Blar i Institutt for klinisk og molekylær medisin på tittel

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    • Discovery of Broad-Spectrum Antiviral Agents by Drug Repurposing for Rapid Response to Emergent Viral Pandemics: Building Digital Tools to Advance Translational Research 

      Yao, Rouan (Master thesis, 2021)
      The ongoing COVID-19 pandemic caused by the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in 2019 has highlighted urgency for a more efficient and comprehensive paradigm for antiviral development. ...

    • Discovery of Drug Synergies in Gastric Cancer Cells Predicted by Logical Modeling 

      Flobak, Åsmund; Baudot, Anaïs; Remy, Elisabeth; Thommesen, Liv; Thieffry, Denis; Kuiper, Martin; Lægreid, Astrid (Peer reviewed; Journal article, 2015)
      Discovery of efficient anti-cancer drug combinations is a major challenge, since experimental testing of all possible combinations is clearly impossible. Recent efforts to computationally predict drug combination responses ...

    • Discovery of host-directed modulators of virus infection by probing the SARS-CoV-2–host protein–protein interaction network 

      Vandana, Vandana; Aittokallio, Tero Antero; Frigessi, Arnoldo; Athanasiadis, Paschalis; Wagoner, Jessica; Hartigh, Andreas B Den; Sidorova, Julia; Ianevski, Aleksandr; Fink, Susan L.; White, Judith M.; Polyak, Stephen J. (Peer reviewed; Journal article, 2022)
      The ongoing coronavirus disease 2019 (COVID-19) pandemic has highlighted the need to better understand virus–host interactions. We developed a network-based method that expands the severe acute respiratory syndrome ...

    • Discrepancies in drug histories at admission to gastrointestinal surgery, internal medicine and geriatric hospital wards in Central Norway: A cross-sectional study 

      Sund, Janne Kutschera; Sletvold, Olav; Mellingsæter, Trude Cecilie; Hukari, Randi; Hole, Torstein; Uggen, Per Einar; Vadset, Petra Thiemann; Spigset, Olav (Journal article; Peer reviewed, 2017)
      Objectives To compare discrepancies in drug histories among patients acutely admitted to different hospital wards, classify the discrepancies according to their potential clinical impact and identify appropriate selection ...

    • Disease activity during pregnancy and the first year postpartum in women with systemic lupus erythematosus 

      Skorpen, Anna Carina G.; Lydersen, Stian; Gilboe, Inge-Margrethe; Skomsvoll, Johan Fredrik; Salvesen, Kjell Å; Palm, Øyvind; Koksvik, Hege; Jakobsen, Bente; Wallenius, Marianne (Journal article; Peer reviewed, 2017)
      Objective Disease activity measured by validated methods has been sparsely examined during and after pregnancy in women with systemic lupus erythematosus (SLE). The aim of this study was to describe the longitudinal course ...

    • Disease knowledge after an educational program in patients with GERD -a randomized controlled trial 

      Urnes, Jørgen; Petersen, Hermod; Farup, Per Grønaas (Journal article; Peer reviewed, 2008)
      Background: Patient education has proved beneficial in several but not all chronic disease. Inconsistent findings may rely on varying educational effects of various programs and differential effects on subgroups of ...

    • Disease-associated reference intervals for twenty laboratory tests in patients with rheumatoid arthritis, Crohn's disease or ulcerative colitis 

      Mikkelsen, Gustav; Lillebo, Børge; Faxvaag, Arild (Peer reviewed; Journal article, 2021)
      Background Population based reference intervals are fundamental for interpreting results for quantitative laboratory tests. In patients with a specific chronic disorder, however, results of various tests may regularly be ...

    • Disease-specific outcomes of Radical Prostatectomies in Northern Norway; A case for the impact of perineural infiltration and postoperative PSA-doubling time 

      Andersen, Sigve; Richardsen, Elin; Nordby, Yngve; Ness, Nora; Størkersen, Øystein; Al-Shibli, Khalid; Dønnem, Tom; Bertilsson, Helena; Busund, Lill-Tove; Angelsen, Anders; Bremnes, Roy M. (Journal article; Peer reviewed, 2014)
      Background: Prostate cancer is the most common male malignancy and a mayor cause of mortality in the western world. The impact of clinicopathological variables on disease related outcomes have mainly been reported from a ...

