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Computational analysis of regulatory mechanism and interactions of microRNAs
(Doktoravhandlinger ved NTNU, 1503-8181; 2011:314, Doctoral thesis, 2011)For years, RNAs were thought to have only two broad functions in cells, transmitting information between DNA and protein as messenger RNA (mRNA), and playing structural, catalytic, information decoding roles in protein ... -
Computational Analysis of Short Linear Motifs in the Spike Protein of SARS-CoV-2 Variants Provides Possible Clues into the Immune Hijack and Evasion Mechanisms of Omicron Variant
(Peer reviewed; Journal article, 2022)Short linear motifs (SLiMs) are short linear sequences that can mediate protein–protein interaction. Mimicking eukaryotic SLiMs to compete with extra- or intracellular binding partners, or to sequester host proteins is the ... -
Computational Drug Repositioning and Experimental Validation of Ivermectin in Treatment of Gastric Cancer
(Peer reviewed; Journal article, 2021)Objective: The aim of the present study was repositioning of ivermectin in treatment of gastric cancer (GC) by computational prediction based on gene expression profiles of human and mouse model of GC and validations with ... -
Computational Modeling of Motile Cilia-Driven Cerebrospinal Flow in the Brain Ventricles of Zebrafish Embryo
(Peer reviewed; Journal article, 2022)Motile cilia are hair-like microscopic structures which generate directional flow to provide fluid transport in various biological processes. Ciliary beating is one of the sources of cerebrospinal flow (CSF) in brain ... -
Computational tools for exploring peptide-membrane interactions in gram-positive bacteria
(Peer reviewed; Journal article, 2023)The vital cellular functions in Gram-positive bacteria are controlled by signaling molecules known as quorum sensing peptides (QSPs), considered promising therapeutic interventions for bacterial infections. In the bacterial ... -
Computationally efficient familywise error rate control in genome‐wide association studies using score tests for generalized linear models
(Peer reviewed; Journal article, 2020)In genetic association studies, detecting phenotype–genotype association is a primary goal. We assume that the relationship between the data—phenotype, genetic markers and environmental covariates—can be modeled by a ... -
Computer-based video analysis identifies infants with absence of fidgety movements
(Journal article; Peer reviewed, 2017)Background: Absence of fidgety movements (FMs) at 3 months’ corrected age is a strong predictor of cerebral palsy (CP) in high-risk infants. This study evaluates the association between computer-based video analysis and ... -
Computerized Decision Support Systems for Evaluation and Treatment of Pain and Other Symptoms in Cancer Patients
(Doctoral theses at NTNU;2018:411, Doctoral thesis, 2018)Norsk sammendrag - Summary in Norwegian Det er kjent at kreftpasienter har en rekke symptomer på grunn av kreftsykdommen. Det er anslått at omtrent 30-50% av kreftpasientene har kreftsmerter som ikke er tilfredsstillende ... -
Computerized working memory training effects, brain findings, and gene variants in persons with amnestic and non-amnestic Mild Cognitive Impairment
(Doctoral theses at NTNU;2019:263, Doctoral thesis, 2019) -
Concentration of circulating autoantibodies against HSP 60 is lowered through diving when compared to non-diving rats
(Journal article; Peer reviewed, 2012)Objective: Skin and ear infections, primarily caused by Pseudomonas aeruginosa (P. aeruginosa), are recurrent problems for saturation divers, whereas infections caused by P. aeruginosa are seldom observed in healthy people ... -
Concomitant inactivation of the p53- and pRB- functional pathways predicts resistance to DNA damaging drugs in breast cancer in vivo
(Peer reviewed; Journal article, 2015)Chemoresistance is the main obstacle to cancer cure. Contrasting studies focusing on single gene mutations, we hypothesize chemoresistance to be due to inactivation of key pathways affecting cellular mechanisms such as ... -
Concurrent and predictive validity of the Alberta Infant Motor Scale and the Peabody Developmental Motor Scales-2 administered to infants born preterm in Norway
(Peer reviewed; Journal article, 2023)Background The correlation between the Alberta Infant Motor Scale (AIMS) and the Peabody Developmental Motor Scales-2 (PDMS-2) has not previously been assessed in Norwegian infants. Our purpose was to investigate the ... -
A conformational change of complement C5 is required for thrombin-mediated cleavage, revealed by a novel ex vivo human whole blood model preserving full thrombin activity
(Peer reviewed; Journal article, 2021)Thrombin activation of C5 connects thrombosis to inflammation. Complement research in whole blood ex vivo necessitates anticoagulation, which potentially interferes with the inflammatory modulation by thrombin. We challenged ... -
Congenital anomalies and the severity of impairments for cerebral palsy
(Journal article, 2017)Aim: To study the prevalence of congenital anomalies among children with cerebral palsy (CP) born at term or late preterm, and if CP subtypes and clinical manifestations differ between children with and without congenital ... -
Congenital duodenal obstruction - National trends in management and outcomes during the last quarter of a century in Norway
(Journal article; Peer reviewed, 2023)Introduction During the last quarter of a century, new surgical techniques in neonates have been introduced, and neonatal intensive care has developed. Few studies have explored the implementation of new techniques and if ... -
CONGENITAL THROMBOTIC THROMBOCYTOPENIC PURPURA AND ADAMTS13 MUTATIONS IN NORWAY: Studies on epidemiology, genotype and phenotype
(Doctoral thesis at NTNU;2016:148, Doctoral thesis, 2016)Trombotisk trombocytopenisk purpura (TTP) er en livstruende tilstand som er kjennetegnet ved trombosering (tilstopping) av små blodkar i ulike organer i kroppen samtidig som man blir blodfattig og kan få blødningstendens ... -
Constipation and Diarrhoea: Effectiveness and Adverse Effects of Drugs
(Doktoravhandlinger ved NTNU, 1503-8181; 2012:243, Doctoral thesis, 2012) -
Construct validity of eoSim - a low-cost and portable laparoscopic simulator
(Peer reviewed; Journal article, 2019)Purpose: To examine the construct validity of the low-cost, portable laparoscopic simulator eoSim using motion analysis. Material and methods: Novice and experienced surgeons (≤ 100 and >100 laparoscopic procedures ... -
Construction and evaluation of the performance of genetic risk scores for ankylosing spondylitis, rheumatoid arthritis, and myocardial infarction in the Norwegian population-based Nord- Trøndelag Health Study (HUNT)
(Doctoral theses at NTNU;2020:176, Doctoral thesis, 2020)