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    • Clinical Aspects in Translational Research on Gastric Tumorigenesis and Development of New Treatments 

      Andersen, Gøran Troseth (Doctoral theses at NTNU;2023:360, Doctoral thesis, 2023)
      Kliniske aspekter ved translasjonsforskning på magekreft og utvikling av nye behandlinger Bakgrunn/mål: Medisinsk translasjonsforskning er en toveis prosess for å redusere avstanden fra laboratoriet til sykesengen ved å ...

    • Clinical aspects of a nationwide epidemic of severe haemolytic uremic syndrome (HUS) in children 

      Krogvold, Lars; Henrichsen, Thore Andre; Bjerre, Anna Kristina; Brackman, Damien; Døllner, Henrik; Gudmundsdottir, Helga; Næss, Pål Aksel; Syversen, Gaute; Bangstad, Hans J (Journal article; Peer reviewed, 2011)
      Background: Report a nationwide epidemic of Shiga toxin-producing E. coli (STEC) O103:H25 causing hemolytic uremic syndrome (D+HUS) in children. Methods: Description of clinical presentation, complications and outcome ...

    • Clinical phenotypes and long-term prognosis in white patients with biopsy-verified hypertensive nephrosclerosis 

      Øvrehus, Marius Altern; Oldereid, Tine Simensen; Dadfar, Aydin; Bjørneklett, Rune; Aasarød, Knut; Fogo, Agnes B.; Ix, Joachim H.; Hallan, Stein (Peer reviewed; Journal article, 2020)
      Introduction Hypertensive nephrosclerosis is considered the second most common cause of end-stage renal disease (ESRD), but it is still an insufficiently studied and controversial disease entity. More information on the ...

    • Clinical Predictors for Analgesic Response to Radiotherapy in Patients with Painful Bone Metastases 

      Habberstad, Ragnhild H; Frøseth, Trude Camilla Salvesen; Aass, Nina Kathrine; Bjerkeset, Gunnhild; Abramova, Tatiana Mikhailovna; Garcia-Alonso, Elena; Caputo, Mariangela; Rossi, Romina; Boland, Jason W.; Brunelli, Cinzia; Lund, Jo-Åsmund; Kaasa, Stein; Klepstad, Pål (Peer reviewed; Journal article, 2021)
      Background Radiotherapy (RT) reduces pain in about 60% of patients with painful bone metastases, leaving many patients without clinical benefit. This study assesses predictors for RT effectiveness in patients with painful ...

    • A clinical prognostic scoring system for resectable gastric cancer to predict survival and benefit from paclitaxel- or oxaliplatin-based adjuvant chemotherapy 

      Qian, Jing; Qian, Yingying; Wang, Jian; Gu, Bing; Pei, Dong; He, Shaohua; Zhu, Fang; Røe, Oluf Dimitri; Xu, Jin; Liu, Lianke; Gu, Yanhong; Guo, Renhua; Yin, Yongmei; Shu, Yongqian; Chen, Xiaofeng (Peer reviewed; Journal article, 2016)
      Background: Gastrectomy with D2 lymphadenectomy is a standard procedure of curative resection for gastric cancer (GC). The aim of this study was to develop a simple and reliable prognostic scoring system for GC treated ...

    • Clinical research in end-of-life cancer care Current status, barriers, priorities, and a framework for reporting a sample in clinical trials 

      Sigurdardottir, Katrin Ruth (Doctoral thesis at NTNU;2014:355, Doctoral thesis, 2014)
      Kreft er en av de vanligste dødsårsakene i verden og den globale forekomsten øker. Mange pasienter som dør av kreft, har behov for palliative tiltak, men bare en liten andel av midlene til kreftforskning fordeles til ...

    • Clinical Risk Factors Associated With Late-Onset Invasive Group B Streptococcal Disease: Systematic Review and Meta-Analyses 

      Karampatsas, Konstantinos; Davies, Hannah; Mynarek, Maren; Andrews, Nick; Heath, Paul; Le Doare, Kirsy (Peer reviewed; Journal article, 2022)
      Background Group B streptococcal (GBS) infection remains one of the most significant causes of late-onset sepsis and meningitis (LOGBS) among young infants. However, transmission routes and risk factors for LOGBS are ...

    • Clinical Risk Factors For Kidney Tubule Biomarker Abnormalities Among Hypertensive Adults With Reduced eGFR in the SPRINT Trial 

      Ikeme, Jesse C.; Katz, Ronit; Muiru, Anthony N.; Estrella, Michelle M.; Scherzer, Rebecca; Garimella, Pranav S.; Hallan, Stein; Peralta, Carmen A.; Ix, Joachim H.; Shlipak, Michael G. (Peer reviewed; Journal article, 2022)
      BACKGROUND Urine biomarkers of kidney tubule health may distinguish aspects of kidney damage that cannot be captured by current glomerular measures. Associations of clinical risk factors with specific kidney tubule ...

