Blar i Institutt for klinisk og molekylær medisin på tittel

Viser treff 54-73 av 3434

    • A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair 

      Brickner, Joshua R; Soll, Jennifer M; Lombardi, Patrick M; Vågbø, Cathrine Broberg; Mudge, Miranda C; Oyeniran, Clement; Rabe, Renana; Jackson, Jessica; Sullender, Meagan E; Blazosky, Elyse; Byrum, Andrea K; Zhao, Yu; Corbett, Mark A.; Gècz, Jozef; Field, Michael; Vindigni, Alessandro; Slupphaug, Geir; Wolberger, Cynthia; Mosammaparast, Nima (Journal article; Peer reviewed, 2017)
      DNA repair is essential to prevent the cytotoxic or mutagenic effects of various types of DNA lesions, which are sensed by distinct pathways to recruit repair factors specific to the damage type. Although biochemical ...

    • A Validated Clinical Risk Prediction Model for Lung Cancer in Smokers of All Ages and Exposure Types: A HUNT Study 

      Markaki, Maria Dorothea Haaberg; Tsamardinos, Ioannis; Langhammer, Arnulf; Lagani, Vincenzo; Hveem, Kristian; Røe, Oluf Dimitri (Journal article; Peer reviewed, 2018)
      Lung cancer causes >1·6 million deaths annually, with early diagnosis being paramount to effective treatment. Here we present a validated risk assessment model for lung cancer screening. The prospective HUNT2 population ...

    • abc4pwm: affinity based clustering for position weight matrices in applications of DNA sequence analysis 

      Ali, Omer; Farooq, Amna; Yang, Mingyi; Jin, Victor X.; Bjørås, Magnar; Wang, Junbai (Peer reviewed; Journal article, 2022)
      Background Transcription factor (TF) binding motifs are identified by high throughput sequencing technologies as means to capture Protein-DNA interactions. These motifs are often represented by consensus sequences in form ...

    • Abdominal adipose tissue and liver fat imaging in very low birth weight adults born preterm: birth cohort with sibling-controls 

      Kuula, Juho; Lundbom, Jesper; Hakkarainen, Antti; Hovi, Petteri; Hauta-alus, Helena; Kaseva, Nina; Sandboge, Samuel; Björkqvist, Johan; Eriksson, Johan; Pietiläinen, Kirsi H.; Lundbom, Nina; Kajantie, Eero Olavi (Peer reviewed; Journal article, 2022)
      Preterm birth at very low birth weight (VLBW, < 1500 g) is associated with an accumulation of cardiovascular and metabolic risk factors from childhood at least to middle age. Small-scale studies suggest that this could ...

    • Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction 

      Louwe, Maria Cornelia; Olsen, Maria Belland; Kaasbøll, Ole Jørgen; Yang, Kuan; Fosshaug, Linn Elisabeth Lillerud; Alfsnes, Katrine; Øgaard, Jonas; Rashidi, Azita; Skulberg, Vidar Magne; Yang, Mingyi; Fonseca, Davi de Miranda; Sharma, Animesh; Aronsen, Jan Magnus; Schrumpf, Elisabeth; Ahmed, Muhammad Shakil; Dahl, Christen Peder; Nyman, Tuula Anneli; Ueland, Thor; Melum, Espen; Halvorsen, Bente; Bjørås, Magnar; Attramadal, Håvard; Sjaastad, Ivar; Aukrust, Pål; Yndestad, Arne (Peer reviewed; Journal article, 2020)
      An inflammatory response is required for tissue healing after a myocardial infarction (MI), but the process must be balanced to prevent maladaptive remodeling. This study shows that improved survival and cardiac function ...

    • Absorption and pharmacokinetics of bupivacaine after bilateral topical administration in tonsillar fossae for posttonsillectomy pain relief 

      Berg, Kristin Sandal; Seines, Ellisiv; Gál, Peter; Løberg-Emanuelsen, Lise; Stubhaug, Audun; Nielsen, Erik Waage; Spigset, Olav (Journal article; Peer reviewed, 2024)
      No previous studies have investigated the systemic absorption of bupivacaine when used topically for posttonsillectomy pain. The present study was undertaken to investigate the pharmacokinetics of bupivacaine after ...

    • Academic detailing as a method of continuing medical education 

      Dyrkorn, Roar; Langaas, Harald Chr.; Giverhaug, Trude; Espnes, Ketil Arne; Rowett, Debra; Spigset, Olav (Journal article; Peer reviewed, 2019)
      Introduction: Academic detailing is an interactive educational outreach to prescribers to present unbiased, non-commercial, evidence-based information, mostly about medications, with the goal of improving patient care. ...

