Working Memory Training in Amnestic and Non-amnestic Patients With Mild Cognitive Impairment: Preliminary Findings From Genotype Variants on Training Effects

Hernes, Susanne Miriam Sørensen; Flak, Marianne Møretrø; Løhaugen, Gro Christine Christensen; Skranes, Jon Sverre; Hol, Haakon Ramsland; Madsen, Bengt-Ove; Knapskog, Anne Brita; Engvig, Andreas; Pripp, Are Hugo; Ulstein, Ingun; Lona, Trine Eli.b.; Zhang, Xin; Chang, Linda
Peer reviewed, Journal article
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URI
https://hdl.handle.net/11250/3026893
Date
2021
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Original version
10.3389/fnagi.2021.624253
Abstract
Working memory training (WMT) effects may be modulated by mild cognitive impairment (MCI) subtypes, and variations in APOE-epsilon (APOE-ε) and LMX1A genotypes. Sixty-one individuals (41 men/20 women, mean age 66 years) diagnosed with MCI (31 amnestic/30 non-amnestic) and genotyped for APOE-ε and LMX1A completed 4 weeks/20-25 sessions of WMT. Cognitive functions were assessed before, 4 weeks and 16 weeks after WMT. Except for Processing Speed, the non-amnestic MCI group (naMCI) outperformed the amnestic MCI (aMCI) group in all cognitive domains across all time-points. At 4 weeks, working memory function improved in both groups (p
Publisher
Frontiers
Journal
Frontiers in Aging Neuroscience
Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal