Blar i Institutt for klinisk og molekylær medisin på tittel
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Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
(Journal article; Peer reviewed, 2019)The effectiveness of most cancer targeted therapies is short-lived. Tumors often developresistance that might be overcome with drug combinations. However, the number of possiblecombinations is vast, necessitating data-driven ... -
Comorbidities in cerebral palsy: a patient registry study
(Journal article; Peer reviewed, 2019)Aim To describe the total burden of disease in individuals with cerebral palsy (CP) in Norway. Method A comprehensive set of disorder categories were extracted from the Norwegian Patient Registry using International ... -
Comorbidity and outcomes of concurrent chemo- and radiotherapy in limited disease small cell lung cancer
(Journal article; Peer reviewed, 2016)Background: Many patients with limited disease small cell lung cancer (LD SCLC) suffer from comorbidity. Not all patients with comorbidity are offered standard treatment, though there is little evidence for such a policy. ... -
A Comparative Analysis of Orthotopic and Subcutaneous Pancreatic Tumour Models: Tumour Microenvironment and Drug Delivery
(Peer reviewed; Journal article, 2023)Pancreatic ductal adenocarcinoma (PDAC) remains a challenging malignancy, mainly due to its resistance to chemotherapy and its complex tumour microenvironment characterised by stromal desmoplasia. There is a need for new ... -
Comparative effectiveness of microdecompression and laminectomy for central lumbar spinal stenosis: Study protocol for an observational study
(Journal article; Peer reviewed, 2014)Introduction: This observational study is designed to test the equivalence between the clinical effectiveness of microdecompression and laminectomy in the surgical treatment of central lumbar spinal stenosis. Lumbar spinal ... -
Comparative genomics of Streptococcus agalactiae from adults with invasive infection
(Master thesis, 2019)Introduksjon: Streptococcus agalactiae (gruppe B streptokokker, GBS) er mest kjent for å være årsak til neonatal sepsis. I de senere år har det blitt rapportert en signifikant økning i antall voksne med GBS sykdom fra flere ... -
Comparative genomics to delineate pathogenic potential in Non-O157 Shiga toxin-producing Escherichia coli (STEC) from patients with and without haemolytic uremic syndrome (HUS) in Norway
(Journal article; Peer reviewed, 2014)Shiga toxin-producing Escherichia coli (STEC) cause infections in humans ranging from asymptomatic carriage to bloody diarrhoea and haemolytic uremic syndrome (HUS). Here we present whole genome comparison of Norwegian ... -
Comparative Proteomic Analysis Reveals Varying Impact on Immune Responses in Phorbol 12-Myristate-13-Acetate-Mediated THP-1 Monocyte-to-Macrophage Differentiation
(Journal article; Peer reviewed, 2021)Macrophages are sentinels of the innate immune system, and the human monocytic cell line THP-1 is one of the widely used in vitro models to study inflammatory processes and immune responses. Several monocyte-to-macrophage ... -
Comparative Transcriptome Profiling Reveals a Potential Role of Type VI Secretion System and Fimbriae in Virulence of Non-O157 Shiga Toxin-Producing Escherichia coli
(Journal article; Peer reviewed, 2018)Shiga toxin-producing Escherichia coli (STEC) cause both sporadic infections and outbreaks of enteric disease in humans, with symptoms ranging from asymptomatic carriage to severe disease like haemolytic uremic syndrome ... -
Comparing Human Metapneumovirus and Respiratory Syncytial Virus: Viral Co-Detections, Genotypes and Risk Factors for Severe Disease
(Journal article; Peer reviewed, 2017)Background It is unclarified as to whether viral co-detection and human metapneumovirus (HMPV) genotypes relate to clinical manifestations in children with HMPV and lower respiratory tract infection (LRTI), and if the ... -
Comparing two Classifications of Cancer Cachexia and Their Association with Survival in Patients with Unresected Pancreatic Cancer
(Journal article; Peer reviewed, 2015)There is no universally accepted definition of cancer cachexia. Two classifications have been proposed; the 3-factor classification requiring ≥2 of 3 factors; weight loss ≥10%, food intake ≤1500 kcal/day, and C-reactive ... -
Comparison Between 8-Methoxypsoralen and 5-Aminolevulinic Acid in Killing T Cells of Photopheresis Patients Ex Vivo
(Journal article; Peer reviewed, 2018)Background and Objective Extracorporeal photopheresis (ECP), an established modality for cutaneous T‐cell lymphoma (CTCL) and graft‐versus‐host disease, involves ex vivo treatment of isolated leukocytes of a patient with ... -
Comparison of driving simulator performance with real driving after alcohol intake: A randomised, single blind, placebo-controlled, cross-over trial
(Journal article; Peer reviewed, 2013)The purpose of this study was to establish and validate a driving simulator method for assessing drug effects on driving. To achieve this, we used ethanol as a positive control, and examined whether ethanol affects driving ... -
A comparison of FDG PET/MR and PET/CT for staging, response assessment, and prognostic imaging biomarkers in lymphoma
(Peer reviewed; Journal article, 2022)The aim of the current study was to investigate the diagnostic performance of FDG PET/MR compared to PET/CT in a patient cohort including Hodgkins lymphoma, diffuse large B-cell lymphoma, and high-grade B-cell lymphoma at ... -
A comparison of Generative Adversarial Networks for automated prostate cancer detection on T2-weighted MRI
(Journal article; Peer reviewed, 2023)Generative Adversarial Networks (GANs) have shown potential in medical imaging. In this study, several previously developed GANs were investigated for prostate cancer (PCa) detection on T2-weighted (T2W) magnetic resonance ... -
Comparison of Interferon-Gamma (IFNG) +874 T/A single nucleotide polymorphism in hepatitis C virus infected patients and non-infected controls in Mashhad, Iran
(Journal article; Peer reviewed, 2017)Background and Objectives: Interferon-gamma is an important cytokine, which facilitates immunity against intracellular pathogens. Several factors, including genetic variations of cytokine-producing genes have been shown ... -
Comparison of iron acquisition mechanisms and growth characteristics of Escherichia coli from bloodstream infection in patients with low and normal iron status
(Master thesis, 2019)Sepsis is a systemic inflammatory response to infection which is one of the major public health issues with significant mortality and morbidity. Bloodstream infections are infectious diseases characterised by the presence ... -
Comparison of methods to construct a genetic risk score for prediction of rheumatoid arthritis in the population-based Nord-Trøndelag Health Study, Norway
(Peer reviewed; Journal article, 2020)Objectives: To evaluate selection methods among published single-nucleotide polymorphisms (SNPs) associated with RA to construct predictive genetic risk scores (GRSs) in a population-based setting. Methods: The Nord-Trøndelag ... -
Comparison of microbial community dynamics induced by distinct crude oil dispersions reveals compositional differences
(Journal article; Peer reviewed, 2018)To understand the impact of oil contamination on marine microbial communities, numerous studies have been conducted following microbial dynamics after oil spills and concerning the effects of different environmental ... -
Comparison of surgical skill acquisition by UK surgical trainees and Sierra Leonean associate clinicians in a task-sharing programme
(Journal article; Peer reviewed, 2018)Background Task‐sharing in surgery is well established, with associate clinicians performing successful surgery in many countries. Little is known about the process of surgical skill acquisition by associate clinicians, ...