    • Academic detailing as a method to improve general practitioners’ drug prescribing in type 2 diabetes: evaluation of changes in prescribing 

      Langaas, Harald Chr.; Salvesen, Øyvind Olav; Dyrkorn, Roar; Blix, Hege Salvesen; Spigset, Olav (Peer reviewed; Journal article, 2023)
      Objective To investigate the effect of an academic detailing intervention on the utilisation of type 2 diabetes medication among general practitioners. Design We developed an academic detailing campaign based on the ...

    • Actigraphy assessment of motor activity and sleep in patients with alcohol withdrawal syndrome and the effects of intranasal oxytocin 

      Melby, Katrine; Fasmer, Ole Bernt; Henriksen, Tone Elise Gjøtterud; Gråwe, Rolf W.; Aamo, Trond Oskar; Spigset, Olav (Peer reviewed; Journal article, 2020)
      Background and aims The alcohol withdrawal syndrome increases autonomic activation and stress in patients during detoxification, leading to alterations in motor activity and sleep irregularities. Intranasal oxytocin has ...

    • Activating the Cpx response induces tolerance to antisense PNA delivered by an arginine-rich peptide in Escherichia coli 

      Frimodt-Møller, Jakob; Koulouktsis, Andreas; Charbon, Godefroid; Otterlei, Marit; Nielsen, Peter E.; Løbner-Olesen, Anders (Peer reviewed; Journal article, 2021)
      Cell-penetrating peptides (CPPs) are increasingly used for cellular drug delivery in both pro- and eukaryotic cells, and oligoarginines have attracted special attention. How arginine-rich CPPs translocate across the cell ...

    • Activation of multiple stress responses in Staphylococcus aureus substantially lowers the minimal inhibitory concentration when combining two novel antibiotic drug candidates 

      Singleton, Amanda Holstad; Bergum, Olaug Elisabeth Torheim; Søgaard, Caroline Krogh; Røst, Lisa M.; Olsen, Cecilie Elisabeth; Blindheim, Fredrik Heen; Ræder, Synnøve Brandt; Bjørnstad, Frithjof Andreas; Sundby, Eirik; Hoff, Bård Helge; Bruheim, Per; Otterlei, Marit (Peer reviewed; Journal article, 2023)
      The past few decades have been plagued by an increasing number of infections caused by antibiotic resistant bacteria. To mitigate the rise in untreatable infections, we need new antibiotics with novel targets and drug ...

    • Active components of commonly prescribed medicines affect influenza a virus–host cell interaction: A pilot study 

      Ianevski, Aleksandr; Yao, Rouan; Zusinaite, Eva; Lysvand, Hilde; Oksenych, Valentyn; Tenson, Tanel; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2021)
      Background: Every year, millions of people are hospitalized and thousands die from influenza A virus (FLUAV) infection. Most cases of hospitalizations and death occur among the elderly. Many of these elderly patients are ...

    • Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B 

      Olsen, Oddrun Elise; Wader, Karin Fahl; Hella, Hanne; Mylin, Anne K.; Turesson, Ingemar; Nesthus, Ingerid; Waage, Anders; Sundan, Anders; Holien, Toril (Journal article; Peer reviewed, 2015)
      Background: Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue. Serum levels of activin A were found to be elevated ...

    • Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors 

      Olsen, Oddrun Elise; Hella, Hanne; Elsaadi, Samah; Jacobi, Carsten; Martinez-Hackert, Erik; Holien, Toril (Peer reviewed; Journal article, 2020)
      Activins belong to the transforming growth factor (TGF)-β family of multifunctional cytokines and signal via the activin receptors ALK4 or ALK7 to activate the SMAD2/3 pathway. In some cases, activins also signal via the ...

    • Acute and potentially persistent effects of scuba diving on the blood transcriptome of experienced divers 

      Eftedal, Ingrid; Ljubkovic, Marko; Flatberg, Arnar; Jørgensen, Arve; Brubakk, Alf O; Dujic, Zeljko (Journal article; Peer reviewed, 2013)
      During scuba diving, the circulatory system is stressed by an elevated partial pressure of oxygen while the diver is submerged and by decompression-induced gas bubbles on ascent to the surface. This diving-induced stress ...

