Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 1565-1584 av 3426
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Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice
(Peer reviewed; Journal article, 2022)Increased astrocytic Ca2+ signaling has been shown in Alzheimer’s disease mouse models, but to date no reports have characterized behaviorally induced astrocytic Ca2+ signaling in such mice. Here, we employ an event-based ... -
Impaired HDL function amplifies systemic inflammation in common variable immunodeficiency
(Journal article; Peer reviewed, 2019)Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency, characterized by inadequate antibody responses and recurrent bacterial infections. Paradoxically, a majority of CVID patients ... -
Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability
(Journal article; Peer reviewed, 2017)Mutations in the HECT, UBA and WWE domain-containing 1 (HUWE1) E3 ubiquitin ligase cause neurodevelopmental disorder X-linked intellectual disability (XLID). HUWE1 regulates essential processes such as genome integrity ... -
Impaired skeletal health and neuromuscular function among amphetamine users in clinical treatment
(Journal article; Peer reviewed, 2016)Summary This study examined musculoskeletal health in amphetamine users, compared with healthy age-matched controls. We show that amphetamine users have reduced bone mass at several skeletal sites and attenuated maximal ... -
Impaired verbal learning is associated with larger caudate volumes in early onset schizophrenia spectrum disorders
(Journal article, 2015)Background: Both brain structural abnormalities and neurocognitive impairments are core features of schizophrenia. We have previously reported enlargements in subcortical brain structure volumes and impairment of ... -
Implementation and evaluation of new surgical methods for treatment of abdominal compartment syndrome, open abdomen and entero-atmospheric fistulas: A clinical study
(Doctoral theses at NTNU;2017:118, Doctoral thesis, 2017) -
Implementation of improvement strategies in palliative care: An integrative review
(Journal article; Peer reviewed, 2015)Background The European population is ageing, and as a consequence, an increasing number of patients are in need of palliative care, including those with dementia. Although a growing number of new insights and best ... -
Implementation of transanal minimally invasive surgery (TAMIS) for rectal neoplasms: results from a single centre
(Peer reviewed; Journal article, 2021)Background Local excisions are important in a tailored approach to treatment of rectal neoplasms. In cases of low risk T1 local excision facilitates rectal-preserving treatment. Transanal minimally invasive surgery (TAMIS) ... -
Implementing a Standardized Care Pathway Integrating Oncology, Palliative Care and Community Care in a Rural Region of Mid-Norway
(Peer reviewed; Journal article, 2021)Introduction To improve quality across levels of care, we developed a standardized care pathway (SCP) integrating palliative and oncology services for hospitalized and home-dwelling palliative cancer patients in a rural ... -
Implementing Complementary Approaches to Shape the Mechanism of α-Synuclein Oligomerization as a Model of Amyloid Aggregation
(Peer reviewed; Journal article, 2021)The aggregation of proteins into amyloid fibers is linked to more than forty still incurable cellular and neurodegenerative diseases such as Parkinson’s disease (PD), multiple system atrophy, Alzheimer’s disease and type ... -
Implementing the European Renal Best Practice Guidelines suggests that prediction equations work well to differentiate risk of end-stage renal disease vs. death in older patients with low estimated glomerular filtration rate
(Journal article; Peer reviewed, 2019)Recent European guidelines suggest using the kidney failure risk equation (KFRE) and mortality risk equation for kidney disease (MREK) to guide decisions on whether elderly patients with chronic kidney disease should be ... -
Improved benchmarks for computational motif discovery
(Journal article; Peer reviewed, 2007-06-08)Background An important step in annotation of sequenced genomes is the identification of transcription factor binding sites. More than a hundred different computational methods have been proposed, and it is difficult ... -
Improved determination of genomic uracil content by high performance liquid chromatography-tandem mass spectrometry
(Master thesis, 2011)Uracil, a nitrogen base usually found in RNA, may be found in small quantities in genomic DNA. Genomic uracil may arise as a result of deamination of cytosine or misincorporation of deoxyuridine monophosphate (dUMP) instead ... -
Improved prognosis in Norwegian patients with glomerulonephritis associated with anti-neutrophil cytoplasmic antibodies
(Peer reviewed; Journal article, 2014)Background: Glomerulonephritis associated with anti-neutrophil cytoplasmic antibodies (ANCA) is associated with increased mortality and a high risk of end-stage renal disease (ESRD). Here, we investigated whether the ... -
Improved ultrasound imaging ofthe fetus and its consequences forsevere and less severe anomalies
(Doktoravhandlinger ved NTNU, Det Medisisnke Fakultet, 15033465; 2008:322, Doctoral thesis, 2008) -
Improvement in Psoriasis Area and Severity Index Score predicts improvement in skin pain over time in patients with psoriasis
(Journal article; Peer reviewed, 2013)Pain and discomfort are common and often severe skin symptoms in patients with psoriasis. However, no studies have investigated skin pain and discomfort over time, or factors that explain changes in these symptoms. The ... -
Improving assessment quality in professional higher education: Could external peer review be the answer?
(Journal article; Peer reviewed, 2019)Summative assessment in professional higher education is important for student learning and making sound decisions about advancement and certification. Despite rigorous pre-test quality assurance procedures, problematic ... -
Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
(Peer reviewed; Journal article, 2022)Background Matching treatment based on tumour molecular characteristics has revolutionized the treatment of some cancers and has given hope to many patients. Although personalized cancer care is an old concept, renewed ... -
Improving reproductive function in women with polycystic ovary syndrome with high-intensity interval training (IMPROV-IT): study protocol for a two-centre, three-armed randomised controlled trial.
(Journal article; Peer reviewed, 2020)Introduction Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age and the leading cause of anovulatory infertility. Women with PCOS have a 15-fold higher prevalence of infertility, ... -
Improving the organization of palliative care: identification of barriers and facilitators in five European countries
(Journal article; Peer reviewed, 2014)Background Interventions to improve palliative care encounter challenges beyond the usual implementation problems because of palliative care’s complex and changing character. In this study, we explored barriers and ...