Blar i Institutt for klinisk og molekylær medisin på tittel
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TLR9 Trafficking and Signaling
(Master thesis, 2019)Toll-like Receptor 9 (TLR9) is an endosomal receptor found highly expressed in B cells and plasmacytoid dendritic cells (pDCs). It is activated by unmethylated CpG DNA and synthetic CpG oligodeoxyribonucleotides (ODNs) to ... -
Tocilizumab increases citrullinated histone 3 in non-ST segment elevation myocardial infarction
(Peer reviewed; Journal article, 2021)Objective Beyond reducing inflammation and troponin T (TnT) release, the interleukin-6 receptor antagonist tocilizumab reduces neutrophil counts in patients with non-ST segment elevation myocardial infarction (NSTEMI). It ... -
Tofacitinib Downregulates TNF and Poly(I:C)-Dependent MHC-II Expression in the Colonic Epithelium
(Peer reviewed; Journal article, 2022)Major Histocompatibility Complex (MHC)-I and -II genes are upregulated in intestinal epithelial cells (IECs) during active inflammatory bowel diseases (IBD), but little is known about how IBD-relevant pro-inflammatory ... -
Toll-Like Receptor 2 (P631H) Mutant Impairs Membrane Internalization and is a Dominant Negative Allele
(Peer reviewed; Journal article, 2010)We have sequenced 416 Toll‐like receptor‐2 (TLR2) alleles in 208 subjects in a tuberculosis case–control study in Croatian Caucasian population. We found ten single nucleotide polymorphisms (SNP) among which three were ... -
TOLL-LIKE RECEPTOR 2 EXPRESSION, REGULATION AND SIGNALING
(Doktoravhandlinger ved NTNU, 1503-8181; 2008:195, Doctoral thesis, 2008) -
Toll-Like Receptor 3 Signaling in Intestinal Epithelial Cells
(Doctoral thesis at NTNU;2016:77, Doctoral thesis, 2016)Toll-lignende reseptor 3 uttrykk og signalisering i kolonepitelceller: Toll-lignende reseptorer (TLRer) er viktige sensorer i menneskets medfødte immunforsvar og aktiveres av komponenter som representerer fare for verten, ... -
Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages
(Journal article; Peer reviewed, 2017)TLR8 is the major endosomal sensor of degraded RNA in human monocytes and macrophages. It has been implicated in the sensing of viruses and more recently also bacteria. We previously identified a TLR8-IFN regulatory factor ... -
Toll-like receptor profiling of seven trophoblast cell lines warrants caution for translation to primary trophoblasts
(Journal article; Peer reviewed, 2015)Introduction Excessive placental inflammation is associated with pregnancy complications. Toll-like receptors (TLRs) are sensors for danger signals from infections and damaged tissue and initiate inflammation. Trophoblasts ... -
Toll-like receptor-mediated inflammatory responses in keratinocytes
(Doktoravhandlinger ved NTNU, 1503-8181; 2012:232, Doctoral thesis, 2012)Toll-liknende reseptor-mediert inflammasjon i keratinocytter Gjennom arbeidet i denne avhandlingen har vi ønsket å finne mer ut av hvordan hudcellen selv setter i gang reparasjonsmekanismer etter ytre påvirkning, gjennom ... -
Toll-like receptor-mediated regulation of IL-32 in multiple myeloma cells
(Master thesis, 2020)Myelomatose, eller beinmargskreft, skyldes ukontrollert vekst av maligne plasmaceller i beinmargen. Pasienter med myelomatose er spesielt utsatt for infeksjoner, som også er en utbredt dødsårsak hos disse pasientene. ... -
Toll-like receptors and inflammation in pregnancy
(Doctoral thesis at NTNU;2015:263, Doctoral thesis, 2015)Toll-lignende reseptorer og inflammasjon i svangerskapet Et normalt svangerskap kjennetegnes av en mild betennelsestilstand (inflammasjon) som involverer både morkaken og mors blodomløp. Dette er en del av kvinnekroppens ... -
Toll-like receptors in placental tissue from women with and without complication of preeclampsia in pregnancy
(Master thesis, 2014)Human pregnancy is characterized by a mild systemic inflammatory response that is essential for maternal metabolic adaptation and immunological tolerance to the semiallogeneic fetus. Trophoblasts are the placental cells ... -
Toll-like receptors in placental tissue from women with and without complication of preeclampsia in pregnancy
(Master thesis, 2014)Human pregnancy is characterized by a mild systemic inflammatory response that is essential for maternal metabolic adaptation and immunological tolerance to the semiallogeneic fetus. Trophoblasts are the placental cells ... -
A Tool to Ensure Appropriate Drug Use and Maintain Patient Safety When Administering Pro Re Nata Medications: Healthcare Providers’ Experiences With Medicine Lists in Sheltered Housing for Older People
(Chapter, 2022)Residents living in sheltered housing may need assistance with the administration of medications, including medications used as needed. Healthcare providers can then administer medications based on the resident’s medication ... -
Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants
(Peer reviewed; Journal article, 2021)Objectives: More than 40 drugs are available to treat affective disorders. Individual selection of the optimal drug and dose is required to attain the highest possible efficacy and acceptable tolerability for every patient. ... -
Top Ten Tips Palliative Care Clinicians Should Know About Cachexia
(Peer reviewed; Journal article, 2023)Cachexia is a multifactorial syndrome that is common in cancer and chronic disease. It is often underdiagnosed and therefore goes untreated or undertreated. Cachexia causes suffering across biopsychosocial domains and ... -
TOP2A gene copy number change in breast cancer
(Peer reviewed; Journal article, 2014)Aims The clinical significance of TOP2A as a prognostic marker has not been clarified. The aims of this study were to investigate the frequency of TOP2A copy number change; to correlate TOP2A with HER2 status, hormone ... -
Topical moistening of mastectomy wounds with diluted tranexamic acid to reduce bleeding: randomized clinical trial
(Journal article; Peer reviewed, 2019)Background: Topical administration of tranexamic acid (TXA) may be an alternative to intravenous administration to reduce bleeding with a lower risk of systemic adverse events. The aim of this study was to investigate ... -
TopoICSim: A new semantic similarity measure based on gene ontology
(Peer reviewed; Journal article, 2016)Background The Gene Ontology (GO) is a dynamic, controlled vocabulary that describes the cellular function of genes and proteins according to tree major categories: biological process, molecular function and cellular ... -
Topoisomerase IV tracks behind the replication fork and the SeqA complex during DNA replication in Escherichia coli
(Peer reviewed; Journal article, 2021)Topoisomerase IV (TopoIV) is a vital bacterial enzyme which disentangles newly replicated DNA and enables segregation of daughter chromosomes. In bacteria, DNA replication and segregation are concurrent processes. This ...