    • Acute effect of a cod protein hydrolysate on postprandial acylated ghrelin concentration and sensations associated with appetite in healthy subjects: a double-blind crossover trial 

      Dale, Hanna Fjeldheim; Jensen, Caroline; Hausken, Trygve; Lied, Einar; Hatlebakk, Jan Gunnar; Brønstad, Ingeborg; Hoff, Dag Arne Lihaug; Lied, Gülen Arslan (Journal article; Peer reviewed, 2019)
      Background: Fish protein hydrolysates are suggested to contain bioactive sequences capable of affecting metabolic pathways involved in the regulation of glucose metabolism and body weight when consumed in low doses. ...

    • Acute effects of strength and endurance training on bone turnover markers in young adults and elderly men 

      Stunes, Astrid Kamilla; Brobakken, Cathrine Langlie; Sujan, Md Abu Jafar; Aagård, Norun; Brevig, Martin Siksjø; Wang, Eivind; Syversen, Unni; Mosti, Mats Peder (Peer reviewed; Journal article, 2022)
      Context: Exercise is recognized as an important strategy to prevent bone loss, but its acute effects on bone turnover markers (BTMs) and related markers remain uncertain. Objective: To assess the acute effects of two ...

    • Acute flaccid myelitis and Guillain-Barré syndrome in children: A comparative study with evaluation of diagnostic criteria. 

      Helfferich, J; Roodbol, Joyce; de Wit, Marie-Claire; Brouwer, Oebele F; Jacobs, Bart C.; Aberle, Stephan W.; Popow-Kraupp, Theresia; Nikolaeva-Glomb, Lubomira; Rainetova, Petra; Midgley, Sofie; Fischer, Thea Kølsen; Simonlatser, Grethel; Savolainen-Kopra, Carita; Lina, Bruno; Schuffenecker, Isabelle; Aubart, Melodie; Gitiaux, Cyril; Antona, Denise; Eis-Hübinger, Anna Maria; Buderus, Stephan; Panning, Marcus; Nowotny, Markus; Kiechle, Lisa; Böttcher, Sindy; Takas, Maria; Farkas, Agnes; Löve, Arthur; Baldanti, Fausto; Capobianchi, Maria Rosaria; Valli, Maria Beatrice; Esposito, Susanna; Pariani, Elena; Binda, Sandro; Neuteboom, Rinze; Pas, Suzan; Benschop, Kimberley; Meijer, Adam; Nordbø, Svein Arne; Hafström, Maria; Dudman, Susanne Gjeruldsen; Pfeiffer, Helle Cecilie Viekilde; Guiomar, Raquel; Palminha, Paula; Costa, Ines; Dias, Andrea Sofia; Tecu, Cristina; Cherciu, Carmen Maria; Lazarevic, Ivana; Filipovic-Vignjevic, Svetlana; Berginc, Natasa (Peer reviewed; Journal article, 2021)
      Background and purpose Differentiation between acute flaccid myelitis (AFM) and Guillain–Barré syndrome (GBS) can be difficult, particularly in children. Our objective was to improve the diagnostic accuracy by giving ...

    • Acute heart failure following myocardial infarction: complement activation correlates with the severity of heart failure in patients developing cardiogenic shock 

      Orrem, Hilde Lang; Nilsson, Per; Pischke, Søren Erik; Grindheim, Guro; Garred, Peter; Seljeflot, Ingebjørg; Husebye, Trygve Guttorm; Aukrust, Pål; Yndestad, Arne; Andersen, Geir Øystein; Barratt-Due, Andreas; Mollnes, Tom Eirik (Journal article; Peer reviewed, 2018)
      Aims Heart failure (HF) is an impending complication to myocardial infarction. We hypothesized that the degree of complement activation reflects severity of HF following acute myocardial infarction. Methods and ...

    • Adaptive computerized working memory training in patients with mild cognitive impairment. A randomized double-blind active controlled trial 

      Flak, Marianne Møretrø; Hol, Haakon Ramsland; Hernes, Susanne M S; Chang, Linda; Engvig, Andreas; Bjuland, Knut Jørgen; Pripp, Are Hugo; Madsen, Bengt-Ove; Knapskog, Anne Brita; Ulstein, Ingun; Lona, Trine Eli.B.; Skranes, Jon Sverre; Løhaugen, Gro (Journal article; Peer reviewed, 2019)
      Objective: We investigated if a 5-week computerized adaptive working memory training program (Cogmed®) of 20 to 25 sessions would be effective in improving the working memory capacity and other neuropsychological functions ...