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X-ray repair cross complementing protein 1 in base excision repair

Hanssen-Bauer, Audun; Solvang-Garten, Karin; Akbari, Mansour; Otterlei, Marit
Journal article, Peer reviewed
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URI
http://hdl.handle.net/11250/2357220
Date
2012
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  • Institutt for klinisk og molekylær medisin [2599]
  • Institutt for sirkulasjon og bildediagnostikk [1379]
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Original version
International Journal of Molecular Sciences 2012, 13(12):17210-17229   10.3390/ijms131217210
Abstract
X-ray Repair Cross Complementing protein 1 (XRCC1) acts as a scaffolding

protein in the converging base excision repair (BER) and single strand break repair (SSBR)

pathways. XRCC1 also interacts with itself and rapidly accumulates at sites of DNA damage.

XRCC1 can thus mediate the assembly of large multiprotein DNA repair complexes as well

as facilitate the recruitment of DNA repair proteins to sites of DNA damage. Moreover,

XRCC1 is present in constitutive DNA repair complexes, some of which associate with the

replication machinery. Because of the critical role of XRCC1 in DNA repair, its common

variants Arg194Trp, Arg280His and Arg399Gln have been extensively studied. However,

the prevalence of these variants varies strongly in different populations, and their functional

influence on DNA repair and disease remains elusive. Here we present the current knowledge

about the role of XRCC1 and its variants in BER and human disease/cancer.
Publisher
MDPI
Journal
International Journal of Molecular Sciences

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