    • Clinical Validation of a Size-Based Microfluidic Device for Circulating Tumor Cell Isolation and Analysis in Renal Cell Carcinoma 

      Leitão, Tito Palmela; Corredeira, Patrícia; Kucharczak, Sandra; Rodrigues, Margarida; Piairo, Paulina; Rodrigues, Carolina; Alves, Patrícia; Cavaco, Ana Martins; Miranda, Miguel; Antunes, Marília; Ferreira, João; Palma Reis, José; Lopes, Tomé; Diéguez, Lorena; Costa, Luís (Peer reviewed; Journal article, 2023)
      Renal cell carcinoma (RCC) presents as metastatic disease in one third of cases. Research on circulating tumor cells (CTCs) and liquid biopsies is improving the understanding of RCC biology and metastases formation. However, ...

    • Clinical, Pathological, and Molecular Classification of Ovarian Carcinoma 

      Aune, Guro (Doktoravhandlinger ved NTNU, 1503-8181; 2011:26, Doctoral thesis, 2011)
      Kliniske, patologiske og molekylære studiar av eggstokk-kreft Rundt 450 norske kvinner får diagnosen eggstokk-kreft kvart år. Prognosen er dårleg, med ei fem års overleving på rundt 40 %. Når sjukdomen blir oppdaga i ...

    • Clonal evolution after treatment pressure in multiple myeloma: heterogenous genomic aberrations and transcriptomic convergence 

      Misund, Kristine; Hofste op Bruinink, Davine; Coward, Eivind; Hoogenboezem, Remco M.; Rustad, Even Holth; Sanders, Mathijs A.; Rye, Morten Beck; Sponaas, Anne-Marit; van der Holt, Bronno; Zweegman, Sonja; Hovig, Eivind; Meza, Leonardo Zepeda; Sundan, Anders; Myklebost, Ola; Sonneveld, Pieter; Waage, Anders (Peer reviewed; Journal article, 2022)
      We investigated genomic and transcriptomic changes in paired tumor samples of 29 in-house multiple myeloma (MM) patients and 28 patients from the MMRF CoMMpass study before and after treatment. A change in clonal composition ...

    • Cluster Headache Genomewide Association Study and Meta-Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor 

      Winsvold, Bendik Kristoffer Slagsvold; Harder, Aster V. E.; Ran, Caroline; Chalmer, Mona A.; Dalmasso, Maria Carolina; Ferkingstad, Egil; Tripathi, Kumar Parijat; Bacchelli, Elena; Børte, Sigrid; Fourier, Carmen; Petersen, Anja S.; Vijfhuizen, Lisanne S.; Magnusson, Sigurdur H.; O'Connor, Emer; Bjornsdottir, Gyda; Häppölä, Paavo; Wang, Yen-Feng; Callesen, Ida; Kelderman, Tim; Gallardo, Victor J; de Boer, Irene; Olofsgård, Felicia Jennysdotter; Heinze, Katja; Lund, Nunu; Thomas, Laurent Francois; Hsu, Chia-Lin; Pirinen, Matti; Hautakangas, Heidi; Ribasés, Marta; Guerzoni, Simona; Sivakumar, Prasanth; Yip, Janice; Heinze, Axel; Küçükali, Fahri; Ostrowski, Sisse R.; Pedersen, Ole B.; Kristoffersen, Espen Saxhaug; Martinsen, Amy; Artigas, María S.; Lagrata, Susie; Cainazzo, Maria Michela; Adebimpe, Joycee; Quinn, Olivia; Göbel, Carl; Cirkel, Anna; Volk, Alexander E.; Heilmann-Heimbach, Stefanie; Skogholt, Anne Heidi; Gabrielsen, Maiken Elvestad; Wilbrink, Leopoldine A.; Danno, Daisuke; Mehta, Dwij; Guðbjartsson, Daníel F.; Rosendaal, Frits Richard; Willems van Dijk, Ko; Fronczek, Rolf; Wagner, Michael; Scherer, Martin; Göbel, Hartmut; Sleegers, Kristel; Sveinsson, Olafur A.; Pani, Luca; Zoli, Michele; Ramos-Quiroga, Josep A.; Dardiotis, Efthimios; Steinberg, Anna; Riedel-Heller, Steffi; Sjöstrand, Christina; Thorgeirsson, Thorgeir E.; Stefansson, Hreinn; Southgate, Laura; Trembath, Richard C.; Vandrovcova, Jana; Noordam, Raymond; Paemeleire, Koen; Stefansson, Kari; Fann, Cathy Shen-Jang; Waldenlind, Elisabet; Tronvik, Erling Andreas; Jensen, Rigmor H.; Chen, Shih-Pin; Houlden, Henry; Terwindt, Gisela M.; Kubisch, Christian; Maestrini, Elena; Vikelis, Michail; Pozo-Rosich, Patricia; Belin, Andrea C.; Matharu, Manjit; van den Maagdenberg, Arn M.J.M.; Hansen, Thomas; Ramirez, Alfredo; Zwart, John Anker Henrik (Peer reviewed; Journal article, 2023)
      Objective The objective of this study was to aggregate data for the first genomewide association study meta-analysis of cluster headache, to identify genetic risk variants, and gain biological insights. Methods A ...

