Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 1001-1020 of 3426
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Elucidating the gene encoding the R3 surface protein in Streptococcus agalactiae
(Master thesis, 2020)Introduction: S. agalactiae, Lancefield’s group B Streptococcus (GBS), occurs as part of the normal microbial flora of the gastrointestinal and genital tract and can cause critical invasive disease in neonates, including ... -
Elucidating the role of early infections in the etiology of cerebral palsy and other neurodevelopmental disorders
(Doctoral theses at NTNU;2022:381, Doctoral thesis, 2022) -
emba: R package for analysis and visualization of biomarkers in boolean model ensembles
(Journal article; Peer reviewed, 2020) -
Emergency Palliative Cancer Care: Dexmedetomidine Treatment Experiences—A Retrospective Brief Report on Nine Consecutive Cases
(Peer reviewed; Journal article, 2023)Introduction Dexmedetomidine, an alpha-2 adrenergic receptor agonist with potential opioid sparing properties, is utilized in palliative medicine, but the knowledge base for this practice is limited. We describe concomitant ... -
EMT-derived alterations in glutamine metabolism sensitize mesenchymal breast cells to mTOR inhibition
(Peer reviewed; Journal article, 2021)Epithelial-to-mesenchymal transition (EMT) is a fundamental developmental process with strong implications in cancer progression. Understanding the metabolic alterations associated with EMT may open new avenues of treatment ... -
En bloc radical cystectomy: An overview of the technique and oncological results
(Journal article; Peer reviewed, 2022)Objectives To reduce recurrence after radical cystectomy (RC), we developed a technique based on the principles of the circumferential resection margin used during total mesorectal excision for rectal cancer, namely, en ... -
En gutt i tidlig skolealder med smerter i foten
(Peer reviewed; Journal article, 2022)En tidligere frisk gutt søkte helsehjelp flere ganger på grunn av smerter i kne, ankel og fot. Kliniske undersøkelser og supplerende diagnostikk var uten alarmerende funn. Etter fem måneders sykehistorie kom man frem til ... -
En kvinne i 40-årene som brukte vanedannende legemidler i svært høye doser
(Peer reviewed; Journal article, 2020)En kvinne i 40-årene fikk forskrevet opioider i forbindelse med et operativt inngrep. Forskrivningen eskalerte i etterkant til enorme doser som viste seg å skape utfordringer i det videre behandlingsforløpet. -
Enantiomeric separation and quantification of citalopram in serum by ultra-high performance supercritical fluid chromatography-tandem mass spectrometry
(Journal article; Peer reviewed, 2017)A method for enantiomeric separation and quantification of R/S-citalopram in serum was developed and validated using ultra-high performance supercritical fluid chromatography-tandem mass spectrometry (UHPSFC-MS/MS). Sample ... -
Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity
(Journal article; Peer reviewed, 2006)Immune responses are initiated when molecules of microbial origin are sensed by the Toll‐like receptors (TLRs). We now report the identification of essential molecular components for the trafficking of the lipopolysaccharide ... -
Endogenous ligands secreted by multiple myeloma cell lines activate TLRs 7, 8, and 9
(Master thesis, 2020) -
Endometrial cancer: diagnostic accuracy of preoperative imaging and oncologic outcome and treatment complications after implementation of a sentinel lymph node algorithm
(Doctoral theses at NTNU;2023:345, Doctoral thesis, 2023)SAMMENDRAG PÅ NORSK Livmorkreft er den vanligste gynekologiske kreftformen i den vestlige verden, og i Norge rammes drøyt 800 kvinner hvert år. Omtrent 80 % av pasientene diagnostiseres på et tidlig stadium med god prognose. ... -
Endonuclease v regulates atherosclerosis through c-c motif chemokine ligand 2-mediated monocyte infiltration
(Journal article; Peer reviewed, 2021)Background In cardiovascular diseases, atherosclerotic disorder are the most frequent and important with respect to morbidity and mortality. Inflammation mediated by immune cells is central in all parts of the atherosclerotic ... -
Endotoxin removal in septic shock with the Alteco LPS Adsorber was safe but showed no benefit compared to placebo in the double-blind randomized controlled trial - the Asset Study
(Peer reviewed; Journal article, 2020)Purpose: Lipopolysaccharides (LPS) are presumed to contribute to the inflammatory response in sepsis. We investigated if extracorporeal Alteco LPS Adsorber for LPS removal in early gram-negative septic shock was feasible ... -
Endpoints in clinical trials in cancer cachexia: where to start?
(Journal article; Peer reviewed, 2018)Purpose of review The lack of agreement and knowledge of optimal endpoints in cachexia trials have impeded progress in finding interventions counteracting the devastating effects cancer cachexia has on morbidity and ... -
Endringer i bruk av antiepileptika i Skandinavia og Norge (2006-2017/18) med fokus på barn og unge
(Master thesis, 2020)Bakgrunn: I dag finnes det om lag 27 ulike antiepileptika under ATC-koden N03A på markedet i Skandinavia. Bruk av disse hos barn og unge er lite undersøkt. Skandinaviske reseptregistre kan brukes til å kartlegge legemiddelbruk ... -
Energimetabolisme i skjelettmuskelceller fra smertepasienter : myokiner, smerteopplevelse og effekt av trimetylamin N-oksid
(Master thesis, 2016)Background: Dysfunctional energy metabolism in skeletal muscle is associated with obesity, metabolic syndrome, type 2 diabetes (T2DM) and cardiovascular diseases (CVD). Detrimental changes in energy metabolism are result ... -
Enhanced efficacy of bleomycin in bladder cancer cells by photochemical internalization
(Journal article; Peer reviewed, 2014)Bleomycin is a cytotoxic chemotherapeutic agent widely used in cancer treatment. However, its efficacy in different cancers is low, possibly due to limited cellular internalization. In this study, a novel approach known ... -
Enhanced expression of CXCL10 in inflammatory bowel disease: Potential role of mucosal toll-like 3 receptor stimulation
(Journal article, 2013)We explored the gene expression in colonic biopsies of active and inactive inflammatory bowel disease (IBD), in an extensive material of ulcerative colitis (UC) and Crohn`s disease (CD). The chemokine CXCL10 and its receptor ... -
Enhanced identification of significant regulators of gene expression
(Peer reviewed; Journal article, 2020)Background Diseases like cancer will lead to changes in gene expression, and it is relevant to identify key regulatory genes that can be linked directly to these changes. This can be done by computing a Regulatory Impact ...