Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 517-536 av 3585
-
Chemical, Physical and Biological Triggers of Evolutionary Sonserved Bcl-xL-Mediated Apoptosis
(Journal article; Peer reviewed, 2020)Background: The evidence that pan-Bcl-2 or Bcl-xL-specific inhibitors prematurely kill virus-infected or RNA/DNA-transfected cells provides rationale for investigating these apoptotic inducers further. We hypothesized that ... -
Chemotherapy for colorectal cancer - Physical exercise and quality of life
(Doctoral theses at NTNU;2024:34, Doctoral thesis, 2024)Colorectal cancer (CRC) is the third most common cancer worldwide, the second most common cancer in Norway, and the second leading cause of cancer deaths both globally and nationally. In Norway, 4745 new cases were diagnosed ... -
Chemotherapy-induced peripheral neuropathy after modern treatment of Hodgkin’s lymphoma; symptom burden and quality of life
(Peer reviewed; Journal article, 2021)Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect of Hodgkin’s lymphoma (HL) treatment. We aimed to describe the prevalence of CIPN associated symptoms in long-term HL survivors ... -
Child Maltreatment: To Report or Not to Report? It’s More Complex than That
(Journal article; Peer reviewed, 2024)Child maltreatment (CM) is a widespread problem, contributing to health and societal difficulties often throughout the lifespan. Healthcare professionals (HCPs) who see potential warning signs for CM are responsible for ... -
Childhood Acute Lymphoblastic Leukemia: Genetic and Epigenetic Analysis of Archived Samples
(Master thesis, 2012)Acute lymphoblastic leukemia (ALL) is recognized as a fast-developing cancer originated from blood-progenitor cells. Blasts cells are immature cells which generate white blood cells (leukocytes), and it is the malignancy ... -
Childhood epilepsy and ADHD comorbidity in an Indian tertiary medical center outpatient population
(Journal article; Peer reviewed, 2018)This study aimed to assess the prevalence of Attention Deficit Hyperactivity Disorder (ADHD) and its characteristics and risk factors in children with epilepsy at a tertiary medical center in New Delhi. Children with active ... -
Children and Adolescents Surviving Cancer: Psychosocial Health, Quality of Life and Social Support
(Doktoravhandlinger ved NTNU, 1503-8181; 2011:278, Doctoral thesis, 2011)Children and Adolescents Surviving Cancer: Psychosocial Health, Quality of Life and Social Support Background: Childhood cancer involves a crisis for the child and their family where they face many challenges to achieve ... -
Children born to women with polycystic ovary syndrome - short- and long-term impacts on health and development
(Journal article; Peer reviewed, 2019)Maternal PCOS status may negatively influence offspring infant and childhood growth, cardiometabolic health, reproductive health, and neurodevelopment. Current findings across studies are divergent, often because of small ... -
Chimeric Anti-CD14 IGG2/4 Hybrid Antibodies for Therapeutic Intervention in Pig and Human Models of Inflammation
(Journal article; Peer reviewed, 2013)CD14 is a key recognition molecule of innate immune responses, interacting with several TLRs. TLR signaling cross-talks extensively with the complement system, and combined CD14 and complement inhibition has been proved ... -
Choice of immunoassay to evaluate porcine cytokine levels
(Peer reviewed; Journal article, 2020)Background In order to adequately monitor cytokines in experimental models, currently available methods and commercially available kits should be compared. Aim To compare the plasma and tissue concentrations of IL-1β, ... -
Cholesterol crystal-induced endothelial cell activation is complement-dependent and mediated by TNF
(Journal article; Peer reviewed, 2014)Cholesterol crystals are known to be a hallmark of atherosclerosis with recent studies demonstrating deposition of these crystals in early fatty streak formation as well as penetrating the intima following plaque rupture. ... -
Cholesterol crystals (CC) in cardiovascular disease (CVD) - exploring their potential impact on monocytes CD14/CD16 and granulocytes CD16 expression
(Master thesis, 2021)Abstract will be available on 2024-06-15 -
Cholesterol crystals activate the lectin complement pathway via ficolin-2 and mannose-binding lectin: Implications for the progression of atherosclerosis
(Journal article, 2016)Cholesterol crystals (CC) play an essential role in the formation of atherosclerotic plaques. CC activate the classical and the alternative complement pathways, but the role of the lectin pathway is unknown. We hypothesized ... -
Cholesterol crystals and NLRP3 mediated inflammation in the uterine wall decidua in normal and preeclamptic pregnancies
(Peer reviewed; Journal article, 2020)Preeclampsia is a hypertensive and inflammatory pregnancy disorder associated with cholesterol accumulation and inflammation at the maternal-fetal interface. Preeclampsia can be complicated with fetal growth restriction ... -
Cholesterol Crystals Induce coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor
(Journal article; Peer reviewed, 2019)Cholesterol crystals (CC) are strong activators of complement and could potentially be involved in thromboinflammation through complement-coagulation cross-talk. To explore the coagulation-inducing potential of CC, we ... -
Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis
(Peer reviewed; Journal article, 2020)Background: During atherogenesis, cholesterol precipitates into cholesterol crystals (CC) in the vessel wall, which trigger plaque inflammation by activating the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) ... -
Cholesterol synthesis pathway genes in prostate cancer are transcriptionally downregulated when tissue confounding is minimized
(Journal article; Peer reviewed, 2018)Background The relationship between cholesterol and prostate cancer has been extensively studied for decades, where high levels of cellular cholesterol are generally associated with cancer progression and less favorable ... -
Chromatin states reveal functional associations for globally defined transcription start sites in four human cell lines
(Journal article; Peer reviewed, 2014)Background Deciphering the most common modes by which chromatin regulates transcription, and how this is related to cellular status and processes is an important task for improving our understanding of human cellular ... -
Chronic diseases: what about infections of virus and prions via the gut?
(Peer reviewed; Journal article, 2021)