Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 2570-2589 of 3436
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Prostate Cancer – Translational Research: Optimizing tissue sampling suitable for histopathologic, transcriptomic and metabolic profiling
(Doktoravhandlinger ved NTNU, 1503-8181; 2012:240, Doctoral thesis, 2012)Prostate cancer (PCa) is the most common cancer in men in Europe and constitutes a substantial health care problem. In 2009, 4299 new cases were diagnosed in Norway and PCa was the second most common cause of death from ... -
Prostate-Specific Membrane Antigen PET/Magnetic Resonance Imaging for the Planning of Salvage Radiotherapy in Patients with Prostate Cancer with Biochemical Recurrence After Radical Prostatectomy
(Journal article; Peer reviewed, 2019)Prostate-specific membrane antigen (PSMA) PET/magnetic resonance (MR) imaging can help distinguish between patients with prostate cancer with locoregional recurrence and those with distant metastases, even at low ... -
Protect us from ourselves: Balancing the parental instinct of saving
(Peer reviewed; Journal article, 2019)Background: Neonatologists, legal experts and ethicists extensively discuss the ethical challenges of decision-making when a child is born at the limit of viability. The voices of parents are less heard in this discussion. ... -
Protein tyrosine phosphatases in multiple myeloma
(Peer reviewed; Journal article, 2020)Many cell signaling pathways are activated or deactivated by protein tyrosine phosphorylation and dephosphorylation, catalyzed by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), respectively. Even ... -
Protein-protein interactions of the nuclear receprot NR4A2
(Master thesis, 2014)The Gastroenterology and Molecular cell biology research group examines biological mechanisms that are important in the development of gastric cancer. The peptide hormone gastrin is known to play a role in organization ... -
Proteogenomic Analysis to Identify Missing Proteins from Haploid Cell Lines
(Journal article, 2018)Chromosome-centric Human Proteome Project aims at identifying and characterizing protein products encoded from all human protein-coding genes. As of early 2017, 19,837 protein-coding genes have been annotated in the neXtProt ... -
Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia
(Peer reviewed; Journal article, 2017)Plasma cell leukemia is a rare and aggressive plasma cell neoplasm that may either originate de novo (primary PCL) or by leukemic transformation of multiple myeloma (MM) to secondary PCL (sPCL). The prognosis of sPCL is ... -
Proteomic analysis reveals mechanisms underlying increased efficacy of bleomycin by photochemical internalization in bladder cancer cells
(Peer reviewed; Journal article, 2023)Photochemical internalization (PCI) is a promising new technology for site-specific drug delivery, developed from photodynamic therapy (PDT). In PCI, light-induced activation of a photosensitizer trapped inside endosomes ... -
Proteomic approaches to improve cancer therapy – Identifying factors contributing to melphalan resistance in multiple myeloma and to PDT mediated cytotoxicity
(Doktoravhandlinger ved NTNU, 1503-8181; 2014:147, Doctoral thesis, 2014) -
The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function
(Peer reviewed; Journal article, 2020)CD4+ T cells (T helper cells) are cytokine-producing adaptive immune cells that activate or regulate the responses of various immune cells. The activation and functional status of CD4+ T cells is important for adequate ... -
Proteomics Analysis of Proteins Involved in DNA Base Repair and Cancer Therapy
(Doktoravhandlinger ved NTNU, 1503-8181; 2012:72, Doctoral thesis, 2012)Proteomikkbasert analyse av proteiner involvert i DNA reparasjon og kreftbehandling DNA reparasjon er grunnleggende for å opprettholdelse levende organismers genom. Forskning i løpet av det siste tiåret har vesentlig økt ... -
Protocol of a randomised, controlled trial comparing immediate curative therapy with conservative treatment in men aged ≥75 years with non-metastatic high-risk prostate cancer (SPCG 19/GRand-P)
(Peer reviewed; Journal article, 2024)Background Older men (aged ≥75 years) with high risk, non-metastatic prostate cancer (PCa) are increasingly treated with curative therapy (surgery or radiotherapy). However, it is unclear if curative therapy prolongs ... -
Proton pump inhibitors and fracture risk. The HUNT study, Norway.
(Journal article; Peer reviewed, 2019)Summary Proton pump inhibitors (PPIs) have been linked to increased risk of fracture; the data have, however, been diverging. We did not find any increased risk of fractures among users of PPIs in a Norwegian population ... -
Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities
(Journal article; Peer reviewed, 2014)The ALKBH family of Fe(II) and 2-oxoglutarate dependent oxygenases comprises enzymes that display sequence homology to AlkB from E. coli, a DNA repair enzyme that uses an oxidative mechanism to dealkylate methyl and etheno ... -
Pseudo-anaphylaxis to polyethylene glycol (PEG)-coated liposomes: Roles of anti-PEG IgM and complement activation in a porcine model of human infusion reactions
(Journal article; Peer reviewed, 2019)Polyethylene glycol (PEG)-coated nanopharmaceuticals can cause mild to severe hypersensitivity reactions (HSRs), which can occasionally be life threatening or even lethal. The phenomenon represents an unsolved immune barrier ... -
Pseudo-T2 mapping for normalization of T2-weighted prostate MRI
(Peer reviewed; Journal article, 2022)Objective Signal intensity normalization is necessary to reduce heterogeneity in T2-weighted (T2W) magnetic resonance imaging (MRI) for quantitative analysis of multicenter data. AutoRef is an automated dual-reference ... -
Psoriasis and associated variables in classification and outcome of juvenile idiopathic arthritis - an eight-year follow-up study
(Journal article; Peer reviewed, 2017)Background To study the impact of psoriasis and features associated with psoriasis on classification and outcome in a population-based follow-up cohort of children with juvenile idiopathic arthritis (JIA). Methods In ... -
Psoriasis pathogenesis – Pso p27 constitutes a compact structure forming large aggregates
(Journal article; Peer reviewed, 2015)Psoriasis is a chronic inflammatory skin disease. The absence of microbial organisms as potential causal agents has given rise to the hypothesis that the inflammation is due to an autoimmune reaction. The defined inflamed ... -
Psychiatric Disorders and General Functioning in Low Birthweight Adults: A Longitudinal Study
(Journal article; Peer reviewed, 2017)OBJECTIVE: To examine psychiatric morbidity and overall functioning in adults born with low birth weight compared with normal birth weight controls at age 26 years and to study longitudinal trajectories of psychiatric ...