Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 3425-3443 of 3443
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Whole-body computed tomography versus conventional skeletal survey in patients with multiple myeloma: A study of the International Myeloma Working Group
(Journal article; Peer reviewed, 2017)For decades, conventional skeletal survey (CSS) has been the standard imaging technique for multiple myeloma (MM). However, recently whole-body computed tomography (WBCT) has been implemented into the diagnostic criteria ... -
Why babies die in unplanned out-of-institution births: An enquiry into perinatal deaths in Norway 1999-2013.
(Journal article; Peer reviewed, 2017)Introduction The aims were to describe causes of death associated with unplanned out-of-institution births, and to study whether they could be prevented. Material and methods Retrospective population-based observational ... -
Why do myeloma patients have bone disease? A historical perspective.
(Peer reviewed; Journal article, 2019)The question of how myeloma cells cause destruction of skeletal tissue has interested scientists for many years, and knowledge in this field has developed in parallel with the understanding of physiological bone remodeling. ... -
Why intraperitoneal glucose sensing is sometimes surprisingly rapid and sometimes slow: A hypothesis
(Journal article; Peer reviewed, 2019)The artificial pancreas requires fast and reliable glucose measurements. The peritoneal space has shown promising results, and in one of our studies we detected glucose changes in the peritoneal space already at the same ... -
Williams Syndrome neuroanatomical score associates with GTF2IRD1 in large-scale magnetic resonance imaging cohorts: A proof of concept for multivariate endophenotypes
(Journal article; Peer reviewed, 2018)Despite great interest in using magnetic resonance imaging (MRI) for studying the effects of genes on brain structure in humans, current approaches have focused almost entirely on predefined regions of interest and had ... -
Women undergoing assisted fertilisation and high-intensity interval training: a pilot randomised controlled trial
(Journal article; Peer reviewed, 2018)Objectives Overweight and obese women often seek assisted fertilisation. In the obese population, pregnancy rates are 30%–75% below that of normal weight women who undergo assisted fertilisation. We hypothesised that ... -
Women with systemic lupus erythematosus get pregnant more easily than women with rheumatoid arthritis
(Journal article; Peer reviewed, 2018)Objectives To examine possible differences in the ability to get pregnant and time to pregnancy (TTP) in women with SLE and RA, and to study possible influencing factors. Methods Data from RevNatus, a Norwegian ... -
Working Memory Training in Amnestic and Non-amnestic Patients With Mild Cognitive Impairment: Preliminary Findings From Genotype Variants on Training Effects
(Peer reviewed; Journal article, 2021)Working memory training (WMT) effects may be modulated by mild cognitive impairment (MCI) subtypes, and variations in APOE-epsilon (APOE-ε) and LMX1A genotypes. Sixty-one individuals (41 men/20 women, mean age 66 years) ... -
WT1 Promotes Cell Proliferation in Non-Small Cell Lung Cancer Cell Lines Through Up-Regulating Cyclin D1 and p-pRb In Vitro and In Vivo
(Journal article; Peer reviewed, 2013)The Wilms’ tumor suppressor gene (WT1) has been identified as an oncogene in many malignant diseases such as leukaemia, breast cancer, mesothelioma and lung cancer. However, the role of WT1 in non-small-cell lung cancer ... -
X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements
(Peer reviewed; Journal article, 2024)X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis ... -
X-ray repair cross complementing protein 1 in base excision repair
(Journal article; Peer reviewed, 2012)X-ray Repair Cross Complementing protein 1 (XRCC1) acts as a scaffolding protein in the converging base excision repair (BER) and single strand break repair (SSBR) pathways. XRCC1 also interacts with itself and rapidly ... -
X-ray Repair Cross- Complementing protein 1: - the role as a scaffold protein in base excision repair and single strand break repair
(Doktoravhandlinger ved NTNU, 1503-8181; 2012:27, Doctoral thesis, 2012)X-ray Repair Cross-Complementing protein 1 – en plattform for regulering av baseeksisjonsreparasjon og enkelttrådbruddsreparasjon DNA, vårt arvestoff, er et tilsynelatende stabilt molekyl satt sammen av to lange tråder ... -
X-ray repair cross-complementing protein 1 associated multiprotein complexes in base excision repair
(Doktoravhandlinger ved NTNU, 1503-8181; 2012:116, Doctoral thesis, 2012)XRCC1 assoierte multiproteinkomplekser i base eksisjonsreparasjon Arvestoffet (DNA) degraderes konstant av ytre faktorer, som stråling og kjemikalier, og indre faktorer, som produkter av metabolismen. Slik degradering ... -
X-ray Studies of Carbon Dioxide Intercalation in Na-Fluorohectorite Clay at Near-Ambient Conditions
(Journal article, 2012)We show experimentally that gaseous CO2 intercalates into the interlayer space of the synthetic smectite clay Na-fluorohectorite at conditions not too far from ambient. The mean interlayer repetition distance of the clay ... -
Youngs's modulus of tumour tissue from an in vivo breast cancer model - effect of treatment with guluronate oligosaccharides
(Peer reviewed; Journal article, 2019)Increased tissue stiffness is a classic characteristic of solid tumours, and breast tumours are often first identified as a palpable lump. Increased tissue stiffness in tumours is more than just a typical, and often easily ... -
Ythdf2-mediated m6A mRNA clearance modulates neural development in mice
(Journal article; Peer reviewed, 2018)Background N 6 -methyladenosine (m6A) modification in mRNAs was recently shown to be dynamically regulated, indicating a pivotal role in multiple developmental processes. Most recently, it was shown that the Mettl3-Mettl14 ... -
Zopiclone versus placebo for short-term treatment of insomnia in patients with advanced cancer: study protocol for a double-blind, randomized, placebo-controlled, clinical multicenter trial
(Journal article; Peer reviewed, 2018)Background Despite the high prevalence of insomnia in patients with advanced cancer, there are no randomized controlled trials on pharmacological interventions for insomnia in this group of patients. A variety of ... -
μ-opioid receptor splice variants: where are they?
(Master thesis, 2010)Opioids are the preferred drugs for treatment of severe pain in modern medicine. Inpatients with cancer, opioids are important to obtain adequate analgesia, and aretherefore frequently administered in palliative care. The ...