    • Clustered ChIP-Seq-defined transcription factor binding sites and histone modifications map distinct classes of regulatory elements 

      Rye, Morten Beck; Sætrom, Pål; Håndstad, Tony; Drabløs, Finn (Journal article; Peer reviewed, 2011)
      Background Transcription factor binding to DNA requires both an appropriate binding element and suitably open chromatin, which together help to define regulatory elements within the genome. Current methods of identifying ...

    • ClusTrack: Feature extraction and similarity measures for clustering of genome-wide data sets 

      Rydbeck, Halfdan; Sandve, Geir Kjetil F.; Ferkingstad, Egil; Simovski, Boris; Rye, Morten Beck; Hovig, Johannes Eivind (Journal article, 2015)
      Clustering is a popular technique for explorative analysis of data, as it can reveal subgroupings and similarities between data in an unsupervised manner. While clustering is routinely applied to gene expression data, there ...

    • Co-medication among patients diagnosed with Crohn’s disease – an observational health register study. 

      Al-Azawi, Marwan Shakir (Master thesis, 2022)
      Abstract will be available on 2027-05-31

    • Co-prescription of metoprolol and CYP2D6-inhibiting antidepressants before and after implementation of an optimized drug interaction database in Norway 

      Gedde-Dahl, Ane; Spigset, Olav; Molden, Espen (Journal article; Peer reviewed, 2022)

    • Co-Use of Drugs and Herbal Remedies in General Practice and In Vitro Inhibition of CYP3A4, CYP2D6 and P-Glycoprotein by the Common Herb Aloe Vera. 

      Djuv, Ane (Doktoravhandlinger ved NTNU, 1503-8181; 2013:333, Doctoral thesis, 2013)
      There is a widespread use of complementary and alternative medicine (CAM) and herbal remedies in particular in different patients groups, but very few are published about co-use among patients in general practice (GP) and ...

    • Coactivation of TLR2 and TLR8 in Primary Human Monocytes Triggers a Distinct Inflammatory Signaling Response 

      Bösl, Korbinian; Giambelluca, Miriam; Haug, Markus; Bugge, Marit; Espevik, Terje; Kandasamy, Richard Kumaran; Bergstrøm, Bjarte Aune (Journal article; Peer reviewed, 2018)
      Innate immune signaling is essential to mount a fast and specific immune response to pathogens. Monocytes and macrophages are essential cells in the early response in their capacity as ubiquitous phagocytic cells. They ...

    • Code-Free Development and Deployment of Deep Segmentation Models for Digital Pathology 

      Pettersen, Henrik P Sahlin; Belevich, Ilya; Røyset, Elin Synnøve; Smistad, Erik; Simpson, Melanie Rae; Jokitalo, Eija; Reinertsen, Ingerid; Bakke, Ingunn; Pedersen, André (Peer reviewed; Journal article, 2022)
      Application of deep learning on histopathological whole slide images (WSIs) holds promise of improving diagnostic efficiency and reproducibility but is largely dependent on the ability to write computer code or purchase ...

    • Coeliac disease in the Trøndelag Health Study (HUNT), Norway, a population-based cohort of coeliac disease patients 

      Lukina, Polina; Andersen, Ina Lervåg; Eggen, Petter Tinbod; Mjønes, Patricia Gjertrud; Rønne, Elin; Bolstad, Nils; Klaasen, Rolf; Warren, David; Iversen, Rasmus; Hveem, Kristian; Bernklev, Tomm; Jelsness-Jørgensen, Lars-Petter; Pedersen, Lise; Jonkers, Iris; Lagergren, Pernilla; Sollid, Ludvig Magne; Lundin, Knut; Ness-Jensen, Eivind (Peer reviewed; Journal article, 2024)
      Purpose - Coeliac disease (CD) is a common disorder and affects about 1% of the population worldwide. CD in the Trøndelag Health Study (HUNT) is a population-based cohort study which was established to provide new knowledge ...