 1724-1743 av 3426
-
Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells
(Journal article; Peer reviewed, 2021)Interleukin-32 (IL-32) is a nonclassical cytokine expressed in cancers, inflammatory diseases, and infections. Its expression is regulated by two different oxygen sensing systems; HIF1α and cysteamine dioxygenase (ADO), ... -
Intracellular signaling mechanisms in the innate immune response to viral infections
(Doktoravhandlinger ved NTNU, 1503-8181; 2009:120, Doctoral thesis, 2009) -
Intracellular Survival and Immune System Activation Following Viral Scavenging in Murine Liver Sinusoidal Endothelial Cells
(Master thesis, 2021)Lever sinusformede endotelceller (LSEC) er profesjonelle endocytter med en ekstraordinær evne til å fjerne forskjellige avfallsmaterialer som kan være tilstede i blodet. LSECene blir i økende grad anerkjent som sentrale ... -
Intracranial effect of osimertinib in relapsed EGFR-mutated T790M-positive and -negative non-small cell lung cancer patients: results from a phase II study
(Peer reviewed; Journal article, 2021)Introduction Osimertinib is effective for relapsed T790M-positive patients with brain metastases. The high brain permeability suggests that also such patients without T790M could benefit. Therefore, we evaluated the effect ... -
Intraoperative 3D ultrasound-guided resection of diffuse low-grade gliomas: radiological and clinical results
(Peer reviewed; Journal article, 2019)OBJECTIVE Extent of resection (EOR) and residual tumor volume are linked to prognosis in low-grade glioma (LGG) and there are various methods for facilitating safe maximal resection in such patients. In this prospective ... -
Intrapartum ultrasound assessment of cervical dilatation and its value in detecting active labor
(Peer reviewed; Journal article, 2018)Introduction We aimed to examine the agreement between ultrasound and digital vaginal examination in assessing cervical dilatation in an African population and to assess the value of ultrasound in detecting active ... -
Intraperitoneal and subcutaneous glucagon delivery in anaesthetized pigs: effects on circulating glucagon and glucose levels
(Journal article; Peer reviewed, 2020)Glucagon is a pancreatic hormone and increases the blood glucose levels. It may be incorporated in a dual hormone artificial pancreas, a device to automatically and continuously control blood glucose levels of individuals ... -
The intraperitoneal artificial pancreas: glucose sensing and glucagon delivery
(Doctoral theses at NTNU;2020:267, Doctoral thesis, 2020)Norsk sammendrag Diabetes er en gruppe sykdommer som globalt rammer millioner av mennesker. Denne avhandlingen fokuserer på diabetes mellitus type 1 som kjennetegnes av ingen, eller veldig liten, produksjon av insulin. ... -
Intraperitoneal insulin administration - superior choice for an artificial pancreas?
(Doctoral theses at NTNU;2021:334, Doctoral thesis, 2021)The main focus of this thesis is to explore the intraperitoneal (IP) cavity as the location for insulin administration. We hypothesized that IP insulin administration is more physiologic as it mimics endogenous insulin ... -
Intraperitoneal insulin administration in pigs: Effect on circulating insulin and glucose levels
(Peer reviewed; Journal article, 2021)Introduction The effect of intraperitoneal insulin infusion has limited evidence in the literature. Therefore, the aim of the study was to investigate the pharmacokinetics and pharmacodynamics of different intraperitoneal ... -
Intraperitoneal, subcutaneous and intravenous glucagon delivery and subsequent glucose response in rats: A randomized controlled crossover trial
(Journal article; Peer reviewed, 2018)Objective Hypoglycemia is a frequent and potentially dangerous event among patients with diabetes mellitus type 1. Subcutaneous glucagon is an emergency treatment to counteract severe hypoglycemia. The effect of intraperitoneal ... -
Intrauterine blood transfusions at the National Center for Fetal Medicine in Norway, 1988–2007
(Master thesis, 2009) -
Intravenous Iron Treatment in the Prevention of Iron Deficiency and Anaemia After Roux-en-Y Gastric Bypass
(Peer reviewed; Journal article, 2020)Background Iron absorption is disturbed after Roux-en-Y gastric bypass (RYGB) and iron deficiency with or without anaemia affects almost half of all patients. Intravenous iron is an option when per oral iron is insufficient ... -
Invasive lobular breast cancer: The prognostic impact of histopathological grade, E-cadherin and molecular subtypes
(Peer reviewed; Journal article, 2015)Aims The aim of this study was to compare breast cancer specific survival (BCSS) for invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) and, further, to evaluate critically the prognostic value of ... -
Invasive properties of cancer - a treatment target?: In vitro studies in human prostate cancer cell lines
(Doktoravhandlinger ved NTNU, 1503-8181; 2006:215, Doctoral thesis, 2007) -
Investigating a novel function of Ogg1 and Mutyh DNA glycosylases in memory formation
(Master thesis, 2021)Abstract The capacity to form and store new memories is one of the most important cognitive ability that characterizes the human brain. At the same time, is one of the brain faculties most affected by neurodegenerative ... -
Investigating iPSC derived macrophages as a model to study Mtb infection compared to alveolar macrophages, monocyte derived macrophages and THP-1 macrophages
(Master thesis, 2022)Mycobacterium tuberculosis (Mtb) er fortsatt et omfattende folkehelseproblem for en stor del av verdens utviklingsland, og forårsaker mer enn 1,5 millioner dødsfall årlig. Imidlertid forblir mange aspekter av interaksjonene ... -
Investigating novel biomarkers of immune activation and modulation in the context of sedentary behaviour: a multicentre prospective ischemic stroke cohort study
(Peer reviewed; Journal article, 2021)Background Sedentary behaviour is associated with disease, but the molecular mechanisms are not understood. Valid biomarkers with predictive and explanatory properties are required. Therefore, we have investigated traditional ... -
Investigating optimal β-cell-preserving treatment in latent autoimmune diabetes in adults: Results from a 21-month randomized trial
(Peer reviewed; Journal article, 2019)Aims To compare outcomes of glucagon‐stimulated C‐peptide tests (GSCTs) in people with latent autoimmune diabetes in adults (LADA) after a 21‐month intervention with either insulin or the dipeptidyl peptidase‐4 inhibitor ... -
Investigating survival, quality of life and cognition in PROton versus photon therapy for IDH- mutated diffuse grade 2 and 3 GLIOmas (PRO-GLIO): a randomised controlled trial in Norway and Sweden
(Peer reviewed; Journal article, 2023)Abstract Introduction The use of proton therapy increases globally despite a lack of randomised controlled trials demonstrating its efficacy and safety. Proton therapy enables sparing of non-neoplastic tissue from ...