Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 2740-2759 of 3585
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R2* Relaxation Affects Pharmacokinetic Analysis of Dynamic Contrast-Enhanced MRI in Cancer and Underestimates Treatment Response at 7 T
(Journal article, 2019)Effective transverse relaxivity of gadolinium-based contrast agents is often neglected in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Here, we assess time and tissue dependence of R2* enhancement and ... -
Rab11a GTPase controls Toll-like receptor 4 trafficking and signaling
(Master thesis, 2010)Rab GTPases are involved in controlling the endosomal pathway, and we have developed an expression system allowing us to study the expression and trafficking of these molecules in live cells. Toll-like receptor 4 (TLR4) ... -
Radiological and epidemiological aspects of mammographic screening
(Doktoravhandlinger ved NTNU, 1503-8181; 2013:298, Doctoral thesis, 2013)Breast cancer is the most frequent cancer and the most frequent cause of cancer death in women worldwide. Service screening programs have been implemented in many countries in the western world, with the intention to reduce ... -
Radiologisk vekstmåling av glioblastomer
(Master thesis, 2016)Bakgrunn: Anbefalt metode for bedømming av vekst av glioblastomer er i dag todimensjonale mål i henhold til RANO-kriteriene. En viktig svakhet ved denne metoden er at den bruker todimensjonale mål på en irregulær tredimensjonal ... -
Radiotherapy for prostate cancer – Does daily image guidance with tighter margins improve patient reported outcomes compared to weekly orthogonal verified irradiation? Results from a randomized controlled trial
(Journal article; Peer reviewed, 2018)Background Novel cancer drugs are subject to strict scientific evaluation of safety and efficacy and usually undergo a cost effectiveness analysis before approval for use in clinical practice. For new techniques in ... -
Radiotherapy in anal carcinoma and prostate cancer
(Doktoravhandlinger ved NTNU, 1503-8181; 2008:318, Doctoral thesis, 2008)Moderne kreftbehandling har medført at flere pasienter blir friske og flere lever i mange år etter diagnose. Behandlingen består ofte av en kombinasjon av flere behandlingsformer, hvilket medfører en økt risiko for ... -
Radiotherapy in patients with bone metastases; treatment schedules and evaluations
(Doktoravhandlinger ved NTNU, 1503-8181; 2014:162, Doctoral thesis, 2014)Strålebehandling til pasienter med spredning til skjelett; strålefraksjoner og evalueringer Spredning av kreft til skjelett (skjelettmetastaser) den vanligste årsaken til krefsmerte. Strålebehandling gir en effektiv ... -
Radiotherapy of Lung Cancer
(Doctoral theses at NTNU;2024:254, Doctoral thesis, 2024)Strålebehandling av lungekreft Lungekreft er nest hyppigst og forårsaker flest dødsfall av alle kreftformer. Det er to hovedtyper lungekreft: ikke-småcellet lungekreft og småcellet lungekreft (SCLC). SCLC er den mest ... -
Raised serum levels of syndecan-1 (CD138), in a case of acute idiopathic systemic capillary leak syndrome (SCLS) (Clarkson's disease)
(Journal article; Peer reviewed, 2018)BACKGROUND: Systemic capillary leak syndrome (SCLS) (Clarkson’s disease) is a rare disorder of unknown etiology, characterized by transient episodes of hypotension, and the microvascular leak of fluids into the peripheral ... -
Randomised controlled trial of exercise training during lactation on breast milk composition in breastfeeding people with overweight/obesity: a study protocol for the MILKSHAKE trial
(Peer reviewed; Journal article, 2023)Download PDFPDF Protocol Randomised controlled trial of exercise training during lactation on breast milk composition in breastfeeding people with overweight/obesity: a study protocol for the MILKSHAKE trial ... -
Randomised controlled trial of preconception lifestyle intervention on maternal and offspring health in people with increased risk of gestational diabetes: study protocol for the BEFORE THE BEGINNING trial
(Peer reviewed; Journal article, 2023)Introduction: Gestational diabetes mellitus (GDM) is associated with increased risk for type 2 diabetes in the mother and cardiometabolic diseases in the child. The preconception period is an optimal window to adapt the ... -
Randomised, placebo-controlled, double-blinded trial of fecal microbiota transplantation in severe obesity: a study protocol
(Peer reviewed; Journal article, 2023)Introduction - Obesity is one of the main threats to public health in western countries and increases the risk of several diseases, overall morbidity and mortality. Sustained weight loss will reduce risk factors and improve ... -
Randomized clinical trial of topical tranexamic acid after reduction mammoplasty
(Journal article; Peer reviewed, 2015)Background The antifibrinolytic drug tranexamic acid is currently being rediscovered for both trauma and major surgery. Intravenous administration reduces the need for blood transfusion and blood loss by about one-third, ... -
Randomized controlled trial of nasogastric tube use after esophagectomy: Study protocol for the kinetic trial
(Journal article; Peer reviewed, 2024)Summary Esophagectomy is a complex and complication laden procedure. Despite centralization, variations in perioparative strategies reflect a paucity of evidence regarding optimal routines. The use of nasogastric (NG) ... -
Randomized phase II trial comparing twice daily hyperfractionated with once daily hypofractionated thoracic radiotherapy in limited disease small cell lung cancer
(Journal article; Peer reviewed, 2016)Background: Concurrent chemotherapy and thoracic radiotherapy (TRT) is recommended for limited disease small cell lung cancer (LD SCLC). Twice daily TRT is well documented, but not universally implemented – probably mainly ... -
Randomized phase III trial comparing switch-maintenance pemetrexed with observation followed by pemetrexed at progression in advanced NSCLC
(Peer reviewed; Journal article, 2020)Objectives: Two phase III trials show that maintenance pemetrexed therapy after platinum-doublet chemotherapy prolongs overall survival (OS) and progression free survival (PFS) in advanced non-squamous non-small-cell lung ... -
A randomized study of the effect of patient positioning on setup reproducibility and dose distribution to organs at risk in radiotherapy of rectal cancer patients
(Peer reviewed; Journal article, 2015)Background:The patient positioning in pelvic radiotherapy (RT) should be decided based on both reproducibilityand on which position that yields the lowest radiation dose to the organs at risk (OAR), and thereby less ... -
Ranking of substances for monitoring in foods, drinks and dietary supplements - based on risk and knowledge gaps
(VKM Report;, Research report, 2019)The Norwegian Food Safety Authority (NFSA) requested the Norwegian Scientific Committee for Food and Environment (VKM) to provide an overview of substances in foods, drinks and dietary supplements that may constitute a ... -
Rapid acting fentanyl formulations in breakthrough pain in cancer. Drug selection by means of the System of Objectified Judgement Analysis
(Journal article; Peer reviewed, 2017)Drug selection of rapid acting fentanyl formulations in the treatment of breakthrough pain in patients with cancer is performed by the System of Objectified Judgement Analysis method. All seven available formulations were ... -
Rapid systemic surge of IL-33 after severe human trauma: a prospective observational study
(Journal article; Peer reviewed, 2021)Background Alarmins are considered proximal mediators of the immune response after tissue injury. Understanding their biology could pave the way for development of new therapeutic targets and biomarkers in human disease, ...