Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 537-556 of 3438
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Clinical research in end-of-life cancer care Current status, barriers, priorities, and a framework for reporting a sample in clinical trials
(Doctoral thesis at NTNU;2014:355, Doctoral thesis, 2014)Kreft er en av de vanligste dødsårsakene i verden og den globale forekomsten øker. Mange pasienter som dør av kreft, har behov for palliative tiltak, men bare en liten andel av midlene til kreftforskning fordeles til ... -
Clinical Risk Factors Associated With Late-Onset Invasive Group B Streptococcal Disease: Systematic Review and Meta-Analyses
(Peer reviewed; Journal article, 2022)Background Group B streptococcal (GBS) infection remains one of the most significant causes of late-onset sepsis and meningitis (LOGBS) among young infants. However, transmission routes and risk factors for LOGBS are ... -
Clinical Risk Factors For Kidney Tubule Biomarker Abnormalities Among Hypertensive Adults With Reduced eGFR in the SPRINT Trial
(Peer reviewed; Journal article, 2022)BACKGROUND Urine biomarkers of kidney tubule health may distinguish aspects of kidney damage that cannot be captured by current glomerular measures. Associations of clinical risk factors with specific kidney tubule ... -
Clinical Validation of a Size-Based Microfluidic Device for Circulating Tumor Cell Isolation and Analysis in Renal Cell Carcinoma
(Peer reviewed; Journal article, 2023)Renal cell carcinoma (RCC) presents as metastatic disease in one third of cases. Research on circulating tumor cells (CTCs) and liquid biopsies is improving the understanding of RCC biology and metastases formation. However, ... -
Clinical, Pathological, and Molecular Classification of Ovarian Carcinoma
(Doktoravhandlinger ved NTNU, 1503-8181; 2011:26, Doctoral thesis, 2011)Kliniske, patologiske og molekylære studiar av eggstokk-kreft Rundt 450 norske kvinner får diagnosen eggstokk-kreft kvart år. Prognosen er dårleg, med ei fem års overleving på rundt 40 %. Når sjukdomen blir oppdaga i ... -
Clonal evolution after treatment pressure in multiple myeloma: heterogenous genomic aberrations and transcriptomic convergence
(Peer reviewed; Journal article, 2022)We investigated genomic and transcriptomic changes in paired tumor samples of 29 in-house multiple myeloma (MM) patients and 28 patients from the MMRF CoMMpass study before and after treatment. A change in clonal composition ... -
Cluster Headache Genomewide Association Study and Meta-Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor
(Peer reviewed; Journal article, 2023)Objective The objective of this study was to aggregate data for the first genomewide association study meta-analysis of cluster headache, to identify genetic risk variants, and gain biological insights. Methods A ... -
Clustered ChIP-Seq-defined transcription factor binding sites and histone modifications map distinct classes of regulatory elements
(Journal article; Peer reviewed, 2011)Background Transcription factor binding to DNA requires both an appropriate binding element and suitably open chromatin, which together help to define regulatory elements within the genome. Current methods of identifying ... -
ClusTrack: Feature extraction and similarity measures for clustering of genome-wide data sets
(Journal article, 2015)Clustering is a popular technique for explorative analysis of data, as it can reveal subgroupings and similarities between data in an unsupervised manner. While clustering is routinely applied to gene expression data, there ... -
Co-medication among patients diagnosed with Crohn’s disease – an observational health register study.
(Master thesis, 2022)Abstract will be available on 2027-05-31 -
Co-prescription of metoprolol and CYP2D6-inhibiting antidepressants before and after implementation of an optimized drug interaction database in Norway
(Journal article; Peer reviewed, 2022) -
Co-Use of Drugs and Herbal Remedies in General Practice and In Vitro Inhibition of CYP3A4, CYP2D6 and P-Glycoprotein by the Common Herb Aloe Vera.
(Doktoravhandlinger ved NTNU, 1503-8181; 2013:333, Doctoral thesis, 2013)There is a widespread use of complementary and alternative medicine (CAM) and herbal remedies in particular in different patients groups, but very few are published about co-use among patients in general practice (GP) and ... -
Coactivation of TLR2 and TLR8 in Primary Human Monocytes Triggers a Distinct Inflammatory Signaling Response
(Journal article; Peer reviewed, 2018)Innate immune signaling is essential to mount a fast and specific immune response to pathogens. Monocytes and macrophages are essential cells in the early response in their capacity as ubiquitous phagocytic cells. They ... -
Code-Free Development and Deployment of Deep Segmentation Models for Digital Pathology
(Peer reviewed; Journal article, 2022)Application of deep learning on histopathological whole slide images (WSIs) holds promise of improving diagnostic efficiency and reproducibility but is largely dependent on the ability to write computer code or purchase ... -
Coeliac disease in the Trøndelag Health Study (HUNT), Norway, a population-based cohort of coeliac disease patients
(Peer reviewed; Journal article, 2024)Purpose - Coeliac disease (CD) is a common disorder and affects about 1% of the population worldwide. CD in the Trøndelag Health Study (HUNT) is a population-based cohort study which was established to provide new knowledge ... -
Cognitive deficits associated with impaired awareness of hypoglycaemia in type 1 diabetes
(Journal article; Peer reviewed, 2017)Aims/hypothesis The aim of this study was to compare cognitive function in adults with type 1 diabetes who have impaired awareness of hypoglycaemia with those who have normal awareness of hypoglycaemia. A putative ... -
Cognitive function during disease progression in a rat model of Alzheimer’s disease - Effect of a single bout of exhaustive aerobic exercise
(Master thesis, 2018)Alzheimer’s disease (AD), the most prevalent form of dementia, is a devastating neurodegenerative disorder affecting over 35 million people worldwide. As age is the main risk factor for AD, and no current treatment options ... -
Cognitive function in metformin exposed children, born to mothers with PCOS – follow-up of an RCT
(Journal article; Peer reviewed, 2020)Background Metformin is widely used in pregnancy to treat gestational diabetes mellitus and polycystic ovary syndrome (PCOS). Association between PCOS and developmental delay in offspring, and larger head circumference ... -
Cognitive Function, Mental Health, and Quality of Life in Siblings of Preterm Born Children: Protocol for a Systematic Review
(Peer reviewed; Journal article, 2022)Background: Children and adults born preterm are at increased risk of cognitive impairments, mental health disorders, and poorer quality of life. Epidemiological studies have shown that the impact of preterm birth extends ... -
Cognitive impairment in minor Stroke An observational study of the prevalence of cognitive impairment and emotional symptoms and consequences for social functioning and employment
(Doctoral theses at NTNU;2020:320, Doctoral thesis, 2020)Hjerneslag rammer årlig ca 12 000 personer i Norge og er en av de hyppigste årsaker til invaliditet. Data fra Norsk hjerneslagregister viser at 2/3 av pasientene blir selvhjulpne etter et hjerneslag. En betydelig andel av ...