Blar i Institutt for klinisk og molekylær medisin på tittel
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Common nodes of virus–host interaction revealed through an integrated network analysis
(Journal article; Peer reviewed, 2019)Viruses are one of the major causes of acute and chronic infectious diseases and thus a major contributor to the global burden of disease. Several studies have shown how viruses have evolved to hijack basic cellular pathways ... -
Commonly prescribed medicines interfere with cellular response to influenza A virus infection
(Master thesis, 2021)Bakgrunn Hvert år blir millioner av mennesker smittet med influensa A-virus. Mange av disse menneskene har underliggende kroniske sykdommer, slik som leddgikt, diabetes og høyt blodtrykk, og er derfor avhengige av medisinsk ... -
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
(Journal article; Peer reviewed, 2019)The effectiveness of most cancer targeted therapies is short-lived. Tumors often developresistance that might be overcome with drug combinations. However, the number of possiblecombinations is vast, necessitating data-driven ... -
Comorbidities in cerebral palsy: a patient registry study
(Journal article; Peer reviewed, 2019)Aim To describe the total burden of disease in individuals with cerebral palsy (CP) in Norway. Method A comprehensive set of disorder categories were extracted from the Norwegian Patient Registry using International ... -
Comorbidity and outcomes of concurrent chemo- and radiotherapy in limited disease small cell lung cancer
(Journal article; Peer reviewed, 2016)Background: Many patients with limited disease small cell lung cancer (LD SCLC) suffer from comorbidity. Not all patients with comorbidity are offered standard treatment, though there is little evidence for such a policy. ... -
A Comparative Analysis of Orthotopic and Subcutaneous Pancreatic Tumour Models: Tumour Microenvironment and Drug Delivery
(Peer reviewed; Journal article, 2023)Pancreatic ductal adenocarcinoma (PDAC) remains a challenging malignancy, mainly due to its resistance to chemotherapy and its complex tumour microenvironment characterised by stromal desmoplasia. There is a need for new ... -
Comparative effectiveness of microdecompression and laminectomy for central lumbar spinal stenosis: Study protocol for an observational study
(Journal article; Peer reviewed, 2014)Introduction: This observational study is designed to test the equivalence between the clinical effectiveness of microdecompression and laminectomy in the surgical treatment of central lumbar spinal stenosis. Lumbar spinal ... -
Comparative genomics of Streptococcus agalactiae from adults with invasive infection
(Master thesis, 2019)Introduksjon: Streptococcus agalactiae (gruppe B streptokokker, GBS) er mest kjent for å være årsak til neonatal sepsis. I de senere år har det blitt rapportert en signifikant økning i antall voksne med GBS sykdom fra flere ... -
Comparative genomics to delineate pathogenic potential in Non-O157 Shiga toxin-producing Escherichia coli (STEC) from patients with and without haemolytic uremic syndrome (HUS) in Norway
(Journal article; Peer reviewed, 2014)Shiga toxin-producing Escherichia coli (STEC) cause infections in humans ranging from asymptomatic carriage to bloody diarrhoea and haemolytic uremic syndrome (HUS). Here we present whole genome comparison of Norwegian ... -
Comparative Proteomic Analysis Reveals Varying Impact on Immune Responses in Phorbol 12-Myristate-13-Acetate-Mediated THP-1 Monocyte-to-Macrophage Differentiation
(Journal article; Peer reviewed, 2021)Macrophages are sentinels of the innate immune system, and the human monocytic cell line THP-1 is one of the widely used in vitro models to study inflammatory processes and immune responses. Several monocyte-to-macrophage ... -
Comparative Transcriptome Profiling Reveals a Potential Role of Type VI Secretion System and Fimbriae in Virulence of Non-O157 Shiga Toxin-Producing Escherichia coli
(Journal article; Peer reviewed, 2018)Shiga toxin-producing Escherichia coli (STEC) cause both sporadic infections and outbreaks of enteric disease in humans, with symptoms ranging from asymptomatic carriage to severe disease like haemolytic uremic syndrome ... -
Comparing Human Metapneumovirus and Respiratory Syncytial Virus: Viral Co-Detections, Genotypes and Risk Factors for Severe Disease
(Journal article; Peer reviewed, 2017)Background It is unclarified as to whether viral co-detection and human metapneumovirus (HMPV) genotypes relate to clinical manifestations in children with HMPV and lower respiratory tract infection (LRTI), and if the ... -
Comparing two Classifications of Cancer Cachexia and Their Association with Survival in Patients with Unresected Pancreatic Cancer
(Journal article; Peer reviewed, 2015)There is no universally accepted definition of cancer cachexia. Two classifications have been proposed; the 3-factor classification requiring ≥2 of 3 factors; weight loss ≥10%, food intake ≤1500 kcal/day, and C-reactive ... -
Comparison Between 8-Methoxypsoralen and 5-Aminolevulinic Acid in Killing T Cells of Photopheresis Patients Ex Vivo
(Journal article; Peer reviewed, 2018)Background and Objective Extracorporeal photopheresis (ECP), an established modality for cutaneous T‐cell lymphoma (CTCL) and graft‐versus‐host disease, involves ex vivo treatment of isolated leukocytes of a patient with ... -
Comparison of driving simulator performance with real driving after alcohol intake: A randomised, single blind, placebo-controlled, cross-over trial
(Journal article; Peer reviewed, 2013)The purpose of this study was to establish and validate a driving simulator method for assessing drug effects on driving. To achieve this, we used ethanol as a positive control, and examined whether ethanol affects driving ... -
A comparison of FDG PET/MR and PET/CT for staging, response assessment, and prognostic imaging biomarkers in lymphoma
(Peer reviewed; Journal article, 2022)The aim of the current study was to investigate the diagnostic performance of FDG PET/MR compared to PET/CT in a patient cohort including Hodgkins lymphoma, diffuse large B-cell lymphoma, and high-grade B-cell lymphoma at ... -
A comparison of Generative Adversarial Networks for automated prostate cancer detection on T2-weighted MRI
(Journal article; Peer reviewed, 2023)Generative Adversarial Networks (GANs) have shown potential in medical imaging. In this study, several previously developed GANs were investigated for prostate cancer (PCa) detection on T2-weighted (T2W) magnetic resonance ... -
Comparison of Interferon-Gamma (IFNG) +874 T/A single nucleotide polymorphism in hepatitis C virus infected patients and non-infected controls in Mashhad, Iran
(Journal article; Peer reviewed, 2017)Background and Objectives: Interferon-gamma is an important cytokine, which facilitates immunity against intracellular pathogens. Several factors, including genetic variations of cytokine-producing genes have been shown ... -
Comparison of iron acquisition mechanisms and growth characteristics of Escherichia coli from bloodstream infection in patients with low and normal iron status
(Master thesis, 2019)Sepsis is a systemic inflammatory response to infection which is one of the major public health issues with significant mortality and morbidity. Bloodstream infections are infectious diseases characterised by the presence ... -
Comparison of methods to construct a genetic risk score for prediction of rheumatoid arthritis in the population-based Nord-Trøndelag Health Study, Norway
(Peer reviewed; Journal article, 2020)Objectives: To evaluate selection methods among published single-nucleotide polymorphisms (SNPs) associated with RA to construct predictive genetic risk scores (GRSs) in a population-based setting. Methods: The Nord-Trøndelag ...