    • Dispersibility and biotransformation of oils with different properties in seawater 

      Brakstad, Odd Gunnar; Farooq, Umer; Ribicic, Deni; Netzer, Roman (Journal article; Peer reviewed, 2018)
      Dispersants are used to remove oils slicks from sea surfaces and to generate small oil-droplet dispersions, which may result in enhanced biodegradation of the oil. In this study, dispersibility and biodegradation of ...

    • Dissecting the roles of ASPM and Clusterin in gastric oxyntic mucosa - from immature stem cells to metaplastic chief cells 

      Vange, Pål (Doctoral theses at NTNU;2018:289, Doctoral thesis, 2018)
      Gastric cancer is the third most common cause of cancer-related mortality worldwide. Increased understanding of initiation of gastric carcinogenesis and development of tools that enable early diagnosis are of critical ...

    • Distance, accessibility and costs. Decision-making During Childbirth in Rural Sierra Leone: a Qualitative Study 

      Treacy, Laura; Bolkan, Håkon Angell; Sagbakken, Mette (Journal article; Peer reviewed, 2018)
      Sierra Leone has one of the highest maternal mortality ratios in the world. Efforts to reduce maternal mortality have included initiatives to encourage more women to deliver at health facilities. Despite the introduction ...

    • Distinct First Trimester Cytokine Profiles for Gestational Hypertension and Preeclampsia 

      Tangerås, Line Haugstad; Austdal, Marie; Skråstad, Ragnhild; Salvesen, Kjell Å; Austgulen, Rigmor; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2015)
      Objective—Gestational hypertension and preeclampsia involve dysregulated maternal inflammatory responses to pregnancy, but whether such responses differ between the disorders has not been determined. We aimed to investigate ...

    • Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases. 

      de Jesus, Adriana Almeida; Hou, Yangfeng; Brooks, Stephen; Malle, Louise; Biancotto, Angelique; Huang, Yan; Calvo, Katherine R.; Marrero, Bernadette; Moir, Susan; Oler, Andrew J.; Deng, Zuoming; Sanchez, Gina A. Montealegre; Ahmed, Amina; Allenspach, Eric; Srabshahi, Bita; Behrens, Edward M.; Benseler, Susanne; Berzrodnik, Liliana; Bout-Tabaku, Sharon; Brescia, AnneMarie; Brown, Diane; Burnham, Jon M.; Caldirola, Maria Soledad; Carrasco, Ruy; Chan, Alice; Cimaz, Rolando; Dancey, Paul; Dare, Jason; DeGuzman, Marietta; Dimitriades, Victoria; Ferguson, Ian; Ferguson, Polly J.; Finn, Laura; Gattorno, Marco; Grom, Alexei; Hanson, Eric P.; Hashkes, Philip; Hedrich, Christian M.; Herzog, Ronit; Horneff, Gerd; Jerath, Rita; Kessler, Elizabeth; Kim, Hanna; Kingsbury, Daniel J.; Laxer, Ronald M; Lee, Pui Y.; Lee-Kirsch, Min Ae; Lewandowski, Laura; Li, Suzanne; Lilleby, Vibke; Mammadova, Vafa; Moorthy, Lakshmi N.; Nasrullayeva, Gulnara M.; O'Neill, Kathleen; Onel, Karen; Ozen, Seza; Pan, Nancy; Pillet, Pascal; Piotto, Daniela G. P.; Punaro, Marilynn G.; Reiff, Andreas; Reinhardt, Adam L.; Rider, Lisa G.; Rivas-Chacon, Rafael; Ronis, Tova; Rosen-Wolff, Angela; Roth, Johannes; Ruth, Natasha Mckerran; Rygg, Marite; Schmeling, Heinrike; Schulert, Grant; Scott, Christiaan; Seminario, Gisella; Schulman, Andrew; Sivaraman, Vidya; Son, Mary Beth; Stepanovskiy, Yuriy; Stringer, Elizabeth; Taber, Sara; Terreri, Maria Teresa; Tifft, Cynthia J; Torgerson, Troy R.; Tosi, Laura; Royen-Kerkhof, Annet Van; Muskardin, Theresa Wampler; Canna, Scott W.; Goldbach-Mansky, Raphaela (Peer reviewed; Journal article, 2020)
      BACKGROUND. Undifferentiated systemic autoinflammatory diseases (USAIDs) present diagnostic and therapeutic challenges. Chronic interferon (IFN) signaling and cytokine dysregulation may identify diseases with available ...

