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Endpoints in clinical trials in cancer cachexia: where to start?

Balstad, Trude Rakel; Solheim, Tora Skeidsvoll; Laird, Barry J. A.
Journal article, Peer reviewed
Accepted version
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Laird (553.8Kb)
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http://hdl.handle.net/11250/2609317
Utgivelsesdato
2018
Metadata
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  • Institutt for klinisk og molekylær medisin [2067]
  • Publikasjoner fra CRIStin - NTNU [20842]
  • Publikasjoner fra Cristin - St. Olavs hospital [365]
  • St. Olavs hospital [620]
Originalversjon
Current Opinion in Supportive and Palliative Care. 2018, 12 (4), 445-452.   10.1097/SPC.0000000000000387
Sammendrag
Purpose of review The lack of agreement and knowledge of optimal endpoints in cachexia trials have impeded progress in finding interventions counteracting the devastating effects cancer cachexia has on morbidity and mortality. An endpoint should both be sensitive enough to detect change and specific enough not to be influenced by other conditions or treatments.

Recent findings There is a wealth of potential and applied endpoints in trials investigating cachexia. As of today, there is no generally acknowledged consensus, but assessments of key factors such as body composition should continue to be applied. However, the impact and effect size necessary to achieve clinical benefit using these endpoints are not clear. Further, the use of other endpoints assessing physical function, symptom evaluation and quality of life remains to be elucidated.

Summary It is essential that endpoints are clinically relevant and further research is therefore needed to develop endpoints that are meaningful for patients with cachexia.
Utgiver
Lippincott, Williams & Wilkins
Tidsskrift
Current Opinion in Supportive and Palliative Care

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