Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 94-113 av 3426
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Age- and sex-dependent effects of DNA glycosylase Neil3 on amyloid pathology, adult neurogenesis, and memory in a mouse model of Alzheimer's disease
(Peer reviewed; Journal article, 2022)Oxidative stress generating DNA damage has been shown to be a key characteristic in Alzheimer's disease (AD). However, how it affects the pathogenesis of AD is not yet fully understood. Neil3 is a DNA glycosylase initiating ... -
Age-specific prevalence of the metabolic syndrome defined by the international diabetes federation and the National Cholesterol Education Program: The Norwegian HUNT 2 study
(Journal article; Peer reviewed, 2007)Background The 2005 International Diabetes Federation (IDF) definition of the metabolic syndrome was designed to be useful worldwide, but to date few prevalence studies have used that definition in European populations. ... -
Agreement between transperineal ultrasound measurements and digital examinations of cervical dilatation during labor
(Journal article; Peer reviewed, 2015)Background To compare 2D transperineal ultrasound assessment of cervical dilatation with vaginal examination and to investigate intra-observer variability of the ultrasound method. Methods A prospective observational ... -
AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature
(Journal article; Peer reviewed, 2014)tThe most common mutations in cancer are C to T transitions, but their origin has remained elusive.Recently, mutational signatures of APOBEC-family cytosine deaminases were identified in many com-mon cancers, suggesting ... -
Air Bubbles Activate Complement and Trigger Hemostasis and C3-Dependent Cytokine Release Ex Vivo in Human Whole Blood
(Journal article; Peer reviewed, 2021)Venous air embolism, which may complicate medical and surgical procedures, activates complement and triggers thromboinflammation. In lepirudin-anticoagulated human whole blood, we examined the effect of air bubbles on ... -
ALASCA: An R package for longitudinal and cross-sectional analysis of multivariate data by ASCA-based methods
(Journal article; Peer reviewed, 2022) -
Alendronate and omeprazole in combination reduce angiogenic and growth signals from osteoblasts
(Peer reviewed; Journal article, 2021)Objective: Due to gastrointestinal side effects of oral bisphosphonates (BPs), proton pump inhibitors (PPIs) are often prescribed. PPIs may enhance the risk of osteonecrosis of the jaw, a rare side effect of BPs. Therefore, ... -
Alginate capsules as bioreactors for cell therapy
(Doktoravhandlinger ved NTNU, 1503-8181; 2006:24, Doctoral thesis, 2006) -
Alginate microbeads are coagulation compatible, while alginate microcapsules activate coagulation secondary to complement or directly through FXII
(Journal article; Peer reviewed, 2017)Alginate microspheres are presently under evaluation for future cell-based therapy. Their ability to induce harmful host reactions needs to be identified for developing the most suitable devices and efficient prevention ... -
Alginate microbeads are complement compatible, in contrast to polycation containing microcapsules, as revealed in a human whole blood model
(Journal article; Peer reviewed, 2011)Alginate microbeads and microcapsules are presently under evaluation for future cell-based therapy. Defining their inflammatory properties with regard to humans is therefore essential. A lepirudine-based human whole blood ... -
Alginate Microencapsulation of Human Islets Does Not Increase Susceptibility to Acute Hypoxia
(Journal article; Peer reviewed, 2013)Islet transplantation in diabetes is hampered by the need of life-long immunosuppression. Encapsulation provides partial immunoprotection but could possibly limit oxygen supply, a factor that may enhance hypoxia-induced ... -
Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation
(Journal article; Peer reviewed, 2016)The inflammatory potential of 12 types of alginate-based microspheres was assessed in a human whole blood model. The inflammatory potential could be categorized from low to high based on the four main alginate microsphere ... -
ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA
(Peer reviewed; Journal article, 2021)Background: Reversible enzymatic methylation of mammalian mRNA is widespread and serves crucial regulatory functions, but little is known to what degree chemical alkylators mediate overlapping modifcations and whether cells ... -
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA
(Journal article; Peer reviewed, 2011)Mammals have nine different homologues (ALKBH1–9) of the Escherichia coli DNA repair demethylase AlkB. ALKBH2 is a genuine DNA repair enzyme, but the in vivo function of the other ALKBH proteins has remained elusive. It ... -
Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression
(Journal article; Peer reviewed, 2019)Base excision repair (BER) initiated by alkyladenine DNA glycosylase (AAG) is essential for removal of aberrantly methylated DNA bases. Genome instability and accumulation of aberrant bases accompany multiple diseases, ... -
Allergy-related diseases and early gut fungal and bacterial microbiota abundances in children
(Journal article; Peer reviewed, 2021)Background The early gut microbiota has been proposed as an important link between environmental exposures and development of allergy-related diseases. Beyond the widely investigated associations between the gut bacterial ... -
Allmennleger og generisk bytte av legemidler
(Master thesis, 2012)Bakgrunn: Ordningen med generisk bytte ble innført i Norge i 2001. Den innebærer at det i apotek kan byttes fra det legen har forskrevet til et generisk likeverdig legemiddel, og at kun det billigste alternativet dekkes ... -
The allosteric modulation of complement c5 by knob domain peptides
(Peer reviewed; Journal article, 2021)Bovines have evolved a subset of antibodies with ultra-long heavy chain complementarity determining regions that harbour cysteine-rich knob domains. To produce high-affinity peptides, we previously isolated autonomous 3–6 ... -
Alpha-cyclodextrin inhibits cholesterol crystal-induced complement-mediated inflammation: A potential new compound for treatment of atherosclerosis.
(Peer reviewed; Journal article, 2019)Background and aims Cholesterol crystal (CC)-induced inflammation is a critical step in the development of atherosclerosis. CCs activate the complement system and induce an inflammatory response resulting in phagocytosis ... -
Alpha-tocopherol and MRI outcomes in multiple sclerosis - association and prediction
(Journal article; Peer reviewed, 2013)Objective: Alpha-tocopherol is the main vitamin E compound in humans, and has important antioxidative and immunomodulatory properties. The aim of this study was to study alpha-tocopherol concentrations and their relationship ...