    • Disulfiram repurposing combined with nutritional copper supplement as add-on to chemotherapy in recurrent glioblastoma (DIRECT): Study protocol for a randomized controlled trial 

      Jakola, Asgeir S.; Werlenius, Katja; Mudaisi, Munila; Hylin, Sofia; Kinhult, Sara; bartek, Jiri Jr.; Salvesen, Øyvind; Carlsen, Sven Magnus; Strandeus, Michael; Lindskog, Magnus; Lofgren, David; Rydenhaug, Bertil; Carstam, Louise; Gulati, Sasha; Solheim, Ole; Bartek, Jiri; Solheim, Tora Skeidsvoll (Journal article; Peer reviewed, 2018)
      Background: Disulfiram (DSF) is a well-tolerated, inexpensive, generic drug that has been in use to treat alcoholism since the 1950s. There is now independent preclinical data that supports DSF as an anticancer agent, and ...

    • Divalent ligand-monovalent molecule binding 

      Janssen, Mathijs Adriaan; Stenmark, Harald; Carlson, Andreas (Peer reviewed; Journal article, 2021)
      Simultaneous binding of a divalent ligand to two identical monovalent molecules is a widespread phenomenon in biology and chemistry. Here, we describe how two such monovalent molecules B bind to a divalent ligand AA to ...

    • Divergent Regulation of Decidual Oxidative-Stress Response by NRF2 and KEAP1 in Preeclampsia with and without Fetal Growth Restriction 

      Mundal, Siv Boon; Rakner, Johanne Johnsen; Silva, Gabriela; Gierman, Lobke; Austdal, Marie; Basnet, Purusotam; Elschot, Mattijs; Bakke, Siril Skaret; Ostrop, Jenny; Thomsen, Liv Cecilie Vestrheim; Moses, Eric; Acharya, Ganesh; Bjørge, Line; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2022)
      Utero-placental development in pregnancy depends on direct maternal–fetal interaction in the uterine wall decidua. Abnormal uterine vascular remodeling preceding placental oxidative stress and placental dysfunction are ...

    • Diverse functions of DNA glycosylases processing oxidative base lesions in brain 

      Scheffler, Katja; Bjørås, Karine Øian; Bjørås, Magnar (Peer reviewed; Journal article, 2019)
      Endogenous and exogenous oxidative agents continuously damage genomic DNA, with the brain being particularly vulnerable. Thus, preserving genomic integrity is key for brain health and neuronal function. Accumulation of DNA ...

    • Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain 

      Dgama, Percival Paul Menino; Qiu, Tao; Cosacak, Mehmet Ilyas; Rayamajhi, Dheeraj; Konac, Ahsen; Hansen, Jan Niklas; Ringers, Christa; Acuna Hinrichsen, Francisca Daniela; Hui, Subhra; Olstad, Emilie Willoch; Chong, Yan Ling; Lim, Charlton Kang An; Gupta, Astha; Ng, Chee Peng; Nilges, Benedikt S.; Kashikar, Nachiket; Wachten, Dagmar; Liebl, David; Kikuchi, Kazu; Kizil, Caghan; Yaksi, Emre; Roy, Sudipto; Jurisch-Yaksi, Nathalie (Peer reviewed; Journal article, 2021)
      Motile cilia defects impair cerebrospinal fluid (CSF) flow and can cause brain and spine disorders. The development of ciliated cells, their impact on CSF flow, and their function in brain and axial morphogenesis are not ...

    • Diversity in changes of HRQoL over a one-year period after radiotherapy in Norwegian breast cancer survivors – results of cluster analyses 

      Lazarewicz, Magdalena Anna; Wlodarczyk, Dorota; Lundgren, Steinar; Reidunsdatter, Randi Johansen (Journal article; Peer reviewed, 2019)
      Purpose The diversity in long-term changes in health-related quality of life (HRQoL) among breast cancer (BC) survivors is poorly understood. The aim of this study was to identify clusters of trajectories (subgroups of ...

    • Divulging a Pleiotropic Role of Succinate Receptor SUCNR1 in Renal Cell Carcinoma Microenvironment 

      Najm, Rania; Hachim, Mahmood Yaseen; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2022)
      The succinate receptor, SUCNR1, has been attributed to tumor progression, metastasis, and immune response modulation upon its activation via the oncometabolite succinate. Nonetheless, little is known about the